amitriptyline has been researched along with Coma in 41 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of a 15-year-old female who was admitted in a comatose state with no spontaneous respiratory effort and absence of brainstem reflexes after cyclobenzaprine ingestion." | 8.12 | Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange. ( Buyukgoz, C; Gangu, S; Gowani, F; Kimura, D, 2022) |
| "We present a tricyclic antidepressant intoxication, where the patient is thought to have taken a large amount of amitriptyline at once, which, in combination with a cytochrome P450 2D6 poor metabolizer status, led to an unusual long persistence of her coma." | 8.12 | Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report. ( Bruins, P; de Vries Schultink, AHM; Harmsze, A; Meinders, AJ; van de Wint, T, 2022) |
| "We present a case of a 15-year-old female who was admitted in a comatose state with no spontaneous respiratory effort and absence of brainstem reflexes after cyclobenzaprine ingestion." | 4.12 | Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange. ( Buyukgoz, C; Gangu, S; Gowani, F; Kimura, D, 2022) |
| "We present a tricyclic antidepressant intoxication, where the patient is thought to have taken a large amount of amitriptyline at once, which, in combination with a cytochrome P450 2D6 poor metabolizer status, led to an unusual long persistence of her coma." | 4.12 | Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report. ( Bruins, P; de Vries Schultink, AHM; Harmsze, A; Meinders, AJ; van de Wint, T, 2022) |
| " She was on multiple medications including diazepam, oxycodone, and amitriptyline, known to be associated with coma blisters, though she did not overdose on any of them." | 3.78 | Coma blisters with hypoxemic respiratory failure. ( Agarwal, A; Bansal, M; Conner, K, 2012) |
| " Here we report a 25-year-old female presenting with coma and hemodynamic instability following intentional ingestion of amitriptyline." | 3.78 | Lipid therapy for the treatment of a refractory amitriptyline overdose. ( Kiberd, MB; Minor, SF, 2012) |
| " Patients with an amitriptyline overdose were more likely to have seizure, coma, tachycardia, a wide QRS or ventricular dysrhythmia, and have received sodium bicarbonate or be intubated." | 3.77 | Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose. ( Bebarta, VS; Borys, DJ; Maddry, J; Morgan, DL, 2011) |
| "We present the case of a comatose woman who intentionally overdosed on amitriptyline and displayed rising serum total tricyclic antidepressant concentrations for at least 6 days after admission." | 3.77 | Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity. ( Curry, SC; Smith, JC, 2011) |
| " We report a patient in deep coma with complete absence of brain-stem reflexes after she had taken a large quantity of amitriptyline." | 3.68 | Reversible brain death. A manifestation of amitriptyline overdose. ( Dantzker, DR; Yang, KL, 1991) |
| "Prolonged coma due to acute overdosage with hypnotic drugs is shown to be associated with a pronounced increase in the activity of serum creatine kinase and in the concentration of fibrin degradation products and with less pronounced abnormalities of other serum enzymes and of other indices of coagulation and fibrinolysis." | 3.65 | Effects of poisoning on serum enzyme activities, coagulation, and fibrinolysis. ( Brown, SS; Clarkson, AR; Fuster, V; Wright, N, 1971) |
| "Amitriptyline has the potential to cause unusual serious complications, such as abdominal compartment syndrome, irreversible central nervous system disability and lethal arrhythmia." | 1.46 | Unusual complications from amitriptyline intoxication. ( Maruguchi, H; Nakao, A; Nakayama, S; Nishimura, T, 2017) |
| "She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes." | 1.35 | Treatment of severe amitriptyline intoxication with plasmapheresis. ( Akyüz, M; Aydemir, C; Cabuk, H; Eldes, N; Kolsal, E; Numanoglu, V; Piskin, E; Tekin, IO, 2009) |
| "On examination she was comatose, had ventricular tachycardia and multifocal clonic seizures." | 1.33 | Hemoperfusion in a child with amitriptyline intoxication. ( Canbek, R; Cetinkaya, M; Dönmez, O, 2005) |
| "The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)." | 1.33 | Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006) |
| "No correlation between coma grade or QRS duration and cerebral spinal fluid concentration of amitriptyline was found." | 1.28 | Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics. ( Heath, A; Hultén, BA; Knudsen, K; Mårtensson, E; Nyberg, G; Starmark, JE, 1992) |
| "Total external ophthalmoplegia, unresponsive to caloric stimulation, was observed in a gravid woman who had ingested approximately 1." | 1.26 | Amitriptyline-induced ophthalmoplegia. ( Schnapper, R; Spector, RH, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (56.10) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 7 (17.07) | 29.6817 |
| 2010's | 5 (12.20) | 24.3611 |
| 2020's | 3 (7.32) | 2.80 |
| Authors | Studies |
|---|---|
| Buyukgoz, C | 1 |
| Gangu, S | 1 |
| Gowani, F | 1 |
| Kimura, D | 1 |
| Bloom, J | 1 |
| Hoffman, RS | 1 |
| van de Wint, T | 1 |
| de Vries Schultink, AHM | 1 |
| Meinders, AJ | 1 |
| Harmsze, A | 1 |
| Bruins, P | 1 |
| Nishimura, T | 1 |
| Maruguchi, H | 1 |
| Nakao, A | 1 |
| Nakayama, S | 1 |
| Kolsal, E | 1 |
| Tekin, IO | 1 |
| Piskin, E | 1 |
| Aydemir, C | 1 |
| Akyüz, M | 1 |
| Cabuk, H | 1 |
| Eldes, N | 1 |
| Numanoglu, V | 1 |
| Bebarta, VS | 1 |
| Maddry, J | 1 |
| Borys, DJ | 1 |
| Morgan, DL | 1 |
| Smith, JC | 1 |
| Curry, SC | 1 |
| Agarwal, A | 1 |
| Bansal, M | 1 |
| Conner, K | 1 |
| Kiberd, MB | 1 |
| Minor, SF | 1 |
| SUNSHINE, P | 1 |
| YAFFE, SJ | 1 |
| WITTON, K | 1 |
| EHRLY, AM | 1 |
| BEYER, E | 1 |
| STARK, JE | 1 |
| BETHUNE, DW | 1 |
| Dönmez, O | 1 |
| Cetinkaya, M | 1 |
| Canbek, R | 1 |
| Deegan, C | 1 |
| O'Brien, K | 1 |
| Son, BC | 1 |
| Lee, SW | 1 |
| Choi, ES | 1 |
| Sung, JH | 1 |
| Hong, JT | 1 |
| Baysal, T | 1 |
| Oran, B | 1 |
| Doğan, M | 1 |
| Cimen, D | 1 |
| Elmas, S | 1 |
| Karaaslan, S | 1 |
| Forget, P | 1 |
| le Polain de Waroux, B | 1 |
| Wallemacq, P | 1 |
| Gala, JL | 1 |
| Skotte, T | 1 |
| Rumpl, E | 1 |
| Hinterhuber, H | 1 |
| Hultén, BA | 2 |
| Heath, A | 2 |
| Sandyk, R | 1 |
| Hotson, JR | 1 |
| Sachdev, HS | 1 |
| Spector, RH | 1 |
| Schnapper, R | 1 |
| Heard, K | 1 |
| O'Malley, GF | 1 |
| Dart, RC | 1 |
| Roberge, RJ | 1 |
| Krenzelok, EP | 1 |
| Herschthal, D | 1 |
| Robinson, MJ | 1 |
| Crome, P | 1 |
| Newman, B | 1 |
| Hartwich, R | 1 |
| Bräunlich, H | 1 |
| Holinger, PC | 1 |
| Klawans, HL | 1 |
| Knudsen, K | 1 |
| Nyberg, G | 1 |
| Starmark, JE | 1 |
| Mårtensson, E | 1 |
| Yang, KL | 1 |
| Dantzker, DR | 1 |
| Collins, JV | 1 |
| Townsend, J | 1 |
| Harris, PW | 1 |
| Clark, TJ | 1 |
| Goulding, R | 1 |
| Kurtz, D | 1 |
| Feuerstein, J | 1 |
| Weber, M | 1 |
| Reeb, M | 1 |
| Rohmer, F | 1 |
| Bevegård, S | 1 |
| Thorstrand, C | 2 |
| Burks, JS | 1 |
| Walker, JE | 1 |
| Rumack, BH | 1 |
| Ott, JE | 1 |
| Mellerio, F | 1 |
| Gaultier, M | 1 |
| Fournier, E | 1 |
| Gervais, P | 1 |
| Frejaville, JP | 1 |
| Bazhin, EF | 1 |
| Rafalovich, EG | 1 |
| Wright, N | 1 |
| Clarkson, AR | 1 |
| Brown, SS | 1 |
| Fuster, V | 1 |
| Milner, G | 1 |
41 other studies available for amitriptyline and Coma
| Article | Year |
|---|---|
Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange.
Topics: Adolescent; Amitriptyline; Coma; Drug Overdose; Female; Humans; Plasma Exchange; Plasmapheresis | 2022 |
Comment on "Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange".
Topics: Amitriptyline; Coma; Drug Overdose; Humans; Plasma Exchange; Plasmapheresis | 2022 |
Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Cytochrome P-450 CYP2D6; Drug Overdose; | 2022 |
Unusual complications from amitriptyline intoxication.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brain Damage, Chronic; Coma; Humans; Intestinal Obs | 2017 |
Treatment of severe amitriptyline intoxication with plasmapheresis.
Topics: Amitriptyline; Child, Preschool; Coma; Drug Overdose; Female; Humans; Plasmapheresis; Poisoning; Sei | 2009 |
Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Chi-Square Distributio | 2011 |
Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity.
Topics: Alprazolam; Amitriptyline; Antidepressive Agents, Tricyclic; Body Temperature; Brain; Coma; Cytochro | 2011 |
Coma blisters with hypoxemic respiratory failure.
Topics: Amitriptyline; Anti-Bacterial Agents; Blister; Coma; Diazepam; Drug Therapy, Combination; Female; Hu | 2012 |
Lipid therapy for the treatment of a refractory amitriptyline overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Coma; Drug Overdose; Fat Emulsion | 2012 |
AMITRIPTYLINE POISONING. CLINICAL AND PATHOLOGICAL FINDINGS IN A FATAL CASE.
Topics: Amitriptyline; Amobarbital; Antidepressive Agents; Apnea; Arrhythmias, Cardiac; Coma; Dialysis; Flui | 1963 |
SEVERE TOXIC REACTION TO COMBINED AMITRIPTYLINE AND THIORIDAZINE.
Topics: Amitriptyline; Bipolar Disorder; Brain Diseases; Catatonia; Coma; Diagnosis, Differential; Drug Syne | 1965 |
[ACUTE POISONING WITH THE PSYCHOPHARMACON AMITRIPTYLINE (SAROTEN)].
Topics: Amitriptyline; Coma; Poisoning; Toxicology | 1964 |
AMITRIPTYLINE POISONING.
Topics: Amitriptyline; Amobarbital; Barbiturates; Coma; Depression; Depressive Disorder; Diuresis; Drug Ther | 1965 |
Hemoperfusion in a child with amitriptyline intoxication.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Electric Countershock; Female; Hemoperfusion; | 2005 |
Amitriptyline poisoning in a 2-year old.
Topics: Adrenergic beta-Agonists; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Blood Gas Analys | 2006 |
Motor cortex stimulation for central pain following a traumatic brain injury.
Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju | 2006 |
Beta-blocker treatment in an adolescent with amitriptyline intoxication.
Topics: Adolescent; Adrenergic beta-Antagonists; Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Diag | 2007 |
Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antitussive Agents; Coma; Cytochrome P-450 CYP2D6; | 2008 |
[Amitriptyline (Sarotex) poisoning].
Topics: Adolescent; Amitriptyline; Anticonvulsants; Coma; Female; Heart Massage; Humans; Pyridostigmine Brom | 1967 |
Unusual 'spike-wave stupor' in a patient with manic-depressive psychosis treated with amitriptyline.
Topics: Action Potentials; Amitriptyline; Bipolar Disorder; Coma; Electroencephalography; Epilepsy; Humans; | 1981 |
Clinical aspects of tricyclic antidepressant poisoning.
Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Amitriptyline; Antidepressive Agents, Tricyclic; Be | 1983 |
Oculomotor signs in amitriptyline induced coma.
Topics: Adult; Amitriptyline; Coma; Eye Movements; Humans; Male | 1983 |
Amitriptyline: another cause of internuclear ophthalmoplegia with coma.
Topics: Adolescent; Amitriptyline; Coma; Humans; Male; Ophthalmoplegia | 1982 |
Amitriptyline-induced ophthalmoplegia.
Topics: Adult; Amitriptyline; Coma; Female; Humans; Ophthalmoplegia; Physostigmine; Pregnancy; Pregnancy Com | 1981 |
Treatment of amitriptyline poisoning with ovine antibody to tricyclic antidepressants.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Coma; Humans; Immunoglo | 1999 |
Prolonged coma and loss of brainstem reflexes following amitriptyline overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Brain Stem; Coma; Female; Humans; Suicide, A | 2001 |
Blisters of the skin in coma induced by amitriptyline and clorazepate dipotassium. Report of a case with underlying sweat gland necrosis.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Blister; Clorazepate Dipotassium; Coma; Female; Humans; N | 1979 |
The problem of tricyclic antidepressant poisoning.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; C | 1979 |
[The use of direct and indirect parasympathomimetics in poisonings with tricyclic antidepressive agents].
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arecoline; Cholinesterase Inhibitors; Coma | 1978 |
Reversal of tricyclic-overdosage-induced central anticholinergic syndrome by physostigmine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Athetosis; Chorea; Coma; Electroencephalography; Fe | 1976 |
Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics.
Topics: Amitriptyline; Coma; Drug Overdose; Electrocardiography; Erythrocytes; Half-Life; Humans; Intubation | 1992 |
Reversible brain death. A manifestation of amitriptyline overdose.
Topics: Amitriptyline; Brain Death; Coma; Drug Overdose; Female; Humans; Middle Aged; Neurologic Examination | 1991 |
Plasma-11-hydroxycorticosteroid levels in drug-induced coma.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Amitriptyline; Barbiturates; Blood Pressure; Body Temperatu | 1971 |
Value of EEG monitoring in reanimation of comas due to acute drug intoxication.
Topics: Amitriptyline; Coma; Diazepam; Electroencephalography; Humans; Imipramine; Meprobamate; Phenothiazin | 1968 |
Central hemodynamics in severe poisoning by hypnotic drugs. Coma depth and body temperature.
Topics: Adult; Aged; Amitriptyline; Blood Pressure; Body Temperature; Cardiac Output; Central Venous Pressur | 1972 |
Tricyclic antidepressant poisoning. Reversal of coma, choreoathetosis, and myoclonus by physostigmine.
Topics: Adult; Amitriptyline; Antidepressive Agents; Athetosis; Child, Preschool; Chorea; Coma; Female; Huma | 1974 |
Cardiovascular effects of poisoning with tricyclic antidepressants.
Topics: Adult; Amitriptyline; Blood; Blood Pressure; Body Temperature; Carbon Dioxide; Cardiac Output; Coma; | 1974 |
Contribution of electroencephalography to resuscitation in toxicology.
Topics: Amitriptyline; Barbiturates; Carbon Monoxide Poisoning; Coma; Electroencephalography; Fungi; Humans; | 1973 |
[Treatment of hallucinatory disorders in schizophrenia with atropine comas].
Topics: Amitriptyline; Atropine; Chlorpromazine; Coma; Drug Therapy, Combination; Epinephrine; Hallucination | 1973 |
Effects of poisoning on serum enzyme activities, coagulation, and fibrinolysis.
Topics: Adult; Aged; Alanine Transaminase; Amitriptyline; Aspartate Aminotransferases; Blood Coagulation; Bl | 1971 |
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine | 1968 |