amitriptyline has been researched along with Disease Models, Animal in 148 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (9.46) | 18.7374 |
| 1990's | 8 (5.41) | 18.2507 |
| 2000's | 32 (21.62) | 29.6817 |
| 2010's | 82 (55.41) | 24.3611 |
| 2020's | 12 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Abdelhaffez, AS; Ahmed, MA; Elbadr, MM; Farghaly, HSM | 1 |
| Cai, BB; Lu, YN; Xu, M | 1 |
| Huang, F; Jiang, C; Jin, N; Li, C; Li, X; Liu, Q; Qin, Y; Zhang, C; Zhang, Y; Zhao, Y; Zhou, C | 1 |
| Aygun, H; Basol, N; Gul, SS | 2 |
| Edwards, MJ; Goodman, MD; Gulbins, E; Hoehn, RS; Jernigan, PL; Makley, AT; Niziolek, GM; Seitz, AP | 1 |
| Delmas, P; Dietrich, G; Ducrocq, M; Genevois, AL; Greco, C; Hatton, S; Penalba, V; Petitfils, C; Principe, P; Ruel, J | 1 |
| Aoki, Y; Hattori, M; Horikawa, H; Ito, H; Takemura, Y; Yamazaki, M | 1 |
| Chamanara, M; Dehpour, A; Dejban, P; Rashidian, A; Sahraei, M | 1 |
| Edge, AS; Fernandez, KA; Kujawa, SG; Meng, X; Tani, K; Tong, M; Watabe, T | 1 |
| Earnest, R; Goodman, MD; McGlone, E; Morris, MC; Singer, KE; Stevens-Topie, S; Wallen, TE | 1 |
| Hisaoka-Nakashima, K; Kondo, S; Morioka, N; Nakamura, Y; Takimoto, T; Tokunaga, N | 1 |
| Barros, CM; Boralli, VB; Costa, LH; Galdino, G; Kawano, T; Placido, RV; Podesta, MHMC; Rodrigues, RF; Santos, RS | 1 |
| Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C | 1 |
| Chen, M; Hoshino, H; Obata, H; Saito, S; Yang, Y | 1 |
| Demin, KA; Efimova, EV; Kalueff, AV; Khatsko, SL; Kolesnikova, TO; Meshalkina, DA; Morzherin, YY | 1 |
| Anne Becker, K; Chami, M; Fassbender, K; Gulbins, E; Halmer, R; Meier, C; Schnoeder, L; Walter, S | 1 |
| Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G | 1 |
| Benya-Aphikul, H; Boonlert, W; Rodsiri, R; Umka Welbat, J | 1 |
| Depciuch, J; Parlinska-Wojtan, M | 1 |
| Han, B; Hong, S; Hwang, I; Jeon, SA; Kim, CH; Lee, E; Park, S; Son, J; Son, S; Yang, J; Yu, JW | 1 |
| Becker, JU; Becker, KA; Beckmann, N; Carpinteiro, A; Fassbender, K; Göthert, JR; Gulbins, E; Hessler, G; Kramer, M; Walter, S; Weber, S | 1 |
| Belhage, B; Dalhoff, K; Eriksen, T; Haarmark, C; Hoegberg, LCG; Jansen, T | 1 |
| Hori, K; Kuno, M; Matsuura, T; Mori, T; Nishikawa, K; Tsujikawa, S | 1 |
| Abelaira, HM; de Moura, AB; de Souza, TG; Fileti, ME; Garbossa, L; Goldim, MP; Maciel, AL; Mathias, K; Matos, D; Petronilho, F; Quevedo, J; Réus, GZ; Rosa, T; Strassi, AP; Tuon, T | 1 |
| Beckmann, N; Caldwell, CC; Goetzman, HS; Goodman, MD; Gulbins, E; Kim, Y; Nomellini, V; Veile, RE; Winer, LK; Xia, BT | 1 |
| Choi, JW; In, JH; Joo, JD; Jung, HS; Kim, JA; Kim, Y; Kim, YS; Kwon, SY; Park, YJ | 1 |
| Bowen, JM; Coller, JK; Fakiha, K; Gibson, RJ; Logan, RM | 1 |
| Furgała, A; Sałat, K; Sałat, R | 1 |
| Beckmann, N; Caldwell, CC; Gulbins, E; Nomellini, V; Pritts, TA; Pugh, AM; Winer, LK; Xia, BT | 1 |
| Belhage, B; Dalhoff, KP; Eriksen, T; Hoegberg, LCG; Jansen, T; Johansen, SS | 1 |
| Becker, KA; Buer, J; Ebel, JF; Hansen, W; Hermann, DM; Hose, M; Japtok, L; Kleuser, B; Klopfleisch, R; Kolesnick, RN; Meiners, J; Palmieri, V; Schumacher, F; Westendorf, AM; Yusuf, AM; Zöller, J | 1 |
| Beckmann, N; Bercz, A; Goodman, MD; Gulbins, E; Kassam, F; Makley, AT; Morris, MC; Schumacher, F | 1 |
| Gerostamoulos, D; Graudins, A; Perichon, D; Turfus, S | 1 |
| Balsinde, J; Bataller, R; Baulies, A; Caballeria, J; Colell, A; Dubuquoy, L; Elena, M; Fernandez, A; Fernandez-Checa, JC; Fucho, R; Garcia-Ruiz, C; Kaplowitz, N; Mari, M; Martinez, L; Mathurin, P; Matias, N; Morales, A; Nuño, N; Ribas, V; Tarrats, N; Von Montfort, C | 1 |
| Bernardy, CC; Calixto-Campos, C; Cardoso, RD; Casagrande, R; Cecchini, R; Corrêa, M; Crespigio, J; Moreira, EG; Pinho-Ribeiro, FA; Verri, WA; Zarpelon, AC | 1 |
| Dai, W; Dong, Z; Liang, J; Liu, R; Liu, X; Pan, M; Wang, X; Yu, S; Zheng, J | 1 |
| Almeida, A; Amorim, D; David-Pereira, A; Pertovaara, A; Pinto-Ribeiro, F | 1 |
| Aoki, T; Matsuoka, N; Murai, N; Tamura, S; Tsukamoto, M | 1 |
| Jagla, G; Makuch, W; Mika, J; Obara, I; Przewlocka, B; Wordliczek, J | 1 |
| Appelqvist, H; Astudillo, AM; Balsinde, J; Baulies, A; Bergheim, I; Czaja, MJ; Elena, M; Fernandez, A; Fernandez-Checa, JC; Fucho, R; Garcia-Rovés, P; García-Ruiz, C; Kaplowitz, N; Lotersztajn, S; Martínez, L; Paton, AW; Paton, JC; Ribas, V; Tarrats, N; Torres, S; Trautwein, C | 1 |
| Bouma, J; Jensen, L; Kulbida, R; Manning, J; O'Malley, D; Rai, P; Singh, SP; Yilmazer-Hanke, D | 1 |
| Ishikawa, M; Maekawa, K; Murayama, M; Nakatsu, N; Saito, K; Saito, Y; Senoo, Y; Urata, M; Yamada, H | 1 |
| Kotarska, K; Misztak, P; Nowak, G; Pochwat, B; Sowa-Kucma, M; Szewczyk, B | 1 |
| Khan, N; Smith, MT; Woodruff, TM | 1 |
| Celano, SL; Collier, TJ; Daley, B; Green, JJ; Imus, NM; Madhavan, L; Marckini, N; Paumier, KL; Sortwell, CE; Steece-Collier, K; Terpstra, B | 1 |
| Burke, NN; Finn, DP; Roche, M | 1 |
| Amma, J; Becker, KG; Cai, H; Chadwick, W; Cong, WN; Daimon, CM; Martin, B; Maudsley, S; Wang, R; Wood, WH | 1 |
| Faĭzullin, RM; Miroshnichenko, IIu; Priakhina, KE; Rassokhina, LM; Volchegorskiĭ, IA | 1 |
| Kim, HJ | 1 |
| Jurga, AM; Kwiatkowski, K; Makuch, W; Malek, N; Mika, J; Przewlocka, B; Rojewska, E; Starnowska, J; Wasylewski, M | 1 |
| Balakrishnan, S; Evason, KJ; Francisco, MT; Goga, A; Gordan, JD; Juric, V; Kakar, S; Lopez Pazmino, Mdel P; Spitsbergen, J; Stainier, DY | 1 |
| Benati, ÉR; Crema, VO; de Abreu Silva, TE; Murta, BM; Pinheiro, NM; Zanetti, GC; Zanier-Gomes, PH | 1 |
| Liu, Q; Zeng, C; Zhu, Z | 1 |
| Esmaeilpour, K; Ghazvini, H; Keshavarz, H; Mahmoudvand, H; Sheibani, V; Shojaee, S; Ziaali, N | 1 |
| Anier, K; Aonurm-Helm, A; Castrén, E; Järv, J; Rantamäki, T; Stepanov, V; Zharkovsky, A; Zharkovsky, T | 1 |
| Abdulmajeed, WI; Amin, A; Balogun, WG; Cobham, AE; Ibrahim, RB; Ishola, AO | 1 |
| Aydin, B; Ergur, BU; Hocaoglu, N; Kalkan, S; Micili, SC | 1 |
| Bhatt, S; Goswami, S; Raval, J; Shukla, P | 1 |
| Edwards, MJ; Grassmé, H; Gulbins, E; Hoehn, RS; Jernigan, PL; Kornhuber, J; Müller, CP; Soddemann, M; Wilker, B | 1 |
| Dogishi, K; Kaneko, S; Kodera, M; Nakagawa, T; Oyama, S; Shirakawa, H | 1 |
| Depciuch, J; Misztak, P; Nowak, G; Pankiewicz, P; Parlińska-Wojtan, M; Sowa-Kućma, M; Szewczyk, B | 1 |
| Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN | 1 |
| Matsuoka, H; Obata, H; Saito, S; Suto, T | 1 |
| Kotarska, K; Misztak, P; Nowak, B; Nowak, G; Pochwat, B; Rafalo, A; Sowa-Kucma, M; Szewczyk, B; Wiatrowska, K; Zadrozna, M | 1 |
| Deuis, JR; Lewis, RJ; Vetter, I; Yin, K | 1 |
| Gulbins, E; Kornhuber, J; Reichel, M; Zoicas, I | 1 |
| Galeotti, N; Ghelardini, C; Sanna, MD | 1 |
| Fredholm, BB; Reid, AR; Sawynok, J | 1 |
| Hocaoglu, N; Kalkan, S; Kaplan, YC; Oransay, K; Tuncok, Y | 1 |
| Kang, X; Liu, H; Song, L; Xiao, H; Yang, B; Yang, F | 1 |
| Liang, AH; Su, X; Urban, MO | 1 |
| Pettersen, VL; Raimundo, JM; Sudo, RT; Trachez, MM; Zapata-Sudo, G | 1 |
| Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T | 1 |
| Hu, Y; Li, W; Wang, Y; Yang, J | 1 |
| Arneric, SP; Buccafusco, JJ; Snutch, TP; Terry, AV; Vazdarjanova, A | 1 |
| Alves-da-Silva, G; Giusti-Paiva, A; Padilha, Mde M; Soncini, R; Vilela, FC | 1 |
| Densmore, VS; Kalous, A; Keast, JR; Osborne, PB | 1 |
| Jesse, CR; Nogueira, CW; Wilhelm, EA | 1 |
| Alves, GJ; Palermo-Neto, J; Vismari, L | 1 |
| Arici, A; Hocaoglu, N; Kalkan, S; Oransay, K; Tuncok, Y | 1 |
| Gold, R; Hartwig, S; Hovemann, B; Juckel, G; Linker, RA; Peruga, I; Thöne, J | 1 |
| Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O | 1 |
| Jarosik, J; Legutko, B; Unsicker, K; von Bohlen Und Halbach, O; Werner, S | 1 |
| Berton, G; Bezzerri, V; Cabrini, G; Cioffi, F; Dechecchi, MC; Gambari, R; Huang, S; Lampronti, I; Mazzi, P; Nicolis, E; Scupoli, MT; Wiszniewski, L | 1 |
| Amom, Z; Fakurazi, S; Mat Jais, AM; Moklas, M; Saleem, AM; Sulaiman, MR; Taufik Hidayat, M | 1 |
| Galeotti, N; Ghelardini, C | 1 |
| Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A | 1 |
| Chen, X; Dong, Z; Li, Z; Liang, J; Liu, R; Wang, X; Yu, S | 1 |
| Alves, GJ; Muscará, MN; Palermo-Neto, J; Vismari, L | 1 |
| Gold, R; Hartwig, S; Hovemann, B; Juckel, G; Linker, RA; Merkler, D; Peruga, I; Thöne, J | 1 |
| Lacroix, P | 1 |
| Kaziakhmetova, VN; Valeeva, IKh; Ziganshina, LE | 1 |
| de Almeida Prado, PS; Lima, FO; Schor, N; Soares, MF; Teixeira, VP | 1 |
| Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ | 1 |
| Abriel, H; Decosterd, I; Kirschmann, G; Laedermann, CJ; Suter, MR | 1 |
| Diamond, DM; Fleshner, M; Zoladz, PR | 1 |
| Cheng, KI; Chu, CC; Huang, KL; Lin, MT; Shieh, JP; Wang, JJ; Yeh, MY | 1 |
| Barer, GR; Cope, G; Emery, CJ; Gill, G; Herget, J; Laude, E; Liu, X | 1 |
| Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM | 1 |
| Caldarone, BJ; Harrist, A; Hunsberger, JG; Jatlow, P; Karthigeyan, K; King, SL; Picciotto, MR; Wittmack, E | 1 |
| Sung, B; Wang, GK | 1 |
| Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I | 1 |
| Hemrick-Luecke, SK; Iyengar, S; Simmons, RM; Webster, AA; Xu, JY | 1 |
| Ecoffey, C; Estebe, JP; Gentili, ME; Le Corre, P; Leduc, C; Moulinoux, JP | 1 |
| Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD | 1 |
| Miki, S; Senba, E; Yasuda, T; Yoshinaga, N | 1 |
| Beaulieu, P; Desbiens, K; Leblond, F; Pichette, V; Walczak, JS | 1 |
| Barrueto, F; Chuang, A; Cotter, BW; Hoffman, RS; Nelson, LS | 1 |
| Kanda, S; Kawamoto, K; Kuriyama, H; Nishiyama, T; Osumi, Y; Shibata, SB; Yagi, M; Yamashita, T | 1 |
| Bhattacharya, SK; Das, BP; Deo, S; Paudel, KR; Rauniar, GP; Sangraula, H | 1 |
| Gross, G; Groth, I; Jongen-Relo, A; Rex, A; Wicke, KM | 1 |
| Barrot, M; Benbouzid, M; Freund-Mercier, MJ; Gavériaux-Ruff, C; Kieffer, BL; Muller, A; Tessier, LH; Waltisperger, E; Yalcin, I | 1 |
| Cheevers, CV; Donello, JE; Gil, DW | 1 |
| Duman, RS; Gourley, SL; Kedves, AT; Kiraly, DD; Ploski, JE; Taylor, JR; Wu, FJ | 1 |
| Duman, CH; Duman, RS; Russell, DS; Schlesinger, L | 1 |
| Barrot, M; Benbouzid, M; Choucair-Jaafar, N; Freund-Mercier, MJ; Muller, A; Waltisperger, E; Yalcin, I | 1 |
| Glotzbach, RK; Irwin, GH; Kent, TA; Preskorn, SH; Solnick, JV | 1 |
| Bradford, D; Krijzer, F; Snelder, M | 1 |
| Aprison, MH; Hendrie, HC; Hingtgen, JN | 1 |
| Aprison, MH; Hingtgen, JN; Nagayama, H | 2 |
| Hersh, S; Katz, RJ | 1 |
| Rasmussen, KL; Reite, M | 1 |
| Blengio, M; Ferretti, C; Gamalero, SR; Ghi, P | 1 |
| Allen, D; De Leon, I; Malatynska, E; Yamamura, HI | 1 |
| Bobkova, NV; Gurevich, EV; Katkov, YA; Nesterova, IV; Otmakhova, NA | 1 |
| Beylich, KM; Bjørneboe, A; Bugge, A; Hilberg, T; Ingum, J; Mørland, J | 1 |
| Abrahamsson, J; Knudsen, K | 1 |
| Blomgren, B; Dahlin, KL; Lâstbom, L; Ryrfeldt, A | 1 |
| Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T | 1 |
| Kishimoto, S; Kohri, H; Koshitani, O; Tsusumi, K | 1 |
| Esser, MJ; Sawynok, J | 1 |
| Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I | 1 |
| Litvinenko, GI; Mel'nikova, EV; Shurlygina, AV; Taradanova, LV; Tenditnik, MV; Trufakin, VA; Verbitskaya, LV | 1 |
| Barden, N; Beaulieu, S; Cyr, M; Di Paolo, T; Morissette, M; Rochford, J | 1 |
| Allen, GV; Chase, T; Esser, MJ; Sawynok, J | 1 |
| Lipscomb, DJ; Widdop, B | 1 |
| Hersh, EV; Kaplan, P | 1 |
| Aitken, DH; Bodnoff, SR; Meaney, MJ; Quirion, R; Suranyi-Cadotte, B | 1 |
| Dailey, JW; Jobe, PC | 1 |
| Jesberger, JA; Richardson, JS | 1 |
| Kameyama, T; Nagasaka, M; Yamada, K | 1 |
| Gomita, Y; Ogawa, N; Ueki, S | 1 |
| Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J | 1 |
1 trial(s) available for amitriptyline and Disease Models, Animal
| Article | Year |
|---|---|
Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Charcoal; Combined Modality Therapy; Disease Models, Animal; Drug Overdose; Electrocardiography; Female; Hemoperfusion; Humans; Poisoning; Sus scrofa; Treatment Outcome | 2018 |
147 other study(ies) available for amitriptyline and Disease Models, Animal
| Article | Year |
|---|---|
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraperitoneal; Isoxazoles; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship | 2016 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Effect of single and repeated administration of amitriptyline on neuropathic pain model in rats: Focus on glutamatergic and upstream nitrergic systems.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Glutamic Acid; Male; Neuralgia; Nitric Oxide Synthase Type II; Nitrogen; Pain Threshold; Rats; Rats, Wistar | 2019 |
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.
Topics: Amitriptyline; Animals; Biocatalysis; Cells, Cultured; Disease Models, Animal; Down-Regulation; Endothelial Cells; Enzyme Inhibitors; Imipramine; Leptin; Male; Palmitic Acid; Rats; Rats, Sprague-Dawley; Receptors, Leptin; Sphingomyelin Phosphodiesterase | 2020 |
Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury.
Topics: Acute Lung Injury; Amitriptyline; Animals; Azacitidine; Calcitriol; Disease Models, Animal; Drug Repositioning; Female; Flavin-Adenine Dinucleotide; Humans; Influenza A Virus, H5N1 Subtype; Influenza, Human; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL | 2020 |
Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [
Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biomarkers; Cardiotoxicity; Disease Models, Animal; Electrocardiography; Ergocalciferols; Heart; Heart Diseases; Heart Rate; Male; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Radiopharmaceuticals; Rats, Wistar; Technetium Tc 99m Pyrophosphate; Troponin T | 2020 |
The Role of Acid Sphingomyelinase Inhibition in Repetitive Mild Traumatic Brain Injury.
Topics: Amitriptyline; Animals; Brain Concussion; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Protein Aggregation, Pathological; Sphingomyelin Phosphodiesterase; tau Proteins | 2021 |
Analgesic Effects of Topical Amitriptyline in Patients With Chemotherapy-Induced Peripheral Neuropathy: Mechanistic Insights From Studies in Mice.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Behavior, Animal; Child; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; NAV1.7 Voltage-Gated Sodium Channel; NAV1.8 Voltage-Gated Sodium Channel; NAV1.9 Voltage-Gated Sodium Channel; Nociceptive Pain; Nociceptors; Peripheral Nervous System Diseases; TRPA1 Cation Channel; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels; Young Adult | 2021 |
Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chronic Pain; Disease Models, Animal; Fluorobenzenes; Male; Mice; Neuralgia; Piperidines; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Sleep Wake Disorders | 2020 |
Anti-inflammatory effect of amitriptyline in a rat model of acetic acid-induced colitis: the involvement of the TLR4/NF-kB signaling pathway.
Topics: Acetic Acid; Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Male; NF-kappa B; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Trk agonist drugs rescue noise-induced hidden hearing loss.
Topics: Amitriptyline; Animals; Auditory Threshold; Cochlea; Cochlear Nerve; Coculture Techniques; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Flavones; Hair Cells, Auditory, Inner; Hearing Loss, Noise-Induced; Membrane Glycoproteins; Mice; Mice, Inbred CBA; Protein-Tyrosine Kinases; Regeneration; Synapses | 2021 |
Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
Topics: Adenosine; Air Ambulances; Allopurinol; Amitriptyline; Animals; Brain; Brain Chemistry; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Emergency Medical Services; Lidocaine; Magnesium; Male; Mice; Mice, Inbred C57BL; Propranolol; Rotarod Performance Test | 2021 |
Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Connexin 43; Disease Models, Animal; Down-Regulation; Hippocampus; Male; Mice; Neuralgia | 2021 |
Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; Male; Neuralgia; Pain Measurement; Pregabalin; Rats; Rats, Wistar | 2021 |
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigenesis, Genetic; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Neuralgia; Pain Management; Pregabalin; Receptors, Metabotropic Glutamate; Time Factors; Tramadol | 2017 |
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Disease Models, Animal; Dopamine; Dopamine Antagonists; Duloxetine Hydrochloride; Fluoxetine; Hyperalgesia; Male; Milnacipran; Neuralgia; Pain Threshold; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Sulpiride | 2017 |
Acute effects of amitriptyline on adult zebrafish: Potential relevance to antidepressant drug screening and modeling human toxidromes.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Male; Motor Activity; Swimming; Zebrafish | 2017 |
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Topics: Amitriptyline; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Axons; Cell Count; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Multiple Sclerosis; Nerve Regeneration; Oligodendroglia; Recovery of Function; Sphingomyelin Phosphodiesterase; Synaptophysin | 2017 |
Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
Topics: Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Antipruritics; Aprepitant; Behavior, Animal; Chloroquine; Cyproheptadine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Morphinans; Morpholines; Motor Activity; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Pattern Recognition, Automated; Pruritus; Signal Processing, Computer-Assisted; Skin; Spiro Compounds; Vibration; Video Recording | 2017 |
Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Hippocampus; Locomotion; Male; Mice, Inbred ICR; Panax; Phytotherapy; Plant Extracts; Plants, Medicinal; Prefrontal Cortex; Swimming; Up-Regulation | 2017 |
Qualitative and quantitative changes in phospholipids and proteins investigated by spectroscopic techniques in olfactory bulbectomy animal depression model.
Topics: Amitriptyline; Animals; Depression; Disease Models, Animal; Male; Phospholipids; Proteins; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared | 2018 |
NLRP3 Inflammasome Contributes to Lipopolysaccharide-induced Depressive-Like Behaviors via Indoleamine 2,3-dioxygenase Induction.
Topics: Amitriptyline; Analysis of Variance; Animals; Brain; Caspase 1; Cells, Cultured; Cytokines; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; NLR Family, Pyrin Domain-Containing 3 Protein; RNA, Messenger | 2017 |
Regulation of Arthritis Severity by the Acid Sphingomyelinase.
Topics: Amitriptyline; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Gene Deletion; Joints; Mice, Inbred C57BL; Mice, Knockout; Sphingomyelin Phosphodiesterase | 2017 |
Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig.
Topics: Acid-Base Equilibrium; Action Potentials; Alkalies; Amitriptyline; Animals; Arterial Pressure; Cardiotoxicity; Disease Models, Animal; Emulsions; Guinea Pigs; Heart Diseases; Heart Rate; Hydrogen-Ion Concentration; Infusions, Intravenous; Isolated Heart Preparation; Kinetics; Male; Myocytes, Cardiac; Phospholipids; Recovery of Function; Sodium; Sodium Bicarbonate; Soybean Oil; Ventricular Function, Left | 2018 |
Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antioxidants; Brain; Chronic Disease; Depressive Disorder, Major; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Ketamine; Male; Maternal Deprivation; Minocycline; Oxidative Stress; Rats, Wistar; Stress, Psychological | 2018 |
Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.
Topics: Amitriptyline; Animals; Blood Coagulation Disorders; Disease Models, Animal; Gene Expression Regulation; Macrophages, Peritoneal; Mice; Sepsis; Tumor Necrosis Factor-alpha | 2019 |
Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models.
Topics: Adenosine A3 Receptor Antagonists; Amitriptyline; Animals; Cyclic AMP Response Element-Binding Protein; Cytokines; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Male; MAP Kinase Signaling System; Neuralgia; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3 | 2019 |
Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis.
Topics: Amitriptyline; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Colon; Diarrhea; Disease Models, Animal; Irinotecan; Male; Mucositis; Rats; Rats, Wistar | 2019 |
Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Behavior, Animal; Cold Temperature; Disease Models, Animal; Hyperalgesia; Male; Mice; Neuralgia; Oxaliplatin; Pain Threshold | 2018 |
Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.
Topics: Amitriptyline; Animals; Bronchoalveolar Lavage Fluid; Ceramides; Chemokine CCL2; Cytokines; Disease Models, Animal; Inflammation; Interleukin-10; Lipopolysaccharides; Lung; Macrophages, Peritoneal; Male; Mice; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Sepsis; Signal Transduction; Survival Rate | 2019 |
Amitriptyline accumulation in tissues after coated activated charcoal hemoperfusion-a randomized controlled animal poisoning model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antidotes; Charcoal; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Hemoperfusion; Nortriptyline; Swine; Tandem Mass Spectrometry; Tissue Distribution | 2019 |
Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cardiotonic Agents; Cardiotoxicity; Disease Models, Animal; Edaravone; Electrocardiography; Heart; Heart Diseases; Heart Rate; Male; Myocardial Perfusion Imaging; Rats; Rats, Wistar; Troponin T | 2019 |
Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis.
Topics: Amitriptyline; Animals; Biomarkers; Citrobacter rodentium; Colitis; Disease Models, Animal; Disease Resistance; Disease Susceptibility; Enterobacteriaceae Infections; Enzyme Activation; Host-Pathogen Interactions; Intestinal Mucosa; Macrophages; Mice; Mice, Knockout; Sphingomyelin Phosphodiesterase; T-Lymphocyte Subsets | 2019 |
The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury.
Topics: Amitriptyline; Animals; Aspirin; Blood Coagulation; Brain Injuries, Traumatic; Disease Models, Animal; Enoxaparin; Humans; Lipid Metabolism; Male; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Sphingolipids; Thrombelastography; Venous Thromboembolism | 2019 |
An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiovascular System; Disease Models, Animal; Drug Overdose; Emulsions; Fat Emulsions, Intravenous; Heart; Heart Rate; Hemodynamics; Intestinal Absorption; Male; Phospholipids; Pilot Projects; Random Allocation; Rats; Rats, Wistar; Soybean Oil; Survival Analysis | 2013 |
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.
Topics: Amitriptyline; Animals; Cholesterol; Disease Models, Animal; Endoplasmic Reticulum Stress; Hepatitis, Alcoholic; Humans; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; N-Terminal Acetyltransferase A; N-Terminal Acetyltransferase E; Sphingomyelin Phosphodiesterase | 2013 |
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Edema; Hyperalgesia; Indomethacin; Male; Mice; Morphine; Neoplasm Transplantation; Nociception; Pain; Subcutaneous Tissue; Temperature | 2013 |
Blockade of Nav1.8 currents in nociceptive trigeminal neurons contributes to anti-trigeminovascular nociceptive effect of amitriptyline.
Topics: Afferent Pathways; Amitriptyline; Aniline Compounds; Animals; Blood Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Furans; Ion Channel Gating; Male; Migraine Disorders; NAV1.8 Voltage-Gated Sodium Channel; Nociception; Nociceptors; Rats; Rats, Sprague-Dawley; Single-Blind Method; Sodium; Sodium Channel Blockers; Superior Sagittal Sinus; Tetrodotoxin; Trigeminal Nerve | 2014 |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Arthritis; Carrageenan; Disease Models, Animal; Exploratory Behavior; Food Preferences; Hyperalgesia; Kaolin; Male; Maze Learning; Mood Disorders; Motor Activity; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Swimming | 2014 |
Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Spinal; Male; Mice, Inbred ICR; Morpholines; Neuralgia; Prostaglandins; Spinal Cord; Stereoisomerism; Thiophenes | 2014 |
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Animal; Doxepin; Hyperalgesia; Male; Morphine; Neuralgia; Pain Measurement; Pain Threshold; Rats; Sciatic Nerve; Venlafaxine Hydrochloride | 2014 |
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Topics: Amitriptyline; Animals; Autophagy; Ceramides; Cholesterol; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Endoplasmic Reticulum Stress; Humans; Liver; Lysosomes; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Permeability; Sphingomyelin Phosphodiesterase; Sphingomyelins | 2014 |
Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Disease Models, Animal; Inflammation; Learning; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne | 2014 |
Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.
Topics: Amitriptyline; Animals; Bile Ducts; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Clomipramine; Discriminant Analysis; Disease Models, Animal; Glucosylceramides; Hepatocytes; Imipramine; Least-Squares Analysis; Liver; Lysophosphatidylcholines; Lysosomal Storage Diseases; Male; Mass Spectrometry; Metabolomics; Multivariate Analysis; Predictive Value of Tests; Rats | 2014 |
Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amitriptyline; Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Magnesium; Male; Metabolic Networks and Pathways; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2015 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxylic Acids; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Gabapentin; Gait; gamma-Aminobutyric Acid; Gliosis; Hyperalgesia; Mice; Morphine; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuralgia; Peptide Fragments; Pertussis Toxin; Quillaja Saponins | 2014 |
Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism.
Topics: Adrenergic Agents; Amitriptyline; Analgesics, Non-Narcotic; Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Disease Models, Animal; Food Preferences; Gene Expression Regulation; Hindlimb Suspension; Male; Neurodegenerative Diseases; Oxidopamine; Parkinsonian Disorders; Psychomotor Performance; Rats; Rats, Wistar; Saccharin; Substantia Nigra; Tyrosine 3-Monooxygenase | 2015 |
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hyperalgesia; Interleukin-10; Male; Neuralgia; Pain Measurement; Peripheral Nerve Injuries; Phenotype; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Spinal Nerves; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.
Topics: Amitriptyline; Animals; Brain-Derived Neurotrophic Factor; Computational Biology; Disease Models, Animal; Female; Huntington Disease; Male; Mice; Mitochondria; Nerve Growth Factors | 2015 |
[The effect of 3-oxypyridine and succinic acid derivatives on obsessive-compulsive activity of mice in marble-burying test].
Topics: Amitriptyline; Animals; Behavior, Animal; Disease Models, Animal; Female; Humans; Hypnotics and Sedatives; Male; Meglumine; Mice; Motor Activity; Obsessive-Compulsive Disorder; Picolines; Psychotropic Drugs; Succinates; Thioctic Acid | 2014 |
Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats.
Topics: Amitriptyline; Analgesics; Animals; Berberine; Cold Temperature; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Malondialdehyde; Neuralgia; Pain Perception; Pain Threshold; Peroxidase; Rats; Sciatic Nerve; Treatment Outcome | 2015 |
Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal; Doxepin; Hyperalgesia; Male; Mice; Neuralgia; Pain Measurement; Pain Threshold; Sciatic Nerve | 2015 |
Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
Topics: Amitriptyline; Animals; Animals, Genetically Modified; Antidepressive Agents, Tricyclic; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Liver Neoplasms; MAP Kinase Signaling System; Mesothelin; Mice; Selective Serotonin Reuptake Inhibitors; Xenopus laevis; Zebrafish | 2015 |
Depressive behavior induced by social isolation of predisposed female rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Disease Models, Animal; Female; Genetic Predisposition to Disease; Individuality; Motor Activity; Psychological Tests; Rats, Wistar; Social Isolation; Stress, Psychological; Swimming; Treatment Outcome | 2015 |
HMGB1 is responsible for Amitriptyline-mediated cardiac protection from ischemic-reperfusion injury.
Topics: Amitriptyline; Animals; Biomarkers; Disease Models, Animal; HMGB1 Protein; Myocardial Reperfusion Injury; Myocardium; Rats | 2016 |
Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Cytokines; Disease Models, Animal; Hyperalgesia; Inflammation; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Neuralgia; Real-Time Polymerase Chain Reaction; RNA, Messenger; Toxoplasma; Toxoplasmosis; Tumor Necrosis Factor-alpha | 2016 |
NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Brain; Brain Diseases, Metabolic; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Electrochemical Techniques; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Cell Adhesion Molecules; Phosphorylation; Protein Binding; Receptor, trkB; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2015 |
Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain.
Topics: Amitriptyline; Animals; Disease Models, Animal; Ligation; Male; Memory Disorders; Neuralgia; Pain Measurement; Pain Threshold; Phenytoin; Rats; Rats, Wistar; Recognition, Psychology; Sciatic Nerve | 2016 |
Effects of 2-Hydroxypropyl-Beta-Cyclodextrin on Cardiovascular Signs of Amitriptyline Poisoning in a Rat Model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Amitriptyline; Animals; Antidotes; Apoptosis; Arterial Pressure; beta-Cyclodextrins; Cardiotoxicity; Cardiovascular Diseases; Chelating Agents; Disease Models, Animal; Electrocardiography; Glucose; Heart Rate; Hemodynamics; Male; Rats, Wistar; Time Factors | 2016 |
Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Aspirin; Behavior, Animal; Brain; Depression; Dexamethasone; Disease Models, Animal; Dopamine; Hydrocortisone; Male; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin; Stress, Psychological | 2016 |
Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression.
Topics: Adaptation, Ocular; Amitriptyline; Animals; Antidepressive Agents; Corticosterone; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Exploratory Behavior; Gene Expression Regulation, Enzymologic; Hippocampus; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; p38 Mitogen-Activated Protein Kinases; Pyrimidines; Reaction Time; Sphingomyelin Phosphodiesterase; Sphingomyelins; Stress, Psychological | 2015 |
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide.
Topics: Administration, Intravesical; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Chronic Disease; Cystitis; Disease Models, Animal; Hydrogen Peroxide; Morphine; Motor Activity; Pain; Syndrome; Time Factors | 2015 |
Olfactory bulbectomy-induced changes in phospholipids and protein profiles in the hippocampus and prefrontal cortex of rats. A preliminary study using a FTIR spectroscopy.
Topics: Amitriptyline; Animals; Depression; Disease Models, Animal; Hippocampus; Male; Nerve Tissue Proteins; Olfactory Bulb; Phospholipids; Prefrontal Cortex; Rats; Spectroscopy, Fourier Transform Infrared | 2016 |
Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats.
Topics: Adenine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Fluoxetine; Food Preferences; Imipramine; Male; Motor Activity; Paroxetine; Rats; Reserpine; Sertraline; Venlafaxine Hydrochloride | 2016 |
Amitriptyline, but Not Pregabalin, Reverses the Attenuation of Noxious Stimulus-Induced Analgesia After Nerve Injury in Rats.
Topics: Adrenergic Neurons; Amitriptyline; Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Microdialysis; Neuralgia; Norepinephrine; Pain Threshold; Peripheral Nerve Injuries; Pregabalin; Rats; Rats, Sprague-Dawley; Reaction Time; Sensory System Agents; Spinal Nerves; Time Factors | 2016 |
The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Carrier Proteins; Depression; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Homeostasis; Male; Metallothionein; Olfactory Bulb; Rats; Rats, Sprague-Dawley; RNA, Messenger; Zinc | 2017 |
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gait Disorders, Neurologic; gamma-Aminobutyric Acid; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Male; Metacarpus; Mice; Mice, Inbred C57BL; Motor Activity; Oxycodone; Pain; Pain Threshold; Proglumide; Receptor, Cholecystokinin B; Sensory Receptor Cells; Transcriptome; Weight-Bearing | 2016 |
Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression; Male; Memory; Mice; Mice, Transgenic; Pattern Recognition, Visual; Sex Factors; Social Behavior; Sphingomyelin Phosphodiesterase; Transgenes | 2016 |
Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression.
Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; CA3 Region, Hippocampal; Chronic Disease; Citalopram; Depressive Disorder; Disease Models, Animal; Male; Mice; Neurofilament Proteins; Phosphorylation; Random Allocation | 2017 |
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Genotype; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Pain Measurement; Pain Threshold; Receptor, Adenosine A1 | 2008 |
Effect of glucagon on amitriptyline-induced cardiovascular toxicity in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiovascular Diseases; Cardiovascular System; Disease Models, Animal; Electrocardiography; Gastrointestinal Agents; Glucagon; Heart Conduction System; Heart Rate; Infusions, Intravenous; Injections, Intravenous; Male; Rats; Rats, Wistar | 2008 |
[Peripheral anti-hyperalgesic effect of amitriptyline for sciatic nerve blockade on neuropathic pain of rats].
Topics: Amitriptyline; Animals; Disease Models, Animal; Male; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatic Neuropathy | 2008 |
The effect of amitriptyline on ectopic discharge of primary afferent fibers in the L5 dorsal root in a rat model of neuropathic pain.
Topics: Action Potentials; Amitriptyline; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Laminectomy; Ligation; Lumbar Vertebrae; Male; Neuralgia; Neurons, Afferent; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spinal Nerve Roots; Time Factors | 2009 |
The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Injections, Spinal; Male; Maprotiline; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Selective Serotonin Reuptake Inhibitors; Time Factors; Yohimbine | 2009 |
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease Models, Animal; Fibromyalgia; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Morphine; Muscle, Skeletal; Neuronal Plasticity; Nociceptors; Pain Measurement; Pain Threshold; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord; Vagotomy; Vagus Nerve; Vagus Nerve Diseases; Visceral Afferents | 2009 |
Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain-Derived Neurotrophic Factor; Cognition Disorders; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Male; Maze Learning; Memory Disorders; Neuralgia; Piroxicam; Rats; Rats, Sprague-Dawley | 2010 |
Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gabapentin; gamma-Aminobutyric Acid; Macaca nemestrina; Male; Memory, Short-Term; Neuralgia; Neuropsychological Tests; Psychomotor Performance; Reaction Time | 2010 |
Antidepressant-like activity of Sonchus oleraceus in mouse models of immobility tests.
Topics: Amitriptyline; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Hindlimb Suspension; Immobility Response, Tonic; Locomotion; Male; Mice; Movement; Phytotherapy; Plant Components, Aerial; Plant Extracts; Sonchus; Swimming | 2010 |
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Acids; Disease Models, Animal; Double-Blind Method; Early Growth Response Protein 1; Functional Laterality; Gabapentin; gamma-Aminobutyric Acid; Gene Expression Regulation; Hyperalgesia; Male; Morphine; Pain Threshold; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2010 |
Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Depression; Disease Models, Animal; Fluoxetine; Hyperalgesia; Ligation; Male; Mice; Motor Activity; Organoselenium Compounds; Pain Measurement; Sciatic Nerve; Sciatica; Swimming; Time Factors | 2010 |
Amitriptyline and acute inflammation: a study using intravital microscopy and the carrageenan-induced paw edema model.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Half-Life; Inflammation; Leukocytes; Male; Microscopy; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Glucocorticoid | 2010 |
An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline.
Topics: Amitriptyline; Animals; Antidotes; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Drug Administration Schedule; Electrocardiography; Glucose; Heart Rate; Infusions, Intravenous; Injections, Intravenous; Male; Oxygen; Poisoning; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Theophylline; Time Factors | 2011 |
Inflammation modulates anxiety in an animal model of multiple sclerosis.
Topics: Acoustic Stimulation; Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Anxiety; Central Nervous System; Chromatography, High Pressure Liquid; Cytokines; Dark Adaptation; Demyelinating Diseases; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Gene Expression Regulation; Glycoproteins; Helplessness, Learned; Inflammation; Mice; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Pertussis Toxin; Phosphopyruvate Hydratase; Psychoacoustics; Reflex, Startle; Rotarod Performance Test; Stereotaxic Techniques; Time Factors | 2011 |
Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Behavior, Animal; Cold Temperature; Constriction; Cyclopropanes; Disease Models, Animal; Hyperalgesia; Milnacipran; Neuralgia; Rats; Sciatic Nerve; Time Factors | 2011 |
Roles of exogenous and endogenous FGF-2 in animal models of depression.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Avoidance Learning; Brain; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Exploratory Behavior; Fibroblast Growth Factor 2; Fluoresceins; Hindlimb Suspension; Humans; Immobility Response, Tonic; Indoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Motor Activity; Neuropeptides; Olfactory Bulb; Organic Chemicals; Silver Staining | 2011 |
Modulators of sphingolipid metabolism reduce lung inflammation.
Topics: 1-Deoxynojirimycin; Amitriptyline; Animals; Anti-Inflammatory Agents; Cell Line; Ceramides; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunity, Innate; Inflammation Mediators; Interleukin-8; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Pneumonia; Pseudomonas aeruginosa; Respiratory Mucosa | 2011 |
Antidepressant-like effect of aqueous extract of Channa striatus fillet in mice models of depression.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Fish Products; Fresh Water; Hindlimb Suspension; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Motor Activity; Perciformes; Swimming; Time Factors; Tissue Extracts | 2011 |
Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Male; Mice; Motor Activity; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C-epsilon; Signal Transduction; Swimming | 2012 |
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats.
Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ligation; Male; Morphine; Morpholines; Naphthalenes; Neuralgia; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Time Factors | 2011 |
The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus.
Topics: Amitriptyline; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dura Mater; Electric Stimulation; Male; Migraine Disorders; Olfactory Bulb; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Superior Sagittal Sinus | 2011 |
A possible role to nitric oxide in the anti-inflammatory effects of amitriptyline.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Cytokines; Disease Models, Animal; Edema; Enzyme Inhibitors; Inflammation; Leukocytes; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peritonitis; Rats; Rats, Sprague-Dawley; Skin Diseases | 2012 |
Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior.
Topics: Amitriptyline; Animals; Anxiety; Biogenic Monoamines; Cell Count; Ciliary Neurotrophic Factor; Citalopram; Depression; Disease Models, Animal; Female; GABAergic Neurons; Helplessness, Learned; Hippocampus; Interneurons; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Motor Skills; Receptor, Serotonin, 5-HT1A; Rotarod Performance Test; Sensory Gating | 2012 |
Electrocardiographic toxicity in the guinea pig.
Topics: Amitriptyline; Anesthesia; Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Guinea Pigs; Heart Arrest; Male; Papaverine; Quinidine; Specimen Handling | 2002 |
[Anti-inflammatory effects of amitriptyline, diazepam and mebicar using model of acute carrageenan-induced paw edema in rats].
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biureas; Carrageenan; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Female; Foot Diseases; Male; Rats | 2011 |
Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction.
Topics: Amitriptyline; Animals; Disease Models, Animal; Fibrosis; Male; Rats; Rats, Wistar; Transforming Growth Factor beta1; Urinary Bladder; Urinary Bladder Neck Obstruction | 2012 |
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine Hydrochloride; Fluoxetine; Immersion; Indomethacin; Male; Mianserin; Mirtazapine; Rats; Rats, Sprague-Dawley; Reserpine; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Thiophenes; Water | 2012 |
Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Mice; Mice, Inbred C57BL; Neuralgia; Physical Stimulation; Triazoles; Voltage-Gated Sodium Channels | 2013 |
Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Anxiety; Blood Pressure; Cats; Clonidine; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fear; Hypertension; Male; Maze Learning; Memory Disorders; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Stress Disorders, Post-Traumatic; Thiazepines | 2013 |
Prolonged analgesic effect of amitriptyline base on thermal hyperalgesia in an animal model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Ligation; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2013 |
Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies.
Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cats; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Overdose; Imipramine; Iprindole; Lung Diseases; Pulmonary Artery; Rats; Rats, Wistar; Vascular Diseases | 2002 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Fluoxetine; Imipramine; Inflammation; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sertraline; Trazodone | 2003 |
Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Disease Models, Animal; Female; Helplessness, Learned; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Motor Activity; Sex Factors; Swimming | 2003 |
Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain.
Topics: Amitriptyline; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley | 2004 |
Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Herpes Simplex; Herpesvirus 1, Human; Mice; Mice, Inbred BALB C; Pain; Physical Stimulation; Time Factors | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cyclohexanols; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Methyltyrosines; Milnacipran; Neuromuscular Junction; Norepinephrine; p-Chloroamphetamine; Pain; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Thiophenes; Venlafaxine Hydrochloride | 2004 |
Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation.
Topics: Amitriptyline; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Hyperalgesia; Male; Microspheres; Nerve Block; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2004 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopram; Disease Models, Animal; Duloxetine Hydrochloride; Male; Mianserin; Mirtazapine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2005 |
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Morphine; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Species Specificity; Treatment Outcome | 2005 |
Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain.
Topics: Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Benzoxazines; Blotting, Western; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Ligation; Lumbosacral Region; Male; Morpholines; Naphthalenes; Neuralgia; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Opioid, mu; Sciatic Nerve; Skin | 2005 |
Amiodarone fails to improve survival in amitriptyline-poisoned mice.
Topics: Amiodarone; Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Disease Models, Animal; Female; Injections, Intraperitoneal; Lethal Dose 50; Longevity; Mice; Poisoning; Survival Rate | 2005 |
Administration of amitriptyline attenuates noise-induced hearing loss via glial cell line-derived neurotrophic factor (GDNF) induction.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Auditory Threshold; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Female; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Guinea Pigs; Hair Cells, Auditory; Hearing Loss, Noise-Induced | 2007 |
Antinociceptive effect of amitriptyline in mice of acute pain models.
Topics: Acute Disease; Amitriptyline; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Pain | 2007 |
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drugs, Investigational; Fluoxetine; Guinea Pigs; Injections, Intraperitoneal; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Paroxetine; Piperidines; Selective Serotonin Reuptake Inhibitors; Swimming; Tranylcypromine | 2007 |
Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia; Nortriptyline; Receptors, Opioid, delta; Sciatica | 2008 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Memantine; Mice; Mice, Inbred C57BL; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System; Phenylephrine; Piperazines; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Reproducibility of Results; Spinal Cord; Spinal Nerves; Time Factors | 2008 |
Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Chronic Disease; Conditioning, Operant; Corticosterone; CREB-Binding Protein; Dentate Gyrus; Depressive Disorder, Major; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Extracellular Signal-Regulated MAP Kinases; Fluoxetine; Heat-Shock Proteins; Hippocampus; Locomotion; Mice; Mice, Inbred C57BL; Molecular Chaperones; Motivation; Selective Serotonin Reuptake Inhibitors | 2008 |
Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Escape Reaction; Helplessness, Learned; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain Measurement; Physical Conditioning, Animal; Reaction Time; Swimming; Time Factors | 2008 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Disease; Cyclohexanecarboxylic Acids; Denervation; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ligation; Male; Mice; Mice, Inbred C57BL; Narcotic Antagonists; Nortriptyline; Opioid Peptides; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Receptors, Opioid; Sciatic Neuropathy | 2008 |
Cerebromicrocirculatory defects in animal model of depression.
Topics: Amitriptyline; Animals; Brain; Carbon Dioxide; Cerebrovascular Circulation; Depression; Disease Models, Animal; Dopamine; Humans; Male; Microcirculation; Norepinephrine; Rats; Rats, Inbred Strains; Tetrabenazine | 1984 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Fluvoxamine; Imipramine; Male; Maprotiline; Mianserin; Oximes; Rats; Rats, Inbred Strains; Seizures; Viloxazine | 1984 |
Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Humans; Male; Methysergide; Mianserin; Piperazines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Synapses; Trazodone | 1984 |
Pre- and postsynaptic serotonergic manipulations in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Drug Synergism; Fluoxetine; Humans; Male; Methysergide; Propylamines; Rats; Serotonin | 1980 |
Postsynaptic action by four antidepressive drugs in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Humans; Imipramine; Iprindole; Male; Methysergide; Mianserin; Rats; Rats, Inbred Strains; Synapses | 1981 |
Amitriptyline and scopolamine in an animal model of depression.
Topics: Amitriptyline; Animals; Antidepressive Agents; Corticosterone; Defecation; Depression; Disease Models, Animal; Drug Therapy, Combination; Humans; Latency Period, Psychological; Male; Motor Activity; Rats; Scopolamine | 1981 |
Loss-induced depression in an adult macaque monkey.
Topics: Amitriptyline; Animals; Depressive Disorder; Disease Models, Animal; Female; Grief; Humans; Macaca nemestrina; Pregnancy; Social Behavior | 1982 |
Biochemical and behaviour changes induced by acute stress in a chronic variate stress model of depression: the effect of amitriptyline.
Topics: Amitriptyline; Animals; Behavior, Animal; Chronic Disease; Depression; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Serotonin; Stress, Physiological | 1995 |
Effects of amitriptyline on GABA-stimulated 36CI- uptake in relation to a behavioral model of depression.
Topics: Amitriptyline; Analysis of Variance; Animals; Chlorine; Depression; Disease Models, Animal; Dominance-Subordination; gamma-Aminobutyric Acid; Male; Radioisotopes; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57B1/6j but not in DBA/2j mice.
Topics: Alcohol Drinking; Amitriptyline; Animals; Antidepressive Agents; Arousal; Depressive Disorder; Disease Models, Animal; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Olfactory Bulb; Smell; Species Specificity; Trazodone | 1994 |
An animal model of postmortem amitriptyline redistribution.
Topics: Amitriptyline; Animals; Disease Models, Animal; Drug Overdose; Liver; Lung; Male; Nortriptyline; Postmortem Changes; Rats; Rats, Wistar; Tissue Distribution | 1993 |
Epinephrine and sodium bicarbonate independently and additively increase survival in experimental amitriptyline poisoning.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Disease Models, Animal; Drug Combinations; Electrolytes; Epinephrine; Hemodynamics; Humans; Male; Norepinephrine; Poisoning; Rats; Rats, Sprague-Dawley; Sodium Bicarbonate; Survival Rate; Sympathomimetics | 1997 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Overdose; Imipramine; Lung; Maprotiline; Mianserin; Microscopy, Electron; Nortriptyline; Organ Size; Perfusion; Pulmonary Edema; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley | 1997 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Clonazepam; Dinoprostone; Disease Models, Animal; Hyperalgesia; Indomethacin; Male; Neuralgia; Pain; Pain Threshold; Peripheral Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Sciatic Nerve; Seminal Vesicles; Sheep; Substance P | 1999 |
Amitriptyline-induced constipation in cynomolgus monkeys is beneficial for the evaluation of laxative efficacy.
Topics: Amitriptyline; Animals; Anthraquinones; Bisacodyl; Cathartics; Constipation; Disease Models, Animal; Eating; Evaluation Studies as Topic; Feces; Macaca fascicularis; Male; Senna Extract; Sennosides | 2000 |
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Ligation; Male; Pain; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Herpes Simplex; Herpesvirus 1, Human; Hyperalgesia; Mice; Mice, Inbred BALB C; Morphine; Neuralgia; Neurons, Afferent; Pain | 2000 |
Effect of amitriptyline on daily variations in cell composition of immune organs in rats with experimental desynchronosis.
Topics: Amitriptyline; Animals; Antidepressive Agents; Chronobiology Disorders; Circadian Rhythm; Disease Models, Animal; Leukocyte Count; Light; Lymphocyte Count; Lymphoid Tissue; Male; Rats; Rats, Wistar; Thymus Gland | 2000 |
Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: effect of antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Binding Sites; Carrier Proteins; Depression; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Fluoxetine; Hypothalamo-Hypophyseal System; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Transgenic; Motor Activity; Neostriatum; Nerve Tissue Proteins; Neurons; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Glucocorticoid; Stress, Physiological; Substantia Nigra | 2001 |
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Ligation; Male; Neuralgia; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Nerves; Time Factors; Weight Gain | 2001 |
Studies with activated charcoal in the treatment of drug overdosage using the pig as an animal model.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Amobarbital; Animals; Charcoal; Disease Models, Animal; Intestinal Absorption; Poisoning; Swine; Time Factors | 1975 |
Antinociceptive action of tricyclic antidepressant drugs in the rat.
Topics: Amitriptyline; Analgesia; Animals; Delayed-Action Preparations; Desipramine; Disease Models, Animal; Male; Rats; Rats, Inbred Strains; Time Factors | 1990 |
The effects of chronic antidepressant treatment in an animal model of anxiety.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anxiety; Desipramine; Diazepam; Disease Models, Animal; Flumazenil; Male; Rats; Time Factors | 1988 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease Models, Animal; Epilepsy; Ethosuximide; Imipramine; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1985 |
Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats.
Topics: 11-Hydroxycorticosteroids; Amitriptyline; Animals; Antidepressive Agents; Brain Diseases; Depressive Disorder; Disease Models, Animal; Iprindole; Male; Mianserin; Olfactory Bulb; Rats; Tranylcypromine | 1986 |
Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.
Topics: Acridines; Amitriptyline; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Diphenhydramine; Disease Models, Animal; Electroshock; Ethanol; Humans; Imipramine; Male; Maprotiline; Mianserin; Mice; Motor Activity; Nialamide; Pargyline; Tranylcypromine | 1985 |
Effects of psychotropic drugs on discrimination conditioning in olfactory bulbectomized rats.
Topics: Amitriptyline; Animals; Avoidance Learning; Chlordiazepoxide; Chlorpromazine; Discrimination Learning; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Male; Mental Disorders; Methamphetamine; Olfactory Bulb; Psychotropic Drugs; Rats; Rats, Inbred Strains | 1985 |
Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis.
Topics: Amitriptyline; Animals; Arthritis; Arthritis, Experimental; Behavior, Animal; Body Weight; Disease Models, Animal; Imipramine; Locomotion; Male; Pain; Rats; Rats, Inbred Strains; Time Factors; Vocalization, Animal | 1985 |