amitriptyline has been researched along with Craniofacial Pain in 23 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain." | 9.06 | The analgesic effect of amitriptyline on chronic facial pain. ( Dionne, RA; Dubner, R; Schmidt, E; Sharav, Y; Singer, E, 1987) |
| "Daily pain scores using a facial pain diary were recorded over eight weeks." | 6.78 | A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Patients often present with chronic facial pain despite normal nasal endoscopy and sinus computerized tomography." | 6.78 | Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Amitriptyline proved to be an efficient alternative treatment for chronic pain in TMD patients." | 6.71 | Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders. ( Ambrosano, GM; de Andrade, ED; de Barbosa, JR; Nogueira, MT; Rizzatti-Barbosa, CM, 2003) |
| "Depression was assessed by the Beck Depression Inventory (BDI) short form." | 6.69 | Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. ( Curtis, D; Levine, J; McCall, WD; Plesh, O, 2000) |
| " There was moderate evidence for amitriptyline in patients with atypical facial pain." | 5.12 | Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis. ( Ananth, A; Do, TM; Kattar, N; McCoul, ED; Unis, GD, 2021) |
| "The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain." | 5.06 | The analgesic effect of amitriptyline on chronic facial pain. ( Dionne, RA; Dubner, R; Schmidt, E; Sharav, Y; Singer, E, 1987) |
| "The most effective long-term treatments for tension-type mid-facial pain and facial migraine were low-dose amitriptyline and low-dose amitriptyline and triptans, respectively." | 3.80 | Prospective three-year follow up of a cohort study of 240 patients with chronic facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2014) |
| "Amitriptyline was the most useful drug in that it provided pain relief in musculoskeletal, vascular, and some neuropathic pain conditions." | 3.69 | Diagnosis and treatment of persistent pain after trauma to the head and neck. ( Benoliel, R; Eliav, E; Elishoov, H; Sharav, Y, 1994) |
| "Daily pain scores using a facial pain diary were recorded over eight weeks." | 2.78 | A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Patients often present with chronic facial pain despite normal nasal endoscopy and sinus computerized tomography." | 2.78 | Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. ( Agius, AM; Jones, NS; Muscat, R, 2013) |
| "Amitriptyline was administered and the dose was gradually increased up to a daily dose of 250 mg." | 2.72 | Efficacy of amitriptyline for treatment of somatoform pain disorder in the orofacial region: A case series. ( Ikawa, M; Ikeuchi, S; Yamada, K, 2006) |
| "Amitriptyline proved to be an efficient alternative treatment for chronic pain in TMD patients." | 2.71 | Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders. ( Ambrosano, GM; de Andrade, ED; de Barbosa, JR; Nogueira, MT; Rizzatti-Barbosa, CM, 2003) |
| "Depression was assessed by the Beck Depression Inventory (BDI) short form." | 2.69 | Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. ( Curtis, D; Levine, J; McCall, WD; Plesh, O, 2000) |
| "Atypical odontalgia describes atypical facial pain in apparently normal teeth." | 2.38 | Atypical odontalgia. ( Graff-Radford, SB; Solberg, WK, 1992) |
| "Recent evidence suggests that facial pain may not be related to the sinuses at all and that doctors may have to rethink their prescribing strategy." | 1.40 | Is 'sinus' pain really sinusitis? ( Agius, AM; Jones, NS; Muscat, R, 2014) |
| "The numbness was predominantly located in the innervated mental area and extended in some cases to the first and second trigeminal divisions." | 1.35 | Idiopathic trigeminal neuropathies: a presentation of 15 cases. ( Bagán, JV; García, B; Mora, E; Peñarrocha, M, 2009) |
| "Amitriptyline is a tricyclic antidepressant that is historically indicated and used to manage depression." | 1.33 | Prevalence of contraindicated medical conditions and use of precluded medications in patients with painful neuropathic disorders prescribed amitriptyline. ( Dukes, E; Gore, M; Leslie, DL; Rowbotham, D; Tai, KS, 2006) |
| "None of the patients reported any facial pain before surgery or trauma." | 1.31 | Facial pain following sinonasal surgery or facial trauma. ( Jones, NS; Khan, OA; Majumdar, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Do, TM | 1 |
| Unis, GD | 1 |
| Kattar, N | 1 |
| Ananth, A | 1 |
| McCoul, ED | 1 |
| Steel, SJ | 1 |
| Robertson, CE | 1 |
| Agius, AM | 4 |
| Jones, NS | 5 |
| Muscat, R | 4 |
| Alencar, FG | 1 |
| Viana, PG | 1 |
| Zamperini, C | 1 |
| Becker, A | 1 |
| Phillips, TJ | 1 |
| Farquhar-Smith, WP | 1 |
| Peñarrocha, M | 2 |
| Mora, E | 1 |
| Bagán, JV | 1 |
| García, B | 1 |
| Kasahara, M | 1 |
| Ichinohe, T | 1 |
| Sano, T | 1 |
| Fukuda, K | 1 |
| Kaneko, Y | 1 |
| Rizzatti-Barbosa, CM | 1 |
| Nogueira, MT | 1 |
| de Andrade, ED | 1 |
| Ambrosano, GM | 1 |
| de Barbosa, JR | 1 |
| Luccarini, P | 1 |
| Perrier, L | 1 |
| Dégoulange, C | 1 |
| Gaydier, AM | 1 |
| Dallel, R | 1 |
| Rokadiya, S | 1 |
| Malden, NJ | 1 |
| Ikawa, M | 1 |
| Yamada, K | 1 |
| Ikeuchi, S | 1 |
| Gore, M | 1 |
| Dukes, E | 1 |
| Rowbotham, D | 1 |
| Tai, KS | 1 |
| Leslie, DL | 1 |
| Benoliel, R | 1 |
| Eliav, E | 1 |
| Elishoov, H | 1 |
| Sharav, Y | 2 |
| Plesh, O | 1 |
| Curtis, D | 1 |
| Levine, J | 1 |
| McCall, WD | 1 |
| Raigrodski, AJ | 1 |
| Mohamed, SE | 1 |
| Gardiner, DM | 1 |
| Kohjitani, A | 1 |
| Miyawaki, T | 1 |
| Kasuya, K | 1 |
| Shimada, M | 1 |
| Khan, OA | 1 |
| Majumdar, S | 1 |
| Graff-Radford, SB | 1 |
| Solberg, WK | 1 |
| Hampf, G | 1 |
| Kuoppasalmi, K | 1 |
| Henriksson, M | 1 |
| Achté, K | 1 |
| Singer, E | 1 |
| Schmidt, E | 1 |
| Dionne, RA | 1 |
| Dubner, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for amitriptyline and Craniofacial Pain
| Article | Year |
|---|---|
Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis.
Topics: Adult; Amitriptyline; Botulinum Toxins, Type A; Carbamazepine; Facial Nerve; Facial Pain; Female; Hu | 2021 |
First Bite Syndrome: What Neurologists Need to Know.
Topics: Acetylcholine Release Inhibitors; Amitriptyline; Analgesics, Non-Narcotic; Botulinum Toxins; Carotid | 2021 |
Atypical odontalgia.
Topics: Adult; Afferent Pathways; Aged; Amitriptyline; Antidepressive Agents; Dental Care; Dental Pulp; Depr | 1992 |
8 trials available for amitriptyline and Craniofacial Pain
| Article | Year |
|---|---|
A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amitriptyline; Analysis of Variance; Antidepre | 2013 |
Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain.
Topics: Adrenergic beta-Antagonists; Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents, Tric | 2013 |
Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Clonidine; Double-Blind Method; Fa | 2014 |
Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Double-Blind Method; Facial Pain; | 2003 |
Efficacy of amitriptyline for treatment of somatoform pain disorder in the orofacial region: A case series.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Facial Pain; Female; Humans; Male; Middle Aged | 2006 |
Amitriptyline treatment of chronic pain in patients with temporomandibular disorders.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depression; Facial Pain; Fe | 2000 |
The effect of amitriptyline on pain intensity and perception of stress in bruxers.
Topics: Amitriptyline; Analysis of Variance; Antidepressive Agents, Tricyclic; Cross-Over Studies; Double-Bl | 2001 |
The analgesic effect of amitriptyline on chronic facial pain.
Topics: Adult; Amitriptyline; Analysis of Variance; Chronic Disease; Depression; Dose-Response Relationship, | 1987 |
12 other studies available for amitriptyline and Craniofacial Pain
| Article | Year |
|---|---|
Prospective three-year follow up of a cohort study of 240 patients with chronic facial pain.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Chronic Pain; Facial Pain | 2014 |
Is 'sinus' pain really sinusitis?
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Diagnosis, Differential; Disease Management; Facial Pai | 2014 |
Pharmacological treatment of a patient with first-bite syndrome.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cranial Nerve Neoplasms; Drug Therapy, Combi | 2009 |
Idiopathic trigeminal neuropathies: a presentation of 15 cases.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Cohort Studies; Facial Pain; Female; Humans; H | 2009 |
A case of zoster sine herpete of the trigeminal nerve.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Facial Pain; Female; Humans; Immunoglobulin G; Middle Aged; | 2011 |
Synergistic antinociceptive effect of amitriptyline and morphine in the rat orofacial formalin test.
Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; | 2004 |
Variable presentation of temporalis hypertrophy--A case report with literature review.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Facial Pain; Female; Humans; Hypertrophy; Muscul | 2006 |
Prevalence of contraindicated medical conditions and use of precluded medications in patients with painful neuropathic disorders prescribed amitriptyline.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Analgesics, | 2006 |
Diagnosis and treatment of persistent pain after trauma to the head and neck.
Topics: Adult; Amitriptyline; Carbamazepine; Chronic Disease; Craniocerebral Trauma; Facial Pain; Female; He | 1994 |
Sympathetic activity-mediated neuropathic facial pain following simple tooth extraction: a case report.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Autonomic Nerve Block; Electroacupuncture; Fa | 2002 |
Facial pain following sinonasal surgery or facial trauma.
Topics: Acetates; Adult; Aged; Amines; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cyclohexaneca | 2002 |
Chronic facial pain together with severe depression is responsive to electroconvulsive therapy. A case report.
Topics: Amitriptyline; Chronic Disease; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Facial P | 1992 |