amitriptyline has been researched along with Fibromyalgia in 93 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT])." | 9.69 | Is low-dose naltrexone effective in chronic pain management? ( DeSanto, K; Huang, H; Lyon, C; Radi, R; Rivera, J, 2023) |
| "After institutional ethics committee approval, 75 female subjects diagnosed with fibromyalgia and in receipt of pregabalin (75 mg/day) were randomly allocated to concurrently receive amitriptyline (25 mg/day; n = 24), venlafaxine (75 mg/day; n = 25), or paroxetine (25 mg/day; n = 26)." | 9.24 | Comparative Efficacy of Newer Antidepressants in Combination with Pregabalin for Fibromyalgia Syndrome: A Controlled, Randomized Study. ( Ramzy, EA, 2017) |
| " Our aim is to identify and compare the efficacy of amitriptyline (AMT), duloxetine (DLX), and pregabalin (PGB) for reducing pain intensity by 30% (R30%) and 50% (R50%) in adult patients with fibromyalgia." | 9.22 | Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis. ( Alberti, FF; Becker, MW; Blatt, CR; da Silva Dal Pizzol, T; Pilger, D; Ziegelmann, PK, 2022) |
| "Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia." | 9.22 | Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. ( Doucette, JA; Eguale, T; Farag, HM; Goswami, H; Sultan, I; Yunusa, I, 2022) |
| "The combination of 240 mg of intravenous lidocaine (once a week for 4 weeks) with 25 mg of amitriptyline for 8 weeks had no meaningful impact in fibromyalgia patients." | 9.22 | Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study. ( Albertoni Giraldes, AL; Brunialti, MK; Leal, PD; Sakata, RK; Salomão, R, 2016) |
| "Our results appear to indicate that quetiapine XR does not provide similar efficacy to amitriptyline for treating patients with fibromyalgia." | 9.19 | Quetiapine extended-release (Seroquel-XR) versus amitriptyline monotherapy for treating patients with fibromyalgia: a 16-week, randomized, flexible-dose, open-label trial. ( Calandre, EP; Galán, J; Hidalgo-Tallon, J; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM; Vilchez, JS, 2014) |
| "Melatonin alone or in combination with amitriptyline reduced significantly pain on the VAS compared with amitriptyline alone (P < 0." | 9.19 | Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014) |
| "The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms." | 9.17 | Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia? ( As, I; Atalay, A; Bagis, S; Erdogan, C; Karabiber, M; Tamer, L, 2013) |
| "Combined administration of 240 mg intravenous lidocaine (once a week) and 25 mg amitriptyline for 4 weeks did not modify pain intensity or plasma serotonin, norepinephrine, or dopamine concentrations in fibromyalgia patients." | 9.15 | Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. ( Issy, AM; Sakata, RK; Vlainich, R, 2011) |
| "To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening." | 9.15 | Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study. ( Archambault, WT; Harris, HW; Kwong, T; Lederman, S; Moldofsky, H, 2011) |
| "0 mg before bedtime) to amitriptyline (10-20 mg before bedtime) in patients with FM with chronic insomnia." | 9.14 | The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. ( Fitzcharles, MA; Joseph, L; Shir, Y; Ware, MA, 2010) |
| "As described elsewhere the oral administration of 5 mg of the 5-HT3-receptor-antagonist Tropisetron in fibromyalgia exhibited less amelioration of pain in patients with a depression in comparison to patients without depression." | 9.10 | [The influence of depression on the effect of Tropisetron in the therapy of fibromyalgia]. ( Müller, W; Stratz, T; Varga, B, 2003) |
| "The purpose of this study was to examine the effectiveness of low power laser (LPL) and low-dose amitriptyline therapy and to investigate effects of these therapy modalities on clinical symptoms and quality of life (QOL) in patients with fibromyalgia (FM)." | 9.10 | Effects of low power laser and low dose amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial. ( Ataoglu, S; Cevik, R; Gür, A; Karakoc, M; Nas, K; Sarac, J, 2002) |
| "To determine the prevalence and clinical correlations of an anomaly consisting of electroencephalographic (EEG) waves within the alpha frequency band during non-rapid eye movement (NREM) sleep in patients with fibromyalgia, and to evaluate the alpha NREM sleep anomaly as a predictor of response to amitriptyline." | 9.08 | Sleep electroencephalography and the clinical response to amitriptyline in patients with fibromyalgia. ( Carette, S; Guimont, C; Oakson, G; Steriade, M, 1995) |
| "To study the usefulness of moclobemide and amitriptyline in the treatment of fibromyalgia (FM) in females without psychiatric disorder." | 9.08 | A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder. ( Hannonen, P; Isomeri, R; Malminiemi, K; Roponen, P; Yli-Kerttula, U, 1998) |
| "To study the effect of fluoxetine (FL) and amitriptyline (AM), alone and in combination, in patients with fibromyalgia (FM)." | 9.08 | A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. ( Goldenberg, D; Mayskiy, M; Mossey, C; Ruthazer, R; Schmid, C, 1996) |
| "Our data confirm the short-term efficacy of amitriptyline and cyclobenzaprine in a small percentage of patients with fibromyalgia." | 9.07 | Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind clinical trial. ( Baron, M; Bell, MJ; Bykerk, VP; Carette, S; Edworthy, SM; Fam, AG; Haraoui, B; Koehler, BE; McCain, GA; Reynolds, WJ, 1994) |
| "A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine." | 9.07 | The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia. ( Lue, FA; Moldofsky, H; Reynolds, WJ; Saskin, P, 1991) |
| "Twenty-three double blind, randomized, multiple crossover trials (N-of-1 RCT) of amitriptyline were conducted in patients with fibromyalgia." | 9.07 | Clinical usefulness of amitriptyline in fibromyalgia: the results of 23 N-of-1 randomized controlled trials. ( Adachi, J; Guyatt, G; Jaeschke, R; Keller, J; Wong, B, 1991) |
| "Non-steroidal antiinflammatory drugs are not very effective, even if commonly used, in primary fibromyalgia syndrome (PFS), whereas cyclobenzaprine (C) has proved to be quite useful." | 9.07 | Combined therapy with cyclobenzaprine and ibuprofen in primary fibromyalgia syndrome. ( De Vita, S; Fossaluzza, V, 1992) |
| "The aim of this study is to evaluate the effectiveness of fluoxetin associated with cyclobenzaprine vs cyclobenzaprine in the treatment of fibromyalgia." | 9.07 | [Fluoxetin combined with cyclobenzaprine in the treatment of fibromyalgia]. ( Bellandi, F; Cantini, F; Di Munno, O; Niccoli, L, 1994) |
| "We attempted a randomized, double blind trial of placebo vs cyclobenzaprine (Flexeril) in 40 female patients with fibromyalgia from a private rheumatology practice in Maine." | 9.06 | A randomized trial of cyclobenzaprine for the treatment of fibromyalgia. ( Block, SR; Gratwick, GM; Quimby, LG; Whitney, CD, 1989) |
| "Sixty-two patients with fibromyalgia were randomly assigned to receive 25 mg of amitriptyline at night, 500 mg of naproxen twice daily, both amitriptyline and naproxen, or placebo in a 6-week, double-blind trial." | 9.06 | A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. ( Dinerman, H; Felson, DT; Goldenberg, DL, 1986) |
| "Duloxetine and amitriptyline are antidepressants used in the treatment of fibromyalgia." | 9.05 | Comparing the efficacy and safety of duloxetine and amitriptyline in the treatment of fibromyalgia: overview of systematic reviews. ( Amador, TA; da Silva Dal Pizzol, T; de Farias, ÁD; Eberle, L, 2020) |
| "To assess the analgesic efficacy of amitriptyline for chronic neuropathic pain and fibromyalgia." | 8.88 | Amitriptyline for neuropathic pain and fibromyalgia in adults. ( Aldington, D; Cole, P; Derry, S; Moore, RA; Wiffen, PJ, 2012) |
| "To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia." | 8.82 | Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. ( Jackson, JL; O'Malley, PG; Tofferi, JK, 2004) |
| "Using US commercial insurance claims data (covering 2007 to 2009), we conducted a cohort study to examine the comparative effectiveness of amitriptyline, duloxetine, gabapentin, and pregabalin on health care utilization in patients with fibromyalgia." | 7.81 | Patterns of health care utilization related to initiation of amitriptyline, duloxetine, gabapentin, or pregabalin in fibromyalgia. ( Kim, SC; Landon, JE; Lee, YC, 2015) |
| "Using US health care utilization data, a large population-based cohort study was conducted to describe clinical characteristics and medication use patterns in patients diagnosed with fibromyalgia who newly started amitriptyline, duloxetine, gabapentin, or pregabalin." | 7.79 | Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. ( Kim, SC; Landon, JE; Solomon, DH, 2013) |
| "Amitriptyline (10mg) was prescribed for 3 months to 21 female patients with fibromyalgia." | 7.78 | Effect of low-dose amitriptyline on autonomic functions and peripheral blood flow in fibromyalgia: a pilot study. ( Bijlani, RL; Deepak, KK; Gupta, R; Kulshreshtha, P; Yadav, RK, 2012) |
| "To evaluate the cost effectiveness of pregabalin in the treatment of fibromyalgia." | 7.76 | Cost effectiveness of pregabalin in the treatment of fibromyalgia from a UK perspective. ( Bowrin, K; Choy, E; Lloyd, A; Richards, S; Sadosky, A; Watson, P; Zlateva, G, 2010) |
| "Amitriptyline has been evaluated in placebo-controlled studies, and it has served as an active comparator to other therapeutic interventions in the treatment of fibromyalgia." | 6.52 | Amitriptyline for the treatment of fibromyalgia: a comprehensive review. ( Calandre, EP; Rico-Villademoros, F; Slim, M, 2015) |
| " Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT])." | 5.69 | Is low-dose naltrexone effective in chronic pain management? ( DeSanto, K; Huang, H; Lyon, C; Radi, R; Rivera, J, 2023) |
| "After institutional ethics committee approval, 75 female subjects diagnosed with fibromyalgia and in receipt of pregabalin (75 mg/day) were randomly allocated to concurrently receive amitriptyline (25 mg/day; n = 24), venlafaxine (75 mg/day; n = 25), or paroxetine (25 mg/day; n = 26)." | 5.24 | Comparative Efficacy of Newer Antidepressants in Combination with Pregabalin for Fibromyalgia Syndrome: A Controlled, Randomized Study. ( Ramzy, EA, 2017) |
| " Our aim is to identify and compare the efficacy of amitriptyline (AMT), duloxetine (DLX), and pregabalin (PGB) for reducing pain intensity by 30% (R30%) and 50% (R50%) in adult patients with fibromyalgia." | 5.22 | Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis. ( Alberti, FF; Becker, MW; Blatt, CR; da Silva Dal Pizzol, T; Pilger, D; Ziegelmann, PK, 2022) |
| "Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia." | 5.22 | Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. ( Doucette, JA; Eguale, T; Farag, HM; Goswami, H; Sultan, I; Yunusa, I, 2022) |
| "The combination of 240 mg of intravenous lidocaine (once a week for 4 weeks) with 25 mg of amitriptyline for 8 weeks had no meaningful impact in fibromyalgia patients." | 5.22 | Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study. ( Albertoni Giraldes, AL; Brunialti, MK; Leal, PD; Sakata, RK; Salomão, R, 2016) |
| "Our results appear to indicate that quetiapine XR does not provide similar efficacy to amitriptyline for treating patients with fibromyalgia." | 5.19 | Quetiapine extended-release (Seroquel-XR) versus amitriptyline monotherapy for treating patients with fibromyalgia: a 16-week, randomized, flexible-dose, open-label trial. ( Calandre, EP; Galán, J; Hidalgo-Tallon, J; Molina-Barea, R; Morillas-Arques, P; Rico-Villademoros, F; Rodriguez-Lopez, CM; Vilchez, JS, 2014) |
| "Melatonin alone or in combination with amitriptyline reduced significantly pain on the VAS compared with amitriptyline alone (P < 0." | 5.19 | Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014) |
| "The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms." | 5.17 | Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia? ( As, I; Atalay, A; Bagis, S; Erdogan, C; Karabiber, M; Tamer, L, 2013) |
| "Combined administration of 240 mg intravenous lidocaine (once a week) and 25 mg amitriptyline for 4 weeks did not modify pain intensity or plasma serotonin, norepinephrine, or dopamine concentrations in fibromyalgia patients." | 5.15 | Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia. ( Issy, AM; Sakata, RK; Vlainich, R, 2011) |
| "To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening." | 5.15 | Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study. ( Archambault, WT; Harris, HW; Kwong, T; Lederman, S; Moldofsky, H, 2011) |
| "0 mg before bedtime) to amitriptyline (10-20 mg before bedtime) in patients with FM with chronic insomnia." | 5.14 | The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. ( Fitzcharles, MA; Joseph, L; Shir, Y; Ware, MA, 2010) |
| "Both amitriptyline administration and fluoxetine administration in patients with fibromyalgia have beneficial effects on anaerobic performance." | 5.12 | Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia. ( Gökbel, H; Levendoğlu, F; Okudan, N; Ozerbil, O, 2006) |
| "The purpose of this study was to examine the effectiveness of low power laser (LPL) and low-dose amitriptyline therapy and to investigate effects of these therapy modalities on clinical symptoms and quality of life (QOL) in patients with fibromyalgia (FM)." | 5.10 | Effects of low power laser and low dose amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial. ( Ataoglu, S; Cevik, R; Gür, A; Karakoc, M; Nas, K; Sarac, J, 2002) |
| "As described elsewhere the oral administration of 5 mg of the 5-HT3-receptor-antagonist Tropisetron in fibromyalgia exhibited less amelioration of pain in patients with a depression in comparison to patients without depression." | 5.10 | [The influence of depression on the effect of Tropisetron in the therapy of fibromyalgia]. ( Müller, W; Stratz, T; Varga, B, 2003) |
| "In this study fibromyalgia sufferers were randomly administered a combination of monoamine-oxidase inhibitors (MAOIs)-A/B with 5-HTP, 5-HTP alone, MAOIs-A/B alone, or the tricyclic drug amitriptyline in order to compare the efficacy of these treatments." | 5.08 | Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy. ( Nicolodi, M; Sicuteri, F, 1996) |
| "To determine the prevalence and clinical correlations of an anomaly consisting of electroencephalographic (EEG) waves within the alpha frequency band during non-rapid eye movement (NREM) sleep in patients with fibromyalgia, and to evaluate the alpha NREM sleep anomaly as a predictor of response to amitriptyline." | 5.08 | Sleep electroencephalography and the clinical response to amitriptyline in patients with fibromyalgia. ( Carette, S; Guimont, C; Oakson, G; Steriade, M, 1995) |
| "To study the effect of fluoxetine (FL) and amitriptyline (AM), alone and in combination, in patients with fibromyalgia (FM)." | 5.08 | A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. ( Goldenberg, D; Mayskiy, M; Mossey, C; Ruthazer, R; Schmid, C, 1996) |
| "To study the usefulness of moclobemide and amitriptyline in the treatment of fibromyalgia (FM) in females without psychiatric disorder." | 5.08 | A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder. ( Hannonen, P; Isomeri, R; Malminiemi, K; Roponen, P; Yli-Kerttula, U, 1998) |
| "A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine." | 5.07 | The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia. ( Lue, FA; Moldofsky, H; Reynolds, WJ; Saskin, P, 1991) |
| "The aim of this study is to evaluate the effectiveness of fluoxetin associated with cyclobenzaprine vs cyclobenzaprine in the treatment of fibromyalgia." | 5.07 | [Fluoxetin combined with cyclobenzaprine in the treatment of fibromyalgia]. ( Bellandi, F; Cantini, F; Di Munno, O; Niccoli, L, 1994) |
| "Our data confirm the short-term efficacy of amitriptyline and cyclobenzaprine in a small percentage of patients with fibromyalgia." | 5.07 | Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind clinical trial. ( Baron, M; Bell, MJ; Bykerk, VP; Carette, S; Edworthy, SM; Fam, AG; Haraoui, B; Koehler, BE; McCain, GA; Reynolds, WJ, 1994) |
| "Non-steroidal antiinflammatory drugs are not very effective, even if commonly used, in primary fibromyalgia syndrome (PFS), whereas cyclobenzaprine (C) has proved to be quite useful." | 5.07 | Combined therapy with cyclobenzaprine and ibuprofen in primary fibromyalgia syndrome. ( De Vita, S; Fossaluzza, V, 1992) |
| "Twenty-three double blind, randomized, multiple crossover trials (N-of-1 RCT) of amitriptyline were conducted in patients with fibromyalgia." | 5.07 | Clinical usefulness of amitriptyline in fibromyalgia: the results of 23 N-of-1 randomized controlled trials. ( Adachi, J; Guyatt, G; Jaeschke, R; Keller, J; Wong, B, 1991) |
| "We attempted a randomized, double blind trial of placebo vs cyclobenzaprine (Flexeril) in 40 female patients with fibromyalgia from a private rheumatology practice in Maine." | 5.06 | A randomized trial of cyclobenzaprine for the treatment of fibromyalgia. ( Block, SR; Gratwick, GM; Quimby, LG; Whitney, CD, 1989) |
| "Sixty-two patients with fibromyalgia were randomly assigned to receive 25 mg of amitriptyline at night, 500 mg of naproxen twice daily, both amitriptyline and naproxen, or placebo in a 6-week, double-blind trial." | 5.06 | A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. ( Dinerman, H; Felson, DT; Goldenberg, DL, 1986) |
| "Duloxetine and amitriptyline are antidepressants used in the treatment of fibromyalgia." | 5.05 | Comparing the efficacy and safety of duloxetine and amitriptyline in the treatment of fibromyalgia: overview of systematic reviews. ( Amador, TA; da Silva Dal Pizzol, T; de Farias, ÁD; Eberle, L, 2020) |
| "Amitriptyline and duloxetine are recommended in the case of comorbid depressive disorders or generalized anxiety disorder and pregabalin in the case of generalized anxiety disorder." | 4.95 | [Drug therapy of fibromyalgia syndrome : Updated guidelines 2017 and overview of systematic review articles]. ( Alten, R; Bär, KJ; Bernateck, M; Brückle, W; Friedel, E; Häuser, W; Henningsen, P; Petzke, F; Sommer, C; Tölle, T; Üçeyler, N; Winkelmann, A, 2017) |
| "We know from adult randomised controlled trials that some antiepileptics, such as gabapentin and pregabalin, can be effective in certain chronic pain conditions." | 4.95 | Antiepileptic drugs for chronic non-cancer pain in children and adolescents. ( Clinch, J; Cooper, TE; Heathcote, LC; Howard, R; Krane, E; Lord, SM; Schechter, N; Sethna, N; Wiffen, PJ; Wood, C, 2017) |
| "We found no convincing, unbiased, high quality evidence suggesting that nabilone is of value in treating people with fibromyalgia." | 4.93 | Cannabinoids for fibromyalgia. ( Fitzcharles, MA; Häuser, W; Klose, P; Phillips, T; Walitt, B, 2016) |
| "To assess the analgesic efficacy of amitriptyline for chronic neuropathic pain and fibromyalgia." | 4.88 | Amitriptyline for neuropathic pain and fibromyalgia in adults. ( Aldington, D; Cole, P; Derry, S; Moore, RA; Wiffen, PJ, 2012) |
| "Amitriptyline 25-50 mg/day reduces pain, fatigue, and depressiveness in patients with FMS and improves sleep and quality of life." | 4.84 | A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. ( Häuser, W; Sommer, C; Uçeyler, N, 2008) |
| "To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia." | 4.82 | Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. ( Jackson, JL; O'Malley, PG; Tofferi, JK, 2004) |
| "The purpose of this review is to present relatively detailed information on the characteristics of tricyclic antidepressants, mainly amitriptyline hydrochloride and doxepin hydrochloride, for use as an integral part of the safe and effective management of fibromyalgia and, to a lesser extent, other chronic pain syndromes." | 4.79 | A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. ( Godfrey, RG, 1996) |
| "Using US commercial insurance claims data (covering 2007 to 2009), we conducted a cohort study to examine the comparative effectiveness of amitriptyline, duloxetine, gabapentin, and pregabalin on health care utilization in patients with fibromyalgia." | 3.81 | Patterns of health care utilization related to initiation of amitriptyline, duloxetine, gabapentin, or pregabalin in fibromyalgia. ( Kim, SC; Landon, JE; Lee, YC, 2015) |
| "Using US health care utilization data, a large population-based cohort study was conducted to describe clinical characteristics and medication use patterns in patients diagnosed with fibromyalgia who newly started amitriptyline, duloxetine, gabapentin, or pregabalin." | 3.79 | Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. ( Kim, SC; Landon, JE; Solomon, DH, 2013) |
| "Amitriptyline (10mg) was prescribed for 3 months to 21 female patients with fibromyalgia." | 3.78 | Effect of low-dose amitriptyline on autonomic functions and peripheral blood flow in fibromyalgia: a pilot study. ( Bijlani, RL; Deepak, KK; Gupta, R; Kulshreshtha, P; Yadav, RK, 2012) |
| "To evaluate the cost effectiveness of pregabalin in the treatment of fibromyalgia." | 3.76 | Cost effectiveness of pregabalin in the treatment of fibromyalgia from a UK perspective. ( Bowrin, K; Choy, E; Lloyd, A; Richards, S; Sadosky, A; Watson, P; Zlateva, G, 2010) |
| "Community- and center-based rheumatologists enrolled patients with fibromyalgia syndrome in randomized, double-blind, multi-crossover, N-of-1 trials comparing amitriptyline and the combination amitriptyline and fluoxetine." | 3.73 | Lessons learned combining N-of-1 trials to assess fibromyalgia therapies. ( Feuer, JM; Fischer, PA; Goldenberg, DL; Kieval, RI; Mogavero, N; Rapoport, RJ; Ruthazer, R; Schmid, CH; Selker, HP; Stotsky, SA; Winston, E; Zucker, DR, 2006) |
| "We assessed cerebral blood flow with a semiquantitative functional brain mapping technique of single-photon emission computed tomography in 14 patients with primary fibromyalgia before and after 3 months of amitriptyline treatment." | 3.72 | The possible effect of clinical recovery on regional cerebral blood flow deficits in fibromyalgia: a prospective study with semiquantitative SPECT. ( Adigüzel, O; Kaptanoglu, E; Nacitarhan, V; Turgut, B, 2004) |
| " We demonstrate this patient-focused method using published data from 23 N-of-1 trial results comparing amitriptyline and placebo for the treatment of fibromyalgia." | 3.69 | Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. ( D'Agostino, RB; Lau, J; McIntosh, MW; Schmid, CH; Selker, HP; Zucker, DR, 1997) |
| "Thirty-six patients with fibrositis received low dose amitriptyline and placebo in a randomized double blind crossover study lasting 10 weeks." | 2.66 | Improvements in pain responsiveness in patients with fibrositis after successful treatment with amitriptyline. ( Harth, M; McCain, GA; Rollman, GB; Scudds, RA, 1989) |
| "We conclude that patients with fibrositis have a neurotransmitter plasma profile like other chronic pain states having stress and increased vasomotor activity with the possible exception of having low circulating epinephrine." | 2.66 | The plasma endorphin, prostaglandin and catecholamine profile of patients with fibrositis treated with cyclobenzaprine and placebo: a 5-month study. ( Hamaty, D; Howard, CW; Howard, R; Patten, MS; Valentine, JL; Wakefield, V, 1989) |
| "Seventy patients with primary fibrositis satisfying Smythe's criteria were studied in a 9-week double-blind trial comparing 50 mg amitriptyline with placebo." | 2.66 | Evaluation of amitriptyline in primary fibrositis. A double-blind, placebo-controlled study. ( Bell, DA; Carette, S; Fam, AG; McCain, GA, 1986) |
| "Fibromyalgia is a chronic widespread pain condition affecting millions of people worldwide." | 2.58 | Combination pharmacotherapy for the treatment of fibromyalgia in adults. ( Gilron, I; Moore, RA; Shum, B; Thorpe, J; Wiffen, PJ, 2018) |
| "Fibromyalgia is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue." | 2.53 | Antipsychotics for fibromyalgia in adults. ( Häuser, W; Klose, P; Phillips, T; Üçeyler, N; Walitt, B, 2016) |
| "Fibromyalgia is a syndrome of chronic widespread pain typically accompanied by fatigue, nonrestorative sleep, cognitive dysfunction, and mood disorders." | 2.53 | Myalgias and Myopathies: Fibromyalgia. ( McCarthy, J, 2016) |
| "Amitriptyline has been evaluated in placebo-controlled studies, and it has served as an active comparator to other therapeutic interventions in the treatment of fibromyalgia." | 2.52 | Amitriptyline for the treatment of fibromyalgia: a comprehensive review. ( Calandre, EP; Rico-Villademoros, F; Slim, M, 2015) |
| "Fibromyalgia is a clinically well-defined chronic condition with a biopsychosocial aetiology." | 2.52 | Selective serotonin reuptake inhibitors for fibromyalgia syndrome. ( Cantrell, SE; Häuser, W; Nishishinya, MB; Urrútia, G; Walitt, B, 2015) |
| "Vgx rats showed sustained hyperalgesia in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma creatine phosphokinase or lactose dehydrogenase levels) accompanied by hypersensitivity to colonic distension." | 1.35 | Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. ( Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T, 2009) |
| "Fibromyalgia is rarely included in the differential diagnosis of dyspnea, and timely diagnosis and treatment may be delayed." | 1.30 | Dyspnea resulting from fibromyalgia. ( Albert, RK; Kreck, T; Weiss, DJ, 1998) |
| "This syndrome has been called fibrositis or fibromyalgia." | 1.28 | Polysomnography in idiopathic muscle pain syndrome (fibrositis). ( Bertorini, TE; Lemmi, H; Silva, AB, 1991) |
| " N of 1 RCTs can also generate initial estimates of the proportion of patients who respond to a new agent and for determining sample size, inclusion criteria, and dosage regimen(s) for subsequent parallel group trials." | 1.28 | N of 1 randomized trials for investigating new drugs. ( Adachi, JD; Guyatt, GH; Heyting, A; Jaeschke, R; Keller, J; Roberts, RS, 1990) |
| "Fibrositis (fibromyalgia) is best treated by attaining patient acceptance of and compliance with a comprehensive treatment program." | 1.27 | Pharmacotherapeutics in fibrositis. ( Gatter, RA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (11.83) | 18.7374 |
| 1990's | 22 (23.66) | 18.2507 |
| 2000's | 22 (23.66) | 29.6817 |
| 2010's | 29 (31.18) | 24.3611 |
| 2020's | 9 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Alberti, FF | 1 |
| Becker, MW | 1 |
| Blatt, CR | 1 |
| Ziegelmann, PK | 1 |
| da Silva Dal Pizzol, T | 2 |
| Pilger, D | 1 |
| Farag, HM | 1 |
| Yunusa, I | 1 |
| Goswami, H | 1 |
| Sultan, I | 1 |
| Doucette, JA | 1 |
| Eguale, T | 1 |
| Staud, R | 1 |
| Aster, HC | 1 |
| Evdokimov, D | 1 |
| Braun, A | 1 |
| Üçeyler, N | 6 |
| Sommer, C | 6 |
| Hung, CH | 1 |
| Lee, YH | 1 |
| Wei, JC | 1 |
| Radi, R | 1 |
| Huang, H | 1 |
| Rivera, J | 1 |
| Lyon, C | 1 |
| DeSanto, K | 1 |
| de Assis, MR | 1 |
| Dos Santos Paiva, E | 1 |
| Helfenstein, M | 1 |
| Heymann, RE | 1 |
| Pollak, DF | 1 |
| Provenza, JR | 1 |
| Ranzolin, A | 1 |
| Rezende, MC | 1 |
| Ribeiro, LS | 1 |
| Souza, EJR | 1 |
| Martinez, JE | 1 |
| Tang, J | 1 |
| Landes, RD | 1 |
| de Farias, ÁD | 1 |
| Eberle, L | 1 |
| Amador, TA | 1 |
| Alten, R | 2 |
| Bär, KJ | 2 |
| Bernateck, M | 1 |
| Brückle, W | 1 |
| Friedel, E | 1 |
| Henningsen, P | 1 |
| Petzke, F | 3 |
| Tölle, T | 2 |
| Winkelmann, A | 2 |
| Häuser, W | 9 |
| Cooper, TE | 1 |
| Wiffen, PJ | 3 |
| Heathcote, LC | 1 |
| Clinch, J | 1 |
| Howard, R | 2 |
| Krane, E | 1 |
| Lord, SM | 1 |
| Sethna, N | 1 |
| Schechter, N | 1 |
| Wood, C | 1 |
| Thorpe, J | 1 |
| Shum, B | 1 |
| Moore, RA | 2 |
| Gilron, I | 1 |
| Braz, AS | 1 |
| Morais, LC | 1 |
| Paula, AP | 1 |
| Diniz, MF | 1 |
| Almeida, RN | 1 |
| Kim, SC | 2 |
| Landon, JE | 2 |
| Solomon, DH | 1 |
| Calandre, EP | 2 |
| Rico-Villademoros, F | 2 |
| Galán, J | 1 |
| Molina-Barea, R | 1 |
| Vilchez, JS | 1 |
| Rodriguez-Lopez, CM | 1 |
| Hidalgo-Tallon, J | 1 |
| Morillas-Arques, P | 1 |
| de Zanette, SA | 1 |
| Vercelino, R | 1 |
| Laste, G | 1 |
| Rozisky, JR | 1 |
| Schwertner, A | 1 |
| Machado, CB | 1 |
| Xavier, F | 1 |
| de Souza, IC | 1 |
| Deitos, A | 1 |
| Torres, IL | 1 |
| Caumo, W | 1 |
| Perrot, S | 2 |
| Russell, IJ | 1 |
| Lee, YC | 1 |
| Walitt, B | 4 |
| Urrútia, G | 2 |
| Nishishinya, MB | 1 |
| Cantrell, SE | 1 |
| Slim, M | 1 |
| Roth-Damas, P | 1 |
| Sempere-Manuel, M | 1 |
| Palop-Larrea, V | 1 |
| McCarthy, J | 1 |
| Ramzy, EA | 1 |
| Klose, P | 2 |
| Phillips, T | 2 |
| Albertoni Giraldes, AL | 1 |
| Salomão, R | 1 |
| Leal, PD | 1 |
| Brunialti, MK | 1 |
| Sakata, RK | 2 |
| Macfarlane, GJ | 1 |
| Kronisch, C | 1 |
| Dean, LE | 1 |
| Atzeni, F | 1 |
| Fluß, E | 1 |
| Choy, E | 2 |
| Kosek, E | 1 |
| Amris, K | 1 |
| Branco, J | 1 |
| Dincer, F | 1 |
| Leino-Arjas, P | 1 |
| Longley, K | 1 |
| McCarthy, GM | 1 |
| Makri, S | 1 |
| Sarzi-Puttini, P | 1 |
| Taylor, A | 1 |
| Jones, GT | 1 |
| Fitzcharles, MA | 2 |
| Adams, SM | 1 |
| Nishishinya, B | 1 |
| Rodriguez, A | 1 |
| Bonfill, X | 1 |
| Alegre, C | 1 |
| Darko, G | 1 |
| Zhao, RH | 1 |
| Zhu, YB | 1 |
| Köllner, V | 1 |
| Bernardy, K | 1 |
| Furuta, S | 1 |
| Shimizu, T | 1 |
| Narita, M | 2 |
| Matsumoto, K | 1 |
| Kuzumaki, N | 1 |
| Horie, S | 1 |
| Suzuki, T | 1 |
| Ware, MA | 1 |
| Joseph, L | 1 |
| Shir, Y | 1 |
| Richards, S | 1 |
| Bowrin, K | 1 |
| Watson, P | 1 |
| Lloyd, A | 1 |
| Sadosky, A | 1 |
| Zlateva, G | 1 |
| White, DH | 1 |
| Faull, K | 1 |
| Jones, PB | 1 |
| Jang, ZY | 1 |
| Li, CD | 1 |
| Qiu, L | 1 |
| Guo, JH | 1 |
| He, LN | 1 |
| Yue, Y | 1 |
| Li, FZ | 1 |
| Qin, WY | 1 |
| Vlainich, R | 1 |
| Issy, AM | 1 |
| Moldofsky, H | 2 |
| Harris, HW | 1 |
| Archambault, WT | 1 |
| Kwong, T | 1 |
| Lederman, S | 1 |
| Thomas, RJ | 1 |
| Kulshreshtha, P | 1 |
| Gupta, R | 1 |
| Yadav, RK | 1 |
| Bijlani, RL | 1 |
| Deepak, KK | 1 |
| Bagis, S | 1 |
| Karabiber, M | 1 |
| As, I | 1 |
| Tamer, L | 1 |
| Erdogan, C | 1 |
| Atalay, A | 1 |
| Späth, M | 1 |
| Winter, E | 1 |
| Derry, S | 1 |
| Aldington, D | 1 |
| Cole, P | 1 |
| Bennett, RM | 2 |
| Gür, A | 1 |
| Karakoc, M | 1 |
| Nas, K | 1 |
| Cevik, R | 1 |
| Sarac, J | 1 |
| Ataoglu, S | 1 |
| Zijlstra, TR | 1 |
| van de Laar, MA | 1 |
| Stratz, T | 1 |
| Varga, B | 1 |
| Müller, W | 1 |
| WRIGHT, F | 1 |
| Tofferi, JK | 1 |
| Jackson, JL | 1 |
| O'Malley, PG | 1 |
| Quisel, A | 1 |
| Gill, J | 1 |
| Walters, D | 1 |
| Adigüzel, O | 1 |
| Kaptanoglu, E | 1 |
| Turgut, B | 1 |
| Nacitarhan, V | 1 |
| Walker, M | 1 |
| Meekins, G | 1 |
| Hu, SC | 1 |
| Schluter, PJ | 1 |
| Ware, RS | 1 |
| Ozerbil, O | 1 |
| Okudan, N | 1 |
| Gökbel, H | 1 |
| Levendoğlu, F | 1 |
| Laske, C | 1 |
| Stransky, E | 1 |
| Eschweiler, GW | 1 |
| Klein, R | 1 |
| Wittorf, A | 1 |
| Leyhe, T | 1 |
| Richartz, E | 1 |
| Köhler, N | 1 |
| Bartels, M | 1 |
| Buchkremer, G | 1 |
| Schott, K | 1 |
| Eksioglu, E | 1 |
| Yazar, D | 1 |
| Bal, A | 1 |
| Usan, HD | 1 |
| Cakci, A | 1 |
| Zucker, DR | 2 |
| Ruthazer, R | 2 |
| Schmid, CH | 2 |
| Feuer, JM | 1 |
| Fischer, PA | 1 |
| Kieval, RI | 1 |
| Mogavero, N | 1 |
| Rapoport, RJ | 1 |
| Selker, HP | 2 |
| Stotsky, SA | 1 |
| Winston, E | 1 |
| Goldenberg, DL | 5 |
| Connolly, RG | 1 |
| Carette, S | 3 |
| Oakson, G | 1 |
| Guimont, C | 1 |
| Steriade, M | 1 |
| Kempenaers, C | 1 |
| Simenon, G | 1 |
| Vander Elst, M | 1 |
| Fransolet, L | 1 |
| Mingard, P | 1 |
| de Maertelaer, V | 1 |
| Appelboom, T | 1 |
| Mendlewicz, J | 1 |
| Bell, MJ | 1 |
| Reynolds, WJ | 2 |
| Haraoui, B | 1 |
| McCain, GA | 3 |
| Bykerk, VP | 1 |
| Edworthy, SM | 1 |
| Baron, M | 1 |
| Koehler, BE | 1 |
| Fam, AG | 2 |
| Cantini, F | 1 |
| Bellandi, F | 1 |
| Niccoli, L | 1 |
| Di Munno, O | 1 |
| Goodnick, PJ | 1 |
| Sandoval, R | 1 |
| Godfrey, RG | 1 |
| Nicolodi, M | 1 |
| Sicuteri, F | 1 |
| Goldenberg, D | 1 |
| Mayskiy, M | 1 |
| Mossey, C | 1 |
| Schmid, C | 1 |
| Johnson, SP | 1 |
| McIntosh, MW | 1 |
| D'Agostino, RB | 1 |
| Lau, J | 1 |
| Weiss, DJ | 1 |
| Kreck, T | 1 |
| Albert, RK | 1 |
| Hannonen, P | 1 |
| Malminiemi, K | 1 |
| Yli-Kerttula, U | 1 |
| Isomeri, R | 1 |
| Roponen, P | 1 |
| Gerster, JC | 1 |
| Azad, KA | 1 |
| Alam, MN | 1 |
| Haq, SA | 1 |
| Nahar, S | 1 |
| Chowdhury, MA | 1 |
| Ali, SM | 1 |
| Ullah, AK | 1 |
| McGurk, C | 1 |
| Wilson, D | 1 |
| Henry, W | 1 |
| Fossaluzza, V | 1 |
| De Vita, S | 1 |
| Simms, RW | 1 |
| Felson, DT | 2 |
| Martín-Calama, J | 1 |
| Bosque Peralta, MT | 1 |
| Labay Matías, M | 1 |
| Valle Sánchez, F | 1 |
| de Miguel Pardo, C | 1 |
| Valero Adán, MT | 1 |
| Silva, AB | 1 |
| Bertorini, TE | 1 |
| Lemmi, H | 1 |
| Jaeschke, R | 2 |
| Adachi, J | 1 |
| Guyatt, G | 1 |
| Keller, J | 2 |
| Wong, B | 1 |
| Saskin, P | 1 |
| Lue, FA | 1 |
| Romano, TJ | 1 |
| Tyber, MA | 1 |
| Guyatt, GH | 1 |
| Heyting, A | 1 |
| Adachi, JD | 1 |
| Roberts, RS | 1 |
| Quimby, LG | 1 |
| Gratwick, GM | 1 |
| Whitney, CD | 1 |
| Block, SR | 1 |
| Scudds, RA | 1 |
| Rollman, GB | 1 |
| Harth, M | 1 |
| Hamaty, D | 1 |
| Valentine, JL | 1 |
| Howard, CW | 1 |
| Wakefield, V | 1 |
| Patten, MS | 1 |
| Gatter, RA | 2 |
| Campbell, SM | 1 |
| Andrews, RP | 1 |
| Clark, SR | 1 |
| Scarola, JA | 1 |
| Bell, DA | 1 |
| Dinerman, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Role of Immune-pineal Axis in Fibromyalgia: Noradrenergic Modulation and Chronotherapeutic Aspects[NCT02041455] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2010-06-30 | Recruiting | ||
| Benefits of Kinesio Taping and Inhibitory Treatment Techniques in Patients With Fibromyalgia Syndrome[NCT02859467] | 64 participants (Anticipated) | Interventional | 2016-08-31 | Suspended | |||
| Museums as Health Spaces: Design and Evaluation of the Effectiveness of an Arts in Health Intervention to Improve the Quality of Life and Functional Capacity Regarding the Pain of People With Fibromyalgia. Mixed Methodology Study.[NCT05993663] | 121 participants (Anticipated) | Interventional | 2023-10-02 | Recruiting | |||
| Effects of Manipulative Therapy in the Lower Thoracic and Cervical Spine in Subjects With Fibromyalgia Syndrome[NCT02864524] | 64 participants (Anticipated) | Interventional | 2016-08-31 | Active, not recruiting | |||
| Effectiveness of Pain Neuroscience Education and Strength Training Program in Patients With Fibromyalgia[NCT04855851] | 60 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | |||
| A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®[NCT03347669] | 100 participants (Anticipated) | Interventional | 2017-11-06 | Recruiting | |||
| Effectiveness of High-intensity Interval Training Combined With Resistance Training in Patients With Fibromyalgia[NCT03924960] | 55 participants (Actual) | Interventional | 2019-04-22 | Completed | |||
| Effectiveness of Spinal Manipulation in Addition to Standard Pharmacological Treatment in Fibromyalgia : A Blinded Randomized Clinical Trial[NCT04673058] | 60 participants (Actual) | Interventional | 2021-01-26 | Completed | |||
| Nabilone and THC/CBD for the Treatment of FBSS Refractory Pain[NCT03210766] | 20 participants (Actual) | Observational | 2014-09-01 | Completed | |||
| Cannabidiol for Fibromyalgia -The CANNFIB Trial Protocol for a Randomized, Double-blind, Placebo-controlled, Parallel-group, Single-center Trial[NCT04729179] | Phase 3 | 200 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| Effect of Oral Magnesium Supplementation on Anesthesia and Postoperative Analgesia After Surgical Removal of the Lower Third Molars.[NCT03398382] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2017-04-15 | Active, not recruiting | ||
| Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313] | 152 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | |||
| Combining N-of-1 Trials to Assess Fibromyalgia Therapies[NCT00000428] | Phase 4 | 58 participants (Actual) | Interventional | 2000-09-30 | Completed | ||
| Internet-Enhanced Management of Fibromyalgia[NCT00423631] | 118 participants (Actual) | Interventional | 2006-09-30 | Completed | |||
| EN20-01: A 24 Week Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Moderate to Severe Knee Osteoarthritis Pain.[NCT05025787] | Phase 2 | 77 participants (Anticipated) | Interventional | 2021-10-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
28 reviews available for amitriptyline and Fibromyalgia
| Article | Year |
|---|---|
Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis.
Topics: Adolescent; Adult; Amitriptyline; Child; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Net | 2022 |
Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis.
Topics: Amitriptyline; Duloxetine Hydrochloride; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; M | 2022 |
Comparing the efficacy and safety of duloxetine and amitriptyline in the treatment of fibromyalgia: overview of systematic reviews.
Topics: Amitriptyline; Antidepressive Agents; Duloxetine Hydrochloride; Fibromyalgia; Humans; Syndrome; Syst | 2020 |
[Drug therapy of fibromyalgia syndrome : Updated guidelines 2017 and overview of systematic review articles].
Topics: Amitriptyline; Anxiety Disorders; Comorbidity; Depressive Disorder; Duloxetine Hydrochloride; Eviden | 2017 |
Antiepileptic drugs for chronic non-cancer pain in children and adolescents.
Topics: Adolescent; Amines; Amitriptyline; Anticonvulsants; Child; Chronic Pain; Complex Regional Pain Syndr | 2017 |
Combination pharmacotherapy for the treatment of fibromyalgia in adults.
Topics: 5-Hydroxytryptophan; Acetaminophen; Adult; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; A | 2018 |
More ubiquitous effects from non-pharmacologic than from pharmacologic treatments for fibromyalgia syndrome: a meta-analysis examining six core symptoms.
Topics: Amitriptyline; Cognitive Behavioral Therapy; Exercise Therapy; Fibromyalgia; Humans; Massage; Treatm | 2014 |
Selective serotonin reuptake inhibitors for fibromyalgia syndrome.
Topics: Amitriptyline; Citalopram; Fibromyalgia; Fluoxetine; Humans; Melatonin; Musculoskeletal Pain; Paroxe | 2015 |
Amitriptyline for the treatment of fibromyalgia: a comprehensive review.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Fibromyalgia; Humans; Randomized Controlled Trials | 2015 |
Myalgias and Myopathies: Fibromyalgia.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Behavior Therapy; Combined Modality Therapy; | 2016 |
Antipsychotics for fibromyalgia in adults.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Antipsychotic Agents; Fibromyalgia; Humans; Quetiapi | 2016 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
Cannabinoids for fibromyalgia.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Cannabinoids; Dronabinol; Fibromyalgia; Health | 2016 |
Cannabinoids for fibromyalgia.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Cannabinoids; Dronabinol; Fibromyalgia; Health | 2016 |
Cannabinoids for fibromyalgia.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Cannabinoids; Dronabinol; Fibromyalgia; Health | 2016 |
Cannabinoids for fibromyalgia.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Cannabinoids; Dronabinol; Fibromyalgia; Health | 2016 |
Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Female; Fibromyalgia; Humans; Male; Middle A | 2008 |
A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome.
Topics: Amitriptyline; Antidepressive Agents; Databases, Bibliographic; Depression; Fatigue; Fibromyalgia; H | 2008 |
[Diagnosis and therapy of fibromyalgia syndrome].
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Behavior Therapy; Comorbidity; Diagnosis, Differenti | 2009 |
Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome: a systematic review with meta-analysis.
Topics: Amitriptyline; Antidepressive Agents; Cyclopropanes; Duloxetine Hydrochloride; Fibromyalgia; Humans; | 2011 |
[Drug therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline].
Topics: Amitriptyline; Analgesics; Analgesics, Opioid; Antidepressive Agents; Anxiety Disorders; Combined Mo | 2012 |
Amitriptyline for neuropathic pain and fibromyalgia in adults.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Fibromyalgia; Huma | 2012 |
Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis.
Topics: Amitriptyline; Databases, Factual; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; Muscle | 2004 |
Exercise and antidepressants improve fibromyalgia.
Topics: Amitriptyline; Antidepressive Agents; Complementary Therapies; Exercise; Fibromyalgia; Humans; Medic | 2004 |
Psychotropic treatment of chronic fatigue syndrome and related disorders.
Topics: 5-Hydroxytryptophan; Amitriptyline; Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disord | 1993 |
A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Doxepin; Fibromyalgia; Humans; Lif | 1996 |
[Fibromyalgia. Past and present].
Topics: Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Diagnosis, Differential; Fibromyalgia; | 1999 |
Diagnosing fibromyalgia.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Cognitive Behavioral Therapy; Fibromyalgia; Fluoxetine; Hum | 2001 |
[Infantile fibromyalgia. Review and case report].
Topics: Age Factors; Amitriptyline; Analgesics; Child; Female; Fibromyalgia; Humans | 1991 |
Treatment of fibromyalgia syndrome.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; F | 1989 |
A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biomechanical Phenomena; Clinical Trials as Topic; | 1989 |
36 trials available for amitriptyline and Fibromyalgia
| Article | Year |
|---|---|
Is low-dose naltrexone effective in chronic pain management?
Topics: Amitriptyline; Fibromyalgia; Humans; Naltrexone; Pain; Pain Management | 2023 |
Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Double-Blind Method; Female; Fibromyalgia; Humans; M | 2013 |
Quetiapine extended-release (Seroquel-XR) versus amitriptyline monotherapy for treating patients with fibromyalgia: a 16-week, randomized, flexible-dose, open-label trial.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety; Delayed-Action Pr | 2014 |
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial.
Topics: Adolescent; Adult; Amitriptyline; Analgesics; Brain-Derived Neurotrophic Factor; Double-Blind Method | 2014 |
Comparative Efficacy of Newer Antidepressants in Combination with Pregabalin for Fibromyalgia Syndrome: A Controlled, Randomized Study.
Topics: Adult; Amitriptyline; Antidepressive Agents; Depression; Drug Therapy, Combination; Female; Fibromya | 2017 |
Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study.
Topics: Administration, Intravenous; Adult; Amitriptyline; Anesthetics, Local; Biomarkers; Brazil; Double-Bl | 2016 |
[Observation on therapeutic effect of herb-partitioned moxibustion on fibromyalgia syndrome].
Topics: Acupuncture Points; Adult; Aged; Amitriptyline; Drugs, Chinese Herbal; Female; Fibromyalgia; Humans; | 2009 |
The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial.
Topics: Adult; Aged; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Cross-Over Studies; Double-B | 2010 |
[Combination of acupuncture, cupping and medicine for treatment of fibromyalgia syndrome: a multi-central randomized controlled trial].
Topics: Acupuncture Points; Acupuncture Therapy; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Com | 2010 |
Effect of intravenous lidocaine associated with amitriptyline on pain relief and plasma serotonin, norepinephrine, and dopamine concentrations in fibromyalgia.
Topics: Adolescent; Adult; Amitriptyline; Analgesics; Catecholamines; Dopamine; Double-Blind Method; Drug Th | 2011 |
Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study.
Topics: Adult; Aged; Amitriptyline; Double-Blind Method; Electroencephalography; Fatigue; Female; Fibromyalg | 2011 |
Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?
Topics: Adult; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Anxiety; Cathartics; Chronic Pain; Citri | 2013 |
Antidepressants do not have better results than placebo in the treatment of fibromyalgia in Brazil.
Topics: Amitriptyline; Antidepressive Agents; Double-Blind Method; Drug Administration Schedule; Female; Fib | 2002 |
Effects of low power laser and low dose amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial.
Topics: Adult; Amitriptyline; Analysis of Variance; Dose-Response Relationship, Drug; Female; Fibromyalgia; | 2002 |
[The influence of depression on the effect of Tropisetron in the therapy of fibromyalgia].
Topics: Adjustment Disorders; Administration, Oral; Adult; Amitriptyline; Depressive Disorder; Drug Therapy, | 2003 |
Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia.
Topics: Adult; Amitriptyline; Antidepressive Agents; Cross-Over Studies; Double-Blind Method; Exercise Test; | 2006 |
Effects of Stanger bath therapy on fibromyalgia.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Combined Modality Therapy; Electric Stimulation Ther | 2007 |
Sleep electroencephalography and the clinical response to amitriptyline in patients with fibromyalgia.
Topics: Adult; Alpha Rhythm; Amitriptyline; Double-Blind Method; Electroencephalography; Electronic Data Pro | 1995 |
Effect of an antidiencephalon immune serum on pain and sleep in primary fibromyalgia.
Topics: Adult; Amitriptyline; Animals; Antibodies, Heterophile; Diencephalon; Double-Blind Method; Female; F | 1994 |
Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind clinical trial.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Double-Blind Method; Fibromyalgia; Humans; Pain Mea | 1994 |
[Fluoxetin combined with cyclobenzaprine in the treatment of fibromyalgia].
Topics: Adult; Amitriptyline; Drug Therapy, Combination; Female; Fibromyalgia; Fluoxetine; Humans; Middle Ag | 1994 |
Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy.
Topics: 5-Hydroxytryptophan; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety; Drug Therapy, Combina | 1996 |
A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia.
Topics: Adolescent; Adult; Amitriptyline; Analysis of Variance; Double-Blind Method; Drug Therapy, Combinati | 1996 |
A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Benzamides; Di | 1998 |
Vegetarian diet in the treatment of fibromyalgia.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chi-Square Distribution; Child; Diet, Vegeta | 2000 |
Combined therapy with cyclobenzaprine and ibuprofen in primary fibromyalgia syndrome.
Topics: Adult; Amitriptyline; Blood Sedimentation; Drug Therapy, Combination; Female; Fibromyalgia; Humans; | 1992 |
Development of preliminary criteria for response to treatment in fibromyalgia syndrome.
Topics: Amitriptyline; Double-Blind Method; Fibromyalgia; Humans; Naproxen; Regression Analysis | 1991 |
Clinical usefulness of amitriptyline in fibromyalgia: the results of 23 N-of-1 randomized controlled trials.
Topics: Adult; Aged; Amitriptyline; Double-Blind Method; Fibromyalgia; Humans; Middle Aged; Surveys and Ques | 1991 |
The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia.
Topics: Adult; Affect; Amitriptyline; Double-Blind Method; Fatigue; Female; Fibromyalgia; Humans; Male; Midd | 1991 |
A randomized trial of cyclobenzaprine for the treatment of fibromyalgia.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Fibromyalgia; Humans; Midd | 1989 |
Improvements in pain responsiveness in patients with fibrositis after successful treatment with amitriptyline.
Topics: Adult; Amitriptyline; Female; Fibromyalgia; Humans; Male; Multivariate Analysis; Pain Measurement; P | 1989 |
The plasma endorphin, prostaglandin and catecholamine profile of patients with fibrositis treated with cyclobenzaprine and placebo: a 5-month study.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; beta-Endorphin; Catecholamines; Dinoprostone | 1989 |
A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biomechanical Phenomena; Clinical Trials as Topic; | 1989 |
A comparison of cyclobenzaprine and placebo in the management of fibrositis. A double-blind controlled study.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Female; Fibromyalgia; Hum | 1988 |
Evaluation of amitriptyline in primary fibrositis. A double-blind, placebo-controlled study.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Female; Fibromyalgia; Humans; M | 1986 |
A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia.
Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Fibromyalgia; Humans; | 1986 |
30 other studies available for amitriptyline and Fibromyalgia
| Article | Year |
|---|---|
In fibromyalgia, amitriptyline is comparable to FDA-approved drugs for symptoms and acceptability.
Topics: Amitriptyline; Fibromyalgia; Humans; Meta-Analysis as Topic; Systematic Reviews as Topic; United Sta | 2022 |
Analgesic Medication in Fibromyalgia Patients: A Cross-Sectional Study.
Topics: Acetaminophen; Amitriptyline; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-St | 2022 |
Amitriptyline for fibromyalgia: Off-label treatment, but non-inferior to approved medication.
Topics: Amitriptyline; Fibromyalgia; Humans; Off-Label Use | 2023 |
Treatment data from the Brazilian fibromyalgia registry (EpiFibro).
Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Brazil; Cohort Studies; Combined Modality Thera | 2020 |
Some t-tests for N-of-1 trials with serial correlation.
Topics: Amitriptyline; Clinical Trials as Topic; Fibromyalgia; Humans; Monte Carlo Method; Opioid-Related Di | 2020 |
Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin.
Topics: Amines; Amitriptyline; Analgesics; Anti-Anxiety Agents; Antidepressive Agents; Cyclohexanecarboxylic | 2013 |
Patterns of health care utilization related to initiation of amitriptyline, duloxetine, gabapentin, or pregabalin in fibromyalgia.
Topics: Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Cohort Studies; Cyclohexanecarboxylic Acids; | 2015 |
Fibromyalgia · anxiety/depression · urinary retention · Dx?
Topics: Adrenergic Uptake Inhibitors; Aged; Amitriptyline; Anxiety; Depression; Female; Fibromyalgia; Humans | 2015 |
Fibromyalgia remains a controversial medical enigma.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Second-Generation; Drug Therapy, Com | 2008 |
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease | 2009 |
Cost effectiveness of pregabalin in the treatment of fibromyalgia from a UK perspective.
Topics: Adult; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Cost-Benefit Analysis; Cyclohexanec | 2010 |
An exploratory study of long-term health outcomes following an in-patient multidisciplinary program for people with fibromyalgia syndrome.
Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Drug Therapy, Co | 2009 |
Sleep as a window into the world of fibromyalgia syndrome.
Topics: Amitriptyline; Female; Fibromyalgia; Humans; Male; Placebos; Sleep; Sleep Wake Disorders | 2011 |
Effect of low-dose amitriptyline on autonomic functions and peripheral blood flow in fibromyalgia: a pilot study.
Topics: Adult; Amitriptyline; Autonomic Nervous System; Blood Flow Velocity; Female; Fibromyalgia; Heart Rat | 2012 |
The lack of a placebo effect in a trial of fluoxetine in the treatment of fibromyalgia.
Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second-Generation; Female; Fibromyalgia | 2002 |
[Amitryptyline (MK-230) in rheumatology].
Topics: Amitriptyline; Antidepressive Agents; Arthritis; Arthritis, Rheumatoid; Fibromyalgia; Humans; Osteoa | 1962 |
The possible effect of clinical recovery on regional cerebral blood flow deficits in fibromyalgia: a prospective study with semiquantitative SPECT.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Cerebrovascular Circulation; Fem | 2004 |
Yoga neuropathy. A snoozer.
Topics: Adult; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Disorders of Excessive S | 2005 |
Single patient (n-of-1) trials with binary treatment preference.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Bayes Theorem; Fibromyalgia; Humans; Models, Statistical; N | 2005 |
Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Depressive Disorder, | 2007 |
Lessons learned combining N-of-1 trials to assess fibromyalgia therapies.
Topics: Adult; Amitriptyline; Antidepressive Agents; Cross-Over Studies; Double-Blind Method; Drug Therapy, | 2006 |
Treatment of fibromyositis with fluphenazine and amitriptyline: a preliminary report.
Topics: Amitriptyline; Female; Fibromyalgia; Fluphenazine; Humans; Joints; Middle Aged; Spine | 1981 |
Fluoxetine and amitriptyline in the treatment of fibromyalgia.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Double-Blind Method; Drug Therap | 1997 |
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bayes Theorem; Chronic Disease; Cross-Over Studies; | 1997 |
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bayes Theorem; Chronic Disease; Cross-Over Studies; | 1997 |
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bayes Theorem; Chronic Disease; Cross-Over Studies; | 1997 |
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bayes Theorem; Chronic Disease; Cross-Over Studies; | 1997 |
Dyspnea resulting from fibromyalgia.
Topics: Adrenergic Uptake Inhibitors; Aged; Amitriptyline; Bronchoscopy; Chest Pain; Chronic Disease; Dyspne | 1998 |
Polysomnography in idiopathic muscle pain syndrome (fibrositis).
Topics: Alprazolam; Amitriptyline; Clonazepam; Electroencephalography; Fatigue Syndrome, Chronic; Female; Fi | 1991 |
Fibromyalgia in children; diagnosis and treatment.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Child; Diagnosis, Differential; Drug Therapy, Comb | 1991 |
Lithium carbonate augmentation therapy in fibromyalgia.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Female; Fibromyalgia; Humans; Lithium; Lithium Carb | 1990 |
N of 1 randomized trials for investigating new drugs.
Topics: Amitriptyline; Chronic Disease; Drug Administration Schedule; Drug Evaluation; Drugs, Investigationa | 1990 |
Pharmacotherapeutics in fibrositis.
Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents; Drug Therapy, Combination; Fibromyalgia; Humans | 1986 |