amitriptyline has been researched along with Facial Pain in 23 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Facial Pain: Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain." | 9.06 | The analgesic effect of amitriptyline on chronic facial pain. ( Dionne, RA; Dubner, R; Schmidt, E; Sharav, Y; Singer, E, 1987) |
| "Daily pain scores using a facial pain diary were recorded over eight weeks." | 6.78 | A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Patients often present with chronic facial pain despite normal nasal endoscopy and sinus computerized tomography." | 6.78 | Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Amitriptyline proved to be an efficient alternative treatment for chronic pain in TMD patients." | 6.71 | Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders. ( Ambrosano, GM; de Andrade, ED; de Barbosa, JR; Nogueira, MT; Rizzatti-Barbosa, CM, 2003) |
| "Depression was assessed by the Beck Depression Inventory (BDI) short form." | 6.69 | Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. ( Curtis, D; Levine, J; McCall, WD; Plesh, O, 2000) |
| " There was moderate evidence for amitriptyline in patients with atypical facial pain." | 5.12 | Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis. ( Ananth, A; Do, TM; Kattar, N; McCoul, ED; Unis, GD, 2021) |
| "The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain." | 5.06 | The analgesic effect of amitriptyline on chronic facial pain. ( Dionne, RA; Dubner, R; Schmidt, E; Sharav, Y; Singer, E, 1987) |
| "The most effective long-term treatments for tension-type mid-facial pain and facial migraine were low-dose amitriptyline and low-dose amitriptyline and triptans, respectively." | 3.80 | Prospective three-year follow up of a cohort study of 240 patients with chronic facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2014) |
| "Amitriptyline was the most useful drug in that it provided pain relief in musculoskeletal, vascular, and some neuropathic pain conditions." | 3.69 | Diagnosis and treatment of persistent pain after trauma to the head and neck. ( Benoliel, R; Eliav, E; Elishoov, H; Sharav, Y, 1994) |
| "Daily pain scores using a facial pain diary were recorded over eight weeks." | 2.78 | A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Patients often present with chronic facial pain despite normal nasal endoscopy and sinus computerized tomography." | 2.78 | Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Amitriptyline was administered and the dose was gradually increased up to a daily dose of 250 mg." | 2.72 | Efficacy of amitriptyline for treatment of somatoform pain disorder in the orofacial region: A case series. ( Ikawa, M; Ikeuchi, S; Yamada, K, 2006) |
| "Amitriptyline proved to be an efficient alternative treatment for chronic pain in TMD patients." | 2.71 | Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders. ( Ambrosano, GM; de Andrade, ED; de Barbosa, JR; Nogueira, MT; Rizzatti-Barbosa, CM, 2003) |
| "Depression was assessed by the Beck Depression Inventory (BDI) short form." | 2.69 | Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. ( Curtis, D; Levine, J; McCall, WD; Plesh, O, 2000) |
| "Atypical odontalgia describes atypical facial pain in apparently normal teeth." | 2.38 | Atypical odontalgia. ( Graff-Radford, SB; Solberg, WK, 1992) |
| "Recent evidence suggests that facial pain may not be related to the sinuses at all and that doctors may have to rethink their prescribing strategy." | 1.40 | Is 'sinus' pain really sinusitis? ( Agius, AM; Jones, NS; Muscat, R, 2014) |
| "The numbness was predominantly located in the innervated mental area and extended in some cases to the first and second trigeminal divisions." | 1.35 | Idiopathic trigeminal neuropathies: a presentation of 15 cases. ( Bagán, JV; García, B; Mora, E; Peñarrocha, M, 2009) |
| "Amitriptyline is a tricyclic antidepressant that is historically indicated and used to manage depression." | 1.33 | Prevalence of contraindicated medical conditions and use of precluded medications in patients with painful neuropathic disorders prescribed amitriptyline. ( Dukes, E; Gore, M; Leslie, DL; Rowbotham, D; Tai, KS, 2006) |
| "None of the patients reported any facial pain before surgery or trauma." | 1.31 | Facial pain following sinonasal surgery or facial trauma. ( Jones, NS; Khan, OA; Majumdar, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Do, TM | 1 |
| Unis, GD | 1 |
| Kattar, N | 1 |
| Ananth, A | 1 |
| McCoul, ED | 1 |
| Steel, SJ | 1 |
| Robertson, CE | 1 |
| Agius, AM | 4 |
| Jones, NS | 5 |
| Muscat, R | 4 |
| Alencar, FG | 1 |
| Viana, PG | 1 |
| Zamperini, C | 1 |
| Becker, A | 1 |
| Phillips, TJ | 1 |
| Farquhar-Smith, WP | 1 |
| Peñarrocha, M | 2 |
| Mora, E | 1 |
| Bagán, JV | 1 |
| García, B | 1 |
| Kasahara, M | 1 |
| Ichinohe, T | 1 |
| Sano, T | 1 |
| Fukuda, K | 1 |
| Kaneko, Y | 1 |
| Rizzatti-Barbosa, CM | 1 |
| Nogueira, MT | 1 |
| de Andrade, ED | 1 |
| Ambrosano, GM | 1 |
| de Barbosa, JR | 1 |
| Luccarini, P | 1 |
| Perrier, L | 1 |
| Dégoulange, C | 1 |
| Gaydier, AM | 1 |
| Dallel, R | 1 |
| Rokadiya, S | 1 |
| Malden, NJ | 1 |
| Ikawa, M | 1 |
| Yamada, K | 1 |
| Ikeuchi, S | 1 |
| Gore, M | 1 |
| Dukes, E | 1 |
| Rowbotham, D | 1 |
| Tai, KS | 1 |
| Leslie, DL | 1 |
| Benoliel, R | 1 |
| Eliav, E | 1 |
| Elishoov, H | 1 |
| Sharav, Y | 2 |
| Plesh, O | 1 |
| Curtis, D | 1 |
| Levine, J | 1 |
| McCall, WD | 1 |
| Raigrodski, AJ | 1 |
| Mohamed, SE | 1 |
| Gardiner, DM | 1 |
| Kohjitani, A | 1 |
| Miyawaki, T | 1 |
| Kasuya, K | 1 |
| Shimada, M | 1 |
| Khan, OA | 1 |
| Majumdar, S | 1 |
| Graff-Radford, SB | 1 |
| Solberg, WK | 1 |
| Hampf, G | 1 |
| Kuoppasalmi, K | 1 |
| Henriksson, M | 1 |
| Achté, K | 1 |
| Singer, E | 1 |
| Schmidt, E | 1 |
| Dionne, RA | 1 |
| Dubner, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for amitriptyline and Facial Pain
| Article | Year |
|---|---|
Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis.
Topics: Adult; Amitriptyline; Botulinum Toxins, Type A; Carbamazepine; Facial Nerve; Facial Pain; Female; Hu | 2021 |
First Bite Syndrome: What Neurologists Need to Know.
Topics: Acetylcholine Release Inhibitors; Amitriptyline; Analgesics, Non-Narcotic; Botulinum Toxins; Carotid | 2021 |
Atypical odontalgia.
Topics: Adult; Afferent Pathways; Aged; Amitriptyline; Antidepressive Agents; Dental Care; Dental Pulp; Depr | 1992 |
8 trials available for amitriptyline and Facial Pain
| Article | Year |
|---|---|
A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amitriptyline; Analysis of Variance; Antidepre | 2013 |
Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain.
Topics: Adrenergic beta-Antagonists; Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents, Tric | 2013 |
Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Clonidine; Double-Blind Method; Fa | 2014 |
Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Double-Blind Method; Facial Pain; | 2003 |
Efficacy of amitriptyline for treatment of somatoform pain disorder in the orofacial region: A case series.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Facial Pain; Female; Humans; Male; Middle Aged | 2006 |
Amitriptyline treatment of chronic pain in patients with temporomandibular disorders.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depression; Facial Pain; Fe | 2000 |
The effect of amitriptyline on pain intensity and perception of stress in bruxers.
Topics: Amitriptyline; Analysis of Variance; Antidepressive Agents, Tricyclic; Cross-Over Studies; Double-Bl | 2001 |
The analgesic effect of amitriptyline on chronic facial pain.
Topics: Adult; Amitriptyline; Analysis of Variance; Chronic Disease; Depression; Dose-Response Relationship, | 1987 |
12 other studies available for amitriptyline and Facial Pain
| Article | Year |
|---|---|
Prospective three-year follow up of a cohort study of 240 patients with chronic facial pain.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Chronic Pain; Facial Pain | 2014 |
Is 'sinus' pain really sinusitis?
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Diagnosis, Differential; Disease Management; Facial Pai | 2014 |
Pharmacological treatment of a patient with first-bite syndrome.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cranial Nerve Neoplasms; Drug Therapy, Combi | 2009 |
Idiopathic trigeminal neuropathies: a presentation of 15 cases.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Cohort Studies; Facial Pain; Female; Humans; H | 2009 |
A case of zoster sine herpete of the trigeminal nerve.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Facial Pain; Female; Humans; Immunoglobulin G; Middle Aged; | 2011 |
Synergistic antinociceptive effect of amitriptyline and morphine in the rat orofacial formalin test.
Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; | 2004 |
Variable presentation of temporalis hypertrophy--A case report with literature review.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Facial Pain; Female; Humans; Hypertrophy; Muscul | 2006 |
Prevalence of contraindicated medical conditions and use of precluded medications in patients with painful neuropathic disorders prescribed amitriptyline.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Analgesics, | 2006 |
Diagnosis and treatment of persistent pain after trauma to the head and neck.
Topics: Adult; Amitriptyline; Carbamazepine; Chronic Disease; Craniocerebral Trauma; Facial Pain; Female; He | 1994 |
Sympathetic activity-mediated neuropathic facial pain following simple tooth extraction: a case report.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Autonomic Nerve Block; Electroacupuncture; Fa | 2002 |
Facial pain following sinonasal surgery or facial trauma.
Topics: Acetates; Adult; Aged; Amines; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cyclohexaneca | 2002 |
Chronic facial pain together with severe depression is responsive to electroconvulsive therapy. A case report.
Topics: Amitriptyline; Chronic Disease; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Facial P | 1992 |