amitriptyline has been researched along with Depressive Disorder, Treatment-Resistant in 3 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Depressive Disorder, Treatment-Resistant: Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)
| Excerpt | Relevance | Reference |
|---|---|---|
| " A cautious dosing of AMI with VPA comedication is advisable, and therapeutic drug monitoring should be performed because this combination may lead to a remarkable increase of AMI and NOR serum levels." | 1.39 | Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions. ( Burger, R; Deckert, J; Hohage, A; Pfuhlmann, B; Unterecker, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferreira-Garcia, R | 1 |
| da Rocha Freire, RC | 1 |
| Appolinário, JC | 1 |
| Levitan, MN | 1 |
| Halkjær-Lassen, RD | 1 |
| Bueno, JR | 1 |
| Nardi, AE | 1 |
| Sobennikov, VS | 1 |
| Prokop'eva, ML | 1 |
| Unterecker, S | 1 |
| Burger, R | 1 |
| Hohage, A | 1 |
| Deckert, J | 1 |
| Pfuhlmann, B | 1 |
3 other studies available for amitriptyline and Depressive Disorder, Treatment-Resistant
| Article | Year |
|---|---|
Tranylcypromine Plus Amitriptyline for Electroconvulsive Therapy-Resistant Depression: A Long-Term Study.
Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cohort Studies; Depre | 2018 |
[The combined therapy with valdoxan and amitriptyline of treatment resistant somatized depression].
Topics: Acetamides; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Circadian Rhythm; Depressive Dis | 2013 |
Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chi-Square Distribution; Delirium; Depressive Dis | 2013 |