amitriptyline has been researched along with Kidney Failure, Chronic in 5 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For trimipramine the AUC was significantly higher in patients." | 2.67 | [Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure]. ( Degen, J; Fischer, W; Höxter, G; Pintar, P; Seiberling, M; Steinhauer, HB; Wölke, E, 1993) |
| "Pain is a hallmark of this condition and can be extremely difficult to control." | 1.56 | Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians. ( Chinnadurai, R; Lowney, AC; Miller, M; Sinha, S, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chinnadurai, R | 1 |
| Sinha, S | 1 |
| Lowney, AC | 1 |
| Miller, M | 1 |
| Sandoz, M | 1 |
| Vandel, S | 1 |
| Vandel, B | 1 |
| Bonin, B | 1 |
| Hory, B | 1 |
| St Hillier, Y | 1 |
| Volmat, R | 1 |
| Degen, J | 1 |
| Wölke, E | 1 |
| Seiberling, M | 1 |
| Pintar, P | 1 |
| Höxter, G | 1 |
| Steinhauer, HB | 1 |
| Fischer, W | 1 |
| Rosser, R | 1 |
| Lieberman, JA | 1 |
| Cooper, TB | 1 |
| Suckow, RF | 1 |
| Steinberg, H | 1 |
| Borenstein, M | 1 |
| Brenner, R | 1 |
| Kane, JM | 1 |
1 trial available for amitriptyline and Kidney Failure, Chronic
| Article | Year |
|---|---|
[Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure].
Topics: Adult; Aged; Amitriptyline; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle | 1993 |
4 other studies available for amitriptyline and Kidney Failure, Chronic
| Article | Year |
|---|---|
Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians.
Topics: Acetaminophen; Advance Care Planning; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesic | 2020 |
Metabolism of amitriptyline in patients with chronic renal failure.
Topics: Adult; Aged; Amitriptyline; Biotransformation; Depressive Disorder; Female; Humans; Kidney Failure, | 1984 |
Depression during renal dialysis and following transplantation.
Topics: Amitriptyline; Depression; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Mi | 1976 |
Tricyclic antidepressant and metabolite levels in chronic renal failure.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chromatography, Liquid; Depression; Desipramine; | 1985 |