amitriptyline has been researched along with Glioblastoma in 1 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline treatment also increased GDNF mRNA expression in rat astrocytes." | 1.31 | Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells. ( Hisaoka, K; Koda, T; Miyata, M; Morinobu, S; Nishida, A; Ohta, M; Yamawaki, S; Zensho, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hisaoka, K | 1 |
| Nishida, A | 1 |
| Koda, T | 1 |
| Miyata, M | 1 |
| Zensho, H | 1 |
| Morinobu, S | 1 |
| Ohta, M | 1 |
| Yamawaki, S | 1 |
1 other study available for amitriptyline and Glioblastoma
| Article | Year |
|---|---|
Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells.
Topics: Amitriptyline; Animals; Antidepressive Agents; Astrocytes; Butadienes; Cell Line; Cells, Cultured; C | 2001 |