Page last updated: 2024-10-22
amitriptyline and Dermatitis, Radiation-Induced
amitriptyline has been researched along with Dermatitis, Radiation-Induced in 1 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| "The University of Washington Neuropathic Pain Scale was used to grade the neuropathic pain before and after use of the interventional gel." | 1.38 | Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction: a pilot study. ( Gerbis, B; Gillis, D; Holwerda, E; Uzaraga, I; Wai, E, 2012) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Uzaraga, I | 1 |
| Gerbis, B | 1 |
| Holwerda, E | 1 |
| Gillis, D | 1 |
| Wai, E | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Mechanical Thresholds (Mechanical Detection and Pain).
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) |
|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold |
|---|
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
,| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
,| Topical Ketamine | 3.464204768 | 135.9 |
,| Topical Lidocaine | 3.546037659 | 126.9 |
,| Topical Vehicle | 3.525692637 | 148.7138273 |
Thermal Threshold Detection (Warmth and Heat Pain)
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) |
|---|
| Warm Detection Threshold | Heat Pain Threshold |
|---|
| Topical Amitriptyline | 33.9 | 40.0 |
,| Topical KeAmLi Combo | 33.6 | 39.8 |
,| Topical Ketamine | 34.0 | 40.0 |
,| Topical Lidocaine | 33.7 | 39.4 |
,| Topical Vehicle | 33.8 | 39.7 |
Other Studies
1 other study available for amitriptyline and Dermatitis, Radiation-Induced