amitriptyline has been researched along with Genetic Predisposition in 4 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our data suggest that amitriptyline-induced inhibition of I(Na) unmasks the Brugada ECG phenotype and facilitates development of an arrhythmogenic substrate only in the setting of a genetic predisposition by creating repolarization heterogeneities that give rise to phase 2 reentry and VT." | 3.78 | Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. ( Antzelevitch, C; Barajas-Martínez, H; Di Diego, JM; Hu, D; Minoura, Y; Sicouri, S; Zygmunt, AC, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zanier-Gomes, PH | 1 |
| de Abreu Silva, TE | 1 |
| Zanetti, GC | 1 |
| Benati, ÉR | 1 |
| Pinheiro, NM | 1 |
| Murta, BM | 1 |
| Crema, VO | 1 |
| Ohnishi, T | 1 |
| Watanabe, A | 1 |
| Ohba, H | 1 |
| Iwayama, Y | 1 |
| Maekawa, M | 1 |
| Yoshikawa, T | 1 |
| Minoura, Y | 1 |
| Di Diego, JM | 1 |
| Barajas-Martínez, H | 1 |
| Zygmunt, AC | 1 |
| Hu, D | 1 |
| Sicouri, S | 1 |
| Antzelevitch, C | 1 |
| Forget, P | 1 |
| le Polain de Waroux, B | 1 |
| Wallemacq, P | 1 |
| Gala, JL | 1 |
4 other studies available for amitriptyline and Genetic Predisposition
| Article | Year |
|---|---|
Depressive behavior induced by social isolation of predisposed female rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Disease Models, Anima | 2015 |
Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antimanic Agents; Avoidance Learning; Behavior, Anima | 2010 |
Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants.
Topics: Action Potentials; Adrenergic beta-Agonists; Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidep | 2012 |
Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antitussive Agents; Coma; Cytochrome P-450 CYP2D6; | 2008 |