amitriptyline has been researched along with Diabetes Mellitus in 10 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diabetic peripheral neuropathic pain (DPNP) is common and often distressing." | 3.11 | Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomise ( Ahmed, SH; Alam, U; Bennett, DL; Bouhassira, D; Bradburn, M; Cooper, C; Devers, M; Gandhi, R; Glover, R; Gouni, R; Hariman, C; Horspool, M; Johnson, M; Jude, EB; Julious, S; Loban, A; Maguire, D; McDougall, C; Petrie, J; Rajbhandari, S; Rayman, G; Rice, ASC; Selvarajah, D; Sharma, S; Sloan, G; Sutherland, K; Tesfaye, S; Tsatlidis, V; Turton, E; Vas, P; Waterhouse, S; White, D, 2022) |
| "amitriptyline treatment for 6 weeks and pregabalin added if needed for a further 10 weeks, duloxetine treatment for 6 weeks and pregabalin added if needed for a further 10 weeks and pregabalin treatment for 6 weeks and amitriptyline added if needed for a further 10 weeks); however, the order of the treatment pathways was decided at random." | 3.11 | Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT. ( Ahmed, SH; Alam, U; Bennett, DL; Bouhassira, D; Bradburn, M; Cooper, C; Devers, M; Gandhi, R; Glover, R; Gouni, R; Hariman, C; Horspool, M; Johnson, M; Jude, E; Julious, SA; Loban, A; Maguire, D; McDougall, C; Petrie, J; Rajbhandari, S; Rayman, G; Selvarajah, D; Sharma, S; Sloan, G; Sutherland, K; Tesfaye, S; Tsatlidis, V; Turton, E; Vas, P; Waterhouse, S; White, D; Young, T, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 5 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tesfaye, S | 3 |
| Sloan, G | 2 |
| Petrie, J | 2 |
| White, D | 2 |
| Bradburn, M | 2 |
| Julious, S | 1 |
| Rajbhandari, S | 2 |
| Sharma, S | 2 |
| Rayman, G | 2 |
| Gouni, R | 2 |
| Alam, U | 2 |
| Cooper, C | 2 |
| Loban, A | 2 |
| Sutherland, K | 2 |
| Glover, R | 2 |
| Waterhouse, S | 2 |
| Turton, E | 2 |
| Horspool, M | 2 |
| Gandhi, R | 2 |
| Maguire, D | 2 |
| Jude, EB | 1 |
| Ahmed, SH | 2 |
| Vas, P | 2 |
| Hariman, C | 2 |
| McDougall, C | 2 |
| Devers, M | 2 |
| Tsatlidis, V | 2 |
| Johnson, M | 2 |
| Rice, ASC | 1 |
| Bouhassira, D | 2 |
| Bennett, DL | 2 |
| Selvarajah, D | 2 |
| Young, T | 1 |
| Julious, SA | 1 |
| Jude, E | 1 |
| Barry, HC | 1 |
| Saul, H | 1 |
| Deeney, B | 1 |
| Imison, C | 1 |
| Eissa, RG | 1 |
| Eissa, NG | 1 |
| Eissa, RA | 1 |
| Diab, NH | 1 |
| Abdelshafi, NA | 1 |
| Shaheen, MA | 1 |
| Elsabahy, M | 1 |
| Hammad, SK | 1 |
| Andersohn, F | 1 |
| Schade, R | 1 |
| Suissa, S | 1 |
| Garbe, E | 1 |
| BATTERMAN, RC | 1 |
| KAUFMAN, JE | 1 |
| MOURATOFF, GJ | 1 |
| Ball, S | 1 |
| Woods, HF | 1 |
| Alberti, KG | 1 |
| Moses, AM | 1 |
| Miller, M | 1 |
| Kilpatrick, R | 1 |
| Smith, AJ | 1 |
2 reviews available for amitriptyline and Diabetes Mellitus
| Article | Year |
|---|---|
Drug-induced dilutional hyponatremia.
Topics: Acetaminophen; Amitriptyline; Animals; Anura; Body Fluids; Carbamazepine; Chlorpropamide; Clofibrate | 1974 |
Advances in medicine.
Topics: Amitriptyline; Cholera; Coronary Disease; Crohn Disease; Diabetes Mellitus; Diet Therapy; Diverticul | 1971 |
3 trials available for amitriptyline and Diabetes Mellitus
| Article | Year |
|---|---|
Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomise
Topics: Amitriptyline; Analgesics; Cross-Over Studies; Diabetes Mellitus; Diabetic Neuropathies; Double-Blin | 2022 |
Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT.
Topics: Adult; Amitriptyline; Cost-Benefit Analysis; Diabetes Mellitus; Duloxetine Hydrochloride; Humans; Ne | 2022 |
Combination therapy for painful diabetic neuropathy is safe and effective.
Topics: Amitriptyline; Analgesics; Diabetes Mellitus; Diabetic Neuropathies; Double-Blind Method; Duloxetine | 2023 |
5 other studies available for amitriptyline and Diabetes Mellitus
| Article | Year |
|---|---|
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better.
Topics: Amitriptyline; Analgesics; Diabetes Mellitus; Diabetic Neuropathies; Duloxetine Hydrochloride; Human | 2023 |
Oral proniosomal amitriptyline and liraglutide for management of diabetic neuropathy: Exceptional control over hyperglycemia and neuropathic pain.
Topics: Amitriptyline; Animals; Blood Glucose; Diabetes Mellitus; Diabetic Neuropathies; Humans; Hyperglycem | 2023 |
Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Body Mass Index; Case-Control Studies; Cyclohexanol | 2009 |
CLINICAL USE OF AMITRIPTYLINE FOR THE TREATMENT OF PSYCHONEUROTIC REACTIVE ANXIETY AND DEPRESSION.
Topics: Amitriptyline; Anxiety; Arthritis, Rheumatoid; Asthma; Coronary Disease; Depression; Diabetes Mellit | 1964 |
Lacticacidosis, ketoacidosis, and hyperalaninaemia in a phenformintreated diabetic patient.
Topics: Acetoacetates; Alanine; Amitriptyline; Bicarbonates; Blood Glucose; Chlorpropamide; Diabetes Mellitu | 1974 |