Page last updated: 2024-10-22
amitriptyline and HbS Disease
amitriptyline has been researched along with HbS Disease in 1 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| "The gene for sickle cell disease is carried by 8% of the African-American population in the United States." | 1.28 | Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Sanders, DY | 1 |
| Severance, HW | 1 |
| Pollack, CV | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887] | Phase 2 | 150 participants (Actual) | Interventional | 2004-10-31 | Completed |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Length of Hospitalization
Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days
| Intervention | Days (Median) |
|---|
| Inhaled Nitric Oxide | 4.06 |
| Placebo | 3.11 |
Number of Participants Discharged to Home Within the First 24 Hours
(NCT00094887)
Timeframe: within 24 hours
| Intervention | Participants (Count of Participants) |
|---|
| Inhaled Nitric Oxide | 5 |
| Placebo | 7 |
Number of Participants With Acute Chest Syndrome/Pneumonia Requiring Blood Transfusion
Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days
| Intervention | Participants (Count of Participants) |
|---|
| Inhaled Nitric Oxide | 8 |
| Placebo | 7 |
Time to Vaso-occlusive Pain Crisis (VOC) Resolution
"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days
| Intervention | Hours (Median) |
|---|
| Inhaled Nitric Oxide | 61.83 |
| Placebo | 55.16 |
Number of Participants Readmitted to Hospital Within 30 Days After Discharge
The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up
| Intervention | Participants (Count of Participants) |
|---|
| during first 24 hours | during 30-day follow-up |
|---|
| Inhaled Nitric Oxide | 0 | 9 |
,| Placebo | 0 | 17 |
Total Dose of Opioids Received
The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days
| Intervention | mg (Median) |
|---|
| within 8 hours | within 40 days |
|---|
| Inhaled Nitric Oxide | 16.25 | 153.75 |
,| Placebo | 17.25 | 211.37 |
Other Studies
1 other study available for amitriptyline and HbS Disease