amitriptyline has been researched along with Drug Withdrawal Symptoms in 57 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effects of amitriptyline and sudden analgesic withdrawal on headache frequency and quality of life in patients suffering from chronic daily headache related to analgesics abuse." | 9.09 | Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. ( Albucher, JF; Brefel-Courbon, C; Descombes, S; Montastruc, JL; Rascol, O; Senard, JM; Thalamas, C, 2001) |
| "A 74-year-old woman developed a slowly progressive hemichorea starting 3 weeks after discontinuation of low-dose amitriptyline and perphenazine." | 7.67 | A case of progressive hemichorea responsive to high-dose reserpine. ( Friedman, JH, 1986) |
| "To assess the effects of amitriptyline and sudden analgesic withdrawal on headache frequency and quality of life in patients suffering from chronic daily headache related to analgesics abuse." | 5.09 | Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. ( Albucher, JF; Brefel-Courbon, C; Descombes, S; Montastruc, JL; Rascol, O; Senard, JM; Thalamas, C, 2001) |
| "A 74-year-old woman developed a slowly progressive hemichorea starting 3 weeks after discontinuation of low-dose amitriptyline and perphenazine." | 3.67 | A case of progressive hemichorea responsive to high-dose reserpine. ( Friedman, JH, 1986) |
| "Anhedonia is often the cause for recurrence in heroine addiction, therefore, an appropriate treatment is an important aspect in recurrence prevention and remission stabilization." | 2.71 | [Pharmacotherapy in heroin addiction: pharmacological approaches to remission stabilization and recurrence prevention]. ( Grinenko, AIa; Krupitskiĭ, EM; Zvartau, EE, 2003) |
| "Benzodiazepine use in the treatment of insomnia may cause benzodiazepine dependence, especially in opiate users." | 2.69 | Amitriptyline vs. lorazepam in the treatment of opiate-withdrawal insomnia: a randomized double-blind study. ( Jarusuraisin, N; Srisurapanont, M, 1998) |
| "The drug also decreased alcohol addiction, had vegetostabilising and sedative effects." | 2.68 | [The efficacy and mechanisms of action of lerivon in alcoholism]. ( Anokhina, IP; Chirko, VV; Ivanets, NN; Kogan, BM; Nebarakova, TP; Rusinov, AV, 1996) |
| "Alternatively, tricyclic antidepressant withdrawal symptoms often respond to anticholinergics, such as atropine or benztropine mesylate." | 2.40 | Antidepressant withdrawal reactions. ( Wolfe, RM, 1997) |
| "366 methadone maintenance treatment patients in Taiwan were recruited and genotyped." | 1.38 | UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients. ( Chen, ACh; Chen, CH; Chen, YT; Fang, CP; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Kuo, HW; Lin, L; Liu, CT; Liu, ML; Liu, SC; Liu, YL; Shih, YH; Su, LW; Tan, HK; Tian, JN; Tsou, HH; Wu, CS; Yang, YH; Yang, YT, 2012) |
| "Further analyses on specific withdrawal symptoms in COWS showed that the genetic variants in rs4646440 are significantly associated with heart rate (allele type p = 0." | 1.37 | Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients. ( Chen, ACh; Chen, CH; Chou, SY; Fang, KC; Fang, YC; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Lin, KM; Lin, YF; Liu, ML; Liu, SC; Liu, YL; Su, LW; Tian, JN; Tsou, HH; Wang, SC; Yu, CJ, 2011) |
| "touching her stool) though neuroleptic malignant syndrome subsided." | 1.30 | [A case of depression manifesting incessant pacing and wandering following discontinuation of antipsychotic drugs due to neuroleptic malignant syndrome: a possible involvement of withdrawal akathisia]. ( Terao, T; Watanabe, H, 1997) |
| "Amitriptyline was not found in plasma 14 days after its withdrawal, while at the same time its levels in erythrocytes were still well measurable." | 1.28 | Plasma levels of antidepressants after their withdrawal. ( Beitlová, D; Krulík, R; Príhoda, P; Sikora, J, 1990) |
| "A 41-year-old man developed sleep apnea following abrupt cessation of amitriptyline." | 1.27 | Sleep apnea following withdrawal of amitriptyline. ( Musa, MN, 1988) |
| "A combined pharmacodynamic and pharmacokinetic approach was made to study the pharmacodynamic half-life (Pd1/2) of amitriptyline (AT)." | 1.26 | Decreased tyramine sensitivity after discontinuation of amitriptyline therapy. An index of pharmacodynamic half-life. ( Ghose, K, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (61.40) | 18.7374 |
| 1990's | 15 (26.32) | 18.2507 |
| 2000's | 5 (8.77) | 29.6817 |
| 2010's | 2 (3.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uppal, HS | 1 |
| Makrides, P | 1 |
| Eltigani, EA | 1 |
| Joshi, RN | 1 |
| Chen, CH | 2 |
| Wang, SC | 1 |
| Tsou, HH | 2 |
| Ho, IK | 2 |
| Tian, JN | 2 |
| Yu, CJ | 1 |
| Hsiao, CF | 2 |
| Chou, SY | 1 |
| Lin, YF | 1 |
| Fang, KC | 1 |
| Huang, CL | 2 |
| Su, LW | 2 |
| Fang, YC | 1 |
| Liu, ML | 2 |
| Lin, KM | 1 |
| Hsu, YT | 2 |
| Liu, SC | 2 |
| Chen, ACh | 2 |
| Liu, YL | 2 |
| Fang, CP | 1 |
| Tan, HK | 1 |
| Lin, L | 1 |
| Wu, CS | 1 |
| Yang, YH | 1 |
| Chen, YT | 1 |
| Kuo, HW | 1 |
| Liu, CT | 1 |
| Yang, YT | 1 |
| Shih, YH | 1 |
| Grinenko, AIa | 1 |
| Krupitskiĭ, EM | 1 |
| Zvartau, EE | 1 |
| Osborne, SF | 1 |
| Vivian, AJ | 1 |
| Schürks, M | 1 |
| Overlack, M | 1 |
| Bonnet, U | 1 |
| Dilsaver, SC | 4 |
| Greden, JF | 2 |
| Charney, DS | 1 |
| Heninger, GR | 1 |
| Sternberg, DE | 1 |
| Harkness, L | 2 |
| Giller, EL | 1 |
| Bialos, D | 2 |
| Waldo, MC | 1 |
| Stiff, JL | 1 |
| Harris, DB | 1 |
| Stolz, JF | 1 |
| Marsden, CA | 1 |
| Agbayewa, MO | 1 |
| Ghose, K | 1 |
| Gawin, FH | 1 |
| Markoff, RA | 1 |
| Mirin, SM | 1 |
| Schatzberg, AF | 1 |
| Creasey, DE | 1 |
| Hantson, P | 1 |
| Clemessy, JL | 1 |
| Baud, FJ | 1 |
| Kaminer, Y | 1 |
| Davison, P | 1 |
| Wardrope, J | 1 |
| Bonuccelli, U | 1 |
| Nuti, A | 1 |
| Lucetti, C | 1 |
| Pavese, N | 1 |
| Dell'Agnello, G | 1 |
| Muratorio, A | 1 |
| Ivanets, NN | 1 |
| Anokhina, IP | 1 |
| Kogan, BM | 1 |
| Chirko, VV | 1 |
| Nebarakova, TP | 1 |
| Rusinov, AV | 1 |
| Watanabe, H | 1 |
| Terao, T | 1 |
| Wolfe, RM | 1 |
| Srisurapanont, M | 1 |
| Jarusuraisin, N | 1 |
| Zed, PJ | 1 |
| Loewen, PS | 1 |
| Robinson, G | 1 |
| Descombes, S | 1 |
| Brefel-Courbon, C | 1 |
| Thalamas, C | 1 |
| Albucher, JF | 1 |
| Rascol, O | 1 |
| Montastruc, JL | 1 |
| Senard, JM | 1 |
| Lynch, MA | 1 |
| Leonard, BE | 1 |
| Mogilnicka, E | 1 |
| Klimek, V | 1 |
| Gualtieri, CT | 1 |
| Staye, J | 1 |
| Cohen, MJ | 1 |
| Hanbury, R | 1 |
| Stimmel, B | 1 |
| Pallanti, S | 1 |
| Mazzi, D | 1 |
| Hering, R | 1 |
| Steiner, TJ | 1 |
| Benazzi, F | 1 |
| Ansseau, M | 1 |
| Devoitille, JM | 1 |
| Papart, P | 1 |
| Vanbrabant, E | 1 |
| Mantanus, H | 1 |
| Timsit-Berthier, M | 1 |
| Hartmann, PM | 1 |
| Sikora, J | 1 |
| Krulík, R | 1 |
| Beitlová, D | 1 |
| Príhoda, P | 1 |
| Musa, MN | 1 |
| Corrigan, FM | 1 |
| Coulter, F | 1 |
| Merriam, AE | 1 |
| Snider, RM | 1 |
| Majchrzak, MJ | 1 |
| Overstreet, DH | 1 |
| Janowsky, DS | 1 |
| Gillin, JC | 1 |
| Shiromani, PJ | 1 |
| Sutin, EL | 1 |
| Giller, E | 1 |
| Jatlow, P | 1 |
| Waldo, M | 1 |
| Friedman, JH | 1 |
| Avrutskii, GIa | 1 |
| Gurovich, IIa | 1 |
| Prokhorova, IS | 1 |
| Tirkel'taub, IuA | 1 |
| Romanov, IuD | 1 |
| Lewis, SA | 1 |
| Oswald, I | 1 |
| Franzén, G | 2 |
| Kamei, C | 1 |
| Shimomura, K | 1 |
| Ueki, S | 1 |
| Kaneto, H | 2 |
| Koida, M | 2 |
| Tsuchie, F | 2 |
| Peters, UH | 1 |
| Glück, A | 1 |
| Sargant, W | 1 |
| Overall, JE | 1 |
| Brown, D | 1 |
| Williams, JD | 1 |
| Neill, LT | 1 |
| Miyagawa, H | 1 |
| Hill, RM | 1 |
| Verniaud, WM | 1 |
| Horning, MG | 1 |
| McCulley, LB | 1 |
| Morgan, NF | 1 |
| Kissin, B | 1 |
| Gross, MM | 1 |
| Dallos, V | 1 |
| Heathfield, K | 1 |
3 reviews available for amitriptyline and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Antidepressant withdrawal phenomena.
Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; | 1984 |
Antidepressant withdrawal reactions.
Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clomipramine; Cyclohe | 1997 |
Medication-induced headache: overview and systematic review of therapeutic approaches.
Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents; Chronic Disease; Ergolines; Headache; Humans; M | 1999 |
10 trials available for amitriptyline and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
[Pharmacotherapy in heroin addiction: pharmacological approaches to remission stabilization and recurrence prevention].
Topics: Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Antidepressive Agents, Second-Gen | 2003 |
Serotonin function and mechanism of action of antidepressant treatment. Effects of amitriptyline and desipramine.
Topics: Aged; Amitriptyline; Animals; Brain Chemistry; Depressive Disorder; Desipramine; Female; Humans; Inf | 1984 |
[The efficacy and mechanisms of action of lerivon in alcoholism].
Topics: Adolescent; Adult; Alcohol Deterrents; Alcoholism; Amitriptyline; Anti-Anxiety Agents; Antidepressiv | 1996 |
Amitriptyline vs. lorazepam in the treatment of opiate-withdrawal insomnia: a randomized double-blind study.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Double-Blind Method; Fe | 1998 |
Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study.
Topics: Adult; Aged; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Chronic Disease; Double-Blind Meth | 2001 |
Abrupt outpatient withdrawal of medication in analgesic-abusing migraineurs.
Topics: Adult; Amitriptyline; Analgesics; Caffeine; Ergotamine; Evaluation Studies as Topic; Female; Follow- | 1991 |
Comparison of adinazolam, amitriptyline, and diazepam in endogenous depressive inpatients exhibiting DST nonsuppression or abnormal contingent negative variation.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Depression; Dexam | 1991 |
Long-term amitriptyline in chronic depression.
Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; | 1985 |
Drug treatment of anxiety and depression in detoxified alcoholic patients.
Topics: Alcoholism; Amitriptyline; Analysis of Variance; Anxiety; Ascorbic Acid; Chlordiazepoxide; Depressio | 1973 |
Drug therapy in alcoholism.
Topics: Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Benactyzine; Carbamates; C | 1968 |
44 other studies available for amitriptyline and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
A case report of acute mania secondary to pedicled latissimus dorsi breast reconstruction and amitriptyline withdrawal.
Topics: Acute Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Female; Humans; Ma | 2009 |
Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients.
Topics: Adult; Amitriptyline; Areca; Biomarkers, Pharmacological; Cytochrome P-450 CYP3A; Female; Genetic As | 2011 |
UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
Topics: Adult; Amitriptyline; Female; Genetic Association Studies; Glucuronosyltransferase; Haplotypes; Hero | 2012 |
Primary position upbeat nystagmus associated with amitriptyline use.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Male; Nystagmus, Pathologic; Substan | 2004 |
Naltrexone treatment of combined alcohol and opioid dependence: deterioration of co-morbid major depression.
Topics: Alcoholism; Amitriptyline; Depressive Disorder, Major; Ethanol; Humans; Male; Middle Aged; Morphine; | 2005 |
Chronic depression: response to amitriptyline after discontinuation.
Topics: Amitriptyline; Chronic Disease; Depressive Disorder; Double-Blind Method; Female; Humans; Long-Term | 1982 |
Clonidine withdrawal complicated by amitriptyline therapy.
Topics: Aged; Amitriptyline; Anxiety; Clonidine; Female; Humans; Hypertension; Intraoperative Care; Methyldo | 1983 |
Withdrawal from chronic treatment with metergoline, dl-propranolol and amitriptyline enhances serotonin receptor mediated behaviour in the rat.
Topics: Amitriptyline; Animals; Behavior, Animal; Clomipramine; Ergolines; Humans; Iprindole; Male; Metergol | 1982 |
Symptoms of withdrawal from tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Diagnosis, Differential; Female; | 1981 |
Decreased tyramine sensitivity after discontinuation of amitriptyline therapy. An index of pharmacodynamic half-life.
Topics: Adult; Amitriptyline; Blood Pressure; Depression; Drug Interactions; Female; Half-Life; Humans; Male | 1980 |
Panic anxiety after abrupt discontinuation of amitriptyline.
Topics: Adult; Amitriptyline; Anxiety Disorders; Depressive Disorder; Fear; Humans; Male; Panic; Substance W | 1981 |
Hypomania and mania after withdrawal of tricyclic antidepressants.
Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Diso | 1981 |
Withdrawal syndrome following midazolam infusion.
Topics: Adult; Amitriptyline; Drug Overdose; Female; Humans; Midazolam; Seizures; Substance Withdrawal Syndr | 1995 |
Cocaine craving.
Topics: Adolescent; Amitriptyline; Cocaine; Desipramine; Humans; Hypotension, Orthostatic; Male; Risk Factor | 1994 |
Acute amitriptyline withdrawal and hyponatraemia. A case report.
Topics: Acute Disease; Amitriptyline; Humans; Hyponatremia; Male; Middle Aged; Substance Withdrawal Syndrome | 1993 |
Amitriptyline and dexamethasone combined treatment in drug-induced headache.
Topics: Adult; Amitriptyline; Analgesics; Dexamethasone; Drug Therapy, Combination; Female; Headache; Humans | 1996 |
[A case of depression manifesting incessant pacing and wandering following discontinuation of antipsychotic drugs due to neuroleptic malignant syndrome: a possible involvement of withdrawal akathisia].
Topics: Adult; Akathisia, Drug-Induced; Amitriptyline; Depression; Female; Humans; Methotrimeprazine; Neurol | 1997 |
Effect of chronic amphetamine administration on the behaviour of rats in the open field apparatus: reversal of post-withdrawal depression by two antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Dextroamphetamine; Huma | 1978 |
Mianserin, danitracen and amitriptyline withdrawal increases the behavioural responses of rats to L-5-HTP.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Behavior, Animal; Dibenzazepines; Humans; Male; Mianser | 1979 |
Withdrawal symptoms after abrupt cessation of amitriptyline in an eight-year-old boy.
Topics: Amitriptyline; Child; Humans; Hyperkinesis; Male; Nausea; Substance Withdrawal Syndrome | 1979 |
Abuse of amitriptyline.
Topics: Amitriptyline; Depression; Heroin Dependence; Humans; Methadone; Self Medication; Substance Withdraw | 1978 |
MDMA (Ecstasy) precipitation of panic disorder.
Topics: 3,4-Methylenedioxyamphetamine; Adult; Agoraphobia; Alcohol Drinking; Amitriptyline; Arousal; Fluvoxa | 1992 |
Lorazepam, amitriptyline, and sulpiride: withdrawal effects.
Topics: Amitriptyline; Anxiety Disorders; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Lo | 1991 |
Mania or hypomania after withdrawal from antidepressants.
Topics: Adult; Amitriptyline; Bipolar Disorder; Depressive Disorder; Female; Humans; Lithium; Phenelzine; Su | 1990 |
Plasma levels of antidepressants after their withdrawal.
Topics: Adrenal Glands; Adrenalectomy; Amitriptyline; Animals; Dealkylation; Erythrocytes; Imipramine; Liver | 1990 |
Sleep apnea following withdrawal of amitriptyline.
Topics: Adult; Amitriptyline; Humans; Male; Sleep Apnea Syndromes; Substance Withdrawal Syndrome | 1988 |
Neuroleptic malignant syndrome, amitriptyline, and thioridazine.
Topics: Amitriptyline; Humans; Male; Middle Aged; Neuroleptic Malignant Syndrome; Substance Withdrawal Syndr | 1988 |
Withdrawal NMS after drug treatment.
Topics: Amitriptyline; Drug Therapy, Combination; Haloperidol; Humans; Imipramine; Neuroleptic Malignant Syn | 1988 |
Amitriptyline produces dose-dependent supersensitivity of a central cholinergic mechanism.
Topics: Amitriptyline; Animals; Body Temperature; Dose-Response Relationship, Drug; Male; Oxotremorine; Para | 1987 |
Decrease in core temperature as an indication of cholinergic overdrive during amitriptyline withdrawal.
Topics: Amitriptyline; Animals; Body Temperature Regulation; Male; Rats; Rats, Inbred Strains; Receptors, Ch | 1987 |
Stress-induced immobility in rats with cholinergic supersensitivity.
Topics: Amitriptyline; Animals; Arousal; Hippocampus; Kinetics; Male; Motor Activity; Oxotremorine; Quinucli | 1986 |
Mania induced by antidepressant withdrawal.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Humans; Substance Withdrawal Synd | 1986 |
A case of progressive hemichorea responsive to high-dose reserpine.
Topics: Aged; Amitriptyline; Chorea; Dyskinesia, Drug-Induced; Female; Humans; Perphenazine; Reserpine; Subs | 1986 |
[Sudden cessation of psychotropic drugs].
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Bipolar Disorder; Blood Pressure; Chlorprom | 1974 |
Overdose of tricyclic anti-depressants and deductions concerning their cerebral action.
Topics: Adolescent; Adult; Amitriptyline; Brain; Brain Chemistry; Dreams; Electroencephalography; Female; Hu | 1969 |
Serum cortisol in chronic schizophrenia. Changes in the response to intravenously administered insulin and ACTH on withdrawal of drugs.
Topics: Adrenocorticotropic Hormone; Aged; Amitriptyline; Blood Glucose; Chronic Disease; Female; Haloperido | 1971 |
Significance of withdrawal jumping response in predicting physical dependence in mice.
Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imip | 1973 |
[Tolerance and physical dependence producing liability of doxepin].
Topics: Amitriptyline; Animals; Body Weight; Diazepam; Dibenzoxepins; Drug Resistance; Humans; Imipramine; M | 1972 |
[Personality at the end of a depressive phase. Observations after cessation of the endogenous depressive phases].
Topics: Amitriptyline; Autistic Disorder; Bipolar Disorder; Defense Mechanisms; Female; Humans; Hypochondria | 1973 |
Prescribing Mandrax.
Topics: Amitriptyline; Dibenzazepines; Diphenhydramine; Electroconvulsive Therapy; Humans; Methaqualone; Sle | 1973 |
[Screening procedure for barbital type physical dependence liability of psychotropic drugs in mice].
Topics: Amitriptyline; Animals; Barbiturates; Behavior, Animal; Benzazepines; Benzodiazepinones; Body Weight | 1973 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Serum cortisol in chronic schizophrenia. Changes in the diurnal rhythm and psychiatric mental status on withdrawal of drugs.
Topics: Aged; Amitriptyline; Chronic Disease; Circadian Rhythm; Cognition; Female; Haloperidol; Humans; Hydr | 1971 |
Iatrogenic epilepsy due to antidepressant drugs.
Topics: Adolescent; Adult; Alcoholism; Amitriptyline; Antidepressive Agents; Barbiturates; Brain Damage, Chr | 1969 |