amitriptyline has been researched along with Cystic Fibrosis of Pancreas in 6 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline, a blocker of acid sphingomyelinase and acid ceramidase, significantly reduces Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) mice with concurrent increase of survival." | 9.14 | Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. ( Anthonysamy, J; Döring, G; Gulbins, E; Riethmüller, J; Schwab, M; Serra, E, 2009) |
| "Amitriptyline, a blocker of acid sphingomyelinase and acid ceramidase, significantly reduces Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) mice with concurrent increase of survival." | 5.14 | Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. ( Anthonysamy, J; Döring, G; Gulbins, E; Riethmüller, J; Schwab, M; Serra, E, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abu-Arish, A | 1 |
| Pandžić, E | 1 |
| Kim, D | 1 |
| Tseng, HW | 1 |
| Wiseman, PW | 1 |
| Hanrahan, JW | 1 |
| Ziobro, R | 1 |
| Henry, B | 1 |
| Edwards, MJ | 1 |
| Lentsch, AB | 1 |
| Gulbins, E | 4 |
| Nährlich, L | 1 |
| Mainz, JG | 1 |
| Adams, C | 2 |
| Engel, C | 1 |
| Herrmann, G | 2 |
| Icheva, V | 2 |
| Lauer, J | 2 |
| Deppisch, C | 2 |
| Wirth, A | 1 |
| Unger, K | 1 |
| Graepler-Mainka, U | 2 |
| Hector, A | 1 |
| Heyder, S | 2 |
| Stern, M | 1 |
| Döring, G | 2 |
| Riethmüller, J | 2 |
| Riethmueller, J | 1 |
| Anthonysamy, J | 1 |
| Serra, E | 1 |
| Schwab, M | 1 |
| Balfour-Lynn, IM | 1 |
2 trials available for amitriptyline and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Therapy of CF-patients with amitriptyline and placebo--a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Ceramides; Cohort Studies; Cystic Fi | 2013 |
Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis.
Topics: Adult; Amitriptyline; Anti-Bacterial Agents; Bacterial Infections; Cystic Fibrosis; Enzyme Inhibitor | 2009 |
4 other studies available for amitriptyline and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains.
Topics: Amitriptyline; Apoptosis; Carbachol; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Condu | 2019 |
Ceramide mediates lung fibrosis in cystic fibrosis.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Ceramides; Cystic Fibrosis; Cystic Fibrosis Tr | 2013 |
Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Body Weight; Ceramides; Clinical Trials, Pha | 2016 |
Cystic fibrosis papers of the year 2009.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Aspergillosis, Allergic Bronchopulmonary; Child; Ch | 2010 |