amitriptyline has been researched along with Itching in 19 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-one dogs with nonlesional pruritus were treated with amitriptyline (1 mg/kg orally q12h) to determine its efficacy in the management of canine allergic pruritus." | 7.68 | Nonsteroidal management of canine pruritus with amitriptyline. ( Miller, WH; Scott, DW; Wellington, JR, 1992) |
| "Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 5.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
| "Thirty-one dogs with nonlesional pruritus were treated with amitriptyline (1 mg/kg orally q12h) to determine its efficacy in the management of canine allergic pruritus." | 3.68 | Nonsteroidal management of canine pruritus with amitriptyline. ( Miller, WH; Scott, DW; Wellington, JR, 1992) |
| "Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 1.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Ferreira, S | 1 |
| Azevedo, A | 1 |
| Velho, GC | 1 |
| Sanches, M | 1 |
| Selores, M | 1 |
| Lee, HG | 1 |
| Grossman, SK | 1 |
| Valdes-Rodriguez, R | 1 |
| Berenato, F | 1 |
| Korbutov, J | 1 |
| Chan, YH | 1 |
| Lavery, MJ | 1 |
| Yosipovitch, G | 2 |
| Tarrasón, G | 1 |
| Carcasona, C | 1 |
| Eichhorn, P | 1 |
| Pérez, B | 1 |
| Gavaldà, A | 1 |
| Godessart, N | 1 |
| Jaller, JA | 1 |
| Yong, A | 1 |
| Chong, WS | 1 |
| Tey, HL | 2 |
| Poterucha, TJ | 2 |
| Murphy, SL | 2 |
| Davis, MD | 3 |
| Sandroni, P | 2 |
| Rho, RH | 2 |
| Warndahl, RA | 2 |
| Weiss, WT | 2 |
| Yeo, B | 1 |
| Martin, CM | 1 |
| Griffin, JR | 1 |
| Cardis, MA | 1 |
| Pasieka, HB | 1 |
| SO, Y | 1 |
| KIMINAMI, A | 1 |
| Bernstein, JE | 1 |
| Whitney, DH | 1 |
| Soltani, K | 1 |
| Freilich, RJ | 1 |
| Seidman, AD | 1 |
| Miller, WH | 1 |
| Scott, DW | 1 |
| Wellington, JR | 1 |
| Hampton, MT | 1 |
| Hampton, AA | 1 |
| Davis, RT | 1 |
| Villar, LA | 1 |
| Borelli, S | 1 |
| Etter, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
3 trials available for amitriptyline and Itching
| Article | Year |
|---|---|
Inhibition of histamine-induced pruritus by topical tricyclic antidepressants.
Topics: Administration, Topical; Amitriptyline; Antidepressive Agents, Tricyclic; Diphenhydramine; Double-Bl | 1981 |
Pruritus caused by 3-hour infusion of high-dose paclitaxel and improvement with tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Breast Neoplasms; Humans; Infusions, Intravenous; N | 1995 |
[Antidepressive therapy of neurodermatitis in atopic subjects].
Topics: Adolescent; Adult; Aged; Amitriptyline; Chlordiazepoxide; Climate; Clinical Trials as Topic; Depress | 1971 |
16 other studies available for amitriptyline and Itching
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Epidermolysis Bullosa Pruriginosa successfully treated with concomitant topical and systemic agents.
Topics: Administration, Topical; Amitriptyline; Analgesics; Drug Therapy, Combination; Epidermolysis Bullosa | 2020 |
Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability.
Topics: Aged; Amines; Amitriptyline; Analgesics; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Therapy, | 2017 |
Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
Topics: Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricy | 2017 |
Successful Treatment of Epidermal Nevus-associated Pruritus with Topical Ketamine-Amitriptyline-Lidocaine.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Antipruritics; Drug Combinations; Forehead; Hu | 2018 |
Effective treatment of uremic pruritus and acquired perforating dermatosis with amitriptyline.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Humans; Male; Middle Aged; Pruritus; Renal Insufficienc | 2014 |
Topical amitriptyline-ketamine for the treatment of brachioradial pruritus.
Topics: Administration, Cutaneous; Adult; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Forearm; Huma | 2013 |
Effective treatment of notalgia paresthetica with amitriptyline.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Male; Middle Aged; Peripheral Nervous Syste | 2013 |
Topical amitriptyline combined with topical ketamine for the management of recalcitrant localized pruritus: a retrospective pilot study.
Topics: Administration, Topical; Adult; Aged; Amitriptyline; Chronic Disease; Female; Follow-Up Studies; Hum | 2013 |
Lessons learned from hospice care.
Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics, Opioid; Drug Monitoring; Fentanyl; Health Servic | 2013 |
Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Drug Combinations; Gels; Herpes Zoster; Humans | 2015 |
Safety of Topical Neuromodulators for the Treatment of Pruritus.
Topics: Administration, Topical; Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Dose-Response R | 2016 |
[USE OF TRYPTANOL IN VARIOUS PRURITIC SKIN DISEASES].
Topics: Adolescent; Amitriptyline; Dermatitis; Eczema; Erythema Multiforme; Exanthema; Female; Geriatrics; H | 1964 |
Nonsteroidal management of canine pruritus with amitriptyline.
Topics: Amitriptyline; Animals; Dermatitis, Atopic; Dog Diseases; Dogs; Female; Follow-Up Studies; Male; Pru | 1992 |
Ciguatera fish poisoning.
Topics: Amitriptyline; Animals; Ciguatera Poisoning; Female; Fishes; Food Contamination; Humans; Marine Toxi | 1989 |
Symptomatic improvement with amitriptyline in ciguatera fish poisoning.
Topics: Amitriptyline; Animals; Ciguatera Poisoning; Fishes, Poisonous; Foodborne Diseases; Humans; Hypesthe | 1986 |