amitriptyline has been researched along with Diarrhea in 10 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effects of low-dose amitriptyline in the treatment of diarrhoea-predominant irritable bowel syndrome in a double-blind randomized-controlled trial." | 9.13 | Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome. ( Ghaffari, N; Kazzazi, AS; Malekzadeh, R; Merat, S; Momtahen, S; Olfati, G; Vahedi, H, 2008) |
| "CPT-11-induced diarrhea and colonic apoptosis were inhibited by amitriptyline at 6 h." | 7.91 | Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis. ( Bowen, JM; Coller, JK; Fakiha, K; Gibson, RJ; Logan, RM, 2019) |
| "To compare the effects of low-dose amitriptyline in the treatment of diarrhoea-predominant irritable bowel syndrome in a double-blind randomized-controlled trial." | 5.13 | Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome. ( Ghaffari, N; Kazzazi, AS; Malekzadeh, R; Merat, S; Momtahen, S; Olfati, G; Vahedi, H, 2008) |
| "CPT-11-induced diarrhea and colonic apoptosis were inhibited by amitriptyline at 6 h." | 3.91 | Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis. ( Bowen, JM; Coller, JK; Fakiha, K; Gibson, RJ; Logan, RM, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Wit, N | 1 |
| Keszthelyi, D | 1 |
| Fakiha, K | 1 |
| Coller, JK | 1 |
| Logan, RM | 1 |
| Gibson, RJ | 1 |
| Bowen, JM | 1 |
| Howell, CA | 1 |
| Mikhalovsky, SV | 1 |
| Markaryan, EN | 1 |
| Khovanov, AV | 1 |
| Lundberg, GD | 1 |
| Lakhan, SE | 1 |
| Chassany, O | 1 |
| Duracinsky, M | 1 |
| Sohn, W | 1 |
| Lee, OY | 1 |
| Kwon, JG | 1 |
| Park, KS | 1 |
| Lim, YJ | 1 |
| Kim, TH | 1 |
| Jung, SW | 1 |
| Kim, JI | 1 |
| Vahedi, H | 1 |
| Merat, S | 1 |
| Momtahen, S | 1 |
| Kazzazi, AS | 1 |
| Ghaffari, N | 1 |
| Olfati, G | 1 |
| Malekzadeh, R | 1 |
| Hislop, IG | 1 |
| Aderhold, RM | 1 |
| Muniz, CE | 1 |
2 trials available for amitriptyline and Diarrhea
| Article | Year |
|---|---|
Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Diarrhea; Female; Humans; Irritable Bo | 2012 |
Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Diarrhea; Double-Blind Method; Fem | 2008 |
8 other studies available for amitriptyline and Diarrhea
| Article | Year |
|---|---|
Low-dose amitriptyline in irritable bowel syndrome: ready for primary care?
Topics: Amitriptyline; Analgesics, Non-Narcotic; Diarrhea; Humans; Irritable Bowel Syndrome; Primary Health | 2023 |
Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis.
Topics: Amitriptyline; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Colon; Diarrhea; Disease Model | 2019 |
Investigation of the adsorption capacity of the enterosorbent Enterosgel for a range of bacterial toxins, bile acids and pharmaceutical drugs.
Topics: Adsorption; Amitriptyline; Bacterial Toxins; Bile Acids and Salts; Cetirizine; Charcoal; Diarrhea; E | 2019 |
Evidence that amitriptyline may be effective in treating diarrhea-predominant irritable bowel syndrome.
Topics: Amitriptyline; Diarrhea; Evidence-Based Medicine; Humans; Irritable Bowel Syndrome; Randomized Contr | 2008 |
A reader responds to "Evidence that amitriptyline may be effective in treating diarrhea-predominant irritable bowel syndrome".
Topics: Amitriptyline; Controlled Clinical Trials as Topic; Diarrhea; Humans; Irritable Bowel Syndrome; Suic | 2008 |
Is amitriptyline really effective in diarrhoea-predominant irritable bowel syndrome?
Topics: Amitriptyline; Analgesics, Non-Narcotic; Diarrhea; Humans; Irritable Bowel Syndrome | 2008 |
Psychological significance of the irritable colon syndrome.
Topics: Abdomen; Adolescent; Adult; Affective Symptoms; Age Factors; Aged; Amitriptyline; Child; Colonic Dis | 1971 |
Acute psychosis with amitriptyline and furazolidone.
Topics: Acute Disease; Amitriptyline; Bipolar Disorder; Diarrhea; Female; Furazolidone; Humans; Middle Aged; | 1970 |