amitriptyline has been researched along with Hypertension in 38 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 5.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| " The workup included an endocrinological examination, which revealed a moderately elevated urine normetanephrine level, suggesting the possibility of a pheochromocytoma." | 3.80 | Obstructive sleep apnea and tricyclic antidepressant use presenting as a pseudopheochromocytoma in an active duty sailor: a case report. ( Brainard, T, 2014) |
| " Patients with an amitriptyline overdose were more likely to have seizure, coma, tachycardia, a wide QRS or ventricular dysrhythmia, and have received sodium bicarbonate or be intubated." | 3.77 | Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose. ( Bebarta, VS; Borys, DJ; Maddry, J; Morgan, DL, 2011) |
| " The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition." | 3.74 | Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. ( Jerome, L, 2007) |
| "The analysis of variance and Student's "t" test were applied in an assessment of the hypotensive effectiveness of three hypotensive protocols: a) diazepam + amitryptiline; b) reserpine + chlorthalidone; c) all drugs in 57 and 32 patients with stabilised essential hypertension." | 3.66 | [Clinical and statistical evaluation of the hypotensive effectiveness of 3 therapeutic plans in essential hypertension]. ( D'Amelio, G; Menozzi, L; Piccoli, A, 1978) |
| "The tricyclic antidepressant drugs: imipramine, opipramol, amitryptiline and nortryptiline inhibit development of experimental arterial hypertension in rats." | 3.65 | Influence of tricyclic antidepressant drugs on experimental arterial hypertension. ( Bobkiewicz, T; Chodera, A; Nowakowska, E; Okulicz-Kozaryn, I, 1975) |
| "Sixty patients meeting DSM-III criteria for major depression were assigned randomly to double-blind treatment for four weeks according to fixed-dosage steps with (1) amitriptyline hydrochloride alone, up to a maximum dosage of 300 mg/day; (2) tranylcypromine alone, up to 40 mg/day; or (3) the combination of amitriptyline hydrochloride, up to 150 mg/day, and tranylcypromine, up to 20 mg/day." | 2.65 | The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. A controlled trial. ( Palmer, R; Razani, J; Rebal, R; Simpson, G; Sloane, RB; White, J; White, KL, 1983) |
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 1.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (78.95) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 2 (5.26) | 29.6817 |
| 2010's | 3 (7.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brainard, T | 1 |
| Bebarta, VS | 1 |
| Maddry, J | 1 |
| Borys, DJ | 1 |
| Morgan, DL | 1 |
| Zoladz, PR | 1 |
| Fleshner, M | 1 |
| Diamond, DM | 1 |
| BATTERMAN, RC | 1 |
| KAUFMAN, JE | 1 |
| MOURATOFF, GJ | 1 |
| WHITE, AG | 1 |
| Jerome, L | 1 |
| Arnold, G | 1 |
| Schuh-Hofer, S | 1 |
| Schmitt, H | 2 |
| Pare, CM | 2 |
| Kline, N | 1 |
| Hallstrom, C | 1 |
| Cooper, TB | 1 |
| Razani, J | 1 |
| White, KL | 1 |
| White, J | 1 |
| Simpson, G | 1 |
| Sloane, RB | 1 |
| Rebal, R | 1 |
| Palmer, R | 1 |
| Stiff, JL | 1 |
| Harris, DB | 1 |
| Sim, MK | 1 |
| Ratnam, KV | 1 |
| Silas, JH | 1 |
| Tucker, GT | 1 |
| Smith, AJ | 2 |
| Fieller, NR | 1 |
| Zedkova, L | 1 |
| Coupland, NJ | 1 |
| Burgess, CD | 1 |
| Turner, P | 1 |
| Wadsworth, J | 1 |
| Chodera, A | 2 |
| Konkiewicz, B | 1 |
| Nowakowska, E | 2 |
| Godlewski, J | 1 |
| D'Amelio, G | 1 |
| Piccoli, A | 1 |
| Menozzi, L | 1 |
| Rampton, DS | 1 |
| Spiker, DG | 1 |
| Pugh, DD | 1 |
| Bobkiewicz, T | 1 |
| Okulicz-Kozaryn, I | 1 |
| Buckley, M | 1 |
| Feely, J | 1 |
| Zajecka, J | 1 |
| Fawcett, J | 1 |
| Babb, SV | 1 |
| Dunlop, SR | 1 |
| Ogura, C | 1 |
| Kimishima, K | 1 |
| Sweet, RL | 1 |
| Sheffield, LT | 1 |
| Lajeunesse, BS | 1 |
| Lamarche, M | 1 |
| Royer, R | 1 |
| Heisel, J | 1 |
| Turkington, RW | 1 |
| Gayral, LF | 1 |
| Drotar, D | 1 |
| Kilpatrick, R | 1 |
| Lance, JW | 1 |
| Curran, DA | 1 |
| Anthony, M | 1 |
| Meyer, JF | 1 |
| McAllister, CK | 1 |
| Goldberg, LI | 1 |
| Schuckit, M | 1 |
| Robins, E | 1 |
| Feighner, J | 1 |
| Marino, A | 2 |
| Colucci D'Amato, F | 1 |
| Miracco, A | 1 |
| De Marino, V | 1 |
| Witton, K | 1 |
3 reviews available for amitriptyline and Hypertension
| Article | Year |
|---|---|
[Comorbidities in migraine patients].
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Anxiety Disorders; Carotid Artery, | 2007 |
New pharmacological developments in antidepressants.
Topics: Amitriptyline; Drug Interactions; Humans; Hypertension; Monoamine Oxidase Inhibitors; Piperidines; T | 1986 |
Advances in medicine.
Topics: Amitriptyline; Cholera; Coronary Disease; Crohn Disease; Diabetes Mellitus; Diet Therapy; Diverticul | 1971 |
5 trials available for amitriptyline and Hypertension
| Article | Year |
|---|---|
The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. A controlled trial.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Thera | 1983 |
Accumulation of debrisoquine by platelets in vivo: a model of events at the peripheral adrenergic neurone.
Topics: Amitriptyline; Blood Platelets; Debrisoquin; Erythrocytes; Humans; Hydroxylation; Hypertension; Isoq | 1980 |
Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bethanidine; Blood Pressure; Cardiovascular | 1978 |
Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa.
Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Clinical Trials as Topic; Fluphenazine; Humans | 1972 |
Investigations into the mechanism and treatment of chronic headache.
Topics: Amitriptyline; Clinical Trials as Topic; Headache; Humans; Hydroxyindoleacetic Acid; Hypertension; M | 1965 |
30 other studies available for amitriptyline and Hypertension
| Article | Year |
|---|---|
Obstructive sleep apnea and tricyclic antidepressant use presenting as a pseudopheochromocytoma in an active duty sailor: a case report.
Topics: Adrenal Gland Neoplasms; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Diagnosis, Differen | 2014 |
Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Chi-Square Distributio | 2011 |
Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antihypertens | 2013 |
CLINICAL USE OF AMITRIPTYLINE FOR THE TREATMENT OF PSYCHONEUROTIC REACTIVE ANXIETY AND DEPRESSION.
Topics: Amitriptyline; Anxiety; Arthritis, Rheumatoid; Asthma; Coronary Disease; Depression; Diabetes Mellit | 1964 |
METHYLDOPA AND AMITRIPTYLINE.
Topics: Amitriptyline; Depression; Depressive Disorder; Drug Synergism; Drug Therapy; Hypertension; Methyldo | 1965 |
Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia.
Topics: Amitriptyline; Analgesics; Anti-Ulcer Agents; Anticoagulants; Antidepressive Agents; Anxiety; Cardio | 2007 |
[Restraining action of antidepressive agents of the imipramine group on the cardiovascular centers].
Topics: Action Potentials; Amitriptyline; Amygdala; Animals; Antidepressive Agents; Blood Pressure; Carotid | 1967 |
Will amitriptyline prevent the "cheese" reaction of monoamine-oxidase inhibitors?
Topics: Adult; Amitriptyline; Blood Pressure; Cheese; Depression; Drug Synergism; Female; Humans; Hypertensi | 1982 |
Clonidine withdrawal complicated by amitriptyline therapy.
Topics: Aged; Amitriptyline; Anxiety; Clonidine; Female; Humans; Hypertension; Intraoperative Care; Methyldo | 1983 |
Treatment of disease without the use of drugs. V. Phasing out of benzodiazepine and amitriptyline medication with thought control.
Topics: Adult; Amitriptyline; Behavior Therapy; Benzodiazepines; Breathing Exercises; Female; Gastritis; Hum | 1980 |
Hypertension during coprescription of mirtazapine and low-dose amitriptyline.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Therapy, Combination; Hum | 1998 |
The effect of tricyclic antidepressants (TA) on the circulatory system in primary arterial hypertension.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Catecholamines; Hemodynamics; Humans; Hypertension; | 1979 |
[Clinical and statistical evaluation of the hypotensive effectiveness of 3 therapeutic plans in essential hypertension].
Topics: Adolescent; Adult; Amitriptyline; Antihypertensive Agents; Chlorthalidone; Diazepam; Drug Therapy, C | 1978 |
Hypertensive crisis in a patient given sinemet, metoclopramide, and amitriptyline.
Topics: Acute Disease; Amitriptyline; Carbidopa; Drug Combinations; Drug Therapy, Combination; Female; Human | 1977 |
Combining tricyclic and monoamine oxidase inhibitor antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Drug Therapy, Combination; Humans; Hype | 1976 |
Influence of tricyclic antidepressant drugs on experimental arterial hypertension.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Female; Hexobarbital; Hype | 1975 |
Antagonism of antihypertensive effect of guanfacine by tricyclic antidepressants.
Topics: Adult; Amitriptyline; Drug Interactions; Female; Guanfacine; Humans; Hypertension; Imipramine | 1991 |
Susceptibility to spontaneous MAOI hypertensive episodes.
Topics: Acute Disease; Adult; Amitriptyline; Depressive Disorder; Drug Interactions; Hospitalization; Humans | 1991 |
Case report of sudden and unexpected death after tricyclic overdose.
Topics: Adult; Amitriptyline; Death, Sudden; Diazepam; Female; Humans; Hypertension; Hypokalemia; Suicide, A | 1985 |
Central nervous actions and screening methods of antidepressants.
Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Amines; Blo | 1972 |
Myocardial infarction after exercise-induced electrocardiographic changes in a patient with variant angina pectoris.
Topics: Amitriptyline; Angina Pectoris; Arteriosclerosis; Catheterization; Diabetes Complications; Electroca | 1974 |
[True and false adverse effects of thymoanaleptic medications].
Topics: Amitriptyline; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressio | 1968 |
[Experimental study of direct vascular activity of amitriptyline].
Topics: Amitriptyline; Animals; Blood Vessels; Central Nervous System Stimulants; Ethanolamines; Heart; Hype | 1967 |
[Tranquillisers in the treatment of psychosomatic diseases].
Topics: Amitriptyline; Asthma; Benzazepines; Benzene Derivatives; Chlordiazepoxide; Colitis, Ulcerative; Dru | 1972 |
Letter: Concern over the categorization of depression in children.
Topics: Amitriptyline; Child; Depression; Female; Humans; Hypertension; Intelligence; Learning Disabilities; | 1974 |
Insidious and prolonged antagonism of guanethidine by amitriptyline.
Topics: Amitriptyline; Blood Pressure; Depression; Guanethidine; Humans; Hypertension; Male; Middle Aged | 1970 |
Tricyclic antidepressants and monoamine oxidase inhibitors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug | 1971 |
[Psychodynamics and psychopahrmacological therapy of essential hypertension].
Topics: Amitriptyline; Chlordiazepoxide; Humans; Hypertension; Psychophysiologic Disorders | 1967 |
Psychopharmacological approach to psychosomatic medicine. Experimental and clinical research.
Topics: Amitriptyline; Amphetamine; Animals; Anxiety Disorders; Benactyzine; Depression; Guinea Pigs; Hostil | 1967 |
Circulatory lability and depression.
Topics: Aged; Amitriptyline; Blood Pressure Determination; Depression; Dysautonomia, Familial; Humans; Hyper | 1966 |