amitriptyline has been researched along with Idiopathic Parkinson Disease in 23 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study." | 9.12 | Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life. ( Antonini, A; Barone, P; Canesi, M; De Gaspari, D; Mariani, C; Meucci, N; Pezzoli, G; Sacilotto, G; Tesei, S; Zecchinelli, A, 2006) |
| "We evaluated the effect of 25 mg bid amitriptyline on muscle contraction headache in 36 patients with Parkinson's disease in a randomized double-blind placebo-controlled study." | 9.06 | Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study. ( Carrieri, PB; Indaco, A, 1988) |
| "We discuss a case of a patient with restless legs syndrome that was responsive to administration of amitriptyline." | 7.67 | Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease. ( Bamford, CR; Iacono, RP; Sandyk, R, 1988) |
| "We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study." | 5.12 | Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life. ( Antonini, A; Barone, P; Canesi, M; De Gaspari, D; Mariani, C; Meucci, N; Pezzoli, G; Sacilotto, G; Tesei, S; Zecchinelli, A, 2006) |
| "We evaluated the effect of 25 mg bid amitriptyline on muscle contraction headache in 36 patients with Parkinson's disease in a randomized double-blind placebo-controlled study." | 5.06 | Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study. ( Carrieri, PB; Indaco, A, 1988) |
| "We discuss a case of a patient with restless legs syndrome that was responsive to administration of amitriptyline." | 3.67 | Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease. ( Bamford, CR; Iacono, RP; Sandyk, R, 1988) |
| "Drooling is a distressing symptom for adults with neurological conditions and can be challenging for health professionals." | 2.48 | The management of drooling in adults with neurological conditions. ( Rowson, J; Squires, N; Wills, A, 2012) |
| "A patient with progressive supranuclear palsy (PSP) showing severe akinesia, postural instability and gait disturbance like frozen gait was treated with amitriptyline (30 mg/day)." | 1.29 | [A case of progressive supranuclear palsy showing marked improvements of frontal hypoperfusion, as well as parkinsonism with amitriptyline]. ( Asanuma, M; Hirata, H; Kondo, Y; Ogawa, N, 1993) |
| " The following report concerns a 62-year-old female Parkinsonian patient with levodopa-induced "On-Off", depression and sleep disturbances, the severity of which was dramatically reduced by administration of low dosage amitriptyline (a serotonergic agent)." | 1.27 | Serotonergic mechanisms in levodopa-induced "on-off" and sleep disorders in Parkinson's disease. ( Sandyk, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (69.57) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Kwon, SH | 1 |
| Kim, S | 1 |
| Park, AY | 1 |
| Lee, S | 2 |
| Gadhe, CG | 1 |
| Seo, BA | 1 |
| Park, JS | 1 |
| Jo, S | 1 |
| Oh, Y | 1 |
| Kweon, SH | 1 |
| Ma, SX | 1 |
| Kim, WR | 1 |
| Kim, M | 1 |
| Kim, H | 1 |
| Kim, JE | 1 |
| Lee, J | 1 |
| Ko, HS | 1 |
| Lee, MY | 1 |
| Hong, S | 1 |
| Kim, N | 1 |
| Shin, KS | 1 |
| Kang, SJ | 1 |
| Squires, N | 1 |
| Wills, A | 1 |
| Rowson, J | 1 |
| GILLINGHAM, FJ | 1 |
| KALYANARAMAN, S | 1 |
| Antonini, A | 1 |
| Tesei, S | 1 |
| Zecchinelli, A | 1 |
| Barone, P | 1 |
| De Gaspari, D | 1 |
| Canesi, M | 1 |
| Sacilotto, G | 1 |
| Meucci, N | 1 |
| Mariani, C | 1 |
| Pezzoli, G | 1 |
| Mastrosimone, F | 1 |
| Colucci d'Amato, C | 1 |
| De Angelis, G | 1 |
| Iaccarino, C | 1 |
| Giordano, L | 1 |
| Marmo, E | 1 |
| Edwards, M | 1 |
| Sim, MK | 1 |
| Ratnam, KV | 1 |
| Asanuma, M | 1 |
| Hirata, H | 1 |
| Kondo, Y | 1 |
| Ogawa, N | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Rampton, DS | 1 |
| Storm, W | 1 |
| Indaco, A | 1 |
| Carrieri, PB | 1 |
| Sandyk, R | 2 |
| Iacono, RP | 1 |
| Bamford, CR | 1 |
| Wagshul, AM | 1 |
| Daroff, RB | 1 |
| Roos, BE | 1 |
| Markham, CH | 1 |
| Yahr, MD | 1 |
| Duvoisin, RC | 1 |
| Presthus, J | 1 |
| Knopp, W | 1 |
| Kilpatrick, R | 1 |
| Smith, AJ | 1 |
6 reviews available for amitriptyline and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
The management of drooling in adults with neurological conditions.
Topics: Administration, Cutaneous; Adult; Amitriptyline; Atropine; Behavior Therapy; Botulinum Toxins, Type | 2012 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
Drug therapy of parkinsonism.
Topics: Amantadine; Amitriptyline; Amphetamine; Antiparkinson Agents; Dihydroxyphenylalanine; Drug Antagonis | 1972 |
[Other trials with drug therapy in parkinsonism].
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Dihydroxyphenylalanine; Disulfiram; Drug Evaluation; Dr | 1973 |
[Therapy of Parkinsonism. II].
Topics: Amantadine; Amitriptyline; Humans; Imipramine; Levodopa; Parkinson Disease; Physical Therapy Modalit | 1974 |
Advances in medicine.
Topics: Amitriptyline; Cholera; Coronary Disease; Crohn Disease; Diabetes Mellitus; Diet Therapy; Diverticul | 1971 |
3 trials available for amitriptyline and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life.
Topics: Amitriptyline; Antidepressive Agents; Depression; Female; Humans; Male; Middle Aged; Parkinson Disea | 2006 |
Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Humans; | 1988 |
Psychiatric changes in patients treated with levodopa. I. The clinical experiment.
Topics: Activities of Daily Living; Adjustment Disorders; Aged; Amitriptyline; Clinical Trials as Topic; Dia | 1970 |
14 other studies available for amitriptyline and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease.
Topics: Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Neuroprotective Ag | 2021 |
Tricyclic Antidepressants Amitriptyline and Desipramine Induced Neurotoxicity Associated with Parkinson's Disease.
Topics: Adenosine Triphosphate; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Apop | 2015 |
PARKINSON'S DISEASE.
Topics: Amitriptyline; Dextroamphetamine; Humans; Imipramine; Muscle Relaxants, Central; Neurosurgery; Orphe | 1963 |
Personal experience with a combination of drugs in subjects with dopa resistant Parkinson's disease.
Topics: Amantadine; Amitriptyline; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Hyper | 1980 |
Adverse interaction of levodopa with tricyclic antidepressants.
Topics: Aged; Amitriptyline; Carbidopa; Drug Combinations; Drug Interactions; Female; Humans; Imipramine; Le | 1982 |
Treatment of disease without the use of drugs. V. Phasing out of benzodiazepine and amitriptyline medication with thought control.
Topics: Adult; Amitriptyline; Behavior Therapy; Benzodiazepines; Breathing Exercises; Female; Gastritis; Hum | 1980 |
[A case of progressive supranuclear palsy showing marked improvements of frontal hypoperfusion, as well as parkinsonism with amitriptyline].
Topics: Amitriptyline; Animals; Cerebrovascular Circulation; Female; Frontal Lobe; Gait; Humans; Middle Aged | 1993 |
Hypertensive crisis in a patient given sinemet, metoclopramide, and amitriptyline.
Topics: Acute Disease; Amitriptyline; Carbidopa; Drug Combinations; Drug Therapy, Combination; Female; Human | 1977 |
Differential diagnosis and treatment of depressive features in Down's syndrome: a case illustration.
Topics: Adult; Amitriptyline; Brain; Depressive Disorder; Diagnosis, Differential; Down Syndrome; Humans; Ma | 1990 |
Serotonergic mechanisms in levodopa-induced "on-off" and sleep disorders in Parkinson's disease.
Topics: Amitriptyline; Female; Humans; Levodopa; Middle Aged; Parkinson Disease; Serotonin; Sleep Wake Disor | 1988 |
Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease.
Topics: Amitriptyline; Humans; Male; Middle Aged; Parkinson Disease; Restless Legs Syndrome; Spinal Cord; Sy | 1988 |
Depression during L-dopa treatment.
Topics: Aged; Amitriptyline; Depression; Dihydroxyphenylalanine; Humans; Male; Middle Aged; Parkinson Diseas | 1969 |
[Parkinson's syndrome. 10. Effects of psychopharmacological agents on central monoamine neurons].
Topics: Amitriptyline; Humans; Imipramine; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Reserpi | 1970 |
The "on-off" side effect of L-DOPA.
Topics: Age Factors; Amitriptyline; Aromatic Amino Acid Decarboxylase Inhibitors; Athetosis; Carbidopa; Cate | 1974 |