amitriptyline has been researched along with Encephalopathy, Toxic in 5 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Selvy, M | 1 |
| Pereira, B | 1 |
| Kerckhove, N | 1 |
| Busserolles, J | 1 |
| Farsi, F | 1 |
| Guastella, V | 1 |
| Merle, P | 1 |
| Pezet, D | 1 |
| Balayssac, D | 1 |
| Gewandter, JS | 1 |
| Mohile, SG | 1 |
| Heckler, CE | 1 |
| Ryan, JL | 1 |
| Kirshner, JJ | 1 |
| Flynn, PJ | 1 |
| Hopkins, JO | 1 |
| Morrow, GR | 1 |
| Makino, H | 1 |
| Sawynok, J | 1 |
| Kitagawa, N | 1 |
| Oda, M | 1 |
| Nobutaka, I | 1 |
| Satoh, H | 1 |
| Totoki, T | 1 |
| Morimoto, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation by Oncologists of Strategies for the Prevention and Treatment of Chemotherapy-induced Peripheral Neuropathies: Observational and Cross-sectional Study[NCT03854864] | 216 participants (Actual) | Observational | 2019-01-14 | Completed | |||
| Assessment of Topical Treatment Response With Amitriptyline and Ketamine: Combination Trial in Chemotherapy Peripheral Neuropathy (ATTRACT-CPN)[NCT00471445] | Phase 3 | 462 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Cancer survivors who completed chemotherapy at least 1 month prior and had Chemotherapy Induced Peripheral Neuropathy (CIPN) (greater than or equal to 4 out of 10) were enrolled. CIPN was assessed using average scores from a 7-day daily diary that asks patients to rate the average pain, numbness, or tingling in their hands and feet over the past 24 hours on an 11-point numeric rating scale at baseline and 6 weeks post intervention. CIPN ranges from 0 (no pain) to 10 (worst possible pain)." (NCT00471445)
Timeframe: Week 6 - Baseline
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | Week 6 | |
| Ketamine/Amitriptyline NP-H Cream | 6.55 | 4.93 |
| Placebo Cream | 6.47 | 5.19 |
1 review available for amitriptyline and Encephalopathy, Toxic
| Article | Year |
|---|---|
Treatment and care of neurotoxicity from taxane anticancer agents.
Topics: Amino Acids; Amitriptyline; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Phytogenic; Bre | 2004 |
1 trial available for amitriptyline and Encephalopathy, Toxic
| Article | Year |
|---|---|
A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study of 462 cancer survivors.
Topics: Administration, Topical; Adult; Aged; Amitriptyline; Antineoplastic Agents; Double-Blind Method; Fem | 2014 |
3 other studies available for amitriptyline and Encephalopathy, Toxic
| Article | Year |
|---|---|
Prevention, diagnosis and management of chemotherapy-induced peripheral neuropathy: a cross-sectional study of French oncologists' professional practices.
Topics: Adult; Amitriptyline; Antineoplastic Agents; Calcium; Cross-Sectional Studies; Duloxetine Hydrochlor | 2021 |
Amitriptyline neurotoxicity.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Injectio | 2005 |
A proposed mechanism for amitriptyline neurotoxicity based on its detergent nature.
Topics: Amitriptyline; Anesthetics, Local; Animals; Detergents; Dose-Response Relationship, Drug; Electric S | 2006 |