amitriptyline has been researched along with Erythermalgia in 6 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We retrospectively evaluated 36 patients with erythromelalgia who were treated with compounded topical amitriptyline-ketamine from January 1, 2004, through January 31, 2011." | 7.79 | Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic. ( Davis, MD; Murphy, SL; Poterucha, TJ; Rho, RH; Sandroni, P; Warndahl, RA; Weiss, WT, 2013) |
| "We retrospectively evaluated 36 patients with erythromelalgia who were treated with compounded topical amitriptyline-ketamine from January 1, 2004, through January 31, 2011." | 3.79 | Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic. ( Davis, MD; Murphy, SL; Poterucha, TJ; Rho, RH; Sandroni, P; Warndahl, RA; Weiss, WT, 2013) |
| "Erythromelalgia is characterized by episodes of erythematous, warm, burning acral skin, which is exacerbated by heat and relieved by cold." | 1.35 | Erythromelalgia of the ears: an unusual variant and response to therapy. ( Berk, DR; Eisen, AZ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Portugal, F | 1 |
| Araújo, A | 1 |
| Silva, C | 1 |
| Campos, M | 1 |
| Valentim, A | 1 |
| Poterucha, TJ | 1 |
| Weiss, WT | 1 |
| Warndahl, RA | 1 |
| Rho, RH | 1 |
| Sandroni, P | 2 |
| Davis, MD | 2 |
| Murphy, SL | 1 |
| Cohen, JS | 1 |
| Berk, DR | 1 |
| Eisen, AZ | 1 |
| Herskovitz, S | 1 |
| Loh, F | 1 |
| Berger, AR | 1 |
| Kucherov, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
6 other studies available for amitriptyline and Erythermalgia
| Article | Year |
|---|---|
Combination gel of 2% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain - a case report of pain control success.
Topics: Amitriptyline; Analgesics; Drug Combinations; Erythromelalgia; Humans; Ketamine; Male; Pain Manageme | 2021 |
Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Amitriptyline; Analgesics; Analgesics, Non-Narco | 2013 |
Combination gel of 1% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain: a new treatment option?
Topics: Adolescent; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Drug Combinations; Erythrom | 2006 |
Transdermal therapy for erythromelalgia.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Drug Therapy, Combination; Erythromelalgia; Hu | 2006 |
Erythromelalgia of the ears: an unusual variant and response to therapy.
Topics: Administration, Oral; Aged; Amitriptyline; Analgesics; Drug Combinations; Ear; Ear Diseases; Erythro | 2008 |
Erythromelalgia: association with hereditary sensory neuropathy and response to amitriptyline.
Topics: Adult; Amitriptyline; Erythromelalgia; Hereditary Sensory and Autonomic Neuropathies; Humans; Male | 1993 |