amitriptyline has been researched along with Fatigue Syndrome, Chronic in 3 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This syndrome has been called fibrositis or fibromyalgia." | 1.28 | Polysomnography in idiopathic muscle pain syndrome (fibrositis). ( Bertorini, TE; Lemmi, H; Silva, AB, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clemons, A | 1 |
| Vasiadi, M | 1 |
| Kempuraj, D | 1 |
| Kourelis, T | 1 |
| Vandoros, G | 1 |
| Theoharides, TC | 1 |
| Goodnick, PJ | 1 |
| Sandoval, R | 1 |
| Silva, AB | 1 |
| Bertorini, TE | 1 |
| Lemmi, H | 1 |
1 review available for amitriptyline and Fatigue Syndrome, Chronic
| Article | Year |
|---|---|
Psychotropic treatment of chronic fatigue syndrome and related disorders.
Topics: 5-Hydroxytryptophan; Amitriptyline; Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disord | 1993 |
2 other studies available for amitriptyline and Fatigue Syndrome, Chronic
| Article | Year |
|---|---|
Amitriptyline and prochlorperazine inhibit proinflammatory mediator release from human mast cells: possible relevance to chronic fatigue syndrome.
Topics: Amitriptyline; Cells, Cultured; Fatigue Syndrome, Chronic; Humans; Inflammation Mediators; Mast Cell | 2011 |
Polysomnography in idiopathic muscle pain syndrome (fibrositis).
Topics: Alprazolam; Amitriptyline; Clonazepam; Electroencephalography; Fatigue Syndrome, Chronic; Female; Fi | 1991 |