amitriptyline has been researched along with Glioma in 4 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we investigated the effects of chronic in vitro administration of amitriptyline, a tricyclic antidepressant, on cyclic GMP formation stimulated by 5-hydroxytryptamine (5-HT) in the neuroblastoma x glioma hybrid cell line, NG 108-15, 5-HT (0." | 3.69 | Chronic amitriptyline exposure reduces 5-HT3 receptor-mediated cyclic GMP formation in NG 108-15 cells. ( Nishida, A; Shimizu, M; Yamawaki, S; Zensho, H, 1996) |
| "Gel electrophoresis of DNA was used for estimation of DNA changes caused in C6 glioma cells by treatment with psychotropic drugs (imipramine, amitryptiline and fluoxetine)." | 3.69 | Estimation of apoptosis in C6 glioma cells treated with antidepressants. ( Kovárů, H; Lisá, V; Lukásová, E; Rittich, B; Spanová, A, 1997) |
| "Amitriptyline treatment also increased the expression of luciferase reporter gene regulated by CRE elements." | 1.35 | Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: a possible contribution to GDNF production. ( Hisaoka, K; Maeda, N; Takebayashi, M; Tsuchioka, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hisaoka, K | 1 |
| Maeda, N | 1 |
| Tsuchioka, M | 1 |
| Takebayashi, M | 1 |
| Shimizu, M | 1 |
| Nishida, A | 1 |
| Zensho, H | 1 |
| Yamawaki, S | 1 |
| Spanová, A | 1 |
| Kovárů, H | 1 |
| Lisá, V | 1 |
| Lukásová, E | 1 |
| Rittich, B | 1 |
| Rabey, JM | 1 |
| Avrahami, E | 1 |
4 other studies available for amitriptyline and Glioma
| Article | Year |
|---|---|
Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: a possible contribution to GDNF production.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Cell Line, Tumor; Co | 2008 |
Chronic amitriptyline exposure reduces 5-HT3 receptor-mediated cyclic GMP formation in NG 108-15 cells.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Benzamides; Bradykinin; Brain Neoplasms; Bridged Bi | 1996 |
Estimation of apoptosis in C6 glioma cells treated with antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Apoptosis; DNA Fragmentation; Fluoxetine; Glioma; Humans; Imip | 1997 |
Unmasking of cerebellar tumours by amitriptyline in depressive patients.
Topics: Aged; Amitriptyline; Astrocytoma; Cerebellar Neoplasms; Depressive Disorder; Diagnosis, Differential | 1985 |