amitriptyline has been researched along with Hypotension in 31 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl." | 7.66 | [Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium]. ( Pallmert, N; Seitz, R; Wehr, M, 1982) |
| "Amitriptyline intoxication was induced by the continuous infusion of amitriptyline 0." | 5.31 | The effect of the nitric oxide synthesis inhibitor L-NAME on amitriptyline-induced hypotension in rats. ( Arkan, F; Aygoren, O; Guven, H; Kalkan, S; Kurt, S; Murat, N; Tuncok, Y, 2002) |
| " Here we report a 25-year-old female presenting with coma and hemodynamic instability following intentional ingestion of amitriptyline." | 3.78 | Lipid therapy for the treatment of a refractory amitriptyline overdose. ( Kiberd, MB; Minor, SF, 2012) |
| " Patients with an amitriptyline overdose were more likely to have seizure, coma, tachycardia, a wide QRS or ventricular dysrhythmia, and have received sodium bicarbonate or be intubated." | 3.77 | Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose. ( Bebarta, VS; Borys, DJ; Maddry, J; Morgan, DL, 2011) |
| "Adenosine antagonists were found to be effective in improving hypotension, QRS prolongation and survival time in our rat model of amitriptyline toxicity." | 3.72 | Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? ( Akgun, A; Aygoren, O; Gidener, S; Guven, H; Kalkan, S; Tuncok, Y, 2004) |
| " Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl." | 3.66 | [Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium]. ( Pallmert, N; Seitz, R; Wehr, M, 1982) |
| " The relative safety of different antidepressants has been assessed by looking at answers to the questions: how safe is the drug in overdose; how dangerous are its side effects at therapeutic dose; and does it have any dangerous interactions with other drugs or substances? Based on current data it can be said with reasonable confidence that fluvoxamine, fluoxetine, paroxetine and moclobemide are "safe" antidepressants, and mianserin and trazodone are also "safe" but to a lesser extent (mainly because of hypnosedation)." | 2.39 | Safety of antidepressants. ( de Jonghe, F; Swinkels, JA, 1995) |
| " This patient presented a problem of difficult intubation as Noonan's syndrome and had a history of a long-term use of antidepressant, which might induce sympathomimetic resistant hypotension." | 1.33 | [General anesthesia for a patient with Noonan's syndrome and long-term antidepressant therapy]. ( Hanaoka, K; Nakamura, S; Nishiyama, T; Takeda, K, 2005) |
| "Amitriptyline intoxication was induced by the continuous infusion of amitriptyline 0." | 1.31 | The effect of the nitric oxide synthesis inhibitor L-NAME on amitriptyline-induced hypotension in rats. ( Arkan, F; Aygoren, O; Guven, H; Kalkan, S; Kurt, S; Murat, N; Tuncok, Y, 2002) |
| " We review the anesthetic implications of chronic use of tricyclic antidepressives as they affect choice of vasopressin for treating hypotensive events during anesthesia." | 1.30 | [Hypotension refractory to ephedrine after sympathetic blockade in a patient on long-term therapy with tricyclic antidepressants]. ( Boada, S; Papaceit, J; Rull, M; Saludes, J; Solsona, B, 1999) |
| "Phenytoin has been proposed as a prophylaxis and treatment of these dysrhythmias, since it is thought to improve conduction in this setting." | 1.27 | Phenytoin prophylaxis of cardiotoxicity in experimental amitriptyline poisoning. ( Callaham, M; Pentel, P; Schumaker, H, 1988) |
| "Imipramine was less arrhythmogenic and caused less fall in blood pressure for a given dose than amitriptyline or doxepin." | 1.26 | Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin. ( Brown, TC; Leversha, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (67.74) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaicker, J | 1 |
| Bostwick, J | 1 |
| Bebarta, VS | 1 |
| Maddry, J | 1 |
| Borys, DJ | 1 |
| Morgan, DL | 1 |
| Kiberd, MB | 1 |
| Minor, SF | 1 |
| Tuncok, Y | 2 |
| Kalkan, S | 2 |
| Murat, N | 1 |
| Arkan, F | 1 |
| Guven, H | 2 |
| Aygoren, O | 2 |
| Kurt, S | 1 |
| BLACHLY, PH | 1 |
| KOLLBERG, H | 1 |
| SORENSEN, NS | 1 |
| ANDREASSEN, J | 1 |
| KIND, H | 1 |
| ANGST, J | 1 |
| Akgun, A | 1 |
| Gidener, S | 1 |
| Nakamura, S | 1 |
| Takeda, K | 1 |
| Nishiyama, T | 1 |
| Hanaoka, K | 1 |
| Barry, JD | 1 |
| Durkovich, DW | 1 |
| Williams, SR | 1 |
| Zuidema, X | 1 |
| Dünser, MW | 1 |
| Wenzel, V | 1 |
| Rozendaal, FW | 1 |
| de Jager, CP | 1 |
| Seitz, R | 1 |
| Wehr, M | 1 |
| Pallmert, N | 1 |
| Marshall, JB | 1 |
| Forker, AD | 1 |
| Langou, RA | 1 |
| Van Dyke, C | 1 |
| Tahan, SR | 1 |
| Cohen, LS | 1 |
| Swinkels, JA | 1 |
| de Jonghe, F | 1 |
| Boada, S | 1 |
| Solsona, B | 1 |
| Papaceit, J | 1 |
| Saludes, J | 1 |
| Rull, M | 1 |
| Brown, TC | 1 |
| Leversha, A | 1 |
| Spiker, DG | 1 |
| Pugh, DD | 1 |
| Zácková, P | 1 |
| Kunová, A | 1 |
| Benetková, M | 1 |
| Hamilton, TC | 1 |
| Norton, J | 1 |
| Poyser, RH | 1 |
| Thormählen, D | 1 |
| Callaham, M | 1 |
| Schumaker, H | 1 |
| Pentel, P | 1 |
| Serle, DG | 1 |
| Collins, JV | 1 |
| Townsend, J | 1 |
| Harris, PW | 1 |
| Clark, TJ | 1 |
| Goulding, R | 1 |
| Rhoads, JM | 1 |
| McCollum, DE | 1 |
| Benoit, JC | 1 |
| Delagrange, G | 1 |
| Richou, A | 1 |
| Souchon, G | 1 |
| Sow, I | 1 |
| Sivadon, P | 1 |
| Deberdt, R | 1 |
| Bossaert, L | 1 |
| Vermeire, P | 1 |
| van Durme, JP | 1 |
| Pannier, R | 1 |
| Schuckit, M | 1 |
| Robins, E | 1 |
| Feighner, J | 1 |
| Kammerer, T | 1 |
| Tyano, S | 1 |
2 reviews available for amitriptyline and Hypotension
| Article | Year |
|---|---|
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular S | 1982 |
Safety of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug In | 1995 |
29 other studies available for amitriptyline and Hypotension
| Article | Year |
|---|---|
Co-ingestion of tricyclic antidepressants with selective norepinephrine reuptake inhibitors: Overdose in the emergency department.
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Consciousness; Depression; Desvenlafaxi | 2016 |
Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Chi-Square Distributio | 2011 |
Lipid therapy for the treatment of a refractory amitriptyline overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Coma; Drug Overdose; Fat Emulsion | 2012 |
The effect of the nitric oxide synthesis inhibitor L-NAME on amitriptyline-induced hypotension in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Drug Interactions; Enzyme | 2002 |
ON DEPRESSIVE REACTIONS.
Topics: Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Drug Therapy; Electroconvulsi | 1964 |
[ACUTE AMITRIPTYLINE POISONING].
Topics: Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Hypotension; Poisoning; Toxic | 1964 |
[AMITRIPTYLINE POISONING].
Topics: Alanine Transaminase; Amitriptyline; Antidepressive Agents; Aspartate Aminotransferases; Clinical En | 1964 |
[ON AMBULATORY AND WARD MANAGEMENT OF DEPRESSIVE STATES WITH A DIBENZODIAZEPINE DERIVATIVE].
Topics: Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Drug Therapy; Hypotension; Hy | 1964 |
Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats?
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiovascular | 2004 |
[General anesthesia for a patient with Noonan's syndrome and long-term antidepressant therapy].
Topics: Adult; Amitriptyline; Anesthesia, General; Antidepressive Agents; Drug Resistance; Ephedrine; Hernia | 2005 |
Vasopressin treatment for cyclic antidepressant overdose.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Humans; Hypotension; Male; Middle Ag | 2006 |
Terlipressin as an adjunct vasopressor in refractory hypotension after tricyclic antidepressant intoxication.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Blood Pressure Dete | 2007 |
[Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Dibenzazepines; Female; Human | 1982 |
Cardiovascular manifestations of tricyclic antidepressant overdose.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiac Ou | 1980 |
[Hypotension refractory to ephedrine after sympathetic blockade in a patient on long-term therapy with tricyclic antidepressants].
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Anesthesia, Epidural; Anesthesia, General; Anesthetics, | 1999 |
Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Cardiovascular System; Dogs; Doxepin; Hypotension; Imi | 1979 |
Combining tricyclic and monoamine oxidase inhibitor antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Drug Therapy, Combination; Humans; Hype | 1976 |
Different cardiovascular effects of tricyclic antidepressants in the conscious and anesthetized rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cardiovascular System; Dose-Response Relat | 1989 |
Comparison of some effects of paroxetine with amitriptyline on the cardiovascular system in animals.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Drug Evaluation, Preclinical; Electrocardiograp | 1986 |
Phenytoin prophylaxis of cardiotoxicity in experimental amitriptyline poisoning.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Dogs; Electrocardiography; Heart; Hypotens | 1988 |
Amitriptyline and ephedrine in subarachnoid anaesthesia.
Topics: Aged; Amitriptyline; Drug Interactions; Ephedrine; Female; Humans; Hypotension | 1985 |
Plasma-11-hydroxycorticosteroid levels in drug-induced coma.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Amitriptyline; Barbiturates; Blood Pressure; Body Temperatu | 1971 |
A hypotensive episode caused by amitriptyline?
Topics: Adult; Amitriptyline; Depression; Female; Humans; Hypotension | 1969 |
[Contribution to the clinical study of a new neuroleptic: sulpiride].
Topics: Adjustment Disorders; Amitriptyline; Anorexia Nervosa; Antidepressive Agents; Anxiety Disorders; Dep | 1969 |
Lorazepam in the treatment of severe anxiety and anxiety associated with psychotic conditions.
Topics: Adult; Aggression; Amitriptyline; Anxiety Disorders; Ataxia; Benzodiazepinones; Bipolar Disorder; Ch | 1973 |
[Cardiovascular complications in acute poisoning with tricyclic antidepressives].
Topics: Adult; Amitriptyline; Antidepressive Agents; Arrhythmia, Sinus; Bundle-Branch Block; Dibenzocyclohep | 1971 |
Amitryptiline and cardiac disease.
Topics: Amitriptyline; Arrhythmias, Cardiac; Depression; Female; Heart Block; Heart Diseases; Humans; Hypote | 1970 |
Tricyclic antidepressants and monoamine oxidase inhibitors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug | 1971 |
[Correction by dihydroergotamine of arterial pressure disorders induced by psychiatric chemotherapy].
Topics: Adolescent; Adult; Aged; Amitriptyline; Amobarbital; Antidepressive Agents; Barbiturates; Butyrophen | 1968 |