amitriptyline has been researched along with Fragile X Syndrome in 1 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Fragile X Syndrome: A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lacivita, E | 1 |
| Niso, M | 1 |
| Stama, ML | 1 |
| Arzuaga, A | 1 |
| Altamura, C | 1 |
| Costa, L | 1 |
| Desaphy, JF | 1 |
| Ragozzino, ME | 1 |
| Ciranna, L | 1 |
| Leopoldo, M | 1 |
1 other study available for amitriptyline and Fragile X Syndrome
| Article | Year |
|---|---|
Privileged scaffold-based design to identify a novel drug-like 5-HT
Topics: Dose-Response Relationship, Drug; Drug Design; Fragile X Syndrome; HEK293 Cells; Humans; Molecular S | 2020 |