amitriptyline has been researched along with Fever in 7 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypersensitivity syndrome is a specific severe idiosyncratic reaction causing skin, liver, joint, and haematological abnormalities, which usually resolve after the discontinuation of the implicated drug." | 5.31 | Hypersensitivity syndrome caused by amitriptyline administration. ( Elisaf, MS; Milionis, HJ; Skopelitou, A, 2000) |
| "Prolonged coma due to acute overdosage with hypnotic drugs is shown to be associated with a pronounced increase in the activity of serum creatine kinase and in the concentration of fibrin degradation products and with less pronounced abnormalities of other serum enzymes and of other indices of coagulation and fibrinolysis." | 3.65 | Effects of poisoning on serum enzyme activities, coagulation, and fibrinolysis. ( Brown, SS; Clarkson, AR; Fuster, V; Wright, N, 1971) |
| "Sixty patients meeting DSM-III criteria for major depression were assigned randomly to double-blind treatment for four weeks according to fixed-dosage steps with (1) amitriptyline hydrochloride alone, up to a maximum dosage of 300 mg/day; (2) tranylcypromine alone, up to 40 mg/day; or (3) the combination of amitriptyline hydrochloride, up to 150 mg/day, and tranylcypromine, up to 20 mg/day." | 2.65 | The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. A controlled trial. ( Palmer, R; Razani, J; Rebal, R; Simpson, G; Sloane, RB; White, J; White, KL, 1983) |
| "Hypersensitivity syndrome is a specific severe idiosyncratic reaction causing skin, liver, joint, and haematological abnormalities, which usually resolve after the discontinuation of the implicated drug." | 1.31 | Hypersensitivity syndrome caused by amitriptyline administration. ( Elisaf, MS; Milionis, HJ; Skopelitou, A, 2000) |
| "The patient died on day 3 from cardiocirculatory collapse and arrhythmias." | 1.29 | Hyperthermia complicating tricyclic antidepressant overdose. ( Baud, FJ; Benaissa, M; Clemessy, JL; Hantson, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Razani, J | 1 |
| White, KL | 1 |
| White, J | 1 |
| Simpson, G | 1 |
| Sloane, RB | 1 |
| Rebal, R | 1 |
| Palmer, R | 1 |
| Hantson, P | 1 |
| Benaissa, M | 1 |
| Clemessy, JL | 1 |
| Baud, FJ | 1 |
| Van der Heyden, JA | 1 |
| Zethof, TJ | 1 |
| Olivier, B | 1 |
| Milionis, HJ | 1 |
| Skopelitou, A | 1 |
| Elisaf, MS | 1 |
| Jori, A | 1 |
| Paglialunga, S | 1 |
| Garattini, S | 1 |
| Wright, N | 1 |
| Clarkson, AR | 1 |
| Brown, SS | 1 |
| Fuster, V | 1 |
| Schuckit, M | 1 |
| Robins, E | 1 |
| Feighner, J | 1 |
1 trial available for amitriptyline and Fever
| Article | Year |
|---|---|
The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. A controlled trial.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Thera | 1983 |
6 other studies available for amitriptyline and Fever
| Article | Year |
|---|---|
Hyperthermia complicating tricyclic antidepressant overdose.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Body Temperature; Bromocripti | 1996 |
Stress-induced hyperthermia in singly housed mice.
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Body Temperature; Diazepam; Fever; Male; Mice; Models, | 1997 |
Hypersensitivity syndrome caused by amitriptyline administration.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Eruptions; Female; Fever; Glucocorticoi | 2000 |
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Body Temperature; Chlorisondamine; Chlorpro | 1967 |
Effects of poisoning on serum enzyme activities, coagulation, and fibrinolysis.
Topics: Adult; Aged; Alanine Transaminase; Amitriptyline; Aspartate Aminotransferases; Blood Coagulation; Bl | 1971 |
Tricyclic antidepressants and monoamine oxidase inhibitors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug | 1971 |