amitriptyline has been researched along with Disease Models, Animal in 148 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The cardiotoxicity of amitriptyline (AMT) is a commonly observed toxicity with high morbidity and mortality rates in emergency departments (ED)." | 7.96 | Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [ ( Aygun, H; Basol, N; Gul, SS, 2020) |
| "CPT-11-induced diarrhea and colonic apoptosis were inhibited by amitriptyline at 6 h." | 7.91 | Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis. ( Bowen, JM; Coller, JK; Fakiha, K; Gibson, RJ; Logan, RM, 2019) |
| "Amitriptyline (AMT) cardiotoxicity is commonly seen with high morbidity and mortality rates in emergency departments." | 7.91 | Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats. ( Aygun, H; Basol, N; Gul, SS, 2019) |
| " We assessed the effect of lipid emulsion on reversing amitriptyline-induced cardiotoxicity, in vivo and in vitro, compared to alkalinization." | 7.88 | Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. ( Hori, K; Kuno, M; Matsuura, T; Mori, T; Nishikawa, K; Tsujikawa, S, 2018) |
| "A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)." | 7.83 | Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016) |
| "The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats." | 7.81 | Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. ( Kim, HJ, 2015) |
| " As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments." | 7.80 | Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. ( Almeida, A; Amorim, D; David-Pereira, A; Pertovaara, A; Pinto-Ribeiro, F, 2014) |
| " Therefore, the study objectives were to investigate the effects of the tricyclic antidepressant amitriptyline on mood, learning, central cytokine expression and skeletal muscle inflammation in mdx mice." | 7.80 | Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy. ( Bouma, J; Jensen, L; Kulbida, R; Manning, J; O'Malley, D; Rai, P; Singh, SP; Yilmazer-Hanke, D, 2014) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 7.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| "The anti-inflammatory activity of amitriptyline, diazepam and a new, Russian tranquilizer mebicar was studied in a wide range of therapeutic doses on carrageenan-induced paw edema in rats." | 7.77 | [Anti-inflammatory effects of amitriptyline, diazepam and mebicar using model of acute carrageenan-induced paw edema in rats]. ( Kaziakhmetova, VN; Valeeva, IKh; Ziganshina, LE, 2011) |
| "Single and multiple doses of amitriptyline were administered to rats submitted to the carrageenan-induced paw edema model." | 7.76 | Amitriptyline and acute inflammation: a study using intravital microscopy and the carrageenan-induced paw edema model. ( Alves, GJ; Palermo-Neto, J; Vismari, L, 2010) |
| " The analgesic activity of amitriptyline was observed in mouse models of acute pain." | 7.74 | Antinociceptive effect of amitriptyline in mice of acute pain models. ( Bhattacharya, SK; Das, BP; Deo, S; Paudel, KR; Rauniar, GP; Sangraula, H, 2007) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 7.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "We assessed if derivatives of amitriptyline could alleviate mechanical allodynia in a rat model of neuropathic pain." | 7.72 | Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain. ( Sung, B; Wang, GK, 2004) |
| "This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions." | 7.71 | Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001) |
| "In an attempt to create an animal model of constipation in monkeys, amitriptyline was administered to cynomolgus monkeys at doses of 10-160 mg/kg body weight via a nasogastric tube." | 7.70 | Amitriptyline-induced constipation in cynomolgus monkeys is beneficial for the evaluation of laxative efficacy. ( Kishimoto, S; Kohri, H; Koshitani, O; Tsusumi, K, 2000) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 7.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule." | 7.67 | Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984) |
| " Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis." | 7.67 | Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985) |
| "Cold allodynia was induced using a single intraperitoneal dose of oxaliplatin." | 5.48 | Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline. ( Furgała, A; Sałat, K; Sałat, R, 2018) |
| "Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 5.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
| "Amitriptyline was also used in combination with aspirin and dexamethasone to inspect any synergistic effects." | 5.43 | Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats. ( Bhatt, S; Goswami, S; Raval, J; Shukla, P, 2016) |
| "At doses alleviating neuropathic pain, amitriptyline showed alteration of behavioral response possibly related to either alteration of basal pain sensitivity or sedative effect or both." | 5.39 | Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. ( Abriel, H; Decosterd, I; Kirschmann, G; Laedermann, CJ; Suter, MR, 2013) |
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 5.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| "Amitriptyline has recently been described as an analgesic, anti-inflammatory and myorelaxant in some experimental models." | 5.38 | Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction. ( de Almeida Prado, PS; Lima, FO; Schor, N; Soares, MF; Teixeira, VP, 2012) |
| "It significantly reduced thermal allodynia in the cold (4°C) plate test (MED=2." | 5.37 | Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain. ( Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O, 2011) |
| "The response frequency to mechanical allodynia in mice was measured with von Frey hairs." | 5.36 | Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. ( Jesse, CR; Nogueira, CW; Wilhelm, EA, 2010) |
| " This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses." | 5.32 | Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004) |
| " The cardiotoxicity of amitriptyline (AMT) is a commonly observed toxicity with high morbidity and mortality rates in emergency departments (ED)." | 3.96 | Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [ ( Aygun, H; Basol, N; Gul, SS, 2020) |
| "CPT-11-induced diarrhea and colonic apoptosis were inhibited by amitriptyline at 6 h." | 3.91 | Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis. ( Bowen, JM; Coller, JK; Fakiha, K; Gibson, RJ; Logan, RM, 2019) |
| "Amitriptyline (AMT) cardiotoxicity is commonly seen with high morbidity and mortality rates in emergency departments." | 3.91 | Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats. ( Aygun, H; Basol, N; Gul, SS, 2019) |
| " We assessed the effect of lipid emulsion on reversing amitriptyline-induced cardiotoxicity, in vivo and in vitro, compared to alkalinization." | 3.88 | Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. ( Hori, K; Kuno, M; Matsuura, T; Mori, T; Nishikawa, K; Tsujikawa, S, 2018) |
| "The cuprizone animal model, also known as the toxic demyelination model, is a well-reproducible model of demyelination- and remyelination in mice, and has been useful in studying important aspect of human demyelinating diseases, including multiple sclerosis." | 3.85 | Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination. ( Anne Becker, K; Chami, M; Fassbender, K; Gulbins, E; Halmer, R; Meier, C; Schnoeder, L; Walter, S, 2017) |
| "Messenger RNA and proteins of ZnT1, ZnT3, ZnT4, ZnT5, ZnT6 and MT1/2 were measured in the prefrontal cortex (PFC) and hippocampus (Hp) of rats subjected to olfactory bulbectomy (OB) (a model of depression) and chronic amitriptyline (AMI) treatment by Real Time PCR and Western Blot/Immunohistochemistry (IHP)." | 3.85 | The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression. ( Kotarska, K; Misztak, P; Nowak, B; Nowak, G; Pochwat, B; Rafalo, A; Sowa-Kucma, M; Szewczyk, B; Wiatrowska, K; Zadrozna, M, 2017) |
| "A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)." | 3.83 | Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016) |
| " Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 3.83 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| "The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats." | 3.81 | Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. ( Kim, HJ, 2015) |
| " As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments." | 3.80 | Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. ( Almeida, A; Amorim, D; David-Pereira, A; Pertovaara, A; Pinto-Ribeiro, F, 2014) |
| " The von Frey and Hargreaves' tests were used to assess mechanical allodynia and thermal hyperalgesia, respectively, after intraplantar (ipl) or subcutaneous (sc) administration of amitriptyline, doxepin, or venlafaxine, or their ipl co-administration with morphine on day 12-16 after injury." | 3.80 | Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. ( Jagla, G; Makuch, W; Mika, J; Obara, I; Przewlocka, B; Wordliczek, J, 2014) |
| " Therefore, the study objectives were to investigate the effects of the tricyclic antidepressant amitriptyline on mood, learning, central cytokine expression and skeletal muscle inflammation in mdx mice." | 3.80 | Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy. ( Bouma, J; Jensen, L; Kulbida, R; Manning, J; O'Malley, D; Rai, P; Singh, SP; Yilmazer-Hanke, D, 2014) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 3.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| "The anti-inflammatory activity of amitriptyline, diazepam and a new, Russian tranquilizer mebicar was studied in a wide range of therapeutic doses on carrageenan-induced paw edema in rats." | 3.77 | [Anti-inflammatory effects of amitriptyline, diazepam and mebicar using model of acute carrageenan-induced paw edema in rats]. ( Kaziakhmetova, VN; Valeeva, IKh; Ziganshina, LE, 2011) |
| "Single and multiple doses of amitriptyline were administered to rats submitted to the carrageenan-induced paw edema model." | 3.76 | Amitriptyline and acute inflammation: a study using intravital microscopy and the carrageenan-induced paw edema model. ( Alves, GJ; Palermo-Neto, J; Vismari, L, 2010) |
| "Amitriptyline is used to treat neuropathic pain in humans." | 3.74 | Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. ( Fredholm, BB; Reid, AR; Sawynok, J, 2008) |
| " The analgesic activity of amitriptyline was observed in mouse models of acute pain." | 3.74 | Antinociceptive effect of amitriptyline in mice of acute pain models. ( Bhattacharya, SK; Das, BP; Deo, S; Paudel, KR; Rauniar, GP; Sangraula, H, 2007) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 3.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "Pretreatment with amiodarone does not appear to significantly alter the lethality of amitriptyline poisoning in mice." | 3.73 | Amiodarone fails to improve survival in amitriptyline-poisoned mice. ( Barrueto, F; Chuang, A; Cotter, BW; Hoffman, RS; Nelson, LS, 2005) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| "We assessed if derivatives of amitriptyline could alleviate mechanical allodynia in a rat model of neuropathic pain." | 3.72 | Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain. ( Sung, B; Wang, GK, 2004) |
| "This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions." | 3.71 | Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "In an attempt to create an animal model of constipation in monkeys, amitriptyline was administered to cynomolgus monkeys at doses of 10-160 mg/kg body weight via a nasogastric tube." | 3.70 | Amitriptyline-induced constipation in cynomolgus monkeys is beneficial for the evaluation of laxative efficacy. ( Kishimoto, S; Kohri, H; Koshitani, O; Tsusumi, K, 2000) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 3.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "In the tetrabenazine (TBZ) model of depression, the cerebromicrocirculation was discovered to respond abnormally to metabolic demand as mimicked by the administration of CO2." | 3.67 | Cerebromicrocirculatory defects in animal model of depression. ( Glotzbach, RK; Irwin, GH; Kent, TA; Preskorn, SH; Solnick, JV, 1984) |
| "Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule." | 3.67 | Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984) |
| " Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis." | 3.67 | Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985) |
| "Rats working on a food-reinforced operant schedule and exhibiting behavioral depression following administration of D,L-5-hydroxytryptophan (5-HTP) were pretreated with one of three drugs: methysergide, fluoxetine, or amitriptyline." | 3.66 | Pre- and postsynaptic serotonergic manipulations in an animal model of depression. ( Aprison, MH; Hingtgen, JN; Nagayama, H, 1980) |
| "To further test the new hypersensitive postsynaptic serotonin (5-HT) receptor theory of depression bases on or animal model, it was necessary to demonstrate that some of the currently used antidepressive drugs can block D,L-5-hydroxytryptophan (5-HTP) induced depression acting through postsynaptic rather than presynaptic mechanisms." | 3.66 | Postsynaptic action by four antidepressive drugs in an animal model of depression. ( Aprison, MH; Hingtgen, JN; Nagayama, H, 1981) |
| "Severe cardiovascular arrhythmias occurred in both groups with 3 in the CAC-HP group versus 1 incident with premature death in the CG." | 2.87 | Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion. ( Belhage, B; Dalhoff, K; Eriksen, T; Haarmark, C; Hoegberg, LCG; Jansen, T, 2018) |
| "Amitriptyline-induced lower post-TBI HR and improved functional outcomes without affecting inflammatory response." | 1.62 | Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI. ( Earnest, R; Goodman, MD; McGlone, E; Morris, MC; Singer, KE; Stevens-Topie, S; Wallen, TE, 2021) |
| "Neuropathic pain was induced by spared nerve injury (SNI) in mice." | 1.62 | Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice. ( Hisaoka-Nakashima, K; Kondo, S; Morioka, N; Nakamura, Y; Takimoto, T; Tokunaga, N, 2021) |
| " Pharmacokinetic analysis of pregabalin or combination (pregabalin + amitriptyline or pregabalin + duloxetine) in the plasma were performed by ultraperformance liquid chromatography tandem mass spectrometry." | 1.62 | Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats. ( Barros, CM; Boralli, VB; Costa, LH; Galdino, G; Kawano, T; Placido, RV; Podesta, MHMC; Rodrigues, RF; Santos, RS, 2021) |
| "Infection with avian influenza A H5N1 virus results in acute lung injury (ALI) and has a high mortality rate (52." | 1.56 | Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury. ( Huang, F; Jiang, C; Jin, N; Li, C; Li, X; Liu, Q; Qin, Y; Zhang, C; Zhang, Y; Zhao, Y; Zhou, C, 2020) |
| "We produced a chronic neuropathic pain model by partial sciatic nerve ligation in mice, analyzed their electroencephalogram (EEG) and electromyogram (EMG) using the SleepSign software, and evaluated the sleep condition of the pain model mice after administration of amitriptyline or MDL 100907." | 1.56 | Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model. ( Aoki, Y; Hattori, M; Horikawa, H; Ito, H; Takemura, Y; Yamazaki, M, 2020) |
| "Amitriptyline or saline was administered intraperitoneally and 3-ethyl-5-benzyl-2-methyl-4-phenylethynyl-6-phenyl-1,4-(±)-dihydropyridine-3,5-dicarboxylate (MRS-1191), an A3AR antagonist, was injected subcutaneously immediately before amitriptyline administration." | 1.51 | Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models. ( Choi, JW; In, JH; Joo, JD; Jung, HS; Kim, JA; Kim, Y; Kim, YS; Kwon, SY; Park, YJ, 2019) |
| "Treatment with ketamine, minocycline and amitriptyline were able to exert antidepressant effects in the forced swimming test." | 1.48 | Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events. ( Abelaira, HM; de Moura, AB; de Souza, TG; Fileti, ME; Garbossa, L; Goldim, MP; Maciel, AL; Mathias, K; Matos, D; Petronilho, F; Quevedo, J; Réus, GZ; Rosa, T; Strassi, AP; Tuon, T, 2018) |
| "Cold allodynia was induced using a single intraperitoneal dose of oxaliplatin." | 1.48 | Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline. ( Furgała, A; Sałat, K; Sałat, R, 2018) |
| "L-acetylcarnitine treatment enhanced mGlu2/3 receptor protein levels in the dorsal region of the spinal cord." | 1.46 | Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. ( Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C, 2017) |
| "Amitriptyline is a commonly used tricyclic antidepressant which acts primarily as a serotonin and noradrenaline reuptake inhibitor." | 1.46 | Acute effects of amitriptyline on adult zebrafish: Potential relevance to antidepressant drug screening and modeling human toxidromes. ( Demin, KA; Efimova, EV; Kalueff, AV; Khatsko, SL; Kolesnikova, TO; Meshalkina, DA; Morzherin, YY, 2017) |
| "Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 1.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
| "Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints." | 1.46 | Regulation of Arthritis Severity by the Acid Sphingomyelinase. ( Becker, JU; Becker, KA; Beckmann, N; Carpinteiro, A; Fassbender, K; Göthert, JR; Gulbins, E; Hessler, G; Kramer, M; Walter, S; Weber, S, 2017) |
| " Chronic administration of amitriptyline reversed the despaired behavior induced by exposure to UCMS paradigm and, fully recovered pNF-H labeling to control values." | 1.46 | Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression. ( Galeotti, N; Ghelardini, C; Sanna, MD, 2017) |
| " Initial pharmacokinetics evaluation indicated an excellent brain exposure following oral dosing in mice, suggesting that further investigation into the use of alkoxyisoxazoles as σ1 ligands for antinociception is warranted." | 1.43 | Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. ( Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM, 2016) |
| "Results revealed that T." | 1.43 | Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice. ( Esmaeilpour, K; Ghazvini, H; Keshavarz, H; Mahmoudvand, H; Sheibani, V; Shojaee, S; Ziaali, N, 2016) |
| "Amitriptyline was also used in combination with aspirin and dexamethasone to inspect any synergistic effects." | 1.43 | Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats. ( Bhatt, S; Goswami, S; Raval, J; Shukla, P, 2016) |
| "Amitriptyline treatment impaired novel object recognition and object discrimination abilities in female, but not in male, wild-type mice, while female t-ASM mice showed unaltered novel object recognition and object discrimination abilities." | 1.43 | Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory. ( Gulbins, E; Kornhuber, J; Reichel, M; Zoicas, I, 2016) |
| " Unexpectedly, chronic administration of doxepin or amitriptyline for 12 days produced allodynia and hyperalgesia in naïve mice." | 1.42 | Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model. ( Jurga, AM; Kwiatkowski, K; Makuch, W; Malek, N; Mika, J; Przewlocka, B; Rojewska, E; Starnowska, J; Wasylewski, M, 2015) |
| " Importantly, chronic administration of antidepressant amitriptyline partially or completely restored these changes in serotonergic and BDNF systems, respectively." | 1.42 | NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline. ( Anier, K; Aonurm-Helm, A; Castrén, E; Järv, J; Rantamäki, T; Stepanov, V; Zharkovsky, A; Zharkovsky, T, 2015) |
| "In the PGE2-induced allodynia model, AS1069562 and duloxetine significantly suppressed allodynia, whereas amitriptyline did not." | 1.40 | Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline. ( Aoki, T; Matsuoka, N; Murai, N; Tamura, S; Tsukamoto, M, 2014) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "At doses alleviating neuropathic pain, amitriptyline showed alteration of behavioral response possibly related to either alteration of basal pain sensitivity or sedative effect or both." | 1.39 | Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. ( Abriel, H; Decosterd, I; Kirschmann, G; Laedermann, CJ; Suter, MR, 2013) |
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 1.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| "The best analgesic drugs for neuropathic pain have a long duration of action, can be given via multiple routes, and can be used preemptively." | 1.39 | Prolonged analgesic effect of amitriptyline base on thermal hyperalgesia in an animal model of neuropathic pain. ( Cheng, KI; Chu, CC; Huang, KL; Lin, MT; Shieh, JP; Wang, JJ; Yeh, MY, 2013) |
| "Amitriptyline has recently been described as an analgesic, anti-inflammatory and myorelaxant in some experimental models." | 1.38 | Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction. ( de Almeida Prado, PS; Lima, FO; Schor, N; Soares, MF; Teixeira, VP, 2012) |
| "It significantly reduced thermal allodynia in the cold (4°C) plate test (MED=2." | 1.37 | Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain. ( Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O, 2011) |
| "Amitriptyline (10 mg/kg) was used as positive control." | 1.37 | Antidepressant-like effect of aqueous extract of Channa striatus fillet in mice models of depression. ( Amom, Z; Fakurazi, S; Mat Jais, AM; Moklas, M; Saleem, AM; Sulaiman, MR; Taufik Hidayat, M, 2011) |
| "In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures." | 1.37 | Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011) |
| "However, whether neuropathic pain can induce cognition dysfunction remains uncertain." | 1.36 | Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory. ( Hu, Y; Li, W; Wang, Y; Yang, J, 2010) |
| "Current clinical treatments for neuropathic pain include amitriptyline, a tricyclic antidepressant with mixed pharmacology that is also clinically reported to impair cognitive performance; and gabapentin, a compound that selectively interacts with alpha2delta-1 calcium channel subunits." | 1.36 | Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin. ( Arneric, SP; Buccafusco, JJ; Snutch, TP; Terry, AV; Vazdarjanova, A, 2010) |
| "Mechanical hyperalgesia was fully reversed by three analgesic drugs used in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)≫morphine (6 h)>gabapentin (2 h)." | 1.36 | Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. ( Densmore, VS; Kalous, A; Keast, JR; Osborne, PB, 2010) |
| "The response frequency to mechanical allodynia in mice was measured with von Frey hairs." | 1.36 | Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. ( Jesse, CR; Nogueira, CW; Wilhelm, EA, 2010) |
| "Amitriptyline infusion rats were then randomized into three groups." | 1.35 | Effect of glucagon on amitriptyline-induced cardiovascular toxicity in rats. ( Hocaoglu, N; Kalkan, S; Kaplan, YC; Oransay, K; Tuncok, Y, 2008) |
| "Vgx rats showed sustained hyperalgesia in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma creatine phosphokinase or lactose dehydrogenase levels) accompanied by hypersensitivity to colonic distension." | 1.35 | Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. ( Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T, 2009) |
| "We used a murine model of neuropathic pain induced by sciatic nerve constriction to study the antiallodynic properties of a chronic treatment with the tricyclic antidepressants nortriptyline and amitriptyline." | 1.35 | Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia. ( Barrot, M; Benbouzid, M; Freund-Mercier, MJ; Gavériaux-Ruff, C; Kieffer, BL; Muller, A; Tessier, LH; Waltisperger, E; Yalcin, I, 2008) |
| "Similar bilateral hyperalgesia was observed when axotomy was performed using silk thread instead of chromic gut." | 1.33 | Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. ( Miki, S; Senba, E; Yasuda, T; Yoshinaga, N, 2005) |
| "Signs of allodynia also extended to the sciatic nerve territory." | 1.33 | Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. ( Beaulieu, P; Desbiens, K; Leblond, F; Pichette, V; Walczak, JS, 2005) |
| " This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses." | 1.32 | Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004) |
| "Bupivacaine (1." | 1.32 | Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation. ( Ecoffey, C; Estebe, JP; Gentili, ME; Le Corre, P; Leduc, C; Moulinoux, JP, 2004) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| "Amitriptyline was studied in greater detail and caused a dose-related (0." | 1.30 | Acute lung failure induced by tricyclic antidepressants. ( Blomgren, B; Dahlin, KL; Lâstbom, L; Ryrfeldt, A, 1997) |
| "Amitriptyline did not produce significant analgesia at the same doses." | 1.28 | Antinociceptive action of tricyclic antidepressant drugs in the rat. ( Hersh, EV; Kaplan, P, 1990) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| " These data suggest that antidepressants acquire anxiolytic properties following chronic administration and that this effect appears to be independent of the benzodiazepine receptor system." | 1.27 | The effects of chronic antidepressant treatment in an animal model of anxiety. ( Aitken, DH; Bodnoff, SR; Meaney, MJ; Quirion, R; Suranyi-Cadotte, B, 1988) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| " Moreover, the endocrine and behavioral deficits of bulbectomized rats are reversed by the chronic administration of drugs that reverse the symptoms of depression in people when given chronically." | 1.27 | Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats. ( Jesberger, JA; Richardson, JS, 1986) |
| " Chronic administration of imipramine-HCl (1 and 5 mg/kg, i." | 1.27 | Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice. ( Kameyama, T; Nagasaka, M; Yamada, K, 1985) |
| " The effect of administering activated charcoal at varying intervals after dosing on the blood drug-level profiles of paracetamol and amylobarbitone was assessed by comparison with the profiles obtained when charcoal therapy was withheld." | 1.25 | Studies with activated charcoal in the treatment of drug overdosage using the pig as an animal model. ( Lipscomb, DJ; Widdop, B, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (9.46) | 18.7374 |
| 1990's | 8 (5.41) | 18.2507 |
| 2000's | 32 (21.62) | 29.6817 |
| 2010's | 82 (55.41) | 24.3611 |
| 2020's | 12 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, H | 1 |
| Shi, M | 1 |
| Zhang, W | 1 |
| Zheng, YM | 1 |
| Xu, YZ | 1 |
| Shi, JJ | 1 |
| Liu, T | 1 |
| Gunosewoyo, H | 1 |
| Pang, T | 1 |
| Gao, ZB | 1 |
| Yang, F | 2 |
| Tang, J | 1 |
| Yu, LF | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 3 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Farghaly, HSM | 1 |
| Elbadr, MM | 1 |
| Ahmed, MA | 1 |
| Abdelhaffez, AS | 1 |
| Cai, BB | 1 |
| Lu, YN | 1 |
| Xu, M | 1 |
| Huang, F | 1 |
| Zhang, C | 1 |
| Liu, Q | 2 |
| Zhao, Y | 1 |
| Zhang, Y | 1 |
| Qin, Y | 1 |
| Li, X | 1 |
| Li, C | 1 |
| Zhou, C | 1 |
| Jin, N | 1 |
| Jiang, C | 1 |
| Aygun, H | 2 |
| Basol, N | 2 |
| Gul, SS | 2 |
| Niziolek, GM | 1 |
| Hoehn, RS | 2 |
| Seitz, AP | 1 |
| Jernigan, PL | 2 |
| Makley, AT | 2 |
| Gulbins, E | 8 |
| Edwards, MJ | 2 |
| Goodman, MD | 4 |
| Genevois, AL | 1 |
| Ruel, J | 1 |
| Penalba, V | 1 |
| Hatton, S | 1 |
| Petitfils, C | 1 |
| Ducrocq, M | 1 |
| Principe, P | 1 |
| Dietrich, G | 1 |
| Greco, C | 1 |
| Delmas, P | 1 |
| Ito, H | 1 |
| Takemura, Y | 1 |
| Aoki, Y | 1 |
| Hattori, M | 1 |
| Horikawa, H | 1 |
| Yamazaki, M | 1 |
| Dejban, P | 1 |
| Sahraei, M | 1 |
| Chamanara, M | 1 |
| Dehpour, A | 1 |
| Rashidian, A | 1 |
| Fernandez, KA | 1 |
| Watabe, T | 1 |
| Tong, M | 1 |
| Meng, X | 1 |
| Tani, K | 1 |
| Kujawa, SG | 1 |
| Edge, AS | 1 |
| Singer, KE | 1 |
| Wallen, TE | 1 |
| Morris, MC | 2 |
| McGlone, E | 1 |
| Stevens-Topie, S | 1 |
| Earnest, R | 1 |
| Morioka, N | 1 |
| Kondo, S | 1 |
| Takimoto, T | 1 |
| Tokunaga, N | 1 |
| Nakamura, Y | 1 |
| Hisaoka-Nakashima, K | 1 |
| Rodrigues, RF | 1 |
| Kawano, T | 1 |
| Placido, RV | 1 |
| Costa, LH | 1 |
| Podesta, MHMC | 1 |
| Santos, RS | 1 |
| Galdino, G | 1 |
| Barros, CM | 1 |
| Boralli, VB | 1 |
| Notartomaso, S | 1 |
| Mascio, G | 1 |
| Bernabucci, M | 1 |
| Zappulla, C | 1 |
| Scarselli, P | 1 |
| Cannella, M | 1 |
| Imbriglio, T | 1 |
| Gradini, R | 1 |
| Battaglia, G | 1 |
| Bruno, V | 1 |
| Nicoletti, F | 1 |
| Chen, M | 1 |
| Hoshino, H | 1 |
| Saito, S | 2 |
| Yang, Y | 1 |
| Obata, H | 2 |
| Demin, KA | 1 |
| Kolesnikova, TO | 1 |
| Khatsko, SL | 1 |
| Meshalkina, DA | 1 |
| Efimova, EV | 1 |
| Morzherin, YY | 1 |
| Kalueff, AV | 1 |
| Chami, M | 1 |
| Halmer, R | 1 |
| Schnoeder, L | 1 |
| Anne Becker, K | 1 |
| Meier, C | 1 |
| Fassbender, K | 2 |
| Walter, S | 2 |
| Tarrasón, G | 1 |
| Carcasona, C | 1 |
| Eichhorn, P | 1 |
| Pérez, B | 1 |
| Gavaldà, A | 1 |
| Godessart, N | 1 |
| Boonlert, W | 1 |
| Benya-Aphikul, H | 1 |
| Umka Welbat, J | 1 |
| Rodsiri, R | 1 |
| Depciuch, J | 2 |
| Parlinska-Wojtan, M | 2 |
| Jeon, SA | 1 |
| Lee, E | 1 |
| Hwang, I | 1 |
| Han, B | 1 |
| Park, S | 1 |
| Son, S | 1 |
| Yang, J | 2 |
| Hong, S | 1 |
| Kim, CH | 1 |
| Son, J | 1 |
| Yu, JW | 1 |
| Beckmann, N | 4 |
| Becker, KA | 2 |
| Becker, JU | 1 |
| Kramer, M | 1 |
| Hessler, G | 1 |
| Weber, S | 1 |
| Göthert, JR | 1 |
| Carpinteiro, A | 1 |
| Jansen, T | 2 |
| Hoegberg, LCG | 2 |
| Eriksen, T | 2 |
| Haarmark, C | 1 |
| Dalhoff, K | 1 |
| Belhage, B | 2 |
| Tsujikawa, S | 1 |
| Matsuura, T | 1 |
| Hori, K | 1 |
| Mori, T | 1 |
| Kuno, M | 1 |
| Nishikawa, K | 1 |
| Maciel, AL | 1 |
| Abelaira, HM | 1 |
| de Moura, AB | 1 |
| de Souza, TG | 1 |
| Rosa, T | 1 |
| Matos, D | 1 |
| Tuon, T | 1 |
| Garbossa, L | 1 |
| Strassi, AP | 1 |
| Fileti, ME | 1 |
| Goldim, MP | 1 |
| Mathias, K | 1 |
| Petronilho, F | 1 |
| Quevedo, J | 1 |
| Réus, GZ | 1 |
| Xia, BT | 2 |
| Winer, LK | 2 |
| Kim, Y | 2 |
| Goetzman, HS | 1 |
| Veile, RE | 1 |
| Nomellini, V | 2 |
| Caldwell, CC | 2 |
| Kwon, SY | 1 |
| Jung, HS | 1 |
| Park, YJ | 1 |
| Kim, YS | 1 |
| In, JH | 1 |
| Choi, JW | 1 |
| Kim, JA | 1 |
| Joo, JD | 1 |
| Fakiha, K | 1 |
| Coller, JK | 1 |
| Logan, RM | 1 |
| Gibson, RJ | 1 |
| Bowen, JM | 1 |
| Furgała, A | 1 |
| Sałat, R | 1 |
| Sałat, K | 1 |
| Pugh, AM | 1 |
| Pritts, TA | 1 |
| Dalhoff, KP | 1 |
| Johansen, SS | 1 |
| Meiners, J | 1 |
| Palmieri, V | 1 |
| Klopfleisch, R | 1 |
| Ebel, JF | 1 |
| Japtok, L | 1 |
| Schumacher, F | 2 |
| Yusuf, AM | 1 |
| Zöller, J | 1 |
| Hose, M | 1 |
| Kleuser, B | 1 |
| Hermann, DM | 1 |
| Kolesnick, RN | 1 |
| Buer, J | 1 |
| Hansen, W | 1 |
| Westendorf, AM | 1 |
| Kassam, F | 1 |
| Bercz, A | 1 |
| Perichon, D | 1 |
| Turfus, S | 1 |
| Gerostamoulos, D | 1 |
| Graudins, A | 1 |
| Fernandez, A | 2 |
| Matias, N | 1 |
| Fucho, R | 2 |
| Ribas, V | 2 |
| Von Montfort, C | 1 |
| Nuño, N | 1 |
| Baulies, A | 2 |
| Martinez, L | 2 |
| Tarrats, N | 2 |
| Mari, M | 1 |
| Colell, A | 1 |
| Morales, A | 1 |
| Dubuquoy, L | 1 |
| Mathurin, P | 1 |
| Bataller, R | 1 |
| Caballeria, J | 1 |
| Elena, M | 2 |
| Balsinde, J | 2 |
| Kaplowitz, N | 2 |
| Garcia-Ruiz, C | 2 |
| Fernandez-Checa, JC | 2 |
| Calixto-Campos, C | 1 |
| Zarpelon, AC | 1 |
| Corrêa, M | 1 |
| Cardoso, RD | 1 |
| Pinho-Ribeiro, FA | 1 |
| Cecchini, R | 1 |
| Moreira, EG | 1 |
| Crespigio, J | 1 |
| Bernardy, CC | 1 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Liang, J | 2 |
| Liu, X | 2 |
| Pan, M | 1 |
| Dai, W | 1 |
| Dong, Z | 2 |
| Wang, X | 2 |
| Liu, R | 2 |
| Zheng, J | 1 |
| Yu, S | 2 |
| Amorim, D | 1 |
| David-Pereira, A | 1 |
| Pertovaara, A | 1 |
| Almeida, A | 1 |
| Pinto-Ribeiro, F | 1 |
| Murai, N | 1 |
| Tsukamoto, M | 1 |
| Tamura, S | 1 |
| Aoki, T | 1 |
| Matsuoka, N | 1 |
| Jagla, G | 1 |
| Mika, J | 2 |
| Makuch, W | 2 |
| Obara, I | 1 |
| Wordliczek, J | 1 |
| Przewlocka, B | 2 |
| Torres, S | 1 |
| Astudillo, AM | 1 |
| Garcia-Rovés, P | 1 |
| Bergheim, I | 1 |
| Lotersztajn, S | 1 |
| Trautwein, C | 1 |
| Appelqvist, H | 1 |
| Paton, AW | 1 |
| Paton, JC | 1 |
| Czaja, MJ | 1 |
| Manning, J | 1 |
| Kulbida, R | 1 |
| Rai, P | 1 |
| Jensen, L | 1 |
| Bouma, J | 1 |
| Singh, SP | 1 |
| O'Malley, D | 1 |
| Yilmazer-Hanke, D | 1 |
| Saito, K | 1 |
| Maekawa, K | 1 |
| Ishikawa, M | 1 |
| Senoo, Y | 1 |
| Urata, M | 1 |
| Murayama, M | 1 |
| Nakatsu, N | 1 |
| Yamada, H | 1 |
| Saito, Y | 1 |
| Pochwat, B | 2 |
| Sowa-Kucma, M | 3 |
| Kotarska, K | 2 |
| Misztak, P | 3 |
| Nowak, G | 3 |
| Szewczyk, B | 3 |
| Khan, N | 1 |
| Woodruff, TM | 1 |
| Smith, MT | 1 |
| Paumier, KL | 1 |
| Sortwell, CE | 1 |
| Madhavan, L | 1 |
| Terpstra, B | 1 |
| Celano, SL | 1 |
| Green, JJ | 1 |
| Imus, NM | 1 |
| Marckini, N | 1 |
| Daley, B | 1 |
| Steece-Collier, K | 1 |
| Collier, TJ | 1 |
| Burke, NN | 1 |
| Finn, DP | 1 |
| Roche, M | 1 |
| Cong, WN | 1 |
| Chadwick, W | 1 |
| Wang, R | 1 |
| Daimon, CM | 1 |
| Cai, H | 1 |
| Amma, J | 1 |
| Wood, WH | 1 |
| Becker, KG | 1 |
| Martin, B | 1 |
| Maudsley, S | 1 |
| Volchegorskiĭ, IA | 1 |
| Miroshnichenko, IIu | 1 |
| Rassokhina, LM | 1 |
| Faĭzullin, RM | 1 |
| Priakhina, KE | 1 |
| Kim, HJ | 1 |
| Jurga, AM | 1 |
| Starnowska, J | 1 |
| Wasylewski, M | 1 |
| Rojewska, E | 1 |
| Kwiatkowski, K | 1 |
| Malek, N | 1 |
| Evason, KJ | 1 |
| Francisco, MT | 1 |
| Juric, V | 1 |
| Balakrishnan, S | 1 |
| Lopez Pazmino, Mdel P | 1 |
| Gordan, JD | 1 |
| Kakar, S | 1 |
| Spitsbergen, J | 1 |
| Goga, A | 1 |
| Stainier, DY | 1 |
| Zanier-Gomes, PH | 1 |
| de Abreu Silva, TE | 1 |
| Zanetti, GC | 1 |
| Benati, ÉR | 1 |
| Pinheiro, NM | 1 |
| Murta, BM | 1 |
| Crema, VO | 1 |
| Zeng, C | 1 |
| Zhu, Z | 1 |
| Mahmoudvand, H | 1 |
| Ziaali, N | 1 |
| Ghazvini, H | 1 |
| Shojaee, S | 1 |
| Keshavarz, H | 1 |
| Esmaeilpour, K | 1 |
| Sheibani, V | 1 |
| Aonurm-Helm, A | 1 |
| Anier, K | 1 |
| Zharkovsky, T | 1 |
| Castrén, E | 1 |
| Rantamäki, T | 1 |
| Stepanov, V | 1 |
| Järv, J | 1 |
| Zharkovsky, A | 1 |
| Abdulmajeed, WI | 1 |
| Ibrahim, RB | 1 |
| Ishola, AO | 1 |
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1 trial available for amitriptyline and Disease Models, Animal
| Article | Year |
|---|---|
Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac | 2018 |
147 other studies available for amitriptyline and Disease Models, Animal
| Article | Year |
|---|---|
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injecti | 2016 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Effect of single and repeated administration of amitriptyline on neuropathic pain model in rats: Focus on glutamatergic and upstream nitrergic systems.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Glutamic Acid; Male; Neura | 2019 |
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Topics: Amitriptyline; Animals; Biocatalysis; Cells, Cultured; Disease Models, Animal; Down-Regulation; Endo | 2020 |
Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury.
Topics: Acute Lung Injury; Amitriptyline; Animals; Azacitidine; Calcitriol; Disease Models, Animal; Drug Rep | 2020 |
Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [
Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biomarkers; Cardiotoxic | 2020 |
The Role of Acid Sphingomyelinase Inhibition in Repetitive Mild Traumatic Brain Injury.
Topics: Amitriptyline; Animals; Brain Concussion; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Pr | 2021 |
Analgesic Effects of Topical Amitriptyline in Patients With Chemotherapy-Induced Peripheral Neuropathy: Mechanistic Insights From Studies in Mice.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics, Non- | 2021 |
Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chronic Pain; Disease Models, Animal; Fluo | 2020 |
Anti-inflammatory effect of amitriptyline in a rat model of acetic acid-induced colitis: the involvement of the TLR4/NF-kB signaling pathway.
Topics: Acetic Acid; Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Colitis; Diseas | 2021 |
Trk agonist drugs rescue noise-induced hidden hearing loss.
Topics: Amitriptyline; Animals; Auditory Threshold; Cochlea; Cochlear Nerve; Coculture Techniques; Disease M | 2021 |
Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
Topics: Adenosine; Air Ambulances; Allopurinol; Amitriptyline; Animals; Brain; Brain Chemistry; Brain Injuri | 2021 |
Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Connexin 43; Disease Models, Animal; Down-Regulation; | 2021 |
Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; | 2021 |
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigen | 2017 |
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Disease Models, Animal; Do | 2017 |
Acute effects of amitriptyline on adult zebrafish: Potential relevance to antidepressant drug screening and modeling human toxidromes.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal; | 2017 |
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Topics: Amitriptyline; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Axons; Cell Count; Cuprizo | 2017 |
Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
Topics: Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricy | 2017 |
Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; | 2017 |
Qualitative and quantitative changes in phospholipids and proteins investigated by spectroscopic techniques in olfactory bulbectomy animal depression model.
Topics: Amitriptyline; Animals; Depression; Disease Models, Animal; Male; Phospholipids; Proteins; Rats; Rat | 2018 |
NLRP3 Inflammasome Contributes to Lipopolysaccharide-induced Depressive-Like Behaviors via Indoleamine 2,3-dioxygenase Induction.
Topics: Amitriptyline; Analysis of Variance; Animals; Brain; Caspase 1; Cells, Cultured; Cytokines; Depressi | 2017 |
Regulation of Arthritis Severity by the Acid Sphingomyelinase.
Topics: Amitriptyline; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Gene | 2017 |
Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig.
Topics: Acid-Base Equilibrium; Action Potentials; Alkalies; Amitriptyline; Animals; Arterial Pressure; Cardi | 2018 |
Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antioxidants; Brain; Chronic Disease; Depressive Diso | 2018 |
Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.
Topics: Amitriptyline; Animals; Blood Coagulation Disorders; Disease Models, Animal; Gene Expression Regulat | 2019 |
Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models.
Topics: Adenosine A3 Receptor Antagonists; Amitriptyline; Animals; Cyclic AMP Response Element-Binding Prote | 2019 |
Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis.
Topics: Amitriptyline; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Colon; Diarrhea; Disease Model | 2019 |
Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Behavior, Animal; Cold Temperature; Disease Models, Animal; Hype | 2018 |
Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.
Topics: Amitriptyline; Animals; Bronchoalveolar Lavage Fluid; Ceramides; Chemokine CCL2; Cytokines; Disease | 2019 |
Amitriptyline accumulation in tissues after coated activated charcoal hemoperfusion-a randomized controlled animal poisoning model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antidotes; Charcoal; Chromatography, High | 2019 |
Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cardiotonic Agents; Cardiotoxicity; Diseas | 2019 |
Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis.
Topics: Amitriptyline; Animals; Biomarkers; Citrobacter rodentium; Colitis; Disease Models, Animal; Disease | 2019 |
The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury.
Topics: Amitriptyline; Animals; Aspirin; Blood Coagulation; Brain Injuries, Traumatic; Disease Models, Anima | 2019 |
An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Card | 2013 |
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.
Topics: Amitriptyline; Animals; Cholesterol; Disease Models, Animal; Endoplasmic Reticulum Stress; Hepatitis | 2013 |
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Mode | 2013 |
Blockade of Nav1.8 currents in nociceptive trigeminal neurons contributes to anti-trigeminovascular nociceptive effect of amitriptyline.
Topics: Afferent Pathways; Amitriptyline; Aniline Compounds; Animals; Blood Vessels; Disease Models, Animal; | 2014 |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Arthritis; Carrageenan; Disease Models, Animal; Ex | 2014 |
Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Rel | 2014 |
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Animal; Do | 2014 |
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Topics: Amitriptyline; Animals; Autophagy; Ceramides; Cholesterol; Choline Deficiency; Diet, High-Fat; Disea | 2014 |
Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Disease Mode | 2014 |
Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.
Topics: Amitriptyline; Animals; Bile Ducts; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatograp | 2014 |
Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amitriptyline; Animals; Antidepressive Age | 2015 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism.
Topics: Adrenergic Agents; Amitriptyline; Analgesics, Non-Narcotic; Animals; Brain-Derived Neurotrophic Fact | 2015 |
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Glial | 2015 |
Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.
Topics: Amitriptyline; Animals; Brain-Derived Neurotrophic Factor; Computational Biology; Disease Models, An | 2015 |
[The effect of 3-oxypyridine and succinic acid derivatives on obsessive-compulsive activity of mice in marble-burying test].
Topics: Amitriptyline; Animals; Behavior, Animal; Disease Models, Animal; Female; Humans; Hypnotics and Seda | 2014 |
Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats.
Topics: Amitriptyline; Analgesics; Animals; Berberine; Cold Temperature; Constriction; Disease Models, Anima | 2015 |
Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal; | 2015 |
Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
Topics: Amitriptyline; Animals; Animals, Genetically Modified; Antidepressive Agents, Tricyclic; beta Cateni | 2015 |
Depressive behavior induced by social isolation of predisposed female rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Disease Models, Anima | 2015 |
HMGB1 is responsible for Amitriptyline-mediated cardiac protection from ischemic-reperfusion injury.
Topics: Amitriptyline; Animals; Biomarkers; Disease Models, Animal; HMGB1 Protein; Myocardial Reperfusion In | 2016 |
Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Cytokines; Disease Models, Animal; Hyperalgesia; I | 2016 |
NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Brain; Brain Diseases, Metabolic; Brain-Derive | 2015 |
Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain.
Topics: Amitriptyline; Animals; Disease Models, Animal; Ligation; Male; Memory Disorders; Neuralgia; Pain Me | 2016 |
Effects of 2-Hydroxypropyl-Beta-Cyclodextrin on Cardiovascular Signs of Amitriptyline Poisoning in a Rat Model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Amitriptyline; Animals; Antidotes; Apoptosis; Arterial Pressure; | 2016 |
Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Aspirin; Behavior, Animal; | 2016 |
Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression.
Topics: Adaptation, Ocular; Amitriptyline; Animals; Antidepressive Agents; Corticosterone; Disease Models, A | 2015 |
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide.
Topics: Administration, Intravesical; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; | 2015 |
Olfactory bulbectomy-induced changes in phospholipids and protein profiles in the hippocampus and prefrontal cortex of rats. A preliminary study using a FTIR spectroscopy.
Topics: Amitriptyline; Animals; Depression; Disease Models, Animal; Hippocampus; Male; Nerve Tissue Proteins | 2016 |
Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats.
Topics: Adenine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models | 2016 |
Amitriptyline, but Not Pregabalin, Reverses the Attenuation of Noxious Stimulus-Induced Analgesia After Nerve Injury in Rats.
Topics: Adrenergic Neurons; Amitriptyline; Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, | 2016 |
The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Carrier Proteins; Depression; Disea | 2017 |
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai | 2016 |
Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Depression; Dis | 2016 |
Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression.
Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; CA3 Region, Hippocampal; Ch | 2017 |
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System | 2008 |
Effect of glucagon on amitriptyline-induced cardiovascular toxicity in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiovascular Diseases; C | 2008 |
[Peripheral anti-hyperalgesic effect of amitriptyline for sciatic nerve blockade on neuropathic pain of rats].
Topics: Amitriptyline; Animals; Disease Models, Animal; Male; Pain Threshold; Rats; Rats, Sprague-Dawley; Sc | 2008 |
The effect of amitriptyline on ectopic discharge of primary afferent fibers in the L5 dorsal root in a rat model of neuropathic pain.
Topics: Action Potentials; Amitriptyline; Analgesics; Animals; Disease Models, Animal; Dose-Response Relatio | 2009 |
The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Anima | 2009 |
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease | 2009 |
Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain-Der | 2010 |
Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Animals; Cyclohexanecarboxylic Acids; D | 2010 |
Antidepressant-like activity of Sonchus oleraceus in mouse models of immobility tests.
Topics: Amitriptyline; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Hindlimb Suspensi | 2010 |
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Ac | 2010 |
Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Depression; | 2010 |
Amitriptyline and acute inflammation: a study using intravital microscopy and the carrageenan-induced paw edema model.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Half-L | 2010 |
An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline.
Topics: Amitriptyline; Animals; Antidotes; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Disease Model | 2011 |
Inflammation modulates anxiety in an animal model of multiple sclerosis.
Topics: Acoustic Stimulation; Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic | 2011 |
Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Behavior, Animal; Cold Temperature; Constriction; Cyclopropanes; | 2011 |
Roles of exogenous and endogenous FGF-2 in animal models of depression.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Avoidance Learning; Brain; Depr | 2011 |
Modulators of sphingolipid metabolism reduce lung inflammation.
Topics: 1-Deoxynojirimycin; Amitriptyline; Animals; Anti-Inflammatory Agents; Cell Line; Ceramides; Disease | 2011 |
Antidepressant-like effect of aqueous extract of Channa striatus fillet in mice models of depression.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; | 2011 |
Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Drug I | 2012 |
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats.
Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexane | 2011 |
The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus.
Topics: Amitriptyline; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dura Mater; Elect | 2011 |
A possible role to nitric oxide in the anti-inflammatory effects of amitriptyline.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; C | 2012 |
Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior.
Topics: Amitriptyline; Animals; Anxiety; Biogenic Monoamines; Cell Count; Ciliary Neurotrophic Factor; Cital | 2012 |
Electrocardiographic toxicity in the guinea pig.
Topics: Amitriptyline; Anesthesia; Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Re | 2002 |
[Anti-inflammatory effects of amitriptyline, diazepam and mebicar using model of acute carrageenan-induced paw edema in rats].
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biureas; Carrageenan; Diazepam; Dis | 2011 |
Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction.
Topics: Amitriptyline; Animals; Disease Models, Animal; Fibrosis; Male; Rats; Rats, Wistar; Transforming Gro | 2012 |
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine | 2012 |
Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Behavior, Animal; Disease Models, | 2013 |
Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antihypertens | 2013 |
Prolonged analgesic effect of amitriptyline base on thermal hyperalgesia in an animal model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Ligation; Male; Neuralgia; | 2013 |
Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies.
Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cats; Chronic Disease; Dise | 2002 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; | 2003 |
Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain.
Topics: Amitriptyline; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pain; Pain M | 2004 |
Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation.
Topics: Amitriptyline; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Hypera | 2004 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra | 2005 |
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxyl | 2005 |
Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain.
Topics: Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Benzoxazines; Blotting, Western; Cyclo | 2005 |
Amiodarone fails to improve survival in amitriptyline-poisoned mice.
Topics: Amiodarone; Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Diseas | 2005 |
Administration of amitriptyline attenuates noise-induced hearing loss via glial cell line-derived neurotrophic factor (GDNF) induction.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Auditory Threshold; Disease Models, Animal; Evoked | 2007 |
Antinociceptive effect of amitriptyline in mice of acute pain models.
Topics: Acute Disease; Amitriptyline; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Respon | 2007 |
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agent | 2007 |
Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Dose-Response Rela | 2008 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Chronic Disease; | 2008 |
Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, A | 2008 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di | 2008 |
Cerebromicrocirculatory defects in animal model of depression.
Topics: Amitriptyline; Animals; Brain; Carbon Dioxide; Cerebrovascular Circulation; Depression; Disease Mode | 1984 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Humans; Male; Methy | 1984 |
Pre- and postsynaptic serotonergic manipulations in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Drug Synergism; Flu | 1980 |
Postsynaptic action by four antidepressive drugs in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Di | 1981 |
Amitriptyline and scopolamine in an animal model of depression.
Topics: Amitriptyline; Animals; Antidepressive Agents; Corticosterone; Defecation; Depression; Disease Model | 1981 |
Loss-induced depression in an adult macaque monkey.
Topics: Amitriptyline; Animals; Depressive Disorder; Disease Models, Animal; Female; Grief; Humans; Macaca n | 1982 |
Biochemical and behaviour changes induced by acute stress in a chronic variate stress model of depression: the effect of amitriptyline.
Topics: Amitriptyline; Animals; Behavior, Animal; Chronic Disease; Depression; Disease Models, Animal; Male; | 1995 |
Effects of amitriptyline on GABA-stimulated 36CI- uptake in relation to a behavioral model of depression.
Topics: Amitriptyline; Analysis of Variance; Animals; Chlorine; Depression; Disease Models, Animal; Dominanc | 1995 |
Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57B1/6j but not in DBA/2j mice.
Topics: Alcohol Drinking; Amitriptyline; Animals; Antidepressive Agents; Arousal; Depressive Disorder; Disea | 1994 |
An animal model of postmortem amitriptyline redistribution.
Topics: Amitriptyline; Animals; Disease Models, Animal; Drug Overdose; Liver; Lung; Male; Nortriptyline; Pos | 1993 |
Epinephrine and sodium bicarbonate independently and additively increase survival in experimental amitriptyline poisoning.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Disease Models, Anim | 1997 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose- | 1997 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
Amitriptyline-induced constipation in cynomolgus monkeys is beneficial for the evaluation of laxative efficacy.
Topics: Amitriptyline; Animals; Anthraquinones; Bisacodyl; Cathartics; Constipation; Disease Models, Animal; | 2000 |
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
Effect of amitriptyline on daily variations in cell composition of immune organs in rats with experimental desynchronosis.
Topics: Amitriptyline; Animals; Antidepressive Agents; Chronobiology Disorders; Circadian Rhythm; Disease Mo | 2000 |
Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: effect of antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Binding Sites; Carrier Proteins; Depression; Disease | 2001 |
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Caffeine; Disease Models | 2001 |
Studies with activated charcoal in the treatment of drug overdosage using the pig as an animal model.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Amobarbital; Animals; Charcoal; Disease Models, | 1975 |
Antinociceptive action of tricyclic antidepressant drugs in the rat.
Topics: Amitriptyline; Analgesia; Animals; Delayed-Action Preparations; Desipramine; Disease Models, Animal; | 1990 |
The effects of chronic antidepressant treatment in an animal model of anxiety.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anxiety; Desipramine; Diazepam; Disease Models, Anima | 1988 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats.
Topics: 11-Hydroxycorticosteroids; Amitriptyline; Animals; Antidepressive Agents; Brain Diseases; Depressive | 1986 |
Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.
Topics: Acridines; Amitriptyline; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Diphenhy | 1985 |
Effects of psychotropic drugs on discrimination conditioning in olfactory bulbectomized rats.
Topics: Amitriptyline; Animals; Avoidance Learning; Chlordiazepoxide; Chlorpromazine; Discrimination Learnin | 1985 |
Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis.
Topics: Amitriptyline; Animals; Arthritis; Arthritis, Experimental; Behavior, Animal; Body Weight; Disease M | 1985 |