amitriptyline has been researched along with Complex Regional Pain Syndromes in 6 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Complex Regional Pain Syndromes: Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment." | 5.51 | [Treatment of complex regional pain syndrome with amitriptyline]. ( Komoly, S, 2019) |
| "We know from adult randomised controlled trials that some antiepileptics, such as gabapentin and pregabalin, can be effective in certain chronic pain conditions." | 4.95 | Antiepileptic drugs for chronic non-cancer pain in children and adolescents. ( Clinch, J; Cooper, TE; Heathcote, LC; Howard, R; Krane, E; Lord, SM; Schechter, N; Sethna, N; Wiffen, PJ; Wood, C, 2017) |
| "Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment." | 1.51 | [Treatment of complex regional pain syndrome with amitriptyline]. ( Komoly, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Komoly, S | 1 |
| Javed, S | 1 |
| Abdi, S | 1 |
| Cooper, TE | 2 |
| Heathcote, LC | 2 |
| Clinch, J | 2 |
| Gold, JI | 1 |
| Howard, R | 2 |
| Lord, SM | 2 |
| Schechter, N | 2 |
| Wood, C | 2 |
| Wiffen, PJ | 2 |
| Krane, E | 1 |
| Sethna, N | 1 |
| Söylev, GÖ | 1 |
| Boya, H | 1 |
| Nordmann, GR | 1 |
| Lauder, GR | 1 |
| Grier, DJ | 1 |
3 reviews available for amitriptyline and Complex Regional Pain Syndromes
| Article | Year |
|---|---|
Use of anticonvulsants and antidepressants for treatment of complex regional pain syndrome: a literature review.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents; Complex Regional Pain Syndromes; Gabapentin; | 2021 |
Antidepressants for chronic non-cancer pain in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Child; Chronic | 2017 |
Antiepileptic drugs for chronic non-cancer pain in children and adolescents.
Topics: Adolescent; Amines; Amitriptyline; Anticonvulsants; Child; Chronic Pain; Complex Regional Pain Syndr | 2017 |
3 other studies available for amitriptyline and Complex Regional Pain Syndromes
| Article | Year |
|---|---|
[Treatment of complex regional pain syndrome with amitriptyline].
Topics: Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Chronic Disease; Complex | 2019 |
A rare complication of total knee arthroplasty: Type l complex regional pain syndrome of the foot and ankle.
Topics: Aged; Amitriptyline; Analgesics; Ankle; Arthroplasty, Replacement, Knee; Complex Regional Pain Syndr | 2016 |
Computed tomography guided lumbar sympathetic block for complex regional pain syndrome in a child: a case report and review.
Topics: Amines; Amitriptyline; Analgesics; Anesthetics, Local; Antidepressive Agents, Tricyclic; Autonomic N | 2006 |