amitriptyline has been researched along with Epidermolysis Bullosa in 2 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Epidermolysis Bullosa: Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There are previous reports of dilated cardiomyopathy (DCM) in recessive dystrophic epidermolysis bullosa (RDEB), a debilitating blistering skin disorder." | 6.43 | Lethal cardiomyopathy in epidermolysis bullosa associated with amitriptyline. ( Brown, R; Moss, C; Ramani, P; Taibjee, SM, 2005) |
| "There are previous reports of dilated cardiomyopathy (DCM) in recessive dystrophic epidermolysis bullosa (RDEB), a debilitating blistering skin disorder." | 2.43 | Lethal cardiomyopathy in epidermolysis bullosa associated with amitriptyline. ( Brown, R; Moss, C; Ramani, P; Taibjee, SM, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mangold, AR | 1 |
| Cole, CM | 1 |
| DiCaudo, DJ | 1 |
| Pittelkow, MR | 1 |
| Sekulic, A | 1 |
| Taibjee, SM | 1 |
| Ramani, P | 1 |
| Brown, R | 1 |
| Moss, C | 1 |
1 review available for amitriptyline and Epidermolysis Bullosa
| Article | Year |
|---|---|
Lethal cardiomyopathy in epidermolysis bullosa associated with amitriptyline.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cardiomyopathy, Dilated; Cisapride; Epidermolysis B | 2005 |
1 other study available for amitriptyline and Epidermolysis Bullosa
| Article | Year |
|---|---|
Treatment of epidermolysis bullosa pruriginosa using systemic and topical agents.
Topics: Administration, Oral; Administration, Topical; Amitriptyline; Drug Therapy, Combination; Epidermolys | 2014 |