amitriptyline has been researched along with Dyspepsia in 22 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Dyspepsia: Impaired digestion, especially after eating.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To observe the therapeutic effect of low-dose amitriptyline (AMT) on epigastric pain syndrome (EPS) in patients with functional dyspepsia." | 9.41 | Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients. ( Jia, L; Jiang, SM; Liu, J; Liu, Y; Xu, J; Zhou, WC, 2021) |
| "Patients meeting the Rome III criteria for functional dyspepsia (FD) were invited to participate in a double blind, randomised, placebo-controlled trial and were treated with either amitriptyline (12." | 9.15 | Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study. ( Boeckxstaens, GE; Braak, B; Klooker, TK; Lei, A; van den Wijngaard, RM; Wouters, MM, 2011) |
| "To observe the therapeutic effect of low-dose amitriptyline (AMT) on epigastric pain syndrome (EPS) in patients with functional dyspepsia." | 5.41 | Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients. ( Jia, L; Jiang, SM; Liu, J; Liu, Y; Xu, J; Zhou, WC, 2021) |
| "The Functional Dyspepsia Treatment Trial reported that amitriptyline (AMI) was associated with adequate relief of functional dyspepsia (FD) symptoms, but the pharmacogenetics of antidepressant response in FD are not known." | 5.24 | Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial. ( Abraham, BP; Almazar, AE; Bouras, EP; Camilleri, M; DiBaise, JK; El-Serag, HB; Hamilton, FA; Herrick, LM; Howden, CW; Lacy, BE; Locke, GR; Moayyedi, P; Prather, CM; Saito, YA; Schleck, CD; Szarka, LA; Talley, NJ; Tilkes, KE; Zinsmeister, AR, 2017) |
| "Combined treatment of DG and EA could increase both plasma motilin and electrogastrographic frequencies, promote gastric emptying, alleviate the symptom of dyspepsia so as to increase quality of life, with better safety and long-term effect." | 5.20 | Dalitong granule combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial. ( Guo, LK; Zhang, CX, 2015) |
| "The Functional Dyspepsia Treatment Trial (FDTT) aims to test whether treatment with an antidepressant (amitriptyline or escitalopram) leads to improvement of symptoms in patients with moderate to severe FD." | 5.16 | Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. ( Abraham, BP; Bouras, EP; Brenner, DM; DiBaise, JK; El-Serag, HB; Herrick, LM; Howden, CW; Lacy, BE; Locke, GR; Moayyedi, P; Prather, CM; Silvernail, VM; Talley, NJ; Zinsmeister, AR, 2012) |
| "Patients meeting the Rome III criteria for functional dyspepsia (FD) were invited to participate in a double blind, randomised, placebo-controlled trial and were treated with either amitriptyline (12." | 5.15 | Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study. ( Boeckxstaens, GE; Braak, B; Klooker, TK; Lei, A; van den Wijngaard, RM; Wouters, MM, 2011) |
| "In this multicenter placebo-controlled trial, children with irritable bowel syndrome, functional abdominal pain, or functional dyspepsia were randomized to 4 weeks of placebo or amitriptyline (10 mg/d, weight <35 kg; 20 mg/d, weight >35 kg)." | 5.14 | Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. ( Cocjin, J; Di Lorenzo, C; Hyman, P; Miranda, A; Nurko, S; Saps, M; Youssef, N, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 16 (72.73) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Jia, L | 1 |
| Jiang, SM | 1 |
| Zhou, WC | 1 |
| Liu, Y | 1 |
| Xu, J | 1 |
| Caviglia, GP | 1 |
| Sguazzini, C | 1 |
| Cisarò, F | 1 |
| Ribaldone, DG | 1 |
| Rosso, C | 1 |
| Fagoonee, S | 1 |
| Smedile, A | 1 |
| Saracco, GM | 1 |
| Astegiano, M | 1 |
| Pellicano, R | 1 |
| Cooper, TE | 1 |
| Heathcote, LC | 1 |
| Clinch, J | 1 |
| Gold, JI | 1 |
| Howard, R | 1 |
| Lord, SM | 1 |
| Schechter, N | 1 |
| Wood, C | 1 |
| Wiffen, PJ | 1 |
| Herrick, LM | 5 |
| Camilleri, M | 4 |
| Schleck, CD | 3 |
| Zinsmeister, AR | 5 |
| Saito, YA | 4 |
| Talley, NJ | 7 |
| Lacy, BE | 4 |
| Bouras, E | 1 |
| DiBaise, JK | 4 |
| Szarka, LA | 3 |
| Tilkes, K | 1 |
| Ding, Z | 1 |
| Xu, X | 1 |
| Ke, M | 1 |
| Locke, GR | 4 |
| Almazar, AE | 2 |
| Bouras, EP | 3 |
| Howden, CW | 3 |
| Prather, CM | 3 |
| Abraham, BP | 3 |
| El-Serag, HB | 3 |
| Moayyedi, P | 3 |
| Hamilton, FA | 2 |
| Tilkes, KE | 2 |
| Hasler, WL | 1 |
| Koch, KL | 1 |
| Zhang, CX | 1 |
| Guo, LK | 1 |
| Naumann, J | 1 |
| Saito, Y | 1 |
| Zinsmeister, A | 1 |
| Jo, Y | 1 |
| Saps, M | 1 |
| Youssef, N | 1 |
| Miranda, A | 1 |
| Nurko, S | 1 |
| Hyman, P | 1 |
| Cocjin, J | 1 |
| Di Lorenzo, C | 1 |
| Benninga, MA | 1 |
| Mayer, EA | 2 |
| Herrick, L | 1 |
| Braak, B | 1 |
| Klooker, TK | 1 |
| Wouters, MM | 1 |
| Lei, A | 1 |
| van den Wijngaard, RM | 1 |
| Boeckxstaens, GE | 1 |
| Teitelbaum, JE | 1 |
| Arora, R | 1 |
| Silvernail, VM | 1 |
| Brenner, DM | 1 |
| Otaka, M | 1 |
| Jin, M | 1 |
| Odashima, M | 1 |
| Matsuhashi, T | 1 |
| Wada, I | 1 |
| Horikawa, Y | 1 |
| Komatsu, K | 1 |
| Ohba, R | 1 |
| Oyake, J | 1 |
| Hatakeyama, N | 1 |
| Watanabe, S | 1 |
| Mertz, H | 1 |
| Fass, R | 1 |
| Kodner, A | 1 |
| Yan-Go, F | 1 |
| Fullerton, S | 1 |
| Vrazda, L | 1 |
| Langos, J | 1 |
| Blazícek, P | 1 |
| Vencel, P | 1 |
| Pekár, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antidepressant Therapy for Functional Dyspepsia[NCT00248651] | Phase 2/Phase 3 | 292 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| A Prospective, Randomized, Investigator Blinded, Controlled Trial to Evaluate the Effectiveness of Dietary Modification in Patients With Functional Dyspepsia[NCT02863822] | 0 participants (Actual) | Interventional | 2016-09-30 | Withdrawn (stopped due to no patients enrolled) | |||
| Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain[NCT01269671] | Phase 1 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI has left institution) | ||
| Effect and Mechanism of Acupuncture on Patients With Functional Dyspepsia: a Protocol for a Randomized, Assessor-blind, Sham-controlled Trial[NCT02358486] | 70 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | |||
| Effect of Nortriptyline on Abdominal Pain/Discomfort and Quality of Life in Patients With Nonulcer Dyspepsia[NCT00547703] | 5 participants (Actual) | Interventional | 2008-02-29 | Terminated (stopped due to Not enough participants - only 5 since the study started) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The time for half of the ingested solids or liquids to leave the stomach. (NCT00248651)
Timeframe: 12 weeks
| Intervention | minutes (Mean) |
|---|---|
| Amitriptyline | 117 |
| Escitalopram | 108 |
| Placebo | 115 |
The nutrient drink test for meal-induced satiety had subjects drink 120 ml of ENSURE every four minutes. Satiety scores were measured on a scale graded 0-5 (1, no symptoms; 5, maximum satiety). When a score of 5 was reached, the maximum tolerated volume intake was measured. Abnormal satiety was defined as inability to consume > 800 ml of Ensure. (NCT00248651)
Timeframe: 12 weeks
| Intervention | ml (Mean) |
|---|---|
| Amitriptyline | 764 |
| Escitalopram | 823 |
| Placebo | 839 |
The first two weeks of treatment were excluded to allow for establishment of steady state drug levels. (NCT00248651)
Timeframe: 3 weeks through 12 weeks
| Intervention | percentage of participants (Number) |
|---|---|
| Amitriptyline | 53 |
| Escitalopram | 38 |
| Placebo | 40 |
The Nepean Dyspepsia Index (NDI) assessed quality of life. NDI scores are summarized into overall quality of life and 5 subscales: Interference, Knowledge/Control, Eating/Drinking, Sleep Disturbance, Work/Study. The scale consists of 25 items, yielding 5 sub-scales. Range 0-100, higher numbers indicate a greater quality of life. (NCT00248651)
Timeframe: 12 Weeks
| Intervention | units on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Overall Quality of Life | Interference Subscale | Knowledge/Control Subscale | Eat/Drink Subscale | Sleep Disturbance Subscale | Work/Study Subscale | |
| Amitriptyline | 80.6 | 83.2 | 78.2 | 72.4 | 86.3 | 86.9 |
| Escitalopram | 82.8 | 82.8 | 76.2 | 70.6 | 80.8 | 87.2 |
| Placebo | 73.5 | 76.2 | 72.9 | 64.8 | 76.4 | 79.7 |
Patient would answer yes or no to a simple question asking whether they had adequate relief of abdominal pain or discomfort. This was measured at weeks 2,4 and 8 of the study but only week 8 was reported. What is being reported is the number of participants who answered yes. (NCT00547703)
Timeframe: 8 weeks
| Intervention | participants (Number) |
|---|---|
| Nortriptyline | 2 |
| Placebo | 1 |
1 review available for amitriptyline and Dyspepsia
| Article | Year |
|---|---|
Antidepressants for chronic non-cancer pain in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Child; Chronic | 2017 |
12 trials available for amitriptyline and Dyspepsia
| Article | Year |
|---|---|
Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients.
Topics: Abdominal Pain; Adult; Amitriptyline; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Dy | 2021 |
Effects of Amitriptyline and Escitalopram on Sleep and Mood in Patients With Functional Dyspepsia.
Topics: Adult; Affect; Amitriptyline; Antidepressive Agents; Citalopram; Dyspepsia; Female; Humans; Male; Ne | 2018 |
Effects of Antidepressants on Gastric Function in Patients with Functional Dyspepsia.
Topics: Adult; Amitriptyline; Antidepressive Agents; Citalopram; Dyspepsia; Female; Gastric Emptying; Gastro | 2018 |
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drinking; D | 2015 |
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drinking; D | 2015 |
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drinking; D | 2015 |
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drinking; D | 2015 |
Dalitong granule combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial.
Topics: Adult; Amitriptyline; Benzamides; Combined Modality Therapy; Drugs, Chinese Herbal; Dyspepsia; Elect | 2015 |
Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial.
Topics: Adult; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bi | 2017 |
Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders.
Topics: Abdominal Pain; Activities of Daily Living; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anx | 2009 |
Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Amitriptyline; Double-Blind Method; Drinking; | 2011 |
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra | 2012 |
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra | 2012 |
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra | 2012 |
Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopra | 2012 |
New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Benzamides; Drug Therapy, Combination; Dyspep | 2005 |
Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Dilatation; Double-Blind Method; Dyspe | 1998 |
Comparison of a combination nortriptyline-amitriptyline and placebo on gastrointestinal diseases in a controlled clinical study.
Topics: Adolescent; Adult; Amitriptyline; Clinical Trials as Topic; Drug Therapy, Combination; Dyspepsia; Hu | 1973 |
9 other studies available for amitriptyline and Dyspepsia
| Article | Year |
|---|---|
Gastric emptying and related symptoms in patients treated with buspirone, amitriptyline or clebopride: a "real world" study by 13C-octanoic Acid Breath Test.
Topics: Adult; Amitriptyline; Benzamides; Breath Tests; Buspirone; Caprylates; Domperidone; Drug Evaluation; | 2017 |
[Current status and recommendations for pediatric clinical trials in functional gastrointestinal disorders].
Topics: Amitriptyline; Child; Constipation; Dyspepsia; Gastrointestinal Agents; Gastrointestinal Diseases; H | 2014 |
Amitriptyline for Functional Dyspepsia: Importance of Symptom Profile and Making a Case for Gastric Emptying Testing.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Female; Humans; Male; Qualit | 2015 |
Effect of Amitriptyline and Escitalopram on Functional Dyspepsia.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Female; Humans; Male; Qualit | 2016 |
Reply.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Female; Humans; Male; Qualit | 2016 |
[Effect of Amitriptyline in Patients with Functional Dyspepsia].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Female; Humans; Male; Qualit | 2015 |
The power of placebo in pediatric functional gastrointestinal disease.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Child; Dyspepsia; Gastrointesti | 2009 |
Antidepressants in functional dyspepsia.
Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Dyspepsia; Human | 2010 |
Long-term efficacy of low-dose tricyclic antidepressants for children with functional gastrointestinal disorders.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool | 2011 |