amitriptyline has been researched along with HIV Coinfection in 15 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a randomized, double-blind, placebo-controlled, crossover study at a single center in South Africa, to ascertain whether amitriptyline is an effective analgesic for painful HIV-associated sensory neuropathy of moderate to severe intensity in: i) antiretroviral drug naive individuals, and ii) antiretroviral drug users." | 9.20 | Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy. ( Dinat, N; Kamerman, PR; Marinda, E; Moch, S; Rice, AS, 2015) |
| "To evaluate the efficacy of a standardized acupuncture regimen (SAR) and amitriptyline hydrochloride for the relief of pain due to HIV-related peripheral neuropathy in HIV-infected patients." | 9.08 | Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS. ( Brizz, B; Chaloner, K; Cohn, DL; Flaws, B; Hillman, S; Max, MB; Reichelderfer, P; Shlay, JC; Wentworth, D, 1998) |
| "Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy." | 9.08 | A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. ( Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C, 1998) |
| "We conducted a randomized, double-blind, placebo-controlled, crossover study at a single center in South Africa, to ascertain whether amitriptyline is an effective analgesic for painful HIV-associated sensory neuropathy of moderate to severe intensity in: i) antiretroviral drug naive individuals, and ii) antiretroviral drug users." | 5.20 | Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy. ( Dinat, N; Kamerman, PR; Marinda, E; Moch, S; Rice, AS, 2015) |
| "To evaluate the efficacy of a standardized acupuncture regimen (SAR) and amitriptyline hydrochloride for the relief of pain due to HIV-related peripheral neuropathy in HIV-infected patients." | 5.08 | Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS. ( Brizz, B; Chaloner, K; Cohn, DL; Flaws, B; Hillman, S; Max, MB; Reichelderfer, P; Shlay, JC; Wentworth, D, 1998) |
| "Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy." | 5.08 | A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. ( Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C, 1998) |
| "This neuropathy causes pain, paresthesias and burning sensations and/or numbness in the feet, which sometimes occurs in the hands as well." | 2.41 | [Sensory neuropathy in HIV infection: pathogenesis and therapy]. ( Portegies, P; Rosenberg, NR, 2001) |
| " Health workers should be mindful of dosing to minimise side effects and considerate of the additional pill burden." | 1.91 | The acceptability of antidepressant treatment in people living with HIV in Malawi: A patient perspective. ( Gaynes, BN; Hosseinipour, MC; Kulisewa, K; Minnick, CE; Mphonda, S; Pence, BW; Sansbury, G; Stockton, MA; Udedi, MM, 2023) |
| " Follow through of antidepressant prescription dosing recommendations by the prescriber was low." | 1.38 | Feasibility of nurse-led antidepressant medication management of depression in an HIV clinic in Tanzania. ( Adams, JL; Almond, ML; Ringo, EJ; Shangali, WH; Sikkema, KJ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kulisewa, K | 1 |
| Minnick, CE | 1 |
| Stockton, MA | 1 |
| Gaynes, BN | 1 |
| Hosseinipour, MC | 1 |
| Mphonda, S | 1 |
| Sansbury, G | 1 |
| Udedi, MM | 1 |
| Pence, BW | 1 |
| Nakimuli-Mpungu, E | 1 |
| Odokonyero, R | 1 |
| Laker, J | 1 |
| Alderman, S | 1 |
| Dinat, N | 1 |
| Marinda, E | 1 |
| Moch, S | 1 |
| Rice, AS | 1 |
| Kamerman, PR | 1 |
| Beadles, WI | 1 |
| Jahn, A | 1 |
| Weigel, R | 1 |
| Clutterbuck, D | 1 |
| Adams, JL | 1 |
| Almond, ML | 1 |
| Ringo, EJ | 1 |
| Shangali, WH | 1 |
| Sikkema, KJ | 1 |
| Koppel, BS | 1 |
| Bharel, C | 1 |
| Holsboer, F | 1 |
| Grasser, A | 1 |
| Friess, E | 1 |
| Wiedemann, K | 1 |
| Valentine, C | 1 |
| Williams, O | 1 |
| Davis, A | 1 |
| Hind, CR | 1 |
| Saltissi, S | 1 |
| Arya, OP | 1 |
| Brown, R | 1 |
| Shlay, JC | 1 |
| Chaloner, K | 1 |
| Max, MB | 2 |
| Flaws, B | 1 |
| Reichelderfer, P | 1 |
| Wentworth, D | 1 |
| Hillman, S | 1 |
| Brizz, B | 1 |
| Cohn, DL | 1 |
| Kieburtz, K | 1 |
| Simpson, D | 1 |
| Yiannoutsos, C | 1 |
| Hall, CD | 1 |
| Ellis, RJ | 1 |
| Marra, CM | 1 |
| McKendall, R | 1 |
| Singer, E | 1 |
| Dal Pan, GJ | 1 |
| Clifford, DB | 1 |
| Tucker, T | 1 |
| Cohen, B | 1 |
| Kaptchuk, TJ | 1 |
| Ulett, GA | 1 |
| King, SA | 1 |
| Portegies, P | 1 |
| Rosenberg, NR | 1 |
| Lein, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients[NCT00000817] | 260 participants (Actual) | Interventional | 1994-11-30 | Completed | |||
| A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection[NCT00000793] | Phase 2 | 240 participants | Interventional | Completed | |||
| A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy[NCT00000842] | Phase 2 | 270 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amitriptyline and HIV Coinfection
| Article | Year |
|---|---|
Steroid effects on central neurons and implications for psychiatric and neurological disorders.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Benzamides; Brain; Corticotropin-Releasing Hormone; Dexa | 1994 |
[Sensory neuropathy in HIV infection: pathogenesis and therapy].
Topics: Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Carba | 2001 |
3 trials available for amitriptyline and HIV Coinfection
| Article | Year |
|---|---|
Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Anti-Retroviral Agents; Cross-Over Studies; Double-B | 2015 |
Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS.
Topics: Acupuncture Therapy; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Double-Blind Method; Fe | 1998 |
A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Anti-Arrhythmia Agents; Double-Blind Method; Dru | 1998 |
10 other studies available for amitriptyline and HIV Coinfection
| Article | Year |
|---|---|
The acceptability of antidepressant treatment in people living with HIV in Malawi: A patient perspective.
Topics: Amitriptyline; Antidepressive Agents; Depression; Fluoxetine; HIV Infections; Humans; Malawi; Pilot | 2023 |
Major depression in postconflict northern Uganda: a case report.
Topics: Amitriptyline; Anti-Retroviral Agents; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; | 2014 |
Peripheral neuropathy in HIV-positive patients at an antiretroviral clinic in Lilongwe, Malawi.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Antiretroviral Therapy, Highly Active; Cross-Sectional Stud | 2009 |
Feasibility of nurse-led antidepressant medication management of depression in an HIV clinic in Tanzania.
Topics: Adult; Ambulatory Care Facilities; Amitriptyline; Anti-Retroviral Agents; Antidepressive Agents, Tri | 2012 |
Use of amitriptyline to offset sleep disturbances caused by efavirenz.
Topics: Alkynes; Amitriptyline; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Fol | 2005 |
Case study of zidovudine overdose.
Topics: Adult; Amitriptyline; Attitude to Health; Drug Overdose; HIV Infections; Humans; Male; Suicide, Atte | 1993 |
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; HIV Infections; Humans; Pain; | 1999 |
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; HIV Infections; Humans; Pain; | 1999 |
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Administration Schedule; | 1999 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |