Page last updated: 2024-10-22

amitriptyline and Drug Overdose

amitriptyline has been researched along with Drug Overdose in 121 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

ExcerptRelevanceReference
"We present a case of a 15-year-old female who was admitted in a comatose state with no spontaneous respiratory effort and absence of brainstem reflexes after cyclobenzaprine ingestion."8.12Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange. ( Buyukgoz, C; Gangu, S; Gowani, F; Kimura, D, 2022)
"We present a tricyclic antidepressant intoxication, where the patient is thought to have taken a large amount of amitriptyline at once, which, in combination with a cytochrome P450 2D6 poor metabolizer status, led to an unusual long persistence of her coma."8.12Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report. ( Bruins, P; de Vries Schultink, AHM; Harmsze, A; Meinders, AJ; van de Wint, T, 2022)
" As with other cardiovascular complications, amitriptyline toxicity may cause acute myocardial infarction."7.73Acute myocardial infarction associated with amitriptyline overdose. ( Aksay, E; Atilla, R; Ersel, M; Kiyan, S; Yanturali, S, 2006)
" We recently encountered a case of reversible amitriptyline-induced external ophthalmoplegia, which was first described by Mladinich and Carlow in 1977."7.71[External ophthalmoplegia caused by amitriptyline poisoning]. ( Pfefferkorn, T; Strupp, M; von Stuckrad-Barre, S; Wekerle, G, 2002)
"I report a case of intestinal pseudo-obstruction, spontaneous caecal perforation and faecal peritonitis caused by an overdose of amitriptyline."7.67Amitriptyline overdose complicated by intestinal pseudo-obstruction and caecal perforation. ( McMahon, AJ, 1989)
"We present a tricyclic antidepressant intoxication, where the patient is thought to have taken a large amount of amitriptyline at once, which, in combination with a cytochrome P450 2D6 poor metabolizer status, led to an unusual long persistence of her coma."4.12Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report. ( Bruins, P; de Vries Schultink, AHM; Harmsze, A; Meinders, AJ; van de Wint, T, 2022)
"We present a case of a 15-year-old female who was admitted in a comatose state with no spontaneous respiratory effort and absence of brainstem reflexes after cyclobenzaprine ingestion."4.12Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange. ( Buyukgoz, C; Gangu, S; Gowani, F; Kimura, D, 2022)
"In this case report, a 22-year-old male developed severe hypothermia after an accidental overdose of cyclobenzaprine."3.81Use of an Intravascular Heat Exchange Catheter and Intravenous Lipid Emulsion for Hypothermic Cardiac Arrest After Cyclobenzaprine Overdose. ( Awad, NI; Bridgeman, PJ; Jeges, J; McCoy, JV; Page, E; Westrol, MS, 2015)
" Here we report a 25-year-old female presenting with coma and hemodynamic instability following intentional ingestion of amitriptyline."3.78Lipid therapy for the treatment of a refractory amitriptyline overdose. ( Kiberd, MB; Minor, SF, 2012)
" Patients with an amitriptyline overdose were more likely to have seizure, coma, tachycardia, a wide QRS or ventricular dysrhythmia, and have received sodium bicarbonate or be intubated."3.77Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose. ( Bebarta, VS; Borys, DJ; Maddry, J; Morgan, DL, 2011)
"We present the case of a comatose woman who intentionally overdosed on amitriptyline and displayed rising serum total tricyclic antidepressant concentrations for at least 6 days after admission."3.77Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity. ( Curry, SC; Smith, JC, 2011)
" As with other cardiovascular complications, amitriptyline toxicity may cause acute myocardial infarction."3.73Acute myocardial infarction associated with amitriptyline overdose. ( Aksay, E; Atilla, R; Ersel, M; Kiyan, S; Yanturali, S, 2006)
"We present a case of delirium due to amitriptyline overdose, which resolved rapidly following initiation of the cholinesterase inhibitor donepezil."3.72Donepezil for anticholinergic drug intoxication: a case report. ( Aksu, H; Elbi, H; Noyan, MA, 2003)
" We recently encountered a case of reversible amitriptyline-induced external ophthalmoplegia, which was first described by Mladinich and Carlow in 1977."3.71[External ophthalmoplegia caused by amitriptyline poisoning]. ( Pfefferkorn, T; Strupp, M; von Stuckrad-Barre, S; Wekerle, G, 2002)
" We report a patient in deep coma with complete absence of brain-stem reflexes after she had taken a large quantity of amitriptyline."3.68Reversible brain death. A manifestation of amitriptyline overdose. ( Dantzker, DR; Yang, KL, 1991)
"I report a case of intestinal pseudo-obstruction, spontaneous caecal perforation and faecal peritonitis caused by an overdose of amitriptyline."3.67Amitriptyline overdose complicated by intestinal pseudo-obstruction and caecal perforation. ( McMahon, AJ, 1989)
"Severe cardiovascular arrhythmias occurred in both groups with 3 in the CAC-HP group versus 1 incident with premature death in the CG."2.87Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion. ( Belhage, B; Dalhoff, K; Eriksen, T; Haarmark, C; Hoegberg, LCG; Jansen, T, 2018)
"Sertraline was without effect on vital signs or electrocardiogram, and had no clinically relevant effects on laboratory values."2.38Toleration and safety of sertraline: experience worldwide. ( Doogan, DP, 1991)
"Acute presentations of acquired exotropia or divergent alignment of either or both eyes are commonly observed following intracranial vascular events, trauma, orbital, and endoscopic sinus surgeries."1.91Amitriptyline overdose-an uncommon cause of acute transient exotropia presenting to the emergency setting: a case report. ( Rajaratnam, A, 2023)
"She suffered a cardiac arrest followed by cardiovascular and neurological complications."1.56Successful Outcome Following Intravenous Lipid Emulsion Rescue Therapy in a Patient with Cardiac Arrest Due to Amitriptyline Overdose. ( Angel-Isaza, AM; Bustamante-Cristancho, LA; Uribe-B, FL, 2020)
"In the present case, arrhythmia and circulatory shock responded neither to alkalization and elevated sodium levels after infusion of sodium bicarbonate, nor to any other established therapies."1.48[Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication]. ( Fischer, B; Otte, S; Sayk, F, 2018)
"A 16 year-old female with a seizure disorder was found unresponsive in pulseless ventricular tachycardia after intentionally ingesting 4."1.42Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report. ( Cao, D; Chua-Tuan, JL; Hoyte, CO; Iwanicki, JL, 2015)
" IFE therapy is being recommended by US PCCs; protocols and dosing regimens are nearly uniform."1.39Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning? ( Christian, MR; Mycyk, MB; Pallasch, EM; Wahl, M, 2013)
"Amitriptyline was used as internal standard."1.37[Determination of doxepin in whole blood by SPE-LC-MS/MS]. ( Gong, FJ; Wu, ZP; Yan, SM; Zhang, RS, 2011)
"Amitriptyline is a tricyclic antidepressant."1.37Analysis of amitriptyline overdose in emergency medicine. ( Altunci, YA; Güloglu, C; Orak, M; Ustündag, M, 2011)
"Amitriptyline was the most frequent agent followed by Nortriptyline."1.37Tricyclic antidepressants intoxication in Tehran, Iran: epidemiology and associated factors. ( Dianat, S; Hassanian-Moghaddam, H; Rahimian, R; Rashidi-Ranjbar, N; Rasouli, MR; Zarei, MR, 2011)
"Naloxone treatment may have a beneficial role in lethal doses of amitriptyline ingestion because amitriptyline may affect opioid receptors."1.36Amitriptyline and tianeptine poisoning treated by naloxone. ( Ari, M; Duru, M; Oktar, S, 2010)
"Physiologically based pharmacokinetic (PBPK) models were developed for design and optimization of liposome therapy for treatment of overdoses of tricyclic antidepressants and local anesthetics."1.36A physiologically based pharmacokinetic (PBPK) model for predicting the efficacy of drug overdose treatment with liposomes in man. ( Chauhan, A; Howell, BA, 2010)
"She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes."1.35Treatment of severe amitriptyline intoxication with plasmapheresis. ( Akyüz, M; Aydemir, C; Cabuk, H; Eldes, N; Kolsal, E; Numanoglu, V; Piskin, E; Tekin, IO, 2009)
"To report the successful use of high dose insulin (HDI) in previously unreported insulin dosing ranges in a patient with severe myocardial toxicity due to an amitriptyline and citalopram overdose."1.35High dose insulin in toxic cardiogenic shock. ( Engebretsen, KM; Holger, JS; Marini, JJ, 2009)
" They denied the suicidal attempt and explained that they used amitriptyline in a dosage of 100 to 200 mg per day as a drug of abuse."1.33Recreational amitriptyline abuse. ( Chodorowski, Z; Habrat, B; Sein Anand, J, 2005)
"7 mg/kg per dose) (the drug dosage was not known in 13 children)."1.33Acute amitriptyline intoxication: an analysis of 44 children. ( Akbayram, S; Akgün, C; Caksen, H; Erol, M; Odabaş, D; Ozbek, H; Tuncer, O; Yilmaz, C, 2006)
" Mechanisms of desipramine toxicity and its dosage recommendations are discussed."1.32Excess fatality from desipramine and dosage recommendations. ( Amitai, Y; Frischer, H, 2004)
"Amitriptyline was studied in greater detail and caused a dose-related (0."1.30Acute lung failure induced by tricyclic antidepressants. ( Blomgren, B; Dahlin, KL; Lâstbom, L; Ryrfeldt, A, 1997)
"Amitriptyline was the agent most commonly involved in suicide or possible suicide caused by antidepressants, and it was also the most commonly sold antidepressant."1.29Antidepressants in suicide: differences in fatality and drug utilisation. ( Löwenhielm, CG; Malmvik, J; Melander, A, 1994)
"Nortriptyline was not detected in most cases, suggesting that it may degrade more rapidly than desipramine."1.29The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions. ( Wahba, WW; Winek, CL; Zaveri, NR, 1993)
"He subsequently developed an adult respiratory distress syndrome but gradually improved after bronchoscopic removal of charcoal and supportive care."1.29Accidental administration of activated charcoal into the lung: aspiration by proxy. ( Filandrinos, D; Harris, CR, 1993)
"Midazolam was replaced by saline in the other 12."1.28Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog. ( Askenasi, R; Leduc, D; Lheureux, P; Vranckx, M, 1992)
"No correlation between coma grade or QRS duration and cerebral spinal fluid concentration of amitriptyline was found."1.28Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics. ( Heath, A; Hultén, BA; Knudsen, K; Mårtensson, E; Nyberg, G; Starmark, JE, 1992)
"Multiple drug overdoses were excluded."1.28Demographic and electrocardiographic factors associated with severe tricyclic antidepressant toxicity. ( Bossart, PJ; Caravati, EM, 1991)

Research

Studies (121)

TimeframeStudies, this research(%)All Research%
pre-19903 (2.48)18.7374
1990's38 (31.40)18.2507
2000's35 (28.93)29.6817
2010's36 (29.75)24.3611
2020's9 (7.44)2.80

Authors

AuthorsStudies
Buyukgoz, C1
Gangu, S1
Gowani, F1
Kimura, D1
Siddiqui, MZ1
Piserchio, JP1
Patel, M1
Park, J1
Foster, ML1
Desrosiers, CE1
Herbert, J1
Nichols, SD1
McCall, KL1
Piper, BJ1
Bloom, J1
Hoffman, RS1
van de Wint, T1
de Vries Schultink, AHM1
Meinders, AJ1
Harmsze, A1
Bruins, P1
Rajaratnam, A1
Angel-Isaza, AM1
Bustamante-Cristancho, LA1
Uribe-B, FL1
Yang, XY1
Song, XT1
Zhang, Y1
Fountoulakis, KN1
Theodorou, T1
Karakasi, MV1
Nimatoudis, I1
Paland, M1
Kim, HS1
Ingalsbe, GS1
Lank, PM1
Otte, S1
Fischer, B1
Sayk, F1
Jansen, T1
Hoegberg, LCG1
Eriksen, T1
Haarmark, C1
Dalhoff, K1
Belhage, B1
Chen, CH1
Huang, TH1
Elzoghby, AO1
Wang, PW1
Chang, CW1
Fang, JY1
Butt, K1
Ambati, S1
Birns, J1
Henderson, K1
Bhalla, A1
Perza, MN1
Schneider, LA1
Rosini, JM1
Perichon, D1
Turfus, S1
Gerostamoulos, D1
Graudins, A1
Heinonen, JA1
Litonius, E1
Backman, JT1
Neuvonen, PJ1
Rosenberg, PH1
Christian, MR1
Pallasch, EM1
Wahl, M1
Mycyk, MB1
Tatli, O1
Karaca, Y1
Gunaydin, M1
Yurtsever, S1
Tuten, G1
Punja, M1
Neill, SG1
Wong, S1
Agarwala, R1
Ahmed, SZ1
Wiegand, TJ1
Paksu, S1
Duran, L1
Altuntas, M1
Zengin, H1
Salis, O1
Ozsevik, SN1
Albayrak, H1
Murat, N1
Guzel, A1
Paksu, MS1
Eren Cevik, S1
Tasyurek, T1
Guneysel, O1
Allibe, N1
Eysseric-Guerin, H1
Kintz, P1
Bartoli, M1
Bost-Bru, C1
Grenier, F1
Scolan, V1
Stanke-Labesque, F1
Kontio, T1
Salo, A1
Kantola, T1
Toivonen, L1
Skrifvars, MB1
Chua-Tuan, JL1
Cao, D1
Iwanicki, JL1
Hoyte, CO1
Westrol, MS1
Awad, NI1
Bridgeman, PJ1
Page, E1
McCoy, JV1
Jeges, J1
Mbuvah, F1
Petrosyan, F1
Thiruchelvam, N1
Kistangari, G1
Scanlon, KA1
Stoppacher, R1
Blum, LM1
Starkey, SJ1
Ramasubbu, B1
James, D1
Scurr, A1
Sandilands, EA1
Kaicker, J1
Bostwick, J1
Le Fevre, P1
Gosling, M1
Acharya, K1
Georgiou, A1
Chan, HY1
Chan, YC1
Lau, FL1
Kolsal, E1
Tekin, IO1
Piskin, E1
Aydemir, C1
Akyüz, M1
Cabuk, H1
Eldes, N1
Numanoglu, V1
Olgun, H1
Yildirim, ZK1
Karacan, M1
Ceviz, N1
Prakash, R1
Munda, S1
Pattojoshi, A1
Choudhary, PP1
Holger, JS1
Engebretsen, KM1
Marini, JJ1
Gillman, PK1
Anand, JS1
Habrat, B2
Sut, M1
Korolkiewicz, R1
Menard-Katcher, C1
Henretig, FM1
Osterhoudt, KC1
Howell, BA1
Chauhan, A2
Dianat, S1
Zarei, MR1
Hassanian-Moghaddam, H1
Rashidi-Ranjbar, N1
Rahimian, R1
Rasouli, MR1
Ari, M1
Oktar, S1
Duru, M1
Bebarta, VS3
Maddry, J2
Borys, DJ2
Morgan, DL2
Güloglu, C1
Orak, M1
Ustündag, M1
Altunci, YA1
Smith, JC1
Curry, SC1
Valente Nabais, JM1
Ledesma, B1
Laginhas, C1
Gong, FJ1
Yan, SM1
Wu, ZP1
Zhang, RS1
Clement, A1
Raney, JJ1
Wasserman, GS1
Lowry, JA1
Kiberd, MB1
Minor, SF1
Levine, M1
Brooks, DE1
Franken, A1
Graham, R1
Liu, X1
Emery, CJ1
Laude, E1
Herget, J1
Gill, G1
Cope, G1
Barer, GR1
Jain, V1
Swartz, CM1
Teece, S2
Hogg, K2
Franssen, EJ1
Kunst, PW1
Bet, PM1
Strack van Schijndel, RJ1
van Loenen, AC1
Wilhelm, AJ1
Spiller, HA1
Cutino, L1
Noyan, MA1
Elbi, H1
Aksu, H1
Bateman, DN1
Chick, J1
Good, AM1
Kelly, CA1
Masterton, G1
Amitai, Y1
Frischer, H1
Lee, DW1
Flint, J1
Morey, T1
Dennis, D1
Partch, R1
Baney, R1
Prahlow, JA1
Landrum, JE1
Nutt, DJ1
Sein Anand, J1
Chodorowski, Z1
Deegan, C1
O'Brien, K1
Caksen, H1
Akbayram, S1
Odabaş, D1
Ozbek, H1
Erol, M1
Akgün, C1
Tuncer, O1
Yilmaz, C1
Kiyan, S1
Aksay, E1
Yanturali, S1
Atilla, R1
Ersel, M1
Barry, JD1
Durkovich, DW1
Williams, SR1
Shinya, H1
Hakoda, S1
Kinouchi, S1
Zuidema, X1
Dünser, MW1
Wenzel, V1
Rozendaal, FW1
de Jager, CP1
Waksman, JC1
O'Ferrall, EK1
Busche, K1
Dickhoff, P1
Zabad, R1
Toth, C1
Avella, J1
Katz, M1
Lehrer, M1
Bek, K1
Ozkaya, O1
Mutlu, B1
Dağdemir, A1
Sungur, M1
Açikgöz, Y1
Işlek, I1
Baysal, K1
Ghoreishi, A1
Howell, B1
Rechlin, T1
Hargreaves, DG1
Gosal, H1
Moss, AL1
Hantson, P1
Clemessy, JL1
Baud, FJ1
Stone, CK1
Kraemer, CM1
Carroll, R1
Low, R1
Pounder, DJ3
Owen, V1
Quigley, C1
Henry, JA1
Alexander, CA1
Sener, EK1
Malmvik, J1
Löwenhielm, CG1
Melander, A1
Guharoy, SR1
Bolster, M1
Curran, J1
Busuttil, A2
Winek, CL1
Zaveri, NR1
Wahba, WW1
Wilson, Z1
Hubbard, S1
Harris, CR1
Filandrinos, D1
Jones, ME1
Brettle, RP1
Inglis, MH1
Bell, JE1
Willocks, L1
Hilberg, T1
Bugge, A1
Beylich, KM1
Ingum, J1
Bjørneboe, A1
Mørland, J1
Valentine, C1
Williams, O1
Davis, A1
Hind, CR1
Saltissi, S1
Arya, OP1
Brown, R1
Retterstøl, N1
Montgomery, SA2
Knudsen, K3
Abrahamsson, J1
Coumbe, A1
Perez-Martinez, AL1
Fegan, AW1
Hill, IR1
Isacsson, G1
Holmgren, P1
Druid, H1
Bergman, U1
Dahlin, KL1
Lâstbom, L1
Blomgren, B1
Ryrfeldt, A1
Zimmermann, PG1
Langford, AM1
Taylor, KK1
Pezzilli, R1
Melandri, R1
Barakat, B1
Broccoli, PL1
Miglio, F1
Moriya, F1
Hashimoto, Y1
Harrigan, RA1
Brady, WJ1
Adams, MH1
Lammon, CB1
Stover, LM1
Malone, SI1
Young, JJ1
Mazzaferri, EL1
Amann, B1
Grunze, H1
Hoffmann, J1
Schäfer, M1
Kuss, HJ1
von Stuckrad-Barre, S1
Wekerle, G1
Pfefferkorn, T1
Strupp, M1
Köppel, C1
Wiegreffe, A1
Tenczer, J1
Lheureux, P2
Vranckx, M2
Leduc, D2
Askenasi, R2
Hultén, BA2
Heath, A2
Nyberg, G2
Starmark, JE1
Mårtensson, E2
Svensson, C1
Doogan, DP1
Caravati, EM1
Bossart, PJ1
Wimbish, G1
Shores, J1
Spiehler, V1
Yang, KL1
Dantzker, DR1
Leys, D1
Petit, H1
Baldwin, D1
Green, M1
McMahon, AJ1
Fagarasan, M1
Fagarasan, E1
Quai, I1
Toma, T1
Florescu, A1

Reviews

5 reviews available for amitriptyline and Drug Overdose

ArticleYear
Gastric lavage in tricyclic antidepressant overdose.
    Emergency medicine journal : EMJ, 2003, Volume: 20, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Female; Gastric Lavage; Human

2003
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Glucagon in tricyclic overdose.
    Emergency medicine journal : EMJ, 2003, Volume: 20, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Emergencies; Evidence-Based M

2003
Death due to overdose of antidepressants: experiences from Norway.
    Acta psychiatrica Scandinavica. Supplementum, 1993, Volume: 371

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Doxepin; Drug Overdose; Female; Human

1993
Safety of mirtazapine: a review.
    International clinical psychopharmacology, 1995, Volume: 10 Suppl 4

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Dose-Response Rel

1995
Toleration and safety of sertraline: experience worldwide.
    International clinical psychopharmacology, 1991, Volume: 6 Suppl 2

    Topics: 1-Naphthylamine; Amitriptyline; Antidepressive Agents; Depressive Disorder; Desipramine; Drug Overdo

1991

Trials

1 trial available for amitriptyline and Drug Overdose

ArticleYear
Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 122, Issue:4

    Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac

2018

Other Studies

115 other studies available for amitriptyline and Drug Overdose

ArticleYear
Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange.
    Journal of clinical apheresis, 2022, Volume: 37, Issue:3

    Topics: Adolescent; Amitriptyline; Coma; Drug Overdose; Female; Humans; Plasma Exchange; Plasmapheresis

2022
Examination of multiple drug arrests reported to the Maine Diversion Alert Program.
    Forensic science, medicine, and pathology, 2022, Volume: 18, Issue:2

    Topics: Amitriptyline; Analgesics, Opioid; Carisoprodol; Central Nervous System Stimulants; Drug Overdose; H

2022
Comment on "Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange".
    Journal of clinical apheresis, 2022, Volume: 37, Issue:4

    Topics: Amitriptyline; Coma; Drug Overdose; Humans; Plasma Exchange; Plasmapheresis

2022
Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report.
    Journal of medical case reports, 2022, Mar-16, Volume: 16, Issue:1

    Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Cytochrome P-450 CYP2D6; Drug Overdose;

2022
Amitriptyline overdose-an uncommon cause of acute transient exotropia presenting to the emergency setting: a case report.
    Journal of medical case reports, 2023, Sep-08, Volume: 17, Issue:1

    Topics: Adolescent; Amitriptyline; Cognition; Drug Overdose; Exotropia; Eye; Female; Humans; India

2023
Successful Outcome Following Intravenous Lipid Emulsion Rescue Therapy in a Patient with Cardiac Arrest Due to Amitriptyline Overdose.
    The American journal of case reports, 2020, May-24, Volume: 21

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Electrocardiography; Fat Emul

2020
Wide QRS Complex Tachycardia With a Dominant R-Wave in Lead aVR-Is It Ventricular Tachycardia?
    JAMA internal medicine, 2020, 12-01, Volume: 180, Issue:12

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Diagnosis, Differential; Doxepin; Drug Overdose; El

2020
Non-lethal Amitriptyline Overdosage Mimicking Brain Death.
    Psychiatria Danubina, 2020,Autumn, Volume: 32, Issue:3-4

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Brain Death; Diagnosis, Differential; Drug O

2020
Use of CytoSorb in cases of acute amitriptyline intoxication.
    Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:5

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Continuous Renal

2021
Unresponsive Male.
    Annals of emergency medicine, 2017, Volume: 69, Issue:5

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brugada Syndrome; Drug Overdose; Electrocardiograph

2017
[Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication].
    Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2018, Volume: 113, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Arrhythmias, Cardiac; Drug Overdose; Female; Hum

2018
Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antidotes; Drug Overdose; Inactivation, Me

2017
A Peculiar Wide Complex Tachycardia.
    Circulation, 2019, 03-12, Volume: 139, Issue:11

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cardiotoxicity; Drug Overdose; Electrocardiography;

2019
Recreational amitriptyline toxicity mimicking basilar artery stroke.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2013, Volume: 20, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Basilar Artery; Blood Chemical Analysis; Dia

2013
Suspected tricyclic antidepressant overdose successfully treated with lipids.
    Journal of emergency nursing, 2013, Volume: 39, Issue:3

    Topics: Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Doxepin; Drug Overdose; Fat Em

2013
An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:4

    Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Card

2013
Intravenous lipid emulsion entraps amitriptyline into plasma and can lower its brain concentration--an experimental intoxication study in pigs.
    Basic & clinical pharmacology & toxicology, 2013, Volume: 113, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Drug Overdose; Fat Emulsions, Intravenous;

2013
Lipid rescue 911: Are poison centers recommending intravenous fat emulsion therapy for severe poisoning?
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013, Volume: 9, Issue:3

    Topics: Acute Disease; Adult; Amitriptyline; Bupivacaine; Drug Overdose; Fat Emulsions, Intravenous; Guideli

2013
Cerebellitis developing after tricyclic antidepressant poisoning.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:9

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brain; Cerebellar Diseases; Child, Preschool; Drug

2013
Caution with interpreting laboratory results after lipid rescue therapy.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:10

    Topics: Acetaminophen; Amitriptyline; Aspartate Aminotransferases; Diphenhydramine; Drug Overdose; False Neg

2013
Prolonged use of intravenous lipid emulsion in a severe tricyclic antidepressant overdose.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2014, Volume: 10, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Drug Overdose; Fa

2014
Amitriptyline overdose in emergency department of university hospital: evaluation of 250 patients.
    Human & experimental toxicology, 2014, Volume: 33, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Area Un

2014
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications.
    The American journal of emergency medicine, 2014, Volume: 32, Issue:9

    Topics: Adolescent; Adult; Alprazolam; Amitriptyline; Antidotes; Blood Pressure; Dibenzothiazepines; Drug Ov

2014
Amitriptyline poisoning of a baby: how informative can hair analysis be?
    Forensic science international, 2015, Volume: 249

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child Abuse; Chromatography, Liquid; Drug Overdose;

2015
Successful use of therapeutic hypothermia after cardiac arrest due to amitriptyline and venlafaxine intoxication.
    Therapeutic hypothermia and temperature management, 2015, Volume: 5, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Body Temperature Regulation; Cold Temperature; Drug Ove

2015
Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:6

    Topics: Acetamides; Adolescent; Amitriptyline; Anticonvulsants; Drug Interactions; Drug Overdose; Electrocar

2015
Use of an Intravascular Heat Exchange Catheter and Intravenous Lipid Emulsion for Hypothermic Cardiac Arrest After Cyclobenzaprine Overdose.
    Therapeutic hypothermia and temperature management, 2015, Volume: 5, Issue:3

    Topics: Amitriptyline; Cardiopulmonary Bypass; Cardiopulmonary Resuscitation; Drug Overdose; Fat Emulsions,

2015
Electrocardiographic changes in amitriptyline overdose.
    Cleveland Clinic journal of medicine, 2015, Volume: 82, Issue:7

    Topics: Amitriptyline; Drug Overdose; Electrocardiography; Female; Humans; Middle Aged

2015
Comprehensive Duloxetine Analysis in a Fatal Overdose.
    Journal of analytical toxicology, 2016, Volume: 40, Issue:2

    Topics: Aged; Alcoholism; Amitriptyline; Depression; Diphenhydramine; Drug Overdose; Duloxetine Hydrochlorid

2016
Serum alkalinisation is the cornerstone of treatment for amitriptyline poisoning.
    BMJ case reports, 2016, Apr-11, Volume: 2016

    Topics: Adult; Amitriptyline; Antacids; Antidepressive Agents, Tricyclic; Drug Overdose; Female; Humans; Sod

2016
Co-ingestion of tricyclic antidepressants with selective norepinephrine reuptake inhibitors: Overdose in the emergency department.
    Canadian family physician Medecin de famille canadien, 2016, Volume: 62, Issue:6

    Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Consciousness; Depression; Desvenlafaxi

2016
Dramatic resuscitation with Intralipid in an epinephrine unresponsive cardiac arrest following overdose of amitriptyline and propranolol.
    BMJ case reports, 2017, Mar-02, Volume: 2017

    Topics: Adult; Amitriptyline; Drug Overdose; Epinephrine; Fat Emulsions, Intravenous; Female; Heart Arrest;

2017
Reversal of Brugada electrocardiographic pattern with sodium bicarbonate solution after amitriptyline overdose.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:9

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Brugada Syndrome; Drug Overdose; Electrocard

2008
Treatment of severe amitriptyline intoxication with plasmapheresis.
    Journal of clinical apheresis, 2009, Volume: 24, Issue:1

    Topics: Amitriptyline; Child, Preschool; Coma; Drug Overdose; Female; Humans; Plasmapheresis; Poisoning; Sei

2009
Clinical, electrocardiographic, and laboratory findings in children with amitriptyline intoxication.
    Pediatric emergency care, 2009, Volume: 25, Issue:3

    Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Drug Overdose;

2009
Benign clinical picture after ingestion of 780 milligrams of aripiprazole and 1050 milligrams of amitriptyline.
    Indian journal of medical sciences, 2009, Volume: 63, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Aripiprazole; Drug Ove

2009
High dose insulin in toxic cardiogenic shock.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:4

    Topics: Aged; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Car

2009
Is there sufficient evidence to suggest cyclobenzaprine might be implicated in causing serotonin toxicity?
    The American journal of emergency medicine, 2009, Volume: 27, Issue:4

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Humans; Selective Serotonin Reuptake

2009
[Misuse of substances theoretically without abuse potential--case series].
    Przeglad lekarski, 2009, Volume: 66, Issue:6

    Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents; Antidepressive Agents; Baclofen; Benzydamine; C

2009
A 19-month-old girl with recurrent illness: over the hills and through the woods.
    Pediatric emergency care, 2009, Volume: 25, Issue:12

    Topics: Amitriptyline; Drug Overdose; Female; Humans; Infant; Lethargy; Muscle Relaxants, Central; Psychomot

2009
A physiologically based pharmacokinetic (PBPK) model for predicting the efficacy of drug overdose treatment with liposomes in man.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:8

    Topics: Algorithms; Amitriptyline; Anesthetics, Local; Antidepressive Agents, Tricyclic; Area Under Curve; B

2010
Tricyclic antidepressants intoxication in Tehran, Iran: epidemiology and associated factors.
    Human & experimental toxicology, 2011, Volume: 30, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Cross-Sectional Studies; Drug Overdose; Fema

2011
Amitriptyline and tianeptine poisoning treated by naloxone.
    Human & experimental toxicology, 2010, Volume: 29, Issue:9

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Female; Humans; Naloxone; Nar

2010
Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:6

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Chi-Square Distributio

2011
Analysis of amitriptyline overdose in emergency medicine.
    Emergency medicine journal : EMJ, 2011, Volume: 28, Issue:4

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chi-Square Distribution; Drug Overdose; Emergency S

2011
Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:3

    Topics: Alprazolam; Amitriptyline; Antidepressive Agents, Tricyclic; Body Temperature; Brain; Coma; Cytochro

2011
Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons.
    Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:12

    Topics: Adsorption; Amitriptyline; Antidepressive Agents, Tricyclic; Body Fluids; Carbon; Charcoal; Drug Ove

2011
Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:2

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Humans; Incidence; Poison Control Ce

2012
[Determination of doxepin in whole blood by SPE-LC-MS/MS].
    Fa yi xue za zhi, 2011, Volume: 27, Issue:5

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biomarkers; Chromatography, Liquid; Doxepin; Drug O

2011
Chronic amitriptyline overdose in a child.
    Clinical toxicology (Philadelphia, Pa.), 2012, Volume: 50, Issue:5

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child; Drug Overdose; Electrocardiography; Female;

2012
Lipid therapy for the treatment of a refractory amitriptyline overdose.
    CJEM, 2012, Volume: 14, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Coma; Drug Overdose; Fat Emulsion

2012
Delayed-onset seizure and cardiac arrest after amitriptyline overdose, treated with intravenous lipid emulsion therapy.
    Pediatrics, 2012, Volume: 130, Issue:2

    Topics: Adolescent; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Combined Modality Ther

2012
Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies.
    The European respiratory journal, 2002, Volume: 20, Issue:2

    Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cats; Chronic Disease; Dise

2002
Charcoal enhancement of treatment for tricyclic-induced mania.
    Pharmacopsychiatry, 2002, Volume: 35, Issue:5

    Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Bipolar Disorder; Charcoal; Depres

2002
Toxicokinetics of nortriptyline and amitriptyline: two case reports.
    Therapeutic drug monitoring, 2003, Volume: 25, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Drug O

2003
Fatal cyclobenzaprine overdose with postmortem values.
    Journal of forensic sciences, 2003, Volume: 48, Issue:4

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Diazepam; Drug Overdose; Ethanol; Female; Humans; Ma

2003
Donepezil for anticholinergic drug intoxication: a case report.
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:5

    Topics: Amitriptyline; Cholinergic Antagonists; Delirium; Donepezil; Drug Overdose; Humans; Indans; Male; Mi

2003
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose?
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Ove

2004
Excess fatality from desipramine and dosage recommendations.
    Therapeutic drug monitoring, 2004, Volume: 26, Issue:5

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Databases, Factual; Desipramine; Drug Overdose; Hum

2004
Aromatic-aromatic interaction of amitriptyline: implication of overdosed drug detoxification.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:2

    Topics: Adsorption; Amitriptyline; Animals; Benzenesulfonates; Chitosan; Drug Interactions; Drug Overdose; F

2005
Amitriptyline abuse and misuse.
    The American journal of forensic medicine and pathology, 2005, Volume: 26, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Autopsy; Diagnosis, Differential; Drug Overd

2005
Death by tricyclic: the real antidepressant scandal?
    Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:2

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Drug Utilization; Humans; Selective

2005
Recreational amitriptyline abuse.
    Przeglad lekarski, 2005, Volume: 62, Issue:6

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Overdose; Humans;

2005
Amitriptyline poisoning in a 2-year old.
    Paediatric anaesthesia, 2006, Volume: 16, Issue:2

    Topics: Adrenergic beta-Agonists; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Blood Gas Analys

2006
Acute amitriptyline intoxication: an analysis of 44 children.
    Human & experimental toxicology, 2006, Volume: 25, Issue:3

    Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Drug Overdose;

2006
Acute myocardial infarction associated with amitriptyline overdose.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 98, Issue:5

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Creatine Kinase, MB Form; Drug Overdose; Ele

2006
Vasopressin treatment for cyclic antidepressant overdose.
    The Journal of emergency medicine, 2006, Volume: 31, Issue:1

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Humans; Hypotension; Male; Middle Ag

2006
[Plasma drug levels in amitriptyline overdose patient with complicated delayed cardiac arrhythmia and convulsions].
    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2006, Volume: 19, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Drug Overdose; Female;

2006
Terlipressin as an adjunct vasopressor in refractory hypotension after tricyclic antidepressant intoxication.
    Resuscitation, 2007, Volume: 72, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Blood Pressure Dete

2007
Amitriptyline-induced Brugada pattern fails to respond to sodium bicarbonate.
    Clinical toxicology (Philadelphia, Pa.), 2007, Volume: 45, Issue:2

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brugada Syndrome; Drug Overdose; Electrocardiograph

2007
A patient with bilateral sciatic neuropathies.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2007, Volume: 34, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents; Buttocks; Compartment Syndromes; Drug Overdose; Female;

2007
Assessing free and total morphine following heroin overdose when complicated by the presence of toxic amitriptyline levels.
    Journal of analytical toxicology, 2007, Volume: 31, Issue:8

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interactions; Drug Overdose; Fatal Outc

2007
Charcoal haemoperfusion in amitriptyline poisoning: experience in 20 children.
    Nephrology (Carlton, Vic.), 2008, Volume: 13, Issue:3

    Topics: Acute Disease; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Charcoal; Chi

2008
A somatic type delusional disorder secondary to peripheral neuropathy: a case report.
    Psychiatria Danubina, 2008, Volume: 20, Issue:1

    Topics: Adult; Amitriptyline; Biperiden; Brachial Plexus; Delusions; Drug Overdose; Drug Therapy, Combinatio

2008
Amitriptyline overdose treatment by pegylated anionic liposomes.
    Journal of colloid and interface science, 2008, Volume: 324, Issue:1-2

    Topics: Amitriptyline; Anions; Binding Sites; Drug Evaluation, Preclinical; Drug Overdose; Drug Stability; H

2008
[Effects of psychopharmacologic therapy on heart rate variation].
    Der Nervenarzt, 1995, Volume: 66, Issue:9

    Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Autonomic Nervous System; Clozapine; Depressive Disorder

1995
Another cause for acute carpal tunnel syndrome: tricyclic overdose.
    Journal of accident & emergency medicine, 1995, Volume: 12, Issue:2

    Topics: Acute Disease; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Blister; Carpal Tunnel Syndro

1995
Withdrawal syndrome following midazolam infusion.
    Intensive care medicine, 1995, Volume: 21, Issue:2

    Topics: Adult; Amitriptyline; Drug Overdose; Female; Humans; Midazolam; Seizures; Substance Withdrawal Syndr

1995
Does a sodium-free buffer affect QRS width in experimental amitriptyline overdose?
    Annals of emergency medicine, 1995, Volume: 26, Issue:1

    Topics: Amitriptyline; Animals; Dogs; Drug Overdose; Electrocardiography; Hydrogen-Ion Concentration; Prospe

1995
Postmortem changes in blood amitriptyline concentration.
    The American journal of forensic medicine and pathology, 1994, Volume: 15, Issue:3

    Topics: Adult; Amitriptyline; Body Fluids; Chromatography, High Pressure Liquid; Drug Overdose; Humans; Male

1994
Relative mortality from overdose of antidepressants.
    BMJ (Clinical research ed.), 1995, Jan-28, Volume: 310, Issue:6974

    Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Dothiepin; Drug Overdose; En

1995
Antidepressants in suicide: differences in fatality and drug utilisation.
    European journal of clinical pharmacology, 1994, Volume: 46, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Autopsy; Drug Overdose; Female

1994
Adult respiratory distress syndrome associated with amitriptyline overdose.
    Veterinary and human toxicology, 1994, Volume: 36, Issue:4

    Topics: Adult; Amitriptyline; Drug Overdose; Female; Humans; Respiratory Distress Syndrome

1994
A five year review of fatal self-ingested overdoses involving amitriptyline in Edinburgh 1983-'87.
    Human & experimental toxicology, 1994, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Aged; Amitriptyline; Drug Overdose; Female; Humans; Male; Middle Aged; Suicide; U

1994
The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions.
    Forensic science international, 1993, Volume: 61, Issue:2-3

    Topics: Amitriptyline; Cryopreservation; Desipramine; Drug Overdose; Drug Stability; Embalming; Evaluation S

1993
Drug analysis in fly larvae.
    The American journal of forensic medicine and pathology, 1993, Volume: 14, Issue:2

    Topics: Acetaminophen; Amitriptyline; Animals; Dextropropoxyphene; Diptera; Drug Combinations; Drug Overdose

1993
Accidental administration of activated charcoal into the lung: aspiration by proxy.
    Annals of emergency medicine, 1993, Volume: 22, Issue:9

    Topics: Adult; Amitriptyline; Blood Gas Analysis; Bronchi; Bronchoscopy; Charcoal; Drug Overdose; Drug Thera

1993
Sudden death in HIV-infected drug users. Presumptive overdose in an HIV-positive narcotic addict.
    The Journal of infection, 1993, Volume: 27, Issue:1

    Topics: Adult; Amitriptyline; Cause of Death; Codeine; Death, Sudden; Drug Overdose; Encephalitis; Female; H

1993
An animal model of postmortem amitriptyline redistribution.
    Journal of forensic sciences, 1993, Volume: 38, Issue:1

    Topics: Amitriptyline; Animals; Disease Models, Animal; Drug Overdose; Liver; Lung; Male; Nortriptyline; Pos

1993
Case study of zidovudine overdose.
    AIDS (London, England), 1993, Volume: 7, Issue:3

    Topics: Adult; Amitriptyline; Attitude to Health; Drug Overdose; HIV Infections; Humans; Male; Suicide, Atte

1993
Magnesium sulphate in the treatment of ventricular fibrillation in amitriptyline poisoning.
    European heart journal, 1997, Volume: 18, Issue:5

    Topics: Adult; Amitriptyline; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Combined Modality Th

1997
Arrhythmogenic right ventricular dysplasia (ARVD): an overlooked and underdiagnosed condition?
    Medicine, science, and the law, 1997, Volume: 37, Issue:3

    Topics: Adolescent; Amitriptyline; Death, Sudden; Diagnosis, Differential; Drug Overdose; Female; Heart Vent

1997
The utilization of antidepressants--a key issue in the prevention of suicide: an analysis of 5281 suicides in Sweden during the period 1992-1994.
    Acta psychiatrica Scandinavica, 1997, Volume: 96, Issue:2

    Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agent

1997
Acute lung failure induced by tricyclic antidepressants.
    Toxicology and applied pharmacology, 1997, Volume: 146, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose-

1997
Emergency! Tricyclic antidepressant overdose.
    The American journal of nursing, 1997, Volume: 97, Issue:10

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Emergencies; Humans; Male; Su

1997
Drug concentration in selected skeletal muscles.
    Journal of forensic sciences, 1998, Volume: 43, Issue:1

    Topics: Acetaminophen; Adult; Aged; Amitriptyline; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Anti

1998
Pancreatic involvement associated with tricyclic overdose.
    Italian journal of gastroenterology and hepatology, 1998, Volume: 30, Issue:4

    Topics: Adult; Amitriptyline; Amylases; Antidepressive Agents, Tricyclic; Drug Overdose; Female; Humans; Lip

1998
Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages postmortem.
    Journal of forensic sciences, 1999, Volume: 44, Issue:1

    Topics: Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Autopsy; Central Nervous System Sti

1999
ECG abnormalities in tricyclic antidepressant ingestion.
    The American journal of emergency medicine, 1999, Volume: 17, Issue:4

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; An

1999
Responding to tricyclic antidepressant overdose.
    Nursing, 1999, Volume: 29, Issue:10

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Critical Care; Drug Overdose; Family; Female

1999
An unconscious and unresponsive young man.
    Hospital practice (1995), 1999, Sep-15, Volume: 34, Issue:10

    Topics: Acidosis, Lactic; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Diabetic Ketoacidosis; Dia

1999
[Non-fatal effect of highly toxic amitriptyline level after suicide attempt. A case report].
    Der Nervenarzt, 2001, Volume: 72, Issue:1

    Topics: Adult; Amitriptyline; Critical Care; Depressive Disorder, Major; Dose-Response Relationship, Drug; D

2001
[External ophthalmoplegia caused by amitriptyline poisoning].
    Der Nervenarzt, 2002, Volume: 73, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Blinking; Depressive Disorder; Diagnosis, Di

2002
Clinical course, therapy, outcome and analytical data in amitriptyline and combined amitriptyline/chlordiazepoxide overdose.
    Human & experimental toxicology, 1992, Volume: 11, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Animals; Chlordiazepoxide; Dose-Response Relationship

1992
Risks of flumazenil in mixed benzodiazepine-tricyclic antidepressant overdose: report of a preliminary study in the dog.
    Journal de toxicologie clinique et experimentale, 1992, Volume: 12, Issue:1

    Topics: Amitriptyline; Animals; Clomipramine; Dogs; Drug Overdose; Female; Flumazenil; Male; Risk Factors

1992
Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.
    The American journal of emergency medicine, 1992, Volume: 10, Issue:3

    Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drug Overdose; Electrocardiog

1992
Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:2

    Topics: Amitriptyline; Coma; Drug Overdose; Electrocardiography; Erythrocytes; Half-Life; Humans; Intubation

1992
Amitriptyline and amitriptyline metabolites in blood and cerebrospinal fluid following human overdose.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:2

    Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Dialysis; Drug Overdose; Erythrocytes; F

1992
Demographic and electrocardiographic factors associated with severe tricyclic antidepressant toxicity.
    Journal of toxicology. Clinical toxicology, 1991, Volume: 29, Issue:1

    Topics: Adult; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Cohort Studies; Drug Overdose;

1991
A comparison of three computer models for prediction of dose in acute amitriptyline overdose.
    Journal of forensic sciences, 1991, Volume: 36, Issue:1

    Topics: Amitriptyline; Animals; Chi-Square Distribution; Computer Simulation; Discriminant Analysis; Dogs; D

1991
Reversible brain death. A manifestation of amitriptyline overdose.
    Chest, 1991, Volume: 99, Issue:4

    Topics: Amitriptyline; Brain Death; Coma; Drug Overdose; Female; Humans; Middle Aged; Neurologic Examination

1991
Clinical signs of amyotrophic lateral sclerosis developing after polyradiculoneuropathy associated with amitriptyline.
    BMJ (Clinical research ed.), 1990, Mar-03, Volume: 300, Issue:6724

    Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Drug Overdose; Humans; Polyradiculoneuropathy; Reflex,

1990
Why do amitriptyline and dothiepin appear to be so dangerous in overdose?
    Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 354

    Topics: Amitriptyline; Cross-Sectional Studies; Dibenzothiepins; Dose-Response Relationship, Drug; Dothiepin

1989
Amitriptyline overdose complicated by intestinal pseudo-obstruction and caecal perforation.
    Postgraduate medical journal, 1989, Volume: 65, Issue:770

    Topics: Adult; Amitriptyline; Cecal Diseases; Drug Overdose; Humans; Intestinal Pseudo-Obstruction; Male; Ra

1989
Amitriptyline and its metabolites: blood and urine levels in overdose.
    Acta medicinae legalis et socialis, 1985, Volume: 35, Issue:1

    Topics: Adult; Amitriptyline; Chromatography, Gas; Drug Overdose; Humans; Mass Spectrometry; Middle Aged; Ti

1985