amitriptyline has been researched along with Delirium in 29 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Delirium: A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a case of acute intoxication with a tricyclic antidepressant (amitriptyline) delirium was prolonged without there being prominent peripheral anticholinergic or electrocardiographic signs." | 7.66 | Prolonged delirium without anticholinergic signs following amitriptyline overdose. ( Gomolin, IH; Melmed, CA, 1983) |
| " We report an unusual case of a patient who experienced symptoms of delirium and hyperkinetic movement disorders shortly after initiating treatment with cyclobenzaprine and oxycodone." | 3.79 | Neuropsychiatric side effects of cyclobenzaprine. ( Sederholm, B; Shprecher, D; Sloan, CT, 2013) |
| "We present a case of delirium due to amitriptyline overdose, which resolved rapidly following initiation of the cholinesterase inhibitor donepezil." | 3.72 | Donepezil for anticholinergic drug intoxication: a case report. ( Aksu, H; Elbi, H; Noyan, MA, 2003) |
| "In a case of acute intoxication with a tricyclic antidepressant (amitriptyline) delirium was prolonged without there being prominent peripheral anticholinergic or electrocardiographic signs." | 3.66 | Prolonged delirium without anticholinergic signs following amitriptyline overdose. ( Gomolin, IH; Melmed, CA, 1983) |
| "Successful treatment of delirium depends on the detection of the reversible contributors." | 1.72 | Incidence of Drug-Induced Delirium During Treatment With Antidepressants or Antipsychotics: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2016. ( Engel, R; Frey, R; Friedrich, ME; Grohmann, R; Kasper, S; Konstantinidis, A; Rabl, U; Seifert, J; Stübner, S; Toto, S; Winkler, D, 2022) |
| " A cautious dosing of AMI with VPA comedication is advisable, and therapeutic drug monitoring should be performed because this combination may lead to a remarkable increase of AMI and NOR serum levels." | 1.39 | Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions. ( Burger, R; Deckert, J; Hohage, A; Pfuhlmann, B; Unterecker, S, 2013) |
| "Drug-induced delirium is a common matter in the elderly and anticholinergics, together with a number of different drugs, may significantly contribute to the delirium onset, especially in demented people." | 1.34 | Anticholinergic drug-induced delirium in an elderly Alzheimer's dementia patient. ( Cotroneo, A; De Fazio, P; De Fazio, S; De Sarro, G; Gallelli, L; Gareri, P; Lacava, R, 2007) |
| "Delirium was documented in 10 cases." | 1.27 | Tricyclic antidepressants and delirium. ( Isenberg, K; Livingston, RL; Wetzel, RD; Zucker, DK, 1983) |
| " Thus, this adverse effect could be avoided by monitoring levels and reducing dosage when appropriate." | 1.26 | Tricyclic-antidepressant-induced delirium and plasma drug concentration. ( Preskorn, SH; Simpson, S, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (72.41) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 2 (6.90) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Friedrich, ME | 1 |
| Grohmann, R | 1 |
| Rabl, U | 1 |
| Winkler, D | 1 |
| Konstantinidis, A | 1 |
| Engel, R | 1 |
| Seifert, J | 1 |
| Toto, S | 1 |
| Stübner, S | 1 |
| Frey, R | 1 |
| Kasper, S | 1 |
| Shprecher, D | 1 |
| Sloan, CT | 1 |
| Sederholm, B | 1 |
| Unterecker, S | 1 |
| Burger, R | 1 |
| Hohage, A | 1 |
| Deckert, J | 1 |
| Pfuhlmann, B | 1 |
| Brennan-Taylor, MK | 1 |
| Noyan, MA | 1 |
| Elbi, H | 1 |
| Aksu, H | 1 |
| ARNOLD, OH | 2 |
| KRYSPIN-EXNER, K | 1 |
| Gareri, P | 1 |
| De Fazio, P | 1 |
| Cotroneo, A | 1 |
| Lacava, R | 1 |
| Gallelli, L | 1 |
| De Fazio, S | 1 |
| De Sarro, G | 1 |
| Kahr, H | 1 |
| Battegay, R | 1 |
| Pöldinger, W | 1 |
| Krypsin-Exner, K | 1 |
| Werner, V | 1 |
| Diehl, LW | 1 |
| Zechnich, R | 1 |
| Gomolin, IH | 1 |
| Melmed, CA | 1 |
| Stern, TA | 1 |
| Livingston, RL | 1 |
| Zucker, DK | 1 |
| Isenberg, K | 1 |
| Wetzel, RD | 1 |
| Pies, R | 1 |
| Preskorn, SH | 1 |
| Simpson, S | 1 |
| Teas, GA | 1 |
| Rechlin, T | 1 |
| Weis, M | 1 |
| Claus, D | 1 |
| Kaschka, WP | 1 |
| Engel, PA | 1 |
| Chapron, D | 1 |
| Hollender, MH | 1 |
| Jamieson, RC | 1 |
| McKee, EA | 1 |
| Roback, HB | 1 |
| Mühlendahl, KE | 1 |
| Hammersen, G | 1 |
| Krienke, EG | 1 |
| Figiel, GS | 1 |
| Krishnan, KR | 1 |
| Breitner, JC | 1 |
| Nemeroff, CB | 1 |
| Schwartz, J | 1 |
| Speed, N | 1 |
| Clavier, E | 1 |
| Heiser, JF | 1 |
| Wilbert, DE | 1 |
| Sommer, J | 1 |
| Spiegelberg, U | 1 |
| Rawson, RA | 1 |
| Lipscomb, WR | 1 |
| Rozynko, J | 1 |
| Voelkel, A | 1 |
| Mikhalenko, IN | 1 |
| Nuller, IuL | 1 |
| Boleloucky-Bolen, P | 1 |
| Hofmann, G | 1 |
1 review available for amitriptyline and Delirium
| Article | Year |
|---|---|
[The state of psychopharmacotherapy in geriatrics 2].
Topics: Actihaemyl; Aged; Amitriptyline; Bencyclane; Cerebrovascular Circulation; Clorazepate Dipotassium; D | 1980 |
1 trial available for amitriptyline and Delirium
| Article | Year |
|---|---|
[Noxiptilin in clinic and practice].
Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Central Nervous System; Clinical Trials as T | 1969 |
27 other studies available for amitriptyline and Delirium
| Article | Year |
|---|---|
Incidence of Drug-Induced Delirium During Treatment With Antidepressants or Antipsychotics: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2016.
Topics: Adverse Drug Reaction Reporting Systems; Amitriptyline; Antidepressive Agents; Antipsychotic Agents; | 2022 |
Neuropsychiatric side effects of cyclobenzaprine.
Topics: Amitriptyline; Antidepressive Agents; Delirium; Humans; Male; Middle Aged; Movement Disorders; Muscl | 2013 |
Interaction of valproic acid and amitriptyline: analysis of therapeutic drug monitoring data under naturalistic conditions.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chi-Square Distribution; Delirium; Depressive Dis | 2013 |
"Mom, You Have to Trust Me".
Topics: Aged, 80 and over; Amitriptyline; Cross Infection; Delirium; Fatal Outcome; Female; Humans; Medicati | 2015 |
Donepezil for anticholinergic drug intoxication: a case report.
Topics: Amitriptyline; Cholinergic Antagonists; Delirium; Donepezil; Drug Overdose; Humans; Indans; Male; Mi | 2003 |
[EXPERIMENTAL DELIRIUM].
Topics: Amitriptyline; Delirium; Pharmacology; Toxicology | 1964 |
Anticholinergic drug-induced delirium in an elderly Alzheimer's dementia patient.
Topics: Acute Disease; Aged, 80 and over; Alzheimer Disease; Amitriptyline; Antipsychotic Agents; Cholinergi | 2007 |
[Psychopathological complications in antidepressant medication].
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Delirium; Depression; Desipramine; Do | 1966 |
[Spontaneous and experimental delirium].
Topics: Alcoholism; Amitriptyline; Brain; Delirium; Hallucinations; Hallucinogens; Humans; Judgment; Psychos | 1966 |
Delirium and tricyclic antidepressants.
Topics: Akathisia, Drug-Induced; Amitriptyline; Confusion; Delirium; Female; Humans | 1984 |
Prolonged delirium without anticholinergic signs following amitriptyline overdose.
Topics: Amitriptyline; Delirium; Depression; Female; Humans; Nortriptyline; Parasympatholytics; Physostigmin | 1983 |
Continuous infusion of physostigmine in anticholinergic delirium: case report.
Topics: Adult; Amitriptyline; Benztropine; Delirium; Female; Humans; Infusions, Parenteral; Parasympatholyti | 1983 |
Tricyclic antidepressants and delirium.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Black People; | 1983 |
Capgras phenomenon, delirium, and transient hepatic dysfunction.
Topics: Adolescent; Amitriptyline; Capgras Syndrome; Chemical and Drug Induced Liver Injury; Delirium; Drug | 1982 |
Tricyclic-antidepressant-induced delirium and plasma drug concentration.
Topics: Adult; Aged; Amitriptyline; Delirium; Depressive Disorder; Dose-Response Relationship, Drug; Female; | 1982 |
Toxic delirium resulting from combination antidepressant therapy.
Topics: Amitriptyline; Bipolar Disorder; Delirium; Drug Therapy, Combination; Humans; Male; Middle Aged; Phe | 1981 |
Identifying delirious states and autonomic cardiovascular dysfunction associated with amitriptyline treatment by standardized analysis of heart rate.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Autonomic Nervous System Diseases; Car | 1995 |
Cyclobenzaprine-induced delirium in two octogenarians.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amitriptyline; Delirium; Female; Humans; Ma | 1993 |
Anticholinergic delirium in a case of Munchausen syndrome.
Topics: Adult; Amitriptyline; Chlorpromazine; Delirium; Female; Humans; Munchausen Syndrome; Ophthalmic Solu | 1978 |
[Physostigmine treatment in poisoning with anticholinergicagent].
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidotes; Child; Child, Preschool; Delirium; Female; Humans | 1977 |
Radiologic correlates of antidepressant-induced delirium: the possible significance of basal-ganglia lesions.
Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Basal Ganglia; Basal Ganglia Diseases | 1989 |
Antidepressant side effects in the medically ill: the value of psychiatric consultation.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Delirium; Doxepin; Humans; Mal | 1988 |
Reversal of delirium induced by tricyclic antidepressant drugs with physostigmine.
Topics: Amitriptyline; Antidotes; Delirium; Drug Combinations; Female; Humans; Male; Middle Aged; Perphenazi | 1974 |
Acute delirium in amitriptyline-perphenazine therapy of alcoholism.
Topics: Acute Disease; Adult; Alcoholism; Amitriptyline; Delirium; Diazepam; Drug Combinations; Hallucinatio | 1971 |
[Complications caused by anonymous preclinical medication].
Topics: Amitriptyline; Antidepressive Agents; Barbiturates; Bromides; Cannabis; Chlordiazepoxide; Delirium; | 1970 |
[Clinical trial of damilen (amitriptylene)].
Topics: Adolescent; Adult; Aged; Amitriptyline; Delirium; Depression; Female; Humans; Male; Middle Aged; Uri | 1967 |
[Delirious syndrome in connection with treatment and overdosis (SMV) amitriptyline].
Topics: Adult; Age Factors; Aged; Alcoholism; Amitriptyline; Central Nervous System Diseases; Delirium; Fema | 1968 |