amitriptyline has been researched along with Hemolysis in 8 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The leading candidate, 4,4'-bis((E)-1-(2-(4-fluorophenyl)hydrazono)ethyl)-1,1'-biphenyl, displayed less hemolysis of murine red blood cells at concentrations at or below that of a control antifungal agent (voriconazole), was fungistatic in a time-kill study, and possessed no mammalian cytotoxicity and no toxicity with respect to hERG inhibition." | 3.91 | N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents. ( Deaciuc, AG; Dennis, EK; Dwoskin, LP; Garneau-Tsodikova, S; Green, KD; Kwiatkowski, S; Ngo, HX; Shrestha, SK; Thamban Chandrika, N; Watt, DS, 2019) |
| "Amitriptyline treatment decreased hemolysis in a dose-dependent manner." | 1.43 | Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage. ( Caldwell, CC; Chang, AL; Edwards, MJ; Gulbins, E; Hoehn, RS; Jernigan, PL; Pritts, TA, 2016) |
| "Cellular phototoxicity was investigated on a murine fibroblast cell line (3T3)." | 1.31 | In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine. ( Dall'Acqua, F; Miolo, G; Vedaldi, D; Viola, G, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thamban Chandrika, N | 1 |
| Dennis, EK | 1 |
| Shrestha, SK | 1 |
| Ngo, HX | 1 |
| Green, KD | 1 |
| Kwiatkowski, S | 1 |
| Deaciuc, AG | 1 |
| Dwoskin, LP | 1 |
| Watt, DS | 1 |
| Garneau-Tsodikova, S | 1 |
| Zhang, L | 1 |
| Liu, J | 1 |
| Tian, T | 1 |
| Gao, Y | 1 |
| Ji, X | 1 |
| Li, Z | 1 |
| Luan, Y | 1 |
| Hoehn, RS | 1 |
| Jernigan, PL | 1 |
| Chang, AL | 1 |
| Edwards, MJ | 1 |
| Caldwell, CC | 1 |
| Gulbins, E | 1 |
| Pritts, TA | 1 |
| Kitagawa, N | 1 |
| Oda, M | 1 |
| Nobutaka, I | 1 |
| Satoh, H | 1 |
| Totoki, T | 1 |
| Morimoto, M | 1 |
| Viola, G | 1 |
| Miolo, G | 1 |
| Vedaldi, D | 1 |
| Dall'Acqua, F | 1 |
| Kobayashi, R | 1 |
| Tawata, M | 1 |
| Hidaka, H | 1 |
| Ferber, E | 1 |
| Munder, PG | 1 |
| Kohlschütter, A | 1 |
| Fischer, H | 1 |
| Elonen, E | 1 |
8 other studies available for amitriptyline and Hemolysis
| Article | Year |
|---|---|
N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents.
Topics: Animals; Antifungal Agents; Biphenyl Compounds; Drug-Related Side Effects and Adverse Reactions; Ery | 2019 |
Pharmaceutically active ionic liquid self-assembled vesicles for the application as an efficient drug delivery system.
Topics: Administration, Oral; Amitriptyline; Animals; Drug Carriers; Erythrocytes; Half-Life; Hemolysis; Ion | 2013 |
Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage.
Topics: Amitriptyline; Animals; Anion Exchange Protein 1, Erythrocyte; Blood Transfusion; Dose-Response Rela | 2016 |
A proposed mechanism for amitriptyline neurotoxicity based on its detergent nature.
Topics: Amitriptyline; Anesthetics, Local; Animals; Detergents; Dose-Response Relationship, Drug; Electric S | 2006 |
In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cells, Cultured; Chromatography, High Pres | 2000 |
Ca2+ regulated modulator protein interacting agents: inhibition of Ca2+-Mg2+-ATPase of human erythrocyte ghost.
Topics: Amitriptyline; Brain; Calcium-Transporting ATPases; Calmodulin; Carrier Proteins; Chlorpromazine; Er | 1979 |
[Studies on the lysolecithin-metabolizing enzymes of intact erythrocytes and modified stromas].
Topics: Acyltransferases; Adenosine Triphosphate; Amitriptyline; Antibodies; Cell Membrane; Chlorpromazine; | 1968 |
Correlation of the cardiotoxicity of tricyclic antidepressants to their membrane effects.
Topics: Amitriptyline; Anesthesia, Local; Animals; Cell Membrane; Cornea; Depression, Chemical; Dibenzocyclo | 1974 |