amitriptyline has been researched along with Cystic Fibrosis in 6 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline, a blocker of acid sphingomyelinase and acid ceramidase, significantly reduces Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) mice with concurrent increase of survival." | 9.14 | Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. ( Anthonysamy, J; Döring, G; Gulbins, E; Riethmüller, J; Schwab, M; Serra, E, 2009) |
| "Amitriptyline, a blocker of acid sphingomyelinase and acid ceramidase, significantly reduces Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) mice with concurrent increase of survival." | 5.14 | Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. ( Anthonysamy, J; Döring, G; Gulbins, E; Riethmüller, J; Schwab, M; Serra, E, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abu-Arish, A | 1 |
| Pandžić, E | 1 |
| Kim, D | 1 |
| Tseng, HW | 1 |
| Wiseman, PW | 1 |
| Hanrahan, JW | 1 |
| Ziobro, R | 1 |
| Henry, B | 1 |
| Edwards, MJ | 1 |
| Lentsch, AB | 1 |
| Gulbins, E | 4 |
| Nährlich, L | 1 |
| Mainz, JG | 1 |
| Adams, C | 2 |
| Engel, C | 1 |
| Herrmann, G | 2 |
| Icheva, V | 2 |
| Lauer, J | 2 |
| Deppisch, C | 2 |
| Wirth, A | 1 |
| Unger, K | 1 |
| Graepler-Mainka, U | 2 |
| Hector, A | 1 |
| Heyder, S | 2 |
| Stern, M | 1 |
| Döring, G | 2 |
| Riethmüller, J | 2 |
| Riethmueller, J | 1 |
| Anthonysamy, J | 1 |
| Serra, E | 1 |
| Schwab, M | 1 |
| Balfour-Lynn, IM | 1 |
2 trials available for amitriptyline and Cystic Fibrosis
| Article | Year |
|---|---|
Therapy of CF-patients with amitriptyline and placebo--a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Ceramides; Cohort Studies; Cystic Fi | 2013 |
Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis.
Topics: Adult; Amitriptyline; Anti-Bacterial Agents; Bacterial Infections; Cystic Fibrosis; Enzyme Inhibitor | 2009 |
4 other studies available for amitriptyline and Cystic Fibrosis
| Article | Year |
|---|---|
Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains.
Topics: Amitriptyline; Apoptosis; Carbachol; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Condu | 2019 |
Ceramide mediates lung fibrosis in cystic fibrosis.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Ceramides; Cystic Fibrosis; Cystic Fibrosis Tr | 2013 |
Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Body Weight; Ceramides; Clinical Trials, Pha | 2016 |
Cystic fibrosis papers of the year 2009.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Aspergillosis, Allergic Bronchopulmonary; Child; Ch | 2010 |