amitriptyline has been researched along with Epilepsy in 36 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-two patients with depression and epilepsy were entered into an antidepressant trial of amitriptyline, nomifensine and placebo." | 5.05 | The treatment of depression in patients with epilepsy. A double-blind trial. ( Robertson, MM; Trimble, MR, 1985) |
| "Pregabalin (PGB) is used in drug-resistant epilepsy." | 4.31 | The investigation of antidepressant and anxiolytic effects of pregabalin and its mechanisms of action in rats. ( Aydın, Ş; Çivgin, ME; Dinçer Öner, S; Kılıç Tatlıcı, C; Kılıç, FS; Yazıcı, ZG; Yıldırım, C, 2023) |
| "He discusses treatment of headache in relation to management of the acute attack, avoidance of trigger factors, and pharmacological and nonpharmacological prophylaxis." | 2.37 | An overview of the classification, causes, and treatment of headache. ( Ziegler, DK, 1984) |
| "The absence of neonatal seizures is a robust and important clinical differentiator between KCNQ2 gain-of-function and loss-of-function variants." | 1.72 | KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism. ( Ambrosino, P; Amin, H; Bayat, A; Brilstra, E; Carotenuto, L; Cooper, EC; de Bellescize, J; Devinsky, O; Edery, P; Emrick, L; Goizet, C; Hong, W; Kleefstra, T; Kluger, G; Korenke, GC; Lee, HK; Lesca, G; Mefford, HC; Miceli, F; Michaud, V; Milh, M; Millevert, C; Mosca, I; Møller, RS; Risen, S; Riviello, J; Sands, T; Schrader, D; Soldovieri, MV; Taglialatela, M; Van-Gils, J; Ville, D; Weckhuysen, S; Willemsen, MH, 2022) |
| "Cyclobenzaprine has potential for sodium channel blockade and ventricular dysrhythmias although cardiac toxicity due to cyclobenzaprine alone is rare." | 1.42 | Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report. ( Cao, D; Chua-Tuan, JL; Hoyte, CO; Iwanicki, JL, 2015) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "Amitriptyline was the most effective antidepressant, attenuating both seizure severity and afterdischarge duration." | 1.27 | Acute effects of antidepressants on hippocampal seizures. ( Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF, 1985) |
| "Amitriptyline was effective on 11 patients, but in two instances, gave rise to an epileptic fit." | 1.26 | [EEG and the action of TRH: comparison with amitriptyline]. ( Bianchi, L; Bramanti, P; Di Perri, R; Meduri, M, 1980) |
| "could increase the risk of seizures." | 1.26 | [Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents]. ( Escande, M; Gayral, L; Golberger, E; Jarrige, A; Kulik, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (77.78) | 18.7374 |
| 1990's | 2 (5.56) | 18.2507 |
| 2000's | 2 (5.56) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 3 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Miceli, F | 1 |
| Millevert, C | 1 |
| Soldovieri, MV | 1 |
| Mosca, I | 1 |
| Ambrosino, P | 1 |
| Carotenuto, L | 1 |
| Schrader, D | 1 |
| Lee, HK | 1 |
| Riviello, J | 1 |
| Hong, W | 1 |
| Risen, S | 1 |
| Emrick, L | 1 |
| Amin, H | 1 |
| Ville, D | 1 |
| Edery, P | 1 |
| de Bellescize, J | 1 |
| Michaud, V | 1 |
| Van-Gils, J | 1 |
| Goizet, C | 1 |
| Willemsen, MH | 1 |
| Kleefstra, T | 1 |
| Møller, RS | 1 |
| Bayat, A | 1 |
| Devinsky, O | 1 |
| Sands, T | 1 |
| Korenke, GC | 1 |
| Kluger, G | 1 |
| Mefford, HC | 1 |
| Brilstra, E | 1 |
| Lesca, G | 1 |
| Milh, M | 1 |
| Cooper, EC | 1 |
| Taglialatela, M | 1 |
| Weckhuysen, S | 1 |
| Aydın, Ş | 1 |
| Kılıç Tatlıcı, C | 1 |
| Çivgin, ME | 1 |
| Yazıcı, ZG | 1 |
| Yıldırım, C | 1 |
| Dinçer Öner, S | 1 |
| Kılıç, FS | 1 |
| McLaren, JR | 1 |
| Shi, W | 1 |
| Misko, AL | 1 |
| Emerton, BC | 1 |
| Chu, CJ | 1 |
| Chua-Tuan, JL | 1 |
| Cao, D | 1 |
| Iwanicki, JL | 1 |
| Hoyte, CO | 1 |
| LEREBOULLET, J | 1 |
| MANS, J | 1 |
| SENES, M | 1 |
| DAVISON, K | 2 |
| VERGA, G | 1 |
| BENTE, D | 1 |
| PFEIFFER, WM | 1 |
| Sterr, A | 1 |
| Padberg, F | 1 |
| Amann, B | 1 |
| Mergl, R | 1 |
| Mulert, C | 1 |
| Juckel, G | 1 |
| Hegerl, U | 1 |
| Pogarell, O | 1 |
| Olesen, OV | 1 |
| Small, JG | 1 |
| Small, IF | 1 |
| Rumpl, E | 1 |
| Hinterhuber, H | 1 |
| Ziegler, DK | 1 |
| Trimble, MR | 2 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Bramanti, P | 1 |
| Meduri, M | 1 |
| Bianchi, L | 1 |
| Di Perri, R | 1 |
| Lowry, MR | 1 |
| Dunner, FJ | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Vol'f, MSh | 1 |
| Escande, M | 1 |
| Gayral, L | 1 |
| Golberger, E | 1 |
| Jarrige, A | 1 |
| Kulik, J | 1 |
| Glötzner, FL | 1 |
| Samland, O | 1 |
| Dommasch, D | 1 |
| Burcet Darde, J | 1 |
| Förstl, H | 1 |
| Zagorski, A | 1 |
| Pohlmann-Eden, B | 1 |
| Robertson, MM | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Clifford, DB | 1 |
| Rutherford, JL | 1 |
| Hicks, FG | 1 |
| Zorumski, CF | 1 |
| Houghton, AW | 1 |
| Redding, FK | 1 |
| Palem, RM | 1 |
| Palem, L | 1 |
| Hill, RM | 1 |
| Verniaud, WM | 1 |
| Horning, MG | 1 |
| McCulley, LB | 1 |
| Morgan, NF | 1 |
| Zuska, K | 1 |
| Nievoll, A | 1 |
| Dallos, V | 1 |
| Heathfield, K | 1 |
| Scharfetter, C | 1 |
3 reviews available for amitriptyline and Epilepsy
| Article | Year |
|---|---|
An overview of the classification, causes, and treatment of headache.
Topics: Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Biofeedback, Psychology; Cerebrovascula | 1984 |
Epilepsy, antidepressants, and the role of nomifensine.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Double-Bl | 1984 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
3 trials available for amitriptyline and Epilepsy
| Article | Year |
|---|---|
Epilepsy, antidepressants, and the role of nomifensine.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Double-Bl | 1984 |
The treatment of depression in patients with epilepsy. A double-blind trial.
Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind | 1985 |
EEG activation after intravenous amitriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Electroencephalography | 1965 |
31 other studies available for amitriptyline and Epilepsy
| Article | Year |
|---|---|
KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism.
Topics: Amitriptyline; Autistic Disorder; Epilepsy; Gain of Function Mutation; Humans; Infant, Newborn; Infa | 2022 |
The investigation of antidepressant and anxiolytic effects of pregabalin and its mechanisms of action in rats.
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Antidepressive Agents; Epilepsy; Fluoxetine; Humans; Ke | 2023 |
Hippocampal sharp wave ripples during invasive monitoring: A physiologic finding.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Electroencephalography; Epilepsy; Hippocampus; Huma | 2021 |
Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report.
Topics: Acetamides; Adolescent; Amitriptyline; Anticonvulsants; Drug Interactions; Drug Overdose; Electrocar | 2015 |
[THE NEW ANTIEPILEPTIC AGENTS].
Topics: Acetazolamide; Adrenocorticotropic Hormone; Amitriptyline; Anticonvulsants; Chlordiazepoxide; Dichlo | 1963 |
[AMITRIPTYLINE OR LAROXYL IN DEPRESSIVE SYNDROMES].
Topics: Amitriptyline; Bipolar Disorder; Depression; Depressive Disorder; Depressive Disorder, Major; Epilep | 1964 |
EPISODIC DEPERSONALIZATION; OBSERVATIONS ON 7 PATIENTS.
Topics: Alcoholic Beverages; Amitriptyline; Amobarbital; Cochlea; Convulsive Therapy; Depersonalization; Dep | 1964 |
[AMITRIPTYLINE IN AMBULATORY PSYCHIATRIC PRACTICE].
Topics: Amitriptyline; Autonomic Nervous System Diseases; Depression; Drug Eruptions; Drug Hypersensitivity; | 1964 |
[DYNAMIC COURSE CHARACTERISTIC OF AMITRIPTYLINE MEDICATION WITH REGARD TO ELECTROENCEPHALOGRAPHIC FINDINGS].
Topics: Affect; Amitriptyline; Electroencephalography; Epilepsy; Psychopharmacology; Schizophrenia; Toxicolo | 1964 |
Electroencephalographic abnormalities associated with antidepressant treatment: a comparison of mirtazapine, venlafaxine, citalopram, reboxetine, and amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents; Cerebral Cortex; Citalopram; Cyclohexanols; Electroence | 2006 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
EEG spikes in non-epileptic psychiatric patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antisocial Personality Disorder; Barbiturates; Brain; Brain | 1967 |
Unusual 'spike-wave stupor' in a patient with manic-depressive psychosis treated with amitriptyline.
Topics: Action Potentials; Amitriptyline; Bipolar Disorder; Coma; Electroencephalography; Epilepsy; Humans; | 1981 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
[EEG and the action of TRH: comparison with amitriptyline].
Topics: Adolescent; Adult; Amitriptyline; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Age | 1980 |
Seizures during tricyclic therapy.
Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Electroencephalography; Epilepsy; Femal | 1980 |
[Psychotropic drugs in the clinical picture of epilepsy (review of the literature)].
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbamazepine; C | 1975 |
[Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Electroencephalography; | 1976 |
[Brain stem seizures with circumscrbed elementary symptoms].
Topics: Adult; Amitriptyline; Ataxia; Brain Neoplasms; Brain Stem; Carbamazepine; Epilepsy; Female; Humans; | 1976 |
[Accidental epileptic crises. Importance of drugs and the genetic factor in their presentation].
Topics: Adult; Amitriptyline; Epilepsy; Humans; Male; Middle Aged; Theophylline | 1992 |
Somatosensory evoked potentials as indicators of altered cerebral excitability during psychotropic drug treatment.
Topics: Aged; Amitriptyline; Antidepressive Agents; Arousal; Depressive Disorder; Electroencephalography; Ep | 1991 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Acute effects of antidepressants on hippocampal seizures.
Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hi | 1985 |
Convulsions precipitated by amitriptyline.
Topics: Adult; Amitriptyline; Electroencephalography; Epilepsy; Humans; Male; Seizures | 1971 |
EEG activation with amitriptyline.
Topics: Adolescent; Adult; Amitriptyline; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Humans; | 1969 |
[Is the amitriptyline-perphenazine association epileptogenic?].
Topics: Amitriptyline; Drug Interactions; Electroencephalography; Epilepsy; Humans; Mental Disorders; Perphe | 1972 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
[Significance of amitriptyline activation in clinical electroencephalography].
Topics: Adolescent; Adult; Amitriptyline; Child; Electroencephalography; Epilepsy; Female; Humans; Male; Mid | 1970 |
[Therapeutic experiences with oxazepam--a derivative of the benzodiazepine series--in child and adolescent psychiatry].
Topics: Adolescent; Adolescent Psychiatry; Adult; Aggression; Amitriptyline; Anticonvulsants; Brain Damage, | 1971 |
Iatrogenic epilepsy due to antidepressant drugs.
Topics: Adolescent; Adult; Alcoholism; Amitriptyline; Antidepressive Agents; Barbiturates; Brain Damage, Chr | 1969 |
[Poisoning with an antidepressive agent. Status epilepticus in suicidal amitriptyline intoxication. Remarks on the neurology of severe poisonings].
Topics: Amitriptyline; Antidepressive Agents; Epilepsy; Humans; Neurologic Manifestations; Pupil; Reflex, St | 1965 |