amitriptyline has been researched along with Inadequate Sleep in 13 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a cross-over design, 44 patients with a major depressive episode (ICD-10) were randomly allocated to 4 weeks treatment with amitriptyline (150 mg/d) in combination with either late sleep deprivation (of the second half of the night, LSD) twice weekly during week 1 and 2 followed by LSDs once weekly during week 3 and 4 or vice versa." | 2.69 | Repeated sleep deprivation once versus twice a week in combination with amitriptyline. ( Kemper, B; Kuhs, H; Lippe-Neubauer, U; Meyer-Dunker, J; Tölle, R, 1998) |
| "The immediate antidepressive effect of sleep deprivation diminished in the course of the sleep deprivation series." | 2.68 | Amitriptyline in combination with repeated late sleep deprivation versus amitriptyline alone in major depression. A randomised study. ( Borgstädt, S; Färber, D; Kuhs, H; Mrosek, S; Tölle, R, 1996) |
| "Sleep deprivation has been associated with hyperalgesia in humans and in animal models." | 1.35 | Systemic amitriptyline administration does not prevent the increased thermal response induced by paradoxical sleep deprivation. ( Araújo, PC; Damasceno, F; de Almeida, OM; Gomes, A; Skinner, GO, 2009) |
| "In connection with findings from sleep deprivation research in animals and in healthy subjects, the results suggest that thyroid changes under PSD may be nonspecific and unrelated to antidepressive PSD effects." | 1.29 | Serum prolactin, growth hormone, total corticoids, thyroid hormones and thyrotropine during serial therapeutic sleep deprivation. ( Farber, D; Kuhs, H; Tolle, R, 1996) |
| "31 inpatients suffering from endogenous depression were subjected to walking therapy three times at intervals of one week." | 1.28 | [Repeating antidepressive sleep deprivation therapy (partial sleep deprivation)]. ( Fischer, H; Telger, K; Tölle, R, 1990) |
| "In the treatment of endogenous depression REM sleep deprivation and imipramine have similar efficacy." | 1.27 | Evidence for REM sleep deprivation as the mechanism of action of antidepressant drugs. ( Vogel, GW, 1983) |
| "Forty-six patients with various forms of endogenous depression were treated by night sleep deprivation (NSD) which was used as the cardinal method of treatment." | 1.27 | [Sleep deprivation as a method of treating endogenous depression]. ( Fakturovich, AIa; Vovin, RIa, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (53.85) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Damasceno, F | 1 |
| Skinner, GO | 1 |
| Gomes, A | 1 |
| Araújo, PC | 1 |
| de Almeida, OM | 1 |
| Morgan, LK | 1 |
| Vogel, GW | 2 |
| Kuhs, H | 3 |
| Färber, D | 2 |
| Borgstädt, S | 1 |
| Mrosek, S | 1 |
| Tölle, R | 7 |
| Kemper, B | 1 |
| Lippe-Neubauer, U | 1 |
| Meyer-Dunker, J | 1 |
| Wiegand, MH | 1 |
| Lauer, CJ | 1 |
| Schreiber, W | 1 |
| Telger, K | 1 |
| Fischer, H | 1 |
| Vovin, RIa | 1 |
| Fakturovich, AIa | 1 |
| Bojanovsky, J | 2 |
| Koch, W | 1 |
| Pflug, B | 1 |
| Traub, AC | 1 |
| Ben-Horin, P | 1 |
| Meyers, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjunctive Triple Chronotherapy in the Acute Treatment of Depression and Suicidality in the Adolescent Population: A Randomized Controlled Trial[NCT03679962] | 64 participants (Actual) | Interventional | 2019-01-25 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for amitriptyline and Inadequate Sleep
| Article | Year |
|---|---|
Amitriptyline in combination with repeated late sleep deprivation versus amitriptyline alone in major depression. A randomised study.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Combined Modality Th | 1996 |
Repeated sleep deprivation once versus twice a week in combination with amitriptyline.
Topics: Adult; Aged; Amitriptyline; Analysis of Variance; Circadian Rhythm; Combined Modality Therapy; Cross | 1998 |
Disturbance of the 24-hour rhythm in endogenous depression and the treatment of endogenous depression by sleep deprivation.
Topics: Adjustment Disorders; Adult; Age Factors; Amitriptyline; Antidepressive Agents; Blood Pressure; Circ | 1971 |
10 other studies available for amitriptyline and Inadequate Sleep
| Article | Year |
|---|---|
Systemic amitriptyline administration does not prevent the increased thermal response induced by paradoxical sleep deprivation.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Body Tempe | 2009 |
Restless limbs: a commonly overlooked symptom controlled by "Valium".
Topics: Adolescent; Adult; Amitriptyline; Australia; Child; Diagnosis, Differential; Diazepam; Female; Human | 1967 |
Evidence for REM sleep deprivation as the mechanism of action of antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Humans; Imipra | 1983 |
Serum prolactin, growth hormone, total corticoids, thyroid hormones and thyrotropine during serial therapeutic sleep deprivation.
Topics: Adrenal Cortex Hormones; Amitriptyline; Depressive Disorder; Growth Hormone; Humans; Prolactin; Slee | 1996 |
Patterns of response to repeated total sleep deprivations in depression.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Female; Humans; Male; M | 2001 |
[Repeating antidepressive sleep deprivation therapy (partial sleep deprivation)].
Topics: Adult; Amitriptyline; Circadian Rhythm; Combined Modality Therapy; Depressive Disorder; Female; Huma | 1990 |
[Sleep deprivation as a method of treating endogenous depression].
Topics: Adult; Amitriptyline; Anxiety; Depersonalization; Depressive Disorder; Diazepam; Female; Humans; Imi | 1985 |
[Effect of antidepressive therapy on disordered time estimation in patients with depression].
Topics: Adult; Amitriptyline; Biological Clocks; Depression; Humans; Male; Middle Aged; Perceptual Disorders | 1973 |
[Electrolyte changes with antidepressive therapy. Sleep deprivation and thymoleptic medication (author's transl)].
Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents; Calcium; Chlorides; Depression; E | 1974 |
REM deprivation. II. The effects on depressed patients.
Topics: Amitriptyline; Catecholamines; Depression; Dreams; Electroencephalography; Eye Movements; Female; Hu | 1968 |