amitriptyline has been researched along with Heroin Abuse in 7 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anhedonia is often the cause for recurrence in heroine addiction, therefore, an appropriate treatment is an important aspect in recurrence prevention and remission stabilization." | 2.71 | [Pharmacotherapy in heroin addiction: pharmacological approaches to remission stabilization and recurrence prevention]. ( Grinenko, AIa; Krupitskiĭ, EM; Zvartau, EE, 2003) |
| "366 methadone maintenance treatment patients in Taiwan were recruited and genotyped." | 1.38 | UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients. ( Chen, ACh; Chen, CH; Chen, YT; Fang, CP; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Kuo, HW; Lin, L; Liu, CT; Liu, ML; Liu, SC; Liu, YL; Shih, YH; Su, LW; Tan, HK; Tian, JN; Tsou, HH; Wu, CS; Yang, YH; Yang, YT, 2012) |
| "Further analyses on specific withdrawal symptoms in COWS showed that the genetic variants in rs4646440 are significantly associated with heart rate (allele type p = 0." | 1.37 | Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients. ( Chen, ACh; Chen, CH; Chou, SY; Fang, KC; Fang, YC; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Lin, KM; Lin, YF; Liu, ML; Liu, SC; Liu, YL; Su, LW; Tian, JN; Tsou, HH; Wang, SC; Yu, CJ, 2011) |
| "Amitriptyline was found in 12 (7." | 1.35 | Tricyclic antidepressants abuse, with or without benzodiazepines abuse, in former heroin addicts currently in methadone maintenance treatment (MMT). ( Adelson, M; Peles, E; Schreiber, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CH | 2 |
| Wang, SC | 1 |
| Tsou, HH | 2 |
| Ho, IK | 2 |
| Tian, JN | 2 |
| Yu, CJ | 1 |
| Hsiao, CF | 2 |
| Chou, SY | 1 |
| Lin, YF | 1 |
| Fang, KC | 1 |
| Huang, CL | 2 |
| Su, LW | 2 |
| Fang, YC | 1 |
| Liu, ML | 2 |
| Lin, KM | 1 |
| Hsu, YT | 2 |
| Liu, SC | 2 |
| Chen, ACh | 2 |
| Liu, YL | 2 |
| Fang, CP | 1 |
| Tan, HK | 1 |
| Lin, L | 1 |
| Wu, CS | 1 |
| Yang, YH | 1 |
| Chen, YT | 1 |
| Kuo, HW | 1 |
| Liu, CT | 1 |
| Yang, YT | 1 |
| Shih, YH | 1 |
| Grinenko, AIa | 1 |
| Krupitskiĭ, EM | 1 |
| Zvartau, EE | 1 |
| Avella, J | 1 |
| Katz, M | 1 |
| Lehrer, M | 1 |
| Peles, E | 1 |
| Schreiber, S | 1 |
| Adelson, M | 1 |
| Cohen, MJ | 1 |
| Hanbury, R | 1 |
| Stimmel, B | 1 |
| Feigelson, EB | 1 |
| Cadden, JJ | 1 |
1 trial available for amitriptyline and Heroin Abuse
| Article | Year |
|---|---|
[Pharmacotherapy in heroin addiction: pharmacological approaches to remission stabilization and recurrence prevention].
Topics: Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Antidepressive Agents, Second-Gen | 2003 |
6 other studies available for amitriptyline and Heroin Abuse
| Article | Year |
|---|---|
Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients.
Topics: Adult; Amitriptyline; Areca; Biomarkers, Pharmacological; Cytochrome P-450 CYP3A; Female; Genetic As | 2011 |
UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
Topics: Adult; Amitriptyline; Female; Genetic Association Studies; Glucuronosyltransferase; Haplotypes; Hero | 2012 |
Assessing free and total morphine following heroin overdose when complicated by the presence of toxic amitriptyline levels.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interactions; Drug Overdose; Fatal Outc | 2007 |
Tricyclic antidepressants abuse, with or without benzodiazepines abuse, in former heroin addicts currently in methadone maintenance treatment (MMT).
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Benzodiazepines; Cross-Sectional Studies; Da | 2008 |
Abuse of amitriptyline.
Topics: Amitriptyline; Depression; Heroin Dependence; Humans; Methadone; Self Medication; Substance Withdraw | 1978 |
Changing patterns of drug abuse in New York City.
Topics: Adolescent; Adult; Amitriptyline; Amphetamines; Antipsychotic Agents; Barbiturates; Codeine; Dextrop | 1974 |