Page last updated: 2024-10-22

amitriptyline and Hypothermia

amitriptyline has been researched along with Hypothermia in 12 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.

Research Excerpts

ExcerptRelevanceReference
"In this case report, a 22-year-old male developed severe hypothermia after an accidental overdose of cyclobenzaprine."3.81Use of an Intravascular Heat Exchange Catheter and Intravenous Lipid Emulsion for Hypothermic Cardiac Arrest After Cyclobenzaprine Overdose. ( Awad, NI; Bridgeman, PJ; Jeges, J; McCoy, JV; Page, E; Westrol, MS, 2015)
" Chronic treatment with amitriptyline (AMI) further impaired 5-HT1A-mediated hypothermia."3.685-HT1A receptor function in depression: effect of chronic amitriptyline treatment. ( Disselkamp-Tietze, J; Lesch, KP; Schmidtke, A, 1990)
"3."1.28Chronic treatment with amitriptyline produces subsensitivity to the hypothermic effects of clonidine. ( Davidson, R; Dilsaver, SC; Majchrzak, M, 1989)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19909 (75.00)18.7374
1990's1 (8.33)18.2507
2000's1 (8.33)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Martínez-Esparza, J1
Oficialdegui, AM1
Pérez-Silanes, S1
Heras, B1
Orús, L1
Palop, JA1
Lasheras, B1
Roca, J1
Mourelle, M1
Bosch, A1
Del Castillo, JC1
Tordera, R1
Del Río, J1
Monge, A1
Westrol, MS1
Awad, NI1
Bridgeman, PJ1
Page, E1
McCoy, JV1
Jeges, J1
METYSOVA, J2
METYS, J2
ASKEW, BM1
Lesch, KP1
Disselkamp-Tietze, J1
Schmidtke, A1
Dilsaver, SC2
Davidson, RK1
Davidson, R1
Majchrzak, M1
Collins, JV1
Townsend, J1
Harris, PW1
Clark, TJ1
Goulding, R1
Yom-Tov, B1
Gronowitz, S1
Ross, SB1
Stjernström, NE1
Lapin, IP1
Zetler, G1

Other Studies

12 other studies available for amitriptyline and Hypothermia

ArticleYear
New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.
    Journal of medicinal chemistry, 2001, Feb-01, Volume: 44, Issue:3

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Carrier Proteins; Colony-Forming Units Assay; Co

2001
Use of an Intravascular Heat Exchange Catheter and Intravenous Lipid Emulsion for Hypothermic Cardiac Arrest After Cyclobenzaprine Overdose.
    Therapeutic hypothermia and temperature management, 2015, Volume: 5, Issue:3

    Topics: Amitriptyline; Cardiopulmonary Bypass; Cardiopulmonary Resuscitation; Drug Overdose; Fat Emulsions,

2015
[CONTRIBUTION TO THE DIFFERENTIATION OF THYMOLEPTICS AND NEUROLEPTICS].
    Activitas nervosa superior, 1963, Volume: 5

    Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Chlorprothixene; Hypothe

1963
A SIMPLE SCREENING PROCEDURE FOR IMIPRAMINE-LIKE ANTIDEPRESSANT AGENTS.
    Life sciences (1962), 1963, Volume: 10

    Topics: 5-Hydroxytryptophan; Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Atropine; Beme

1963
PHARMACOLOGICAL PROPERTIES OF THE DESMETHYL DERIVATIVES OF SOME ANTIDEPRESSANTS OF IMIPRAMINE TYPE.
    International journal of neuropharmacology, 1965, Volume: 4

    Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Indu

1965
5-HT1A receptor function in depression: effect of chronic amitriptyline treatment.
    Journal of neural transmission. General section, 1990, Volume: 80, Issue:2

    Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Hypothermia; Male; Middle Aged; Pyrimidin

1990
Chronic treatment with amitriptyline produces subsensitivity to the hypothermic effects of yohimbine.
    Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:1-2

    Topics: Amitriptyline; Animals; Body Temperature; Drug Synergism; Hypothermia; Male; Rats; Rats, Inbred Stra

1989
Chronic treatment with amitriptyline produces subsensitivity to the hypothermic effects of clonidine.
    Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:1-2

    Topics: Amitriptyline; Animals; Body Temperature; Clonidine; Drug Administration Schedule; Drug Synergism; H

1989
Plasma-11-hydroxycorticosteroid levels in drug-induced coma.
    Lancet (London, England), 1971, Jul-24, Volume: 2, Issue:7717

    Topics: Adrenal Cortex Hormones; Adrenal Glands; Amitriptyline; Barbiturates; Blood Pressure; Body Temperatu

1971
Antidepressant agents. II. Thiophene analogues of amitriptyline and nortriptyline.
    Acta pharmaceutica Suecica, 1974, Volume: 11, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chemical Phenomena; Chemistry; Cocai

1974
Proceedings: Antagonism of nicotinic acid and other kynurenines to antidepressants: one of the probable reasons of the therapy-resistance in depression?
    Activitas nervosa superior, 1974, Volume: 16, Issue:4

    Topics: Allopurinol; Amitriptyline; Animals; Depression; Drug Interactions; Humans; Hypnotics and Sedatives;

1974
Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs.
    International journal of neuropharmacology, 1968, Volume: 7, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Catalepsy; Desipramine; Hexamethonium Compo

1968