amitriptyline and Headache studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.

Research Excerpts

Excerpt	Relevance	Reference
"Efficacy of antidepressants fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache has been studied."	9.13	[Fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache]. ( Amelin, AV; Skoromets, AA; Tarasova, SV, 2008)
"Headache frequency decreased by 45% in the amitriptyline group and by 28% in the trihexyphenidyl group."	9.09	Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. ( Albucher, JF; Brefel-Courbon, C; Descombes, S; Montastruc, JL; Rascol, O; Senard, JM; Thalamas, C, 2001)
"The aim of this study was to explore the efficacy of buspirone (BSR), in comparison with amitriptyline (AML) in the prophylactic treatment of chronic tension-type headache (CTH), in an open and randomized clinical trial."	9.08	Buspirone vs amitriptyline in the treatment of chronic tension-type headache. ( Gatzonis, S; Ilias, A; Mitsikostas, DD; Thomas, A, 1997)
" The aim of the present study was to investigate whether amitriptyline, a combined serotonin and noradrenaline re-uptake inhibitor, modulates the late exteroceptive suppression period (ES2) of temporal muscle activity in chronic tension-type headache."	9.08	Amitriptyline, a combined serotonin and noradrenaline re-uptake inhibitor, reduces exteroceptive suppression of temporal muscle activity in patients with chronic tension-type headache. ( Bendtsen, L; Jensen, R; Olesen, J, 1996)
"Forty-one recurrent tension headache sufferers were randomly assigned to either cognitive-behavioral therapy (administered in a primarily home-based treatment protocol) or to amitriptyline therapy (with dosage individualized at 25, 50, or 75 mg/day)."	9.07	A comparison of pharmacological (amitriptyline HCL) and nonpharmacological (cognitive-behavioral) therapies for chronic tension headaches. ( Cordingley, GE; Holroyd, KA; Jerome, A; Nash, JM; Pingel, JD, 1991)
"Tricyclic antidepressants, especially amitriptyline, are the medication of first choice in the treatment of chronic tension headache."	9.07	[Effectiveness and tolerance of amitriptyline oxide in chronic tension headache--a multicenter double-blind study versus amitriptyline versus placebo]. ( Diener, HC; Fischer, W; Haase, W; Isler, H; Meyer, C; Pfaffenrath, V; Scholz, E; Taneri, Z; Wessely, P; Zaiser-Kaschel, H, 1993)
"In a double-blind, placebo-controlled trial, the effect of 75 mg of a slow-release formulation of amitriptyline on the clinical severity of chronic tension-type headache and on headache-associated neurophysiological parameters (EMG activity, exteroceptive suppression of temporal muscle activity, contingent negative variation (CNV) and experimental pain sensitivity) was investigated."	9.07	[Amitriptyline in therapy of chronic tension headache]. ( Göbel, H; Hamouz, V; Hansen, C; Heininger, K; Heuss, D; Hirsch, S; Lindner, V; Soyka, D, 1994)
"We evaluated the effect of 25 mg bid amitriptyline on muscle contraction headache in 36 patients with Parkinson's disease in a randomized double-blind placebo-controlled study."	9.06	Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study. ( Carrieri, PB; Indaco, A, 1988)
"Our study supports the common clinical practice of using low doses of amitriptyline to treat chronic headache disorders and suggests that it was effective and well tolerated at doses lower than those used in many clinical trials."	7.83	Amitriptyline Dose and Treatment Outcomes in Specialty Headache Practice: A Retrospective Cohort Study. ( Doyle Strauss, L; Loder, EW; Rizzoli, PB; Weizenbaum, E, 2016)
"Depression was assessed by the Beck Depression Inventory (BDI) short form."	6.69	Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. ( Curtis, D; Levine, J; McCall, WD; Plesh, O, 2000)
"Ritanserin was highly effective in reducing Pain Total Index and analgesic consumption in chronic headache, and its activity was similar to that observed during amitriptyline treatment."	6.67	A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline. ( Blandini, F; Cerutti, G; Facchinetti, F; Granella, F; Manzoni, GC; Nappi, G; Ruiz, L; Sandrini, G, 1990)
"Patients had history of migraine 15/48 (31."	5.72	Amitriptyline for post-COVID headache: effectiveness, tolerability, and response predictors. ( Arias-Rivas, S; Gago-Veiga, AB; García-Azorín, D; Gonzalez-Martinez, A; Guerrero-Peral, ÁL; Sierra, Á; Silva, L, 2022)
"A 26-year-old woman with a history of migraine reported right-sided, severe stabbing orbital pain with cranial autonomic symptoms (CASs) for approximately 2 years."	5.72	A Combination of Indomethacin Farnesyl and Amitriptyline Is Effective for Continuous Interictal Pain with Probable Chronic Paroxysmal Hemicrania. ( Danno, D; Kashiwaya, Y; Kikui, S; Kohashi, M; Miyahara, J; Ota, K; Sugiyama, H; Takeshima, T, 2022)
"Explore predictors of improvement in headache days and migraine-related disability through a secondary analysis of the cognitive-behavioral therapy plus amitriptyline trial in children and adolescents (Clinical Trials Registration Number: NCT00389038)."	5.51	Predictors of Improvement in Pediatric Chronic Migraine: Results from the Cognitive-Behavioral Therapy and Amitriptyline Trial. ( Ergun, G; Hershey, AD; Kabbouche, MA; Kacperski, J; LeCates, SL; Powers, SW; Rettig, EK; Slater, SK; Warfield, JR, 2022)
" Childhood and Adolescent Migraine Prevention study participants completed headache diaries during a 28-day baseline period and a 168-day active treatment period during which youth took amitriptyline, topiramate, or placebo."	5.51	Trajectory of treatment response in the child and adolescent migraine prevention (CHAMP) study: A randomized clinical trial. ( Chamberlin, LA; Coffey, CS; Ecklund, DJ; Hershey, AD; Kabbouche, MA; Kacperski, J; Klingner, EA; Korbee, LL; Peugh, J; Porter, LL; Powers, SW; Reidy, BL; Yankey, JW, 2022)
" Participants were randomly assigned to cognitive-behavioral therapy plus amitriptyline (CBT+A, N=64) or headache education plus amitriptyline (HE+A, N=71)."	5.24	Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial. ( Allen, JR; Hershey, AD; Hommel, K; Kabbouche, MA; Kacperski, J; Kashikar-Zuck, S; Kroner, JW; Kroon Van Diest, AM; LeCates, S; O'Brien, HL; Peugh, J; Powers, SW; Ramsey, RR; Slater, S, 2017)
"To determine the benefits of cognitive behavioral therapy (CBT) when combined with amitriptyline vs headache education plus amitriptyline."	5.17	Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. ( Allen, JR; Hershey, AD; Kabbouche, MA; Kashikar-Zuck, SM; LeCates, SL; O'Brien, HL; Powers, SW; Rausch, JR; Shenk, CE; Slater, SK; Zafar, M, 2013)
"Efficacy of antidepressants fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache has been studied."	5.13	[Fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache]. ( Amelin, AV; Skoromets, AA; Tarasova, SV, 2008)
"Headache frequency decreased by 45% in the amitriptyline group and by 28% in the trihexyphenidyl group."	5.09	Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. ( Albucher, JF; Brefel-Courbon, C; Descombes, S; Montastruc, JL; Rascol, O; Senard, JM; Thalamas, C, 2001)
"Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproex sodium, amitriptyline, amitriptyline plus phenelzine, or methadone."	5.09	Management of chronic daily headache utilizing a uniform treatment pathway. ( Rothrock, JF, 1999)
"The aim of this study was to explore the efficacy of buspirone (BSR), in comparison with amitriptyline (AML) in the prophylactic treatment of chronic tension-type headache (CTH), in an open and randomized clinical trial."	5.08	Buspirone vs amitriptyline in the treatment of chronic tension-type headache. ( Gatzonis, S; Ilias, A; Mitsikostas, DD; Thomas, A, 1997)
" The aim of the present study was to investigate whether amitriptyline, a combined serotonin and noradrenaline re-uptake inhibitor, modulates the late exteroceptive suppression period (ES2) of temporal muscle activity in chronic tension-type headache."	5.08	Amitriptyline, a combined serotonin and noradrenaline re-uptake inhibitor, reduces exteroceptive suppression of temporal muscle activity in patients with chronic tension-type headache. ( Bendtsen, L; Jensen, R; Olesen, J, 1996)
"Tricyclic antidepressants, especially amitriptyline, are the medication of first choice in the treatment of chronic tension headache."	5.07	[Effectiveness and tolerance of amitriptyline oxide in chronic tension headache--a multicenter double-blind study versus amitriptyline versus placebo]. ( Diener, HC; Fischer, W; Haase, W; Isler, H; Meyer, C; Pfaffenrath, V; Scholz, E; Taneri, Z; Wessely, P; Zaiser-Kaschel, H, 1993)
"Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache."	5.07	Efficacy and tolerability of amitriptylinoxide in the treatment of chronic tension-type headache: a multi-centre controlled study. ( Diener, HC; Fischer, W; Haase, W; Isler, H; Meyer, C; Pfaffenrath, V; Scholz, E; Taneri, Z; Wessely, P; Zaiser-Kaschel, H, 1994)
"In a double-blind, placebo-controlled trial, the effect of 75 mg of a slow-release formulation of amitriptyline on the clinical severity of chronic tension-type headache and on headache-associated neurophysiological parameters (EMG activity, exteroceptive suppression of temporal muscle activity, contingent negative variation (CNV) and experimental pain sensitivity) was investigated."	5.07	[Amitriptyline in therapy of chronic tension headache]. ( Göbel, H; Hamouz, V; Hansen, C; Heininger, K; Heuss, D; Hirsch, S; Lindner, V; Soyka, D, 1994)
"Forty-one recurrent tension headache sufferers were randomly assigned to either cognitive-behavioral therapy (administered in a primarily home-based treatment protocol) or to amitriptyline therapy (with dosage individualized at 25, 50, or 75 mg/day)."	5.07	A comparison of pharmacological (amitriptyline HCL) and nonpharmacological (cognitive-behavioral) therapies for chronic tension headaches. ( Cordingley, GE; Holroyd, KA; Jerome, A; Nash, JM; Pingel, JD, 1991)
"We evaluated the effect of 25 mg bid amitriptyline on muscle contraction headache in 36 patients with Parkinson's disease in a randomized double-blind placebo-controlled study."	5.06	Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study. ( Carrieri, PB; Indaco, A, 1988)
"The author compared the response to amitriptyline in headache associated with depression between twelve patients having primary depression (control group) and ten patients with depression after minor closed head injury."	5.06	Antidepressants not effective in headache associated with minor closed head injury. ( Saran, A, 1988)
"Our study supports the common clinical practice of using low doses of amitriptyline to treat chronic headache disorders and suggests that it was effective and well tolerated at doses lower than those used in many clinical trials."	3.83	Amitriptyline Dose and Treatment Outcomes in Specialty Headache Practice: A Retrospective Cohort Study. ( Doyle Strauss, L; Loder, EW; Rizzoli, PB; Weizenbaum, E, 2016)
"Efficacy and safety of the following antidepressants: amitryptiline (tricyclic antidepressant), escitalopram (selective inhibitor of serotonin reuptake), milnacipran (selective inhibitor of serotonin and noradrenalin reuptake) and maprotiline (selective inhibitor of noradrenalin reuptake) have been compared during the treatment of 120 patients with chronic daily headache."	3.74	[Antidepressants with different action mechanisms in the treatment of chronic daily headache]. ( Amelin, AV; Ignatov, IuD; Miatleva, MI; Skoromets, AA; Tarasova, SV, 2007)
"It is concluded that MD is associated with headache that can be handicapping, and tricyclic antidepressants with pain alleviating medication is often needed to treat the headache in MD whereas sumatriptan did not alleviate the headache of the non-migraine patients."	3.70	Headache in Meniere's disease. ( Eklund, S, 1999)
"Amitriptyline was the most useful drug in that it provided pain relief in musculoskeletal, vascular, and some neuropathic pain conditions."	3.69	Diagnosis and treatment of persistent pain after trauma to the head and neck. ( Benoliel, R; Eliav, E; Elishoov, H; Sharav, Y, 1994)
"We measured platelet-rich plasma (PRP) serotonin in patients suffering from tension-type headache, before and after treatment with amitriptyline, comparing them with a healthy control group and patients with untreated depression."	3.68	Platelet-rich plasma serotonin levels in tension-type headache and depression. ( Castillo, J; Leira, R; Martinez, F; Noya, M; Prieto, JM, 1993)
"Self-reported and "nosology-derived" migraine days during the baseline and treatment phases were strongly associated (r's = 0."	3.30	Impact of preventive pill-based treatment on migraine days: A secondary outcome study of the Childhood and Adolescent Migraine Prevention (CHAMP) trial and a comparison of self-report to nosology-derived assessments. ( Chamberlin, LA; Coffey, CS; Ecklund, D; Gibler, RC; Hershey, AD; Kabbouche, M; Kacperski, J; Klingner, E; Korbee, LL; Peugh, JL; Porter, LL; Powers, SW; Reidy, BL; Yankey, J, 2023)
"Patients with complaints of migraine attacks were randomly divided into two groups."	3.11	Venlafaxine can reduce the migraine attacks as well as amitriptyline: A noninferiority randomized trial. ( Hedayat, M; Heidari, M; Nazarbaghi, S; Sharifi, H, 2022)
"The patients with chronic migraine (CM) respond poorly to pharmacological agents including tricyclic antidepressants, beta-blockers, anticonvulsants, calcium channel blockers, flunarizine, and melatonin."	3.01	A Randomized Controlled Trial of High Rate rTMS Versus rTMS and Amitriptyline in Chronic Migraine. ( Kalita, J; Kumar, S; Misra, UK; Singh, VK, 2021)
"Depression was assessed by the Beck Depression Inventory (BDI) short form."	2.69	Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. ( Curtis, D; Levine, J; McCall, WD; Plesh, O, 2000)
"Ritanserin was highly effective in reducing Pain Total Index and analgesic consumption in chronic headache, and its activity was similar to that observed during amitriptyline treatment."	2.67	A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline. ( Blandini, F; Cerutti, G; Facchinetti, F; Granella, F; Manzoni, GC; Nappi, G; Ruiz, L; Sandrini, G, 1990)
"Clomipramine was better tolerated."	2.65	Clomipramine and amitriptyline in the treatment of severe pain. ( Carasso, RL; Streifler, M; Yehuda, S, 1979)
"Amitriptyline has a significant advantage in insomnia problems."	2.65	Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms--a combined analysis of four British clinical trials in depression. ( Huitfeldt, B; Montgomery, SA, 1983)
"The treatment of headache is usually successful and thus highly rewarding for physicians of all medical specialties."	2.58	Hints on Diagnosing and Treating Headache. ( May, A, 2018)
"Chronic daily headache is a heterogeneous group of daily or near-daily headaches that afflicts close to 5% of the general population and accounts for close to 35% to 40% of patients at headache centers."	2.41	Cognitive-behavioral issues in the treatment and management of chronic daily headache. ( Lipchik, GL; Nash, JM, 2002)
"Headache has been documented as the reason for approximately 18 million office visits per year in the United States, and may be the most prevalent central nervous system condition for which patients consult doctors."	2.37	An overview of the classification, causes, and treatment of headache. ( Ziegler, DK, 1984)
"A 26-year-old woman with a history of migraine reported right-sided, severe stabbing orbital pain with cranial autonomic symptoms (CASs) for approximately 2 years."	1.72	A Combination of Indomethacin Farnesyl and Amitriptyline Is Effective for Continuous Interictal Pain with Probable Chronic Paroxysmal Hemicrania. ( Danno, D; Kashiwaya, Y; Kikui, S; Kohashi, M; Miyahara, J; Ota, K; Sugiyama, H; Takeshima, T, 2022)
"Patients had history of migraine 15/48 (31."	1.72	Amitriptyline for post-COVID headache: effectiveness, tolerability, and response predictors. ( Arias-Rivas, S; Gago-Veiga, AB; García-Azorín, D; Gonzalez-Martinez, A; Guerrero-Peral, ÁL; Sierra, Á; Silva, L, 2022)
"Daily migraine medication prevention is indicated when migraine frequency and disability are high."	1.36	The role of prevention. ( Tepper, SJ, 2010)
"Carbamazepine (300 mg/d) was required for pain control."	1.33	Occipital neuralgia secondary to respiratory tract infection. ( Anagnostopoulou, S; Mourouzis, C; Rallis, G; Saranteas, T; Tesseromatis, C, 2005)
"Treatment with amitriptyline was offered to patients in whom no improvement had been achieved."	1.31	Withdrawal therapy improves chronic daily headache associated with long-term misuse of headache medication: a retrospective study. ( Dahlöf, C; Linde, M; Linton-Dahlöf, P, 2000)
"Amitriptyline and pizotifen were effective in prophylactic therapy of vomiting episodes."	1.31	Cyclic vomiting syndrome in Thai children. ( Aanpreung, P; Vajaradul, C, 2002)
"In the prophylaxis of migraine beta-blockers are commonly used."	1.27	Combination headache: practical experience with a combination of a beta-blocker and an antidepressive. ( Kellhammer, U; Pfaffenrath, V; Pöllmann, W, 1986)

Research

Studies (91)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Change in Absolute Headache Disability Score on PedMIDAS

Timeframe	Studies, this research(%)	All Research%
pre-1990	39 (42.86)	18.7374
1990's	21 (23.08)	18.2507
2000's	14 (15.38)	29.6817
2010's	8 (8.79)	24.3611
2020's	9 (9.89)	2.80

Authors	Studies
Kalita, J	1
Kumar, S	1
Singh, VK	1
Misra, UK	1
Hedayat, M	1
Nazarbaghi, S	1
Heidari, M	1
Sharifi, H	1
Gonzalez-Martinez, A	1
Guerrero-Peral, ÁL	2
Arias-Rivas, S	1
Silva, L	1
Sierra, Á	1
Gago-Veiga, AB	1
García-Azorín, D	2
Gibler, RC	1
Peugh, JL	1
Coffey, CS	2
Chamberlin, LA	2
Ecklund, D	1
Klingner, E	1
Yankey, J	1
Korbee, LL	2
Kabbouche, M	1
Kacperski, J	4
Porter, LL	2
Reidy, BL	2
Hershey, AD	5
Powers, SW	5
Lampl, C	1
Versijpt, J	1
Amin, FM	1
Deligianni, CI	1
Gil-Gouveia, R	1
Jassal, T	1
MaassenVanDenBrink, A	1
Ornello, R	1
Paungarttner, J	1
Sanchez-Del-Rio, M	1
Reuter, U	1
Uluduz, D	1
de Vries, T	1
Zeraatkar, D	1
Sacco, S	1
García-Iglesias, C	1
González-Celestino, A	1
Sierra Mencía, Á	1
González Osorio, Y	1
Recio García, A	1
Martínez-Badillo, C	1
Echavarría Íñiguez, A	1
Varona-Galán, B	1
Rettig, EK	1
Ergun, G	1
Warfield, JR	1
Slater, SK	2
LeCates, SL	2
Kabbouche, MA	4
Kikui, S	1
Miyahara, J	1
Sugiyama, H	1
Kohashi, M	1
Ota, K	1
Danno, D	1
Kashiwaya, Y	1
Takeshima, T	1
Peugh, J	2
Ecklund, DJ	1
Klingner, EA	1
Yankey, JW	1
May, A	1
Connelly, M	1
Kashikar-Zuck, SM	1
Allen, JR	2
Zafar, M	1
O'Brien, HL	2
Shenk, CE	1
Rausch, JR	1
Doyle Strauss, L	1
Weizenbaum, E	1
Loder, EW	1
Rizzoli, PB	1
Kroon Van Diest, AM	1
Ramsey, RR	1
Kashikar-Zuck, S	1
Slater, S	1
Hommel, K	1
Kroner, JW	1
LeCates, S	1
Tarasova, SV	2
Amelin, AV	2
Skoromets, AA	2
Robbins, MS	1
Grosberg, BM	1
Bisges, J	1
Baldwin, P	1
Tepper, SJ	1
Taylor, J	1
Goodkin, HP	1
Krishnan, A	1
Silver, N	1
Aanpreung, P	1
Vajaradul, C	1
Lipchik, GL	1
Nash, JM	2
JACKSON, D	1
BERNARD, LA	1
BENTLIF, P	1
ERNST, EM	1
LANCE, JW	3
CURRAN, DA	2
VERGA, G	1
PARE, CM	1
Mourouzis, C	1
Saranteas, T	1
Rallis, G	1
Anagnostopoulou, S	1
Tesseromatis, C	1
Bettucci, D	1
Testa, L	1
Calzoni, S	1
Mantegazza, P	1
Viana, M	1
Monaco, F	1
Keays, AC	1
Neher, JO	1
Safranek, S	1
Webb, CW	1
Ignatov, IuD	1
Miatleva, MI	1
Huitfeldt, B	1
Montgomery, SA	1
Martin, MJ	1
Bonuso, S	1
Di Stasio, E	1
Barone, P	1
Steardo, L	1
Ziegler, DK	1
Pisani, RA	3
Lazzari, R	3
Carfagna, L	2
Franzese, A	3
Arzilli, A	3
Mathew, NT	1
Guy, W	1
Ban, TA	1
McEvoy, JP	1
Petrie, WM	1
Wilson, WH	1
Schaffer, JD	1
Kudrow, L	1
Tyler, GS	1
McNeely, HE	1
Dick, ML	1
Göbel, H	1
Hamouz, V	1
Hansen, C	1
Heininger, K	1
Hirsch, S	1
Lindner, V	1
Heuss, D	1
Soyka, D	1
Benoliel, R	1
Eliav, E	1
Elishoov, H	1
Sharav, Y	1
Pfaffenrath, V	3
Diener, HC	2
Isler, H	2
Meyer, C	2
Scholz, E	3
Taneri, Z	3
Wessely, P	2
Zaiser-Kaschel, H	2
Haase, W	2
Fischer, W	3
Grissom, RJ	1
Leira, R	1
Castillo, J	1
Martinez, F	1
Prieto, JM	1
Noya, M	1
Brañas Fernández, F	1
Cortés Laiño, JA	1
Martínez Vázquez, F	1
Rabuñal Rey, R	1
Bonuccelli, U	1
Nuti, A	1
Lucetti, C	1
Pavese, N	1
Dell'Agnello, G	1
Muratorio, A	1
Bendtsen, L	1
Jensen, R	1
Olesen, J	1
Mitsikostas, DD	1
Gatzonis, S	1
Thomas, A	1
Ilias, A	1
Jevoux, Cda C	1
Moreira Filho, PF	1
de Souza, JA	1
Vasconcellos, E	1
Piña-Garza, JE	1
Millan, EJ	1
Warner, JS	1
Zed, PJ	1
Loewen, PS	1
Robinson, G	1
Eklund, S	1
Feoktistov, AP	1
Filatova, EG	1
Veĭn, AM	1
Plesh, O	1
Curtis, D	1
Levine, J	1
McCall, WD	1
Bauherz, G	1
Linton-Dahlöf, P	1
Linde, M	1
Dahlöf, C	1
Descombes, S	1
Brefel-Courbon, C	1
Thalamas, C	1
Albucher, JF	1
Rascol, O	1
Montastruc, JL	1
Senard, JM	1
Rothrock, JF	1
Roberts, LJ	1
Goucke, CR	1
Diamond, S	4
Sherwin, D	1
Carasso, RL	1
Yehuda, S	1
Streifler, M	1
Becher, B	1
Müller, WE	1
Breyer-Pfaff, U	1
Hering, R	1
Steiner, TJ	1
Holroyd, KA	1
Pingel, JD	1
Cordingley, GE	1
Jerome, A	1
Nappi, G	1
Sandrini, G	1
Granella, F	1
Ruiz, L	1
Cerutti, G	1
Facchinetti, F	1
Blandini, F	1
Manzoni, GC	1
Egbunike, IG	1
Chaffee, BJ	1
Jay, GW	1
Brunson, J	1
Branson, SJ	1
Tuchman, AJ	1
Daras, M	1
Indaco, A	1
Carrieri, PB	1
Saran, A	1
Prager, J	1
Kellhammer, U	1
Pöllmann, W	1
Canepari, C	1
Riva, M	1
Erminio, F	1
Cerbo, R	1
Casacchia, M	1
Anthony, M	2
Bente, D	1
Feder, J	1
Belmchen, H	1
Hippius, H	1
Rosenberg, L	1
Okasha, A	1
Ghaleb, HA	1
Sadek, A	1
Kashiwagi, T	1
McClure, JN	1
Wetzel, RD	1
Kerr, MM	1
Baltes, BJ	2
Pieschl, D	1
Richtberg, W	1
Brüning, J	1
Werner, H	1
Dalessio, DJ	1
Viëtor, WP	1
Zwart, JM	1
Kelly, RE	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Drug and Non-Drug Treatment of Pediatric Chronic Headache[NCT00389038]	Phase 3	132 participants (Anticipated)	Interventional	2006-10-31	Active, not recruiting
Amitriptyline and Topiramate in the Prevention of Childhood Migraine[NCT01581281]	Phase 3	488 participants (Actual)	Interventional	2012-06-30	Terminated (stopped due to Interim assessment provided sufficient data to answer study questions)
Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662]	Phase 4	50 participants (Anticipated)	Interventional	2015-02-28	Recruiting
Effects of Myofascial Trigger Points Therapy in Migraine.[NCT05646160]		100 participants (Anticipated)	Interventional	2018-01-15	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The PedMIDAS scale which evaluated the impact of headaches in school, home, play, and social activities, is comprised of six items that pertain to days missed in various activities over the past 90 days. Questions were answered by the youth in consultation with their parents and reviewed by study staff. The PedMIDAS scale was administered at baseline (covering the three months prior to enrollment) and at the 24-week endpoint visit (the end of the maintenance period, covering three months of enrollment). A total PedMIDAS score (sum of items 1-6) was used in this trial. Scores range from 0-240; with a score of 0-10 indicating no disability, 11-30 mild disability, 31-50 moderate disability, and more than 50 severe disability in daily activities. The main outcome measure for this comparison will be the difference in the baseline and endpoint (24 week) PedMIDAS total scores for:~Amitriptyline vs. Placebo~Topiramate vs. Placebo~Amitriptyline vs Topiramate" (NCT01581281)
Timeframe: baseline and 24 week endpoint

Change in Number of Headache Days

Intervention	units on a scale (Mean)
Topiramate	-26.8
Placebo	-22.6
Amitriptyline	-22.5

"This outcomes measure examines whether the rate of absolute number of headache days, per 28 day period, differs between treatment groups over time. This was assessed longitudinally based on the actual number of headache days from the 28 days prior to randomization to the last 28 days of this 24 week trial. The change in absolute headache days was compared between:~Amitriptyline vs. placebo~Topiramate vs. placebo~Amitriptyline vs. Topiramate" (NCT01581281)
Timeframe: 4 week baseline period and last 4 weeks of the 24-week trial

Number (Percentage) of Participants Reporting a ≥ 50% Reduction in Headache Days

Intervention	days (Mean)
Topiramate	-6.7
Placebo	-5.9
Amitriptyline	-6.7

"The primary endpoint was a ≥ 50% reduction in headache frequency from the 28 days (4 weeks) baseline period prior to randomization to the last 28 days (4 weeks) of the trial. Headache frequency was defined as the number of days with headache for a given four week 28 day (4 week) period. A headache day was defined as any day during which any headache occurs within a 24 hour period, starting and ending at midnight.~For each participant, the primary endpoint involved a determination of whether a 50% or greater reduction in headache frequency was observed during the last 4 weeks of active treatment as compared with the headache frequency during the 4-week baseline period. Results were compared across the three treatment groups." (NCT01581281)
Timeframe: 4 week baseline period and last 4 weeks of the 24-week trial

Occurrence of Treatment Emergent Serious Adverse Events

Intervention	Participants (Count of Participants)
Topiramate	72
Placebo	40
Amitriptyline	69

To determine if amitriptyline or topiramate differ from placebo on the occurrence of treatment emergent serious adverse events. (NCT01581281)
Timeframe: 24 weeks of the trial

Tolerability, as Indicated by the Number (Percentage) of Participants That Completed the 24-week Treatment Phase

Intervention	serious adverse events (Number)
Topiramate	4
Placebo	2
Amitriptyline	6

To assess tolerability, the percentage of subjects who complete the entire 24-week treatment period will be estimated in each of the three groups. (NCT01581281)
Timeframe: 24 weeks

Article	Year
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 1: amitriptyline. The journal of headache and pain, 2023, Apr-11, Volume: 24, Issue:1 Topics: Adult; Amitriptyline; Headache; Humans; Migraine Disorders; Transcription Factors	2023
Hints on Diagnosing and Treating Headache. Deutsches Arzteblatt international, 2018, 04-27, Volume: 115, Issue:17 Topics: Amitriptyline; Analgesics, Non-Narcotic; Antihypertensive Agents; Headache; Humans; Metoprolol; Migr	2018
Dizziness and vertigo in the adolescent. Otolaryngologic clinics of North America, 2011, Volume: 44, Issue:2 Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Dizziness; Female; Headache; H	2011
Headache (chronic tension-type). BMJ clinical evidence, 2009, Jul-22, Volume: 2009 Topics: Amitriptyline; Headache; Humans; Manipulation, Osteopathic; Selective Serotonin Reuptake Inhibitors;	2009
Cognitive-behavioral issues in the treatment and management of chronic daily headache. Current pain and headache reports, 2002, Volume: 6, Issue:6 Topics: Amitriptyline; Analgesics, Non-Narcotic; Biofeedback, Psychology; Chronic Disease; Cognitive Behavio	2002
Muscle-contraction (tension) headache. Psychosomatics, 1983, Volume: 24, Issue:4 Topics: Amitriptyline; Anxiety; Biofeedback, Psychology; Conflict, Psychological; Depressive Disorder; Elect	1983
An overview of the classification, causes, and treatment of headache. Hospital & community psychiatry, 1984, Volume: 35, Issue:3 Topics: Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Biofeedback, Psychology; Cerebrovascula	1984
Medication-induced headache: overview and systematic review of therapeutic approaches. The Annals of pharmacotherapy, 1999, Volume: 33, Issue:1 Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents; Chronic Disease; Ergolines; Headache; Humans; M	1999
[Chronic headaches]. Revue medicale de Bruxelles, 2000, Volume: 21, Issue:4 Topics: Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Craniocerebral Trauma;	2000
Antidepressants in the management of chronic pain syndromes. Pharmacotherapy, 1990, Volume: 10, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Arthritis; Back Pain; Chronic Disease; Diabetic Neuropathies;	1990

Article	Year
A Randomized Controlled Trial of High Rate rTMS Versus rTMS and Amitriptyline in Chronic Migraine. Pain physician, 2021, Volume: 24, Issue:6 Topics: Adolescent; Amitriptyline; Headache; Humans; Migraine Disorders; Transcranial Magnetic Stimulation;	2021
Venlafaxine can reduce the migraine attacks as well as amitriptyline: A noninferiority randomized trial. Clinical neurology and neurosurgery, 2022, Volume: 214 Topics: Adult; Amitriptyline; Drug-Related Side Effects and Adverse Reactions; Female; Headache; Humans; Mal	2022
Impact of preventive pill-based treatment on migraine days: A secondary outcome study of the Childhood and Adolescent Migraine Prevention (CHAMP) trial and a comparison of self-report to nosology-derived assessments. Headache, 2023, Volume: 63, Issue:6 Topics: Adolescent; Amitriptyline; Child; Double-Blind Method; Fructose; Headache; Headache Disorders; Human	2023
Predictors of Improvement in Pediatric Chronic Migraine: Results from the Cognitive-Behavioral Therapy and Amitriptyline Trial. Journal of clinical psychology in medical settings, 2022, Volume: 29, Issue:1 Topics: Adolescent; Amitriptyline; Child; Cognitive Behavioral Therapy; Headache; Humans; Migraine Disorders	2022
Trajectory of treatment response in the child and adolescent migraine prevention (CHAMP) study: A randomized clinical trial. Cephalalgia : an international journal of headache, 2022, Volume: 42, Issue:1 Topics: Adolescent; Amitriptyline; Child; Double-Blind Method; Headache; Headache Disorders; Humans; Migrain	2022
Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. JAMA, 2013, Dec-25, Volume: 310, Issue:24 Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Chronic Disease; Cognitive Behav	2013
Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial. The Clinical journal of pain, 2017, Volume: 33, Issue:10 Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Child; Chronic Disease; Cognitive Behavioral Th	2017
[Fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2008, Volume: 108, Issue:6 Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Chronic Disease; Electric Stimulation Therapy; F	2008
Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life. The journal of headache and pain, 2006, Volume: 7, Issue:1 Topics: Adult; Amitriptyline; Analgesics; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Hea	2006
Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms--a combined analysis of four British clinical trials in depression. Acta psychiatrica Scandinavica. Supplementum, 1983, Volume: 308 Topics: Adult; Amitriptyline; Anxiety; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; F	1983
Timed-release dihydroergotamine in the prophylaxis of mixed headache. A study versus amitriptyline. Cephalalgia : an international journal of headache, 1983, Volume: 3 Suppl 1 Topics: Adolescent; Adult; Amitriptyline; Clinical Trials as Topic; Delayed-Action Preparations; Dihydroergo	1983
Prophylaxis of migraine and mixed headache. A randomized controlled study. Headache, 1981, Volume: 21, Issue:3 Topics: Adult; Amitriptyline; Biofeedback, Psychology; Clinical Trials as Topic; Female; Headache; Humans; M	1981
A collaborative study of a new antidepressant, viloxazine, in neurotic and endogenous depressives. International pharmacopsychiatry, 1982, Volume: 17, Issue:1 Topics: Adolescent; Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Dizziness; Doxepin;	1982
[Amitriptyline in therapy of chronic tension headache]. Der Nervenarzt, 1994, Volume: 65, Issue:10 Topics: Adolescent; Adult; Aged; Amitriptyline; Contingent Negative Variation; Delayed-Action Preparations;	1994
Efficacy and tolerability of amitriptylinoxide in the treatment of chronic tension-type headache: a multi-centre controlled study. Cephalalgia : an international journal of headache, 1994, Volume: 14, Issue:2 Topics: Adolescent; Adult; Aged; Amitriptyline; Chronic Disease; Depression; Dose-Response Relationship, Dru	1994
[Effectiveness and tolerance of amitriptyline oxide in chronic tension headache--a multicenter double-blind study versus amitriptyline versus placebo]. Der Nervenarzt, 1993, Volume: 64, Issue:2 Topics: Adolescent; Adult; Aged; Amitriptyline; Dose-Response Relationship, Drug; Double-Blind Method; Drug	1993
Amitriptyline, a combined serotonin and noradrenaline re-uptake inhibitor, reduces exteroceptive suppression of temporal muscle activity in patients with chronic tension-type headache. Electroencephalography and clinical neurophysiology, 1996, Volume: 101, Issue:5 Topics: Adult; Amitriptyline; Citalopram; Double-Blind Method; Female; Headache; Humans; Male; Middle Aged;	1996
Buspirone vs amitriptyline in the treatment of chronic tension-type headache. Acta neurologica Scandinavica, 1997, Volume: 96, Issue:4 Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Buspirone; Dep	1997
Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. Journal of oral rehabilitation, 2000, Volume: 27, Issue:10 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depression; Facial Pain; Fe	2000
Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. Headache, 2001, Volume: 41, Issue:2 Topics: Adult; Aged; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Chronic Disease; Double-Blind Meth	2001
Management of chronic daily headache utilizing a uniform treatment pathway. Headache, 1999, Volume: 39, Issue:9 Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Dru	1999
Psychogenic headaches with mixed anxiety and depression. IMJ. Illinois medical journal, 1975, Volume: 147, Issue:3 Topics: Adolescent; Adult; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Dextropropoxyphene;	1975
Clomipramine and amitriptyline in the treatment of severe pain. The International journal of neuroscience, 1979, Volume: 9, Issue:3 Topics: Adult; Aged; Amitriptyline; Clomipramine; Female; Headache; Humans; Male; Middle Aged; Neuralgia; Pa	1979
Urinary metabolites of amitriptylinoxide and amitriptyline in single-dose experiments and during continuous therapy. Psychopharmacology, 1992, Volume: 106, Issue:3 Topics: Adult; Amitriptyline; Biotransformation; Chromatography, High Pressure Liquid; Female; Headache; Hum	1992
Abrupt outpatient withdrawal of medication in analgesic-abusing migraineurs. Lancet (London, England), 1991, Jun-15, Volume: 337, Issue:8755 Topics: Adult; Amitriptyline; Analgesics; Caffeine; Ergotamine; Evaluation Studies as Topic; Female; Follow-	1991
A comparison of pharmacological (amitriptyline HCL) and nonpharmacological (cognitive-behavioral) therapies for chronic tension headaches. Journal of consulting and clinical psychology, 1991, Volume: 59, Issue:3 Topics: Adult; Amitriptyline; Cognitive Behavioral Therapy; Female; Headache; Humans; Male; Middle Aged; Per	1991
A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline. Headache, 1990, Volume: 30, Issue:7 Topics: Adult; Amitriptyline; Chronic Disease; Depression; Double-Blind Method; Female; Headache; Humans; Ma	1990
Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study. Neurology, 1988, Volume: 38, Issue:11 Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Humans;	1988
Antidepressants not effective in headache associated with minor closed head injury. International journal of psychiatry in medicine, 1988, Volume: 18, Issue:1 Topics: Adult; Amitriptyline; Brain Concussion; Clinical Trials as Topic; Depressive Disorder; Drug Therapy,	1988
[Effectiveness of flunarizine in chronic headache. Double-blind study of placebo and amitriptyline]. La Clinica terapeutica, 1985, Dec-31, Volume: 115, Issue:6 Topics: Adolescent; Adult; Aged; Amitriptyline; Cinnarizine; Clinical Trials as Topic; Double-Blind Method;	1985
Cyclobenzaprine in the treatment of chronic tension headache. The Medical journal of Australia, 1972, Dec-16, Volume: 2, Issue:25 Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Dibenz	1972
[Double-blind study on 3 antidepressive agents. 2. Clinical comparison of noxiptiline, nor-noxiptiline, and amitryptiline using the AMP system]. Arzneimittel-Forschung, 1973, Volume: 23, Issue:2 Topics: Adjustment Disorders; Adolescent; Adult; Affective Symptoms; Aged; Amitriptyline; Analysis of Varian	1973
A double blind trial for the clinical management of psychogenic headache. The British journal of psychiatry : the journal of mental science, 1973, Volume: 122, Issue:567 Topics: Adolescent; Adult; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Diazepam; Dibenzoxe	1973
Amitriptyline in emotional states at the menopause. The New Zealand medical journal, 1970, Volume: 72, Issue:461 Topics: Adult; Affective Symptoms; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Estrogens;	1970
Chronic tension headache--treated with amitriptyline--a double-blind study. Headache, 1971, Volume: 11, Issue:3 Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Female; Heada	1971
Investigations into the mechanism and treatment of chronic headache. The Medical journal of Australia, 1965, Nov-27, Volume: 2, Issue:22 Topics: Amitriptyline; Clinical Trials as Topic; Headache; Humans; Hydroxyindoleacetic Acid; Hypertension; M	1965

Article	Year
Amitriptyline for post-COVID headache: effectiveness, tolerability, and response predictors. Journal of neurology, 2022, Volume: 269, Issue:11 Topics: Amitriptyline; COVID-19; Female; Headache; Humans; Male; Migraine Disorders; Nausea; Retrospective S	2022
Long-term outcomes of nummular headache: A series of 168 patients and 1198 patient-years of follow-up. Cephalalgia : an international journal of headache, 2023, Volume: 43, Issue:9 Topics: Adult; Amitriptyline; Follow-Up Studies; Headache; Headache Disorders; Humans; Pain	2023
A Combination of Indomethacin Farnesyl and Amitriptyline Is Effective for Continuous Interictal Pain with Probable Chronic Paroxysmal Hemicrania. Internal medicine (Tokyo, Japan), 2022, Feb-01, Volume: 61, Issue:3 Topics: Adult; Amitriptyline; Female; Headache; Humans; Indomethacin; Migraine Disorders; Paroxysmal Hemicra	2022
Cognitive behavioral therapy for treatment of pediatric chronic migraine. JAMA, 2013, Dec-25, Volume: 310, Issue:24 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cognitive Behavioral Therapy; Female; Headache; Hum	2013
Amitriptyline Dose and Treatment Outcomes in Specialty Headache Practice: A Retrospective Cohort Study. Headache, 2016, Volume: 56, Issue:10 Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cohort Studies; Dose-Response Relationship, Drug; Fe	2016
Menstrual-related nummular headache. Cephalalgia : an international journal of headache, 2010, Volume: 30, Issue:4 Topics: Adult; Amitriptyline; Female; Headache; Humans; Menstrual Cycle; Muscle Relaxants, Central	2010
You're the flight surgeon. Concussion and post-concussion syndrome. Aviation, space, and environmental medicine, 2009, Volume: 80, Issue:10 Topics: Accidents, Traffic; Aerospace Medicine; Amitriptyline; Antidepressive Agents, Tricyclic; Brain Concu	2009
The role of prevention. Handbook of clinical neurology, 2010, Volume: 97 Topics: Amitriptyline; Headache; Humans; Migraine Disorders	2010
Cyclic vomiting syndrome in Thai children. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002, Volume: 85 Suppl 2 Topics: Adolescent; Age Distribution; Age of Onset; Amitriptyline; Child; Child, Preschool; Female; Headache	2002
ANTI-DEPRESSANT DRUGS. Medical record and annals, 1963, Volume: 56 Topics: Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Geriatrics; Headache; Imipram	1963
ANXIETY AND DEPRESSION: TREATMENT IN GENERAL PRACTICE. Pennsylvania medical journal (1928), 1963, Volume: 66 Topics: Amitriptyline; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Family Practice; Female;	1963
TREATMENT OF CHRONIC TENSION HEADACHE. Lancet (London, England), 1964, Jun-06, Volume: 1, Issue:7345 Topics: Amitriptyline; Amobarbital; Anxiety; Anxiety Disorders; Biomedical Research; Chlordiazepoxide; Diaze	1964
[AMITRIPTYLINE IN AMBULATORY PSYCHIATRIC PRACTICE]. L' Ospedale maggiore, 1964, Volume: 59 Topics: Amitriptyline; Autonomic Nervous System Diseases; Depression; Drug Eruptions; Drug Hypersensitivity;	1964
TOXICITY OF PSYCHOTROPIC DRUGS. SIDE-EFFECTS AND TOXIC EFFECTS OF ANTIDEPRESSANTS. Proceedings of the Royal Society of Medicine, 1964, Volume: 57 Topics: Amitriptyline; Antidepressive Agents; Convulsive Therapy; Electroconvulsive Therapy; Headache; Imipr	1964
Occipital neuralgia secondary to respiratory tract infection. Journal of orofacial pain, 2005,Summer, Volume: 19, Issue:3 Topics: Amines; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cyclohexanecarboxylic Acids; Diagnos	2005
Clinical inquiries. Is osteopathic manipulation effective for headaches? The Journal of family practice, 2008, Volume: 57, Issue:3 Topics: Amitriptyline; Analgesics, Non-Narcotic; Headache; Humans; Manipulation, Osteopathic; Migraine Disor	2008
[Antidepressants with different action mechanisms in the treatment of chronic daily headache]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2007, Volume: 107, Issue:9 Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepress	2007
[Psychiatric and psychometric study of a group of headache patients treated with antidepressives]. La Clinica terapeutica, 1983, Oct-31, Volume: 107, Issue:2 Topics: Adult; Aged; Amitriptyline; Depression; Female; Headache; Humans; Male; Middle Aged; Personality; Ps	1983
Paradoxical effects of frequent analgesic use. Advances in neurology, 1982, Volume: 33 Topics: Adult; Amitriptyline; Analgesics; Drug Tolerance; Female; Headache; Humans; Hypnotics and Sedatives;	1982
Treatment of post-traumatic headache with amitriptyline. Headache, 1980, Volume: 20, Issue:4 Topics: Adult; Amitriptyline; Craniocerebral Trauma; Headache; Humans; Middle Aged	1980
Diagnosis and treatment of persistent pain after trauma to the head and neck. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1994, Volume: 52, Issue:11 Topics: Adult; Amitriptyline; Carbamazepine; Chronic Disease; Craniocerebral Trauma; Facial Pain; Female; He	1994
Statistical analysis of ordinal categorical status after therapies. Journal of consulting and clinical psychology, 1994, Volume: 62, Issue:2 Topics: Amitriptyline; Chi-Square Distribution; Cognitive Behavioral Therapy; Data Interpretation, Statistic	1994
Platelet-rich plasma serotonin levels in tension-type headache and depression. Cephalalgia : an international journal of headache, 1993, Volume: 13, Issue:5 Topics: Adult; Amitriptyline; Blood Platelets; Depression; Female; Headache; Humans; Male; Middle Aged; Sero	1993
[Transitory algic hemilateral syndrome in relation to spontaneous lobar hematoma]. Neurologia (Barcelona, Spain), 1993, Volume: 8, Issue:9 Topics: Aged; Amitriptyline; Brain; Brain Diseases; Functional Laterality; Headache; Hematoma; Humans; Male;	1993
Amitriptyline and dexamethasone combined treatment in drug-induced headache. Cephalalgia : an international journal of headache, 1996, Volume: 16, Issue:3 Topics: Adult; Amitriptyline; Analgesics; Dexamethasone; Drug Therapy, Combination; Female; Headache; Humans	1996
[Primary chronic daily headache: a report on 52 cases]. Arquivos de neuro-psiquiatria, 1998, Volume: 56, Issue:1 Topics: Adolescent; Adult; Aged; Amitriptyline; Chronic Disease; Drug Administration Schedule; Female; Follo	1998
Analgesic rebound headache in children and adolescents. Journal of child neurology, 1998, Volume: 13, Issue:9 Topics: Adolescent; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics; Child; Female; Headache; Humans	1998
Headache in Meniere's disease. Auris, nasus, larynx, 1999, Volume: 26, Issue:4 Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Carbamazepin	1999
[Medication abuse-related headache]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1999, Volume: 99, Issue:12 Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Depressive Disorder; Female; Headache; Humans;	1999
Withdrawal therapy improves chronic daily headache associated with long-term misuse of headache medication: a retrospective study. Cephalalgia : an international journal of headache, 2000, Volume: 20, Issue:7 Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Drug-Related Side	2000
Retro-orbital tumour--an uncommon cause of headache in pregnancy. Anaesthesia and intensive care, 2001, Volume: 29, Issue:3 Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Headache; Hemangioma, Ca	2001
A new method for treating "headaches". The American journal of psychiatry, 1979, Volume: 136, Issue:9 Topics: Adult; Amitriptyline; Benztropine; Depression; Drug Therapy, Combination; Female; Follow-Up Studies;	1979
The effectiveness of physical therapy in the treatment of chronic daily headaches. Headache, 1989, Volume: 29, Issue:3 Topics: Adult; Aged; Amitriptyline; Biofeedback, Psychology; Chronic Disease; Combined Modality Therapy; Ele	1989
Muscle contraction headache: dexamethasone suppression test and response to amitriptyline. European neurology, 1989, Volume: 29, Issue:5 Topics: Adult; Aged; Amitriptyline; Chronic Disease; Dexamethasone; Female; Headache; Humans; Hydrocortisone	1989
[Further observations on the effects of the treatment with amitriptyline and perphenazine in essential headache]. La Clinica terapeutica, 1987, Sep-15, Volume: 122, Issue:5 Topics: Adult; Amitriptyline; Drug Therapy, Combination; Female; Headache; Humans; Male; Middle Aged; MMPI;	1987
Diagnosis and therapy of headache. Clinical therapeutics, 1986, Volume: 8, Issue:2 Topics: Adult; Affective Symptoms; Amitriptyline; Analgesics; Drug Therapy, Combination; Female; Headache; H	1986
Combination headache: practical experience with a combination of a beta-blocker and an antidepressive. Cephalalgia : an international journal of headache, 1986, Volume: 6 Suppl 5 Topics: Adult; Amitriptyline; Cluster Headache; Drug Therapy, Combination; Female; Headache; Humans; Male; M	1986
[Clinical findings and test results in a group of patients with headaches treated with amitriptyline as compared with perphenazine]. La Clinica terapeutica, 1985, Apr-30, Volume: 113, Issue:2 Topics: Adolescent; Adult; Amitriptyline; Female; Headache; Humans; Male; Perphenazine; Psychological Tests	1985
Headache and psychiatric disorders. Diseases of the nervous system, 1972, Volume: 33, Issue:10 Topics: Adolescent; Adult; Affective Symptoms; Age Factors; Aged; Alcoholism; Amitriptyline; Antisocial Pers	1972
Experience in a headache clinic within the 'ghetto'. Headache, 1972, Volume: 11, Issue:4 Topics: Amitriptyline; Anxiety; Community Health Services; Cyproheptadine; Depression; Emotions; Ergotamine;	1972
[Saroten retard and its therapeutic possibilities in chronic schizophrenic psychoses. Results of clinical-experimental tests]. Der Nervenarzt, 1971, Volume: 42, Issue:12 Topics: Adult; Amitriptyline; Body Weight; Cardiovascular Diseases; Chronic Disease; Delayed-Action Preparat	1971
[Limbatril therapy in psychosomatic diseases]. Die Medizinische Welt, 1969, Oct-25, Volume: 43 Topics: Adult; Amitriptyline; Chlordiazepoxide; Depression; Female; Headache; Humans; Male; Middle Aged; Psy	1969
Some reflections on the etiologic role of depression in head pain. Headache, 1968, Volume: 8, Issue:1 Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Depression; Facial Neuralgia; Headache; Human	1968
[Psychogenic headache and its treatment with hypnosis and autogenic training]. Psychotherapy and psychosomatics, 1968, Volume: 14, Issue:5 Topics: Amitriptyline; Autogenic Training; Headache; Hypnosis; Migraine Disorders; Physician-Patient Relatio	1968
Methysergide and coronary thrombosis. The Practitioner, 1965, Volume: 195, Issue:168 Topics: Amitriptyline; Coronary Disease; Headache; Humans; Male; Methysergide; Middle Aged; Vascular Headach	1965

amitriptyline and Headache