Page last updated: 2024-10-22

amitriptyline and Emesis

amitriptyline has been researched along with Emesis in 31 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Research Excerpts

ExcerptRelevanceReference
" After excluding other diagnoses, we administered amitriptyline, which had been discontinued temporarily at the time of pregnancy diagnosis."7.81Pregnancy complicated by cyclic vomiting syndrome successfully treated with amitriptyline. ( Kinugasa, M; Tamai, H, 2015)
"Our data suggest that a protocol consisting of mitochondrial-targeted cofactors (co-enzyme Q10 and L-carnitine) plus amitriptyline (or possibly cyproheptadine in preschoolers) coupled with blood level monitoring is highly effective in the prevention of vomiting episodes."7.77High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series. ( Boles, RG, 2011)
"To evaluate our experience using the antimigraine prophylactic drugs, amitriptyline and cyproheptadine, for the prophylactic management of cyclic vomiting syndrome (CVS) in children."7.69Effective prophylactic therapy for cyclic vomiting syndrome in children using amitriptyline or cyproheptadine. ( Andersen, JM; Lockhart, JR; Sugerman, KS; Weinberg, WA, 1997)
"In a population of 51 ambulant cancer patients treated with doxorubicin-containing chemotherapy we conducted a double-blind cross-over randomized trial, comparing the anti-emetic efficacy of a combination of amitriptyline (25 mg p."6.65Amitriptyline plus fluphenazine to prevent chemotherapy-induced emesis in cancer patients: a double-blind randomized cross-over study. ( Blijham, GH; Mellink, WA; van Deyk, WA, 1984)
"The syndrome is frequently misdiagnosed, and patients receive redundant investigations and treatments."5.36Efficacy of nebivolol and amitriptyline in the prophylaxis of cyclic vomiting syndrome: a case report. ( Erturk, O; Karaali-Savrun, F; Uluduz, D, 2010)
" After excluding other diagnoses, we administered amitriptyline, which had been discontinued temporarily at the time of pregnancy diagnosis."3.81Pregnancy complicated by cyclic vomiting syndrome successfully treated with amitriptyline. ( Kinugasa, M; Tamai, H, 2015)
"Our data suggest that a protocol consisting of mitochondrial-targeted cofactors (co-enzyme Q10 and L-carnitine) plus amitriptyline (or possibly cyproheptadine in preschoolers) coupled with blood level monitoring is highly effective in the prevention of vomiting episodes."3.77High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series. ( Boles, RG, 2011)
"To evaluate our experience using the antimigraine prophylactic drugs, amitriptyline and cyproheptadine, for the prophylactic management of cyclic vomiting syndrome (CVS) in children."3.69Effective prophylactic therapy for cyclic vomiting syndrome in children using amitriptyline or cyproheptadine. ( Andersen, JM; Lockhart, JR; Sugerman, KS; Weinberg, WA, 1997)
"Amitriptyline was effective in 46 out of 81 (56%) patients (P < 0."2.73Cyclic vomiting syndrome in children: experience with 181 cases from southern Iran. ( Dehghani, SM; Fallahi, GH; Haghighat, M; Nejabat, M; Rafie, SM, 2007)
"In a population of 51 ambulant cancer patients treated with doxorubicin-containing chemotherapy we conducted a double-blind cross-over randomized trial, comparing the anti-emetic efficacy of a combination of amitriptyline (25 mg p."2.65Amitriptyline plus fluphenazine to prevent chemotherapy-induced emesis in cancer patients: a double-blind randomized cross-over study. ( Blijham, GH; Mellink, WA; van Deyk, WA, 1984)
"For the acute treatment of the vomiting episodes antiemetic, antimigraine and sedative medications were used."2.48[Cyclic vomiting syndrome (CVS) in adults - frequently overlooked?]. ( Beule, J; Dippold, W; Keller, K; Pfnür, M; Scholz, M, 2012)
"The syndrome is frequently misdiagnosed, and patients receive redundant investigations and treatments."1.36Efficacy of nebivolol and amitriptyline in the prophylaxis of cyclic vomiting syndrome: a case report. ( Erturk, O; Karaali-Savrun, F; Uluduz, D, 2010)
"Amitriptyline and pizotifen were effective in prophylactic therapy of vomiting episodes."1.31Cyclic vomiting syndrome in Thai children. ( Aanpreung, P; Vajaradul, C, 2002)
"A family history of migraine, primarily maternal, was found in 11 of 12 patients in whom it could be evaluated."1.29Migraine in the infant and toddler. ( Barlow, CF, 1994)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19908 (25.81)18.7374
1990's3 (9.68)18.2507
2000's7 (22.58)29.6817
2010's13 (41.94)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Badihian, N1
Saneian, H1
Badihian, S1
Yaghini, O1
Sagar, RC1
Ford, AC1
Martin, CM1
Keller, K3
Beule, J3
Dippold, W3
Treepongkaruna, S1
Jarasvaraparn, C1
Tanpowpong, P1
Lertudomphonwanit, C1
Felton, D1
Zitomersky, N1
Manzi, S1
Lightdale, JR1
Tamai, H1
Kinugasa, M1
Li, BU2
Lefevre, F1
Chelimsky, GG1
Boles, RG3
Nelson, SP1
Lewis, DW1
Linder, SL1
Issenman, RM1
Rudolph, CD1
Ghosh, JB1
Roy, M1
Peters, T1
Lovett-Barr, MR1
Preston, A1
Adams, K1
Erturk, O1
Uluduz, D1
Karaali-Savrun, F1
Liao, KY1
Chang, FY1
Wu, LT1
Wu, TC1
Scholz, M1
Pfnür, M1
Aanpreung, P1
Vajaradul, C1
Robert, R1
Frat, JP1
Veinstein, A1
Rouffineau, J1
Hattori, M1
Uematsu, N1
Nakazawa, H1
Matsukawa, N1
Yamawaki, T1
Ojika, K1
Haghighat, M1
Rafie, SM1
Dehghani, SM1
Fallahi, GH1
Nejabat, M1
Mellink, WA1
Blijham, GH1
van Deyk, WA1
Barlow, CF1
Andersen, JM1
Sugerman, KS1
Lockhart, JR1
Weinberg, WA1
Barth, N1
Riegels, M1
Hebebrand, J1
Remschmidt, H1
Martin, M1
Diaz-Rubio, E2
Casado, A1
Dominguez, S1
Sastre, J1
Martin-Jimenez, M1
Sangro, B1
Gupta, GP1
Saxena, RC1
Chandra, O1
Dhawan, KN1
Kabes, J1
Taussigová, D1
Dostál, T1
Vinar, O1
Ueki, S1
Ogawa, N1
Watanabe, S1
Gomita, Y1
Araki, Y1
Gannon, P1
Itil, T1
Keskiner, A1
Hsu, B1
Werner, H1
Vakhing, VA1
Allikmets, LKh1

Reviews

2 reviews available for amitriptyline and Emesis

ArticleYear
[Cyclic vomiting syndrome (CVS) in adults - frequently overlooked?].
    Zeitschrift fur Gastroenterologie, 2012, Volume: 50, Issue:7

    Topics: Adult; Amitriptyline; Antiemetics; Humans; Hypnotics and Sedatives; Propranolol; Vomiting

2012
["Cyclic vomiting" in childhood and adolescence].
    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie, 2000, Volume: 28, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Behavior Therapy; Child of Impaired Parents; Child, Pre

2000

Trials

5 trials available for amitriptyline and Emesis

ArticleYear
Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial.
    The American journal of gastroenterology, 2018, Volume: 113, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Child; Child, Preschool; Cyproheptadine; Female; Humans

2018
Cyclic vomiting syndrome in children: experience with 181 cases from southern Iran.
    World journal of gastroenterology, 2007, Mar-28, Volume: 13, Issue:12

    Topics: Adolescent; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Child; Child,

2007
Amitriptyline plus fluphenazine to prevent chemotherapy-induced emesis in cancer patients: a double-blind randomized cross-over study.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:9

    Topics: Adult; Amitriptyline; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Doub

1984
Results of two controlled studies on antiemetic combination against vomiting induced by 5-fluorouracil.
    Tumori, 1987, Oct-31, Volume: 73, Issue:5

    Topics: Adult; Aged; Amitriptyline; Antiemetics; Clinical Trials as Topic; Diphenhydramine; Drug Therapy, Co

1987
Clinical and quantitative electroencephalographical effects of MK 940.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:7

    Topics: Adjustment Disorders; Adult; Amitriptyline; Anorexia Nervosa; Attention; Clinical Trials as Topic; C

1970

Other Studies

24 other studies available for amitriptyline and Emesis

ArticleYear
Cyclic Vomiting Syndrome: Randomized Controlled Trials Are also Needed in Adults.
    The American journal of gastroenterology, 2017, Volume: 112, Issue:11

    Topics: Adult; Amitriptyline; Child; Cyproheptadine; Humans; Randomized Controlled Trials as Topic; Vomiting

2017
Lessons learned from hospice care.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2013, Volume: 28, Issue:10

    Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics, Opioid; Drug Monitoring; Fentanyl; Health Servic

2013
Cyclic vomiting syndrome in adults.
    Wiener medizinische Wochenschrift (1946), 2013, Volume: 163, Issue:21-22

    Topics: Abdominal Pain; Adult; Amitriptyline; Antiemetics; Combined Modality Therapy; Diagnosis, Differentia

2013
Short- and long-term outcomes of children with cyclic vomiting syndrome.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97, Issue:10

    Topics: Adolescent; Adrenergic beta-Antagonists; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Chi

2014
13-year-old girl with recurrent, episodic, persistent vomiting: out of the pot and into the fire.
    Pediatrics, 2015, Volume: 135, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Amitriptyline; Cannabinoids; Diagnostic Errors;

2015
Pregnancy complicated by cyclic vomiting syndrome successfully treated with amitriptyline.
    Obstetrics and gynecology, 2015, Volume: 125, Issue:6

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Female; Humans; Pregnancy; Pregnancy Complic

2015
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome.
    Journal of pediatric gastroenterology and nutrition, 2008, Volume: 47, Issue:3

    Topics: Age Factors; Amitriptyline; Child; Child, Preschool; Cyproheptadine; Female; Humans; Life Style; Mal

2008
Cyclic vomiting syndrome responding to amitryptiline.
    Indian journal of pediatrics, 2009, Volume: 76, Issue:12

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Child; Female; Humans; Periodicity; Syndrome; Vomiting

2009
Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study.
    BMC neurology, 2010, Jan-28, Volume: 10

    Topics: Age of Onset; Amitriptyline; Antiemetics; Humans; Internet; Parents; Patient Satisfaction; Periodici

2010
Efficacy of nebivolol and amitriptyline in the prophylaxis of cyclic vomiting syndrome: a case report.
    The neurologist, 2010, Volume: 16, Issue:5

    Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Ben

2010
Cyclic vomiting syndrome in Taiwanese children.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2011, Volume: 110, Issue:1

    Topics: Adolescent; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Age of Onset; Amitriptyline;

2011
High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series.
    BMC neurology, 2011, Aug-16, Volume: 11

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Carnitine; Child; Child, Preschool;

2011
[Stereotypical episodes of vomiting for 11 years in a 33-year-old patient].
    Der Internist, 2012, Volume: 53, Issue:3

    Topics: Adult; Amitriptyline; Antiemetics; Chronic Disease; Humans; Male; Treatment Outcome; Vomiting

2012
Cyclic vomiting syndrome in Thai children.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002, Volume: 85 Suppl 2

    Topics: Adolescent; Age Distribution; Age of Onset; Amitriptyline; Child; Child, Preschool; Female; Headache

2002
Protective effect of medication bezoar after a massive beta-blocker, digoxin, and amitriptyline poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2005, Volume: 43, Issue:5

    Topics: Administration, Oral; Adult; Amitriptyline; Bezoars; Charcoal; Digoxin; Emergency Medical Services;

2005
[An adult case of cyclic vomiting syndrome in which tricyclic antidepressant was effective].
    Rinsho shinkeigaku = Clinical neurology, 2006, Volume: 46, Issue:9

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Male; Migraine Disorders; Periodicit

2006
Migraine in the infant and toddler.
    Journal of child neurology, 1994, Volume: 9, Issue:1

    Topics: Adolescent; Amitriptyline; Child; Child, Preschool; Diagnosis, Differential; Electroencephalography;

1994
Effective prophylactic therapy for cyclic vomiting syndrome in children using amitriptyline or cyproheptadine.
    Pediatrics, 1997, Volume: 100, Issue:6

    Topics: Adolescent; Amitriptyline; Child; Child, Preschool; Cyproheptadine; Drug Therapy, Combination; Femal

1997
Progressive loss of antiemetic efficacy during subsequent courses of chemotherapy.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 28, Issue:2-3

    Topics: Adult; Aged; Amitriptyline; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclophosph

1992
Assessment of anti-reserpine and anti-apomorphine activities of some psychic energizers in pigeons.
    Psychopharmacologia, 1969, Volume: 15, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents; Apomorphine; Columbidae; Deanol; Desipramine; Female;

1969
L-dopa and tricyclic antidepressants in affective disorders. A pilot study.
    Activitas nervosa superior, 1974, Volume: 16, Issue:3

    Topics: Adult; Amitriptyline; Depression; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Levodo

1974
[Psychopharmacological effects of doxepin hydrochloride].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:6

    Topics: Amitriptyline; Amphetamine; Animals; Behavior, Animal; Blepharoptosis; Body Temperature; Brain Chemi

1972
[Limbatril therapy in psychosomatic diseases].
    Die Medizinische Welt, 1969, Oct-25, Volume: 43

    Topics: Adult; Amitriptyline; Chlordiazepoxide; Depression; Female; Headache; Humans; Male; Middle Aged; Psy

1969
[Behavioral and autonomic reactions provoked by chemical stimulation of the hypothalamus and septum].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1970, Volume: 56, Issue:1

    Topics: Acetylcholine; Amitriptyline; Animals; Behavior, Animal; Benactyzine; Cats; Drug Synergism; Electroe

1970