amitriptyline has been researched along with Electrocardiogram QT Prolonged in 15 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline has been reported to induce long QT syndrome in addition to Brugada syndrome." | 7.88 | Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome. ( Ando, K; Cao, X; Chiba, K; Izumi-Nakaseko, H; Lubna, NJ; Naito, AT; Nakamura, Y; Satoh, Y; Sugiyama, A; Wada, T, 2018) |
| "Amitriptyline has been reported to induce long QT syndrome in addition to Brugada syndrome." | 3.88 | Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome. ( Ando, K; Cao, X; Chiba, K; Izumi-Nakaseko, H; Lubna, NJ; Naito, AT; Nakamura, Y; Satoh, Y; Sugiyama, A; Wada, T, 2018) |
| "We conducted a single-center, retrospective observational study, and evaluated 87 patients (65 amitriptyline, 22 nortriptyline) who underwent 12-lead electrocardiogram (ECG) examinations both before and after receiving TCAs for herpes zoster pain or postherpetic neuralgia from May 2007 to January 2012." | 3.80 | Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval. ( Funai, Y; Funao, T; Hase, I; Ikenaga, K; Nishikawa, K; Takahashi, R, 2014) |
| "Amitriptyline was involved in 37 859 (78." | 1.33 | Frequency of high-risk use of QT-prolonging medications. ( Allen LaPointe, NM; Chan, KA; Curtis, LH; Gurwitz, JH; Kramer, JM; Lafata, JE; Platt, R; Raebel, MA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Sahin, O | 2 |
| Akturk, G | 2 |
| Cilaker Micili, S | 2 |
| Gursoy Doruk, O | 2 |
| Karapinar, F | 2 |
| Hocaoglu, N | 3 |
| Ergur, BU | 2 |
| Akan, P | 2 |
| Tuncok, Y | 3 |
| Kalkan, S | 3 |
| Lubna, NJ | 1 |
| Wada, T | 1 |
| Nakamura, Y | 1 |
| Chiba, K | 1 |
| Cao, X | 1 |
| Izumi-Nakaseko, H | 1 |
| Ando, K | 1 |
| Naito, AT | 1 |
| Satoh, Y | 1 |
| Sugiyama, A | 1 |
| Hefner, G | 1 |
| Hahn, M | 1 |
| Hohner, M | 1 |
| Roll, SC | 1 |
| Klimke, A | 1 |
| Hiemke, C | 1 |
| Funai, Y | 1 |
| Funao, T | 1 |
| Ikenaga, K | 1 |
| Takahashi, R | 1 |
| Hase, I | 1 |
| Nishikawa, K | 1 |
| Unterecker, S | 1 |
| Pfuhlmann, B | 1 |
| Kopf, J | 1 |
| Kittel-Schneider, S | 1 |
| Reif, A | 1 |
| Deckert, J | 1 |
| Kaicker, J | 1 |
| Bostwick, J | 1 |
| Oransay, K | 1 |
| Buyukdeligoz, M | 1 |
| Allen LaPointe, NM | 1 |
| Curtis, LH | 1 |
| Chan, KA | 1 |
| Kramer, JM | 1 |
| Lafata, JE | 1 |
| Gurwitz, JH | 1 |
| Raebel, MA | 1 |
| Platt, R | 1 |
| Roberts-Thomson, KC | 1 |
| Teo, KS | 1 |
| Young, GD | 1 |
| Alderton, HR | 1 |
| Bolognesi, R | 1 |
| Tsialtas, D | 1 |
| Vasini, P | 1 |
| Conti, M | 1 |
| Manca, C | 1 |
| Manikoth, P | 1 |
| Subramanyan, R | 1 |
| Menon, S | 1 |
| Al Khusaiby, SM | 1 |
| Dorsey, ST | 1 |
| Biblo, LA | 1 |
1 review available for amitriptyline and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Tricyclic medication in children and the QT interval: case report and discussion.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Chil | 1995 |
14 other studies available for amitriptyline and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
Topics: Amitriptyline; Animals; KATP Channels; Long QT Syndrome; Myocardium; Nicorandil; Rats | 2023 |
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
Topics: Amitriptyline; Animals; KATP Channels; Long QT Syndrome; Myocardium; Nicorandil; Rats | 2023 |
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
Topics: Amitriptyline; Animals; KATP Channels; Long QT Syndrome; Myocardium; Nicorandil; Rats | 2023 |
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
Topics: Amitriptyline; Animals; KATP Channels; Long QT Syndrome; Myocardium; Nicorandil; Rats | 2023 |
Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome.
Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brugada Syndrome; Dogs; | 2018 |
QTc Time Correlates with Amitriptyline and Venlafaxine Serum Levels in Elderly Psychiatric Inpatients.
Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Databases, Factual; Electrocardiograp | 2019 |
Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval.
Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Electrocardiog | 2014 |
Increase of Heart Rate and QTc by Amitriptyline, But Not by Venlafaxine, Is Correlated to Serum Concentration.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Ant | 2015 |
Co-ingestion of tricyclic antidepressants with selective norepinephrine reuptake inhibitors: Overdose in the emergency department.
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Consciousness; Depression; Desvenlafaxi | 2016 |
Adenosine-mediated cardiovascular toxicity in amitriptyline-poisoned rats.
Topics: Adenine; Adenosine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arterial Pressure; Glu | 2012 |
Frequency of high-risk use of QT-prolonging medications.
Topics: Age Factors; Aged; Amitriptyline; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antidepressive Agen | 2006 |
Drug-induced Brugada syndrome with ST-T wave alternans and long QT.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Cardiac; | 2007 |
Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; | 1997 |
A child with cardiac arrhythmia and convulsions.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child, Preschool; Diagnosis, Differential; Electroc | 1999 |
Prolonged QT interval and torsades de pointes caused by the combination of fluconazole and amitriptyline.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antifungal Agents; Drug Interactions; Electrocardio | 2000 |