amitriptyline has been researched along with Inflammation in 20 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, the study objectives were to investigate the effects of the tricyclic antidepressant amitriptyline on mood, learning, central cytokine expression and skeletal muscle inflammation in mdx mice." | 7.80 | Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy. ( Bouma, J; Jensen, L; Kulbida, R; Manning, J; O'Malley, D; Rai, P; Singh, SP; Yilmazer-Hanke, D, 2014) |
| "Single and multiple doses of amitriptyline were administered to rats submitted to the carrageenan-induced paw edema model." | 7.76 | Amitriptyline and acute inflammation: a study using intravital microscopy and the carrageenan-induced paw edema model. ( Alves, GJ; Palermo-Neto, J; Vismari, L, 2010) |
| "The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats." | 7.76 | The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats. ( Hajhashemi, V; Minaiyan, M; Movahedian, A; Sadeghi, H; Talebi, A, 2010) |
| " treated ureterally obstructed mice with the tricyclic antidepressant amitriptyline and found that this inhibited inflammation, myofibroblast formation, and several other indices of renal fibrosis." | 7.75 | Pleiotropic effects of amitriptyline ameliorate renal fibrosis. ( Morrissey, JJ, 2009) |
| "Amitriptyline is a pleiotropic tricyclic antidepressant, which has anti-oxidant and anti-inflammatory properties." | 5.35 | Amitriptyline attenuates interstitial inflammation and ameliorates the progression of renal fibrosis. ( Achar, E; Collares, CF; Maciel, TT; Schor, N; Teixeira, VP, 2009) |
| "Recent data has signaled that in addition to its therapeutic indications as antidepressant and analgesic, amitriptyline (AM) exerts anti-inflammatory effects in humans and experimental animal models of acute inflammation." | 4.02 | Amitriptyline Downregulates Chronic Inflammatory Response to Biomaterial in Mice. ( Andrade, SP; Campos, PP; Capettini, LSA; Lazari, MGT; Machado, CT; Orellano, LAA; Scheuermann, K; Viana, CTR, 2021) |
| " Therefore, the study objectives were to investigate the effects of the tricyclic antidepressant amitriptyline on mood, learning, central cytokine expression and skeletal muscle inflammation in mdx mice." | 3.80 | Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy. ( Bouma, J; Jensen, L; Kulbida, R; Manning, J; O'Malley, D; Rai, P; Singh, SP; Yilmazer-Hanke, D, 2014) |
| "Single and multiple doses of amitriptyline were administered to rats submitted to the carrageenan-induced paw edema model." | 3.76 | Amitriptyline and acute inflammation: a study using intravital microscopy and the carrageenan-induced paw edema model. ( Alves, GJ; Palermo-Neto, J; Vismari, L, 2010) |
| "The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats." | 3.76 | The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats. ( Hajhashemi, V; Minaiyan, M; Movahedian, A; Sadeghi, H; Talebi, A, 2010) |
| " treated ureterally obstructed mice with the tricyclic antidepressant amitriptyline and found that this inhibited inflammation, myofibroblast formation, and several other indices of renal fibrosis." | 3.75 | Pleiotropic effects of amitriptyline ameliorate renal fibrosis. ( Morrissey, JJ, 2009) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| "L-acetylcarnitine treatment enhanced mGlu2/3 receptor protein levels in the dorsal region of the spinal cord." | 1.46 | Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. ( Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C, 2017) |
| "Results revealed that T." | 1.43 | Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice. ( Esmaeilpour, K; Ghazvini, H; Keshavarz, H; Mahmoudvand, H; Sheibani, V; Shojaee, S; Ziaali, N, 2016) |
| "Amitriptyline treatment initiated at day-0 or day-4 post-ligature placement alleviated hyperalgesia." | 1.35 | Antinociception occurs with a reversal in alpha 2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory. ( Ignatowski, TA; Nader, ND; Spengler, RN; Sud, R, 2008) |
| "Amitriptyline is a pleiotropic tricyclic antidepressant, which has anti-oxidant and anti-inflammatory properties." | 1.35 | Amitriptyline attenuates interstitial inflammation and ameliorates the progression of renal fibrosis. ( Achar, E; Collares, CF; Maciel, TT; Schor, N; Teixeira, VP, 2009) |
| " The relative oral/intramuscular bioavailability of amitriptyline was only 13%, and the steady-state concentrations of this drug on four consecutive days were acutely subtherapeutic (i." | 1.27 | Decreased drug absorption in a patient with Behçet's syndrome. ( Atiyeh, M; Chaleby, K; el-Yazigi, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blaess, M | 1 |
| Bibak, N | 1 |
| Claus, RA | 1 |
| Kohl, M | 1 |
| Bonaterra, GA | 1 |
| Kinscherf, R | 1 |
| Laufer, S | 1 |
| Deigner, HP | 1 |
| Scheuermann, K | 1 |
| Orellano, LAA | 1 |
| Viana, CTR | 1 |
| Machado, CT | 1 |
| Lazari, MGT | 1 |
| Capettini, LSA | 1 |
| Andrade, SP | 1 |
| Campos, PP | 1 |
| Notartomaso, S | 1 |
| Mascio, G | 1 |
| Bernabucci, M | 1 |
| Zappulla, C | 1 |
| Scarselli, P | 1 |
| Cannella, M | 1 |
| Imbriglio, T | 1 |
| Gradini, R | 1 |
| Battaglia, G | 1 |
| Bruno, V | 1 |
| Nicoletti, F | 1 |
| Schneider-Schaulies, J | 1 |
| Beyersdorf, N | 1 |
| Xia, BT | 1 |
| Beckmann, N | 1 |
| Winer, LK | 1 |
| Pugh, AM | 1 |
| Pritts, TA | 1 |
| Nomellini, V | 1 |
| Gulbins, E | 1 |
| Caldwell, CC | 1 |
| Manning, J | 1 |
| Kulbida, R | 1 |
| Rai, P | 1 |
| Jensen, L | 1 |
| Bouma, J | 1 |
| Singh, SP | 1 |
| O'Malley, D | 1 |
| Yilmazer-Hanke, D | 1 |
| Mahmoudvand, H | 1 |
| Ziaali, N | 1 |
| Ghazvini, H | 1 |
| Shojaee, S | 1 |
| Keshavarz, H | 1 |
| Esmaeilpour, K | 1 |
| Sheibani, V | 1 |
| Fanton, GS | 1 |
| Dillingham, MF | 1 |
| Wall, MS | 1 |
| Gillenwater, GE | 1 |
| Khan, AM | 1 |
| Carver, TJ | 1 |
| Perkins, JG | 1 |
| Demopulos, GA | 1 |
| Sud, R | 1 |
| Spengler, RN | 1 |
| Nader, ND | 1 |
| Ignatowski, TA | 1 |
| Achar, E | 1 |
| Maciel, TT | 1 |
| Collares, CF | 1 |
| Teixeira, VP | 1 |
| Schor, N | 1 |
| Morrissey, JJ | 1 |
| Vismari, L | 2 |
| Alves, GJ | 2 |
| Palermo-Neto, J | 2 |
| Hajhashemi, V | 2 |
| Sadeghi, H | 2 |
| Minaiyan, M | 2 |
| Movahedian, A | 2 |
| Talebi, A | 2 |
| Peruga, I | 1 |
| Hartwig, S | 1 |
| Thöne, J | 1 |
| Hovemann, B | 1 |
| Gold, R | 1 |
| Juckel, G | 1 |
| Linker, RA | 1 |
| Muscará, MN | 1 |
| Leduc, C | 1 |
| Gentili, ME | 1 |
| Estèbe, JP | 1 |
| Le Corre, P | 1 |
| Moulinoux, JP | 1 |
| Ecoffey, C | 1 |
| Abdel-Salam, OM | 1 |
| Nofal, SM | 1 |
| El-Shenawy, SM | 1 |
| Tai, YH | 1 |
| Wang, YH | 1 |
| Wang, JJ | 1 |
| Tao, PL | 1 |
| Tung, CS | 1 |
| Wong, CS | 1 |
| Chaleby, K | 1 |
| el-Yazigi, A | 1 |
| Atiyeh, M | 1 |
1 review available for amitriptyline and Inflammation
| Article | Year |
|---|---|
CD4+ Foxp3+ regulatory T cell-mediated immunomodulation by anti-depressants inhibiting acid sphingomyelinase.
Topics: Amitriptyline; Animals; Antidepressive Agents; Autoimmune Diseases; Forkhead Transcription Factors; | 2018 |
1 trial available for amitriptyline and Inflammation
| Article | Year |
|---|---|
Novel drug product to improve joint motion and function and reduce pain after arthroscopic anterior cruciate ligament reconstruction.
Topics: Adult; Amitriptyline; Analgesics; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; A | 2008 |
18 other studies available for amitriptyline and Inflammation
| Article | Year |
|---|---|
NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation.
Topics: Apoptosis; Cell Line; Cells, Cultured; Ceramides; Enzyme Inhibitors; Humans; Inflammation; Lipopolys | 2018 |
Amitriptyline Downregulates Chronic Inflammatory Response to Biomaterial in Mice.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Biocompatible Materials; Biomarkers; Blotting, Wes | 2021 |
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigen | 2017 |
Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.
Topics: Amitriptyline; Animals; Bronchoalveolar Lavage Fluid; Ceramides; Chemokine CCL2; Cytokines; Disease | 2019 |
Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Disease Mode | 2014 |
Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Cytokines; Disease Models, Animal; Hyperalgesia; I | 2016 |
Antinociception occurs with a reversal in alpha 2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory.
Topics: Amitriptyline; Analgesics; Animals; Inflammation; Lipopolysaccharides; Macrophages; Male; Monocytes; | 2008 |
Amitriptyline attenuates interstitial inflammation and ameliorates the progression of renal fibrosis.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biomarkers; Cell Movement; Disease Progres | 2009 |
Pleiotropic effects of amitriptyline ameliorate renal fibrosis.
Topics: Amitriptyline; Animals; Fibroblasts; Fibrosis; Inflammation; Kidney Diseases; Mice | 2009 |
Amitriptyline and acute inflammation: a study using intravital microscopy and the carrageenan-induced paw edema model.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Half-L | 2010 |
The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Amitriptyline; Animals; Anti-Inflammatory Agents; Carrageen | 2010 |
Inflammation modulates anxiety in an animal model of multiple sclerosis.
Topics: Acoustic Stimulation; Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic | 2011 |
A study on the mechanisms involving the anti-inflammatory effect of amitriptyline in carrageenan-induced paw edema in rats.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Extremities; Inflammation; Inf | 2011 |
A possible role to nitric oxide in the anti-inflammatory effects of amitriptyline.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; C | 2012 |
The effect of local anesthetics and amitriptyline on peroxidation in vivo in an inflammatory rat model: preliminary reports.
Topics: Amides; Amitriptyline; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Bupivacaine; C | 2002 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
Amitriptyline suppresses neuroinflammation and up-regulates glutamate transporters in morphine-tolerant rats.
Topics: Amino Acid Transport System X-AG; Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal | 2006 |
Decreased drug absorption in a patient with Behçet's syndrome.
Topics: Acetaminophen; Adult; Amitriptyline; Behcet Syndrome; Biological Availability; Diazepam; Female; Hum | 1987 |