Page last updated: 2024-10-22

amitriptyline and Coma

amitriptyline has been researched along with Coma in 41 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

Excerpt	Relevance	Reference
"We present a case of a 15-year-old female who was admitted in a comatose state with no spontaneous respiratory effort and absence of brainstem reflexes after cyclobenzaprine ingestion."	8.12	Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange. ( Buyukgoz, C; Gangu, S; Gowani, F; Kimura, D, 2022)
"We present a tricyclic antidepressant intoxication, where the patient is thought to have taken a large amount of amitriptyline at once, which, in combination with a cytochrome P450 2D6 poor metabolizer status, led to an unusual long persistence of her coma."	8.12	Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report. ( Bruins, P; de Vries Schultink, AHM; Harmsze, A; Meinders, AJ; van de Wint, T, 2022)
"We present a case of a 15-year-old female who was admitted in a comatose state with no spontaneous respiratory effort and absence of brainstem reflexes after cyclobenzaprine ingestion."	4.12	Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange. ( Buyukgoz, C; Gangu, S; Gowani, F; Kimura, D, 2022)
"We present a tricyclic antidepressant intoxication, where the patient is thought to have taken a large amount of amitriptyline at once, which, in combination with a cytochrome P450 2D6 poor metabolizer status, led to an unusual long persistence of her coma."	4.12	Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report. ( Bruins, P; de Vries Schultink, AHM; Harmsze, A; Meinders, AJ; van de Wint, T, 2022)
" She was on multiple medications including diazepam, oxycodone, and amitriptyline, known to be associated with coma blisters, though she did not overdose on any of them."	3.78	Coma blisters with hypoxemic respiratory failure. ( Agarwal, A; Bansal, M; Conner, K, 2012)
" Here we report a 25-year-old female presenting with coma and hemodynamic instability following intentional ingestion of amitriptyline."	3.78	Lipid therapy for the treatment of a refractory amitriptyline overdose. ( Kiberd, MB; Minor, SF, 2012)
" Patients with an amitriptyline overdose were more likely to have seizure, coma, tachycardia, a wide QRS or ventricular dysrhythmia, and have received sodium bicarbonate or be intubated."	3.77	Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose. ( Bebarta, VS; Borys, DJ; Maddry, J; Morgan, DL, 2011)
"We present the case of a comatose woman who intentionally overdosed on amitriptyline and displayed rising serum total tricyclic antidepressant concentrations for at least 6 days after admission."	3.77	Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity. ( Curry, SC; Smith, JC, 2011)
" We report a patient in deep coma with complete absence of brain-stem reflexes after she had taken a large quantity of amitriptyline."	3.68	Reversible brain death. A manifestation of amitriptyline overdose. ( Dantzker, DR; Yang, KL, 1991)
"Prolonged coma due to acute overdosage with hypnotic drugs is shown to be associated with a pronounced increase in the activity of serum creatine kinase and in the concentration of fibrin degradation products and with less pronounced abnormalities of other serum enzymes and of other indices of coagulation and fibrinolysis."	3.65	Effects of poisoning on serum enzyme activities, coagulation, and fibrinolysis. ( Brown, SS; Clarkson, AR; Fuster, V; Wright, N, 1971)
"Amitriptyline has the potential to cause unusual serious complications, such as abdominal compartment syndrome, irreversible central nervous system disability and lethal arrhythmia."	1.46	Unusual complications from amitriptyline intoxication. ( Maruguchi, H; Nakao, A; Nakayama, S; Nishimura, T, 2017)
"She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes."	1.35	Treatment of severe amitriptyline intoxication with plasmapheresis. ( Akyüz, M; Aydemir, C; Cabuk, H; Eldes, N; Kolsal, E; Numanoglu, V; Piskin, E; Tekin, IO, 2009)
"On examination she was comatose, had ventricular tachycardia and multifocal clonic seizures."	1.33	Hemoperfusion in a child with amitriptyline intoxication. ( Canbek, R; Cetinkaya, M; Dönmez, O, 2005)
"The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)."	1.33	Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006)
"No correlation between coma grade or QRS duration and cerebral spinal fluid concentration of amitriptyline was found."	1.28	Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics. ( Heath, A; Hultén, BA; Knudsen, K; Mårtensson, E; Nyberg, G; Starmark, JE, 1992)
"Total external ophthalmoplegia, unresponsive to caloric stimulation, was observed in a gravid woman who had ingested approximately 1."	1.26	Amitriptyline-induced ophthalmoplegia. ( Schnapper, R; Spector, RH, 1981)

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (56.10)	18.7374
1990's	3 (7.32)	18.2507
2000's	7 (17.07)	29.6817
2010's	5 (12.20)	24.3611
2020's	3 (7.32)	2.80

Authors

Authors	Studies
Buyukgoz, C	1
Gangu, S	1
Gowani, F	1
Kimura, D	1
Bloom, J	1
Hoffman, RS	1
van de Wint, T	1
de Vries Schultink, AHM	1
Meinders, AJ	1
Harmsze, A	1
Bruins, P	1
Nishimura, T	1
Maruguchi, H	1
Nakao, A	1
Nakayama, S	1
Kolsal, E	1
Tekin, IO	1
Piskin, E	1
Aydemir, C	1
Akyüz, M	1
Cabuk, H	1
Eldes, N	1
Numanoglu, V	1
Bebarta, VS	1
Maddry, J	1
Borys, DJ	1
Morgan, DL	1
Smith, JC	1
Curry, SC	1
Agarwal, A	1
Bansal, M	1
Conner, K	1
Kiberd, MB	1
Minor, SF	1
SUNSHINE, P	1
YAFFE, SJ	1
WITTON, K	1
EHRLY, AM	1
BEYER, E	1
STARK, JE	1
BETHUNE, DW	1
Dönmez, O	1
Cetinkaya, M	1
Canbek, R	1
Deegan, C	1
O'Brien, K	1
Son, BC	1
Lee, SW	1
Choi, ES	1
Sung, JH	1
Hong, JT	1
Baysal, T	1
Oran, B	1
Doğan, M	1
Cimen, D	1
Elmas, S	1
Karaaslan, S	1
Forget, P	1
le Polain de Waroux, B	1
Wallemacq, P	1
Gala, JL	1
Skotte, T	1
Rumpl, E	1
Hinterhuber, H	1
Hultén, BA	2
Heath, A	2
Sandyk, R	1
Hotson, JR	1
Sachdev, HS	1
Spector, RH	1
Schnapper, R	1
Heard, K	1
O'Malley, GF	1
Dart, RC	1
Roberge, RJ	1
Krenzelok, EP	1
Herschthal, D	1
Robinson, MJ	1
Crome, P	1
Newman, B	1
Hartwich, R	1
Bräunlich, H	1
Holinger, PC	1
Klawans, HL	1
Knudsen, K	1
Nyberg, G	1
Starmark, JE	1
Mårtensson, E	1
Yang, KL	1
Dantzker, DR	1
Collins, JV	1
Townsend, J	1
Harris, PW	1
Clark, TJ	1
Goulding, R	1
Kurtz, D	1
Feuerstein, J	1
Weber, M	1
Reeb, M	1
Rohmer, F	1
Bevegård, S	1
Thorstrand, C	2
Burks, JS	1
Walker, JE	1
Rumack, BH	1
Ott, JE	1
Mellerio, F	1
Gaultier, M	1
Fournier, E	1
Gervais, P	1
Frejaville, JP	1
Bazhin, EF	1
Rafalovich, EG	1
Wright, N	1
Clarkson, AR	1
Brown, SS	1
Fuster, V	1
Milner, G	1

Other Studies

41 other studies available for amitriptyline and Coma

Article	Year
Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange. Journal of clinical apheresis, 2022, Volume: 37, Issue:3 Topics: Adolescent; Amitriptyline; Coma; Drug Overdose; Female; Humans; Plasma Exchange; Plasmapheresis	2022
Comment on "Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange". Journal of clinical apheresis, 2022, Volume: 37, Issue:4 Topics: Amitriptyline; Coma; Drug Overdose; Humans; Plasma Exchange; Plasmapheresis	2022
Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report. Journal of medical case reports, 2022, Mar-16, Volume: 16, Issue:1 Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Cytochrome P-450 CYP2D6; Drug Overdose;	2022
Unusual complications from amitriptyline intoxication. BMJ case reports, 2017, Oct-10, Volume: 2017 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brain Damage, Chronic; Coma; Humans; Intestinal Obs	2017
Treatment of severe amitriptyline intoxication with plasmapheresis. Journal of clinical apheresis, 2009, Volume: 24, Issue:1 Topics: Amitriptyline; Child, Preschool; Coma; Drug Overdose; Female; Humans; Plasmapheresis; Poisoning; Sei	2009
Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose. The American journal of emergency medicine, 2011, Volume: 29, Issue:6 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Chi-Square Distributio	2011
Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:3 Topics: Alprazolam; Amitriptyline; Antidepressive Agents, Tricyclic; Body Temperature; Brain; Coma; Cytochro	2011
Coma blisters with hypoxemic respiratory failure. Dermatology online journal, 2012, Mar-15, Volume: 18, Issue:3 Topics: Amitriptyline; Anti-Bacterial Agents; Blister; Coma; Diazepam; Drug Therapy, Combination; Female; Hu	2012
Lipid therapy for the treatment of a refractory amitriptyline overdose. CJEM, 2012, Volume: 14, Issue:3 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Coma; Drug Overdose; Fat Emulsion	2012
AMITRIPTYLINE POISONING. CLINICAL AND PATHOLOGICAL FINDINGS IN A FATAL CASE. American journal of diseases of children (1960), 1963, Volume: 106 Topics: Amitriptyline; Amobarbital; Antidepressive Agents; Apnea; Arrhythmias, Cardiac; Coma; Dialysis; Flui	1963
SEVERE TOXIC REACTION TO COMBINED AMITRIPTYLINE AND THIORIDAZINE. The American journal of psychiatry, 1965, Volume: 121 Topics: Amitriptyline; Bipolar Disorder; Brain Diseases; Catatonia; Coma; Diagnosis, Differential; Drug Syne	1965
[ACUTE POISONING WITH THE PSYCHOPHARMACON AMITRIPTYLINE (SAROTEN)]. Munchener medizinische Wochenschrift (1950), 1964, Nov-27, Volume: 106 Topics: Amitriptyline; Coma; Poisoning; Toxicology	1964
AMITRIPTYLINE POISONING. Lancet (London, England), 1965, Aug-21, Volume: 2, Issue:7408 Topics: Amitriptyline; Amobarbital; Barbiturates; Coma; Depression; Depressive Disorder; Diuresis; Drug Ther	1965
Hemoperfusion in a child with amitriptyline intoxication. Pediatric nephrology (Berlin, Germany), 2005, Volume: 20, Issue:1 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Electric Countershock; Female; Hemoperfusion;	2005
Amitriptyline poisoning in a 2-year old. Paediatric anaesthesia, 2006, Volume: 16, Issue:2 Topics: Adrenergic beta-Agonists; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Blood Gas Analys	2006
Motor cortex stimulation for central pain following a traumatic brain injury. Pain, 2006, Volume: 123, Issue:1-2 Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju	2006
Beta-blocker treatment in an adolescent with amitriptyline intoxication. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2007, Volume: 7, Issue:3 Topics: Adolescent; Adrenergic beta-Antagonists; Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Diag	2007
Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. Journal of pain and symptom management, 2008, Volume: 36, Issue:1 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antitussive Agents; Coma; Cytochrome P-450 CYP2D6;	2008
[Amitriptyline (Sarotex) poisoning]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1967, May-15, Volume: 87, Issue:10 Topics: Adolescent; Amitriptyline; Anticonvulsants; Coma; Female; Heart Massage; Humans; Pyridostigmine Brom	1967
Unusual 'spike-wave stupor' in a patient with manic-depressive psychosis treated with amitriptyline. Journal of neurology, 1981, Volume: 226, Issue:2 Topics: Action Potentials; Amitriptyline; Bipolar Disorder; Coma; Electroencephalography; Epilepsy; Humans;	1981
Clinical aspects of tricyclic antidepressant poisoning. Acta medica Scandinavica, 1983, Volume: 213, Issue:4 Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Amitriptyline; Antidepressive Agents, Tricyclic; Be	1983
Oculomotor signs in amitriptyline induced coma. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1983, Apr-23, Volume: 63, Issue:17 Topics: Adult; Amitriptyline; Coma; Eye Movements; Humans; Male	1983
Amitriptyline: another cause of internuclear ophthalmoplegia with coma. Annals of neurology, 1982, Volume: 12, Issue:1 Topics: Adolescent; Amitriptyline; Coma; Humans; Male; Ophthalmoplegia	1982
Amitriptyline-induced ophthalmoplegia. Neurology, 1981, Volume: 31, Issue:9 Topics: Adult; Amitriptyline; Coma; Female; Humans; Ophthalmoplegia; Physostigmine; Pregnancy; Pregnancy Com	1981
Treatment of amitriptyline poisoning with ovine antibody to tricyclic antidepressants. Lancet (London, England), 1999, Nov-06, Volume: 354, Issue:9190 Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Coma; Humans; Immunoglo	1999
Prolonged coma and loss of brainstem reflexes following amitriptyline overdose. Veterinary and human toxicology, 2001, Volume: 43, Issue:1 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Brain Stem; Coma; Female; Humans; Suicide, A	2001
Blisters of the skin in coma induced by amitriptyline and clorazepate dipotassium. Report of a case with underlying sweat gland necrosis. Archives of dermatology, 1979, Volume: 115, Issue:4 Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Blister; Clorazepate Dipotassium; Coma; Female; Humans; N	1979
The problem of tricyclic antidepressant poisoning. Postgraduate medical journal, 1979, Volume: 55, Issue:646 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; C	1979
[The use of direct and indirect parasympathomimetics in poisonings with tricyclic antidepressive agents]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1978, Oct-15, Volume: 33, Issue:20 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arecoline; Cholinesterase Inhibitors; Coma	1978
Reversal of tricyclic-overdosage-induced central anticholinergic syndrome by physostigmine. The American journal of psychiatry, 1976, Volume: 133, Issue:9 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Athetosis; Chorea; Coma; Electroencephalography; Fe	1976
Severe amitriptyline overdose: relationship between toxicokinetics and toxicodynamics. Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:2 Topics: Amitriptyline; Coma; Drug Overdose; Electrocardiography; Erythrocytes; Half-Life; Humans; Intubation	1992
Reversible brain death. A manifestation of amitriptyline overdose. Chest, 1991, Volume: 99, Issue:4 Topics: Amitriptyline; Brain Death; Coma; Drug Overdose; Female; Humans; Middle Aged; Neurologic Examination	1991
Plasma-11-hydroxycorticosteroid levels in drug-induced coma. Lancet (London, England), 1971, Jul-24, Volume: 2, Issue:7717 Topics: Adrenal Cortex Hormones; Adrenal Glands; Amitriptyline; Barbiturates; Blood Pressure; Body Temperatu	1971
Value of EEG monitoring in reanimation of comas due to acute drug intoxication. Electroencephalography and clinical neurophysiology, 1968, Volume: 25, Issue:1 Topics: Amitriptyline; Coma; Diazepam; Electroencephalography; Humans; Imipramine; Meprobamate; Phenothiazin	1968
Central hemodynamics in severe poisoning by hypnotic drugs. Coma depth and body temperature. Acta medica Scandinavica, 1972, Volume: 191, Issue:4 Topics: Adult; Aged; Amitriptyline; Blood Pressure; Body Temperature; Cardiac Output; Central Venous Pressur	1972
Tricyclic antidepressant poisoning. Reversal of coma, choreoathetosis, and myoclonus by physostigmine. JAMA, 1974, Dec-04, Volume: 230, Issue:10 Topics: Adult; Amitriptyline; Antidepressive Agents; Athetosis; Child, Preschool; Chorea; Coma; Female; Huma	1974
Cardiovascular effects of poisoning with tricyclic antidepressants. Acta medica Scandinavica, 1974, Volume: 195, Issue:6 Topics: Adult; Amitriptyline; Blood; Blood Pressure; Body Temperature; Carbon Dioxide; Cardiac Output; Coma;	1974
Contribution of electroencephalography to resuscitation in toxicology. Clinical toxicology, 1973, Volume: 6, Issue:2 Topics: Amitriptyline; Barbiturates; Carbon Monoxide Poisoning; Coma; Electroencephalography; Fungi; Humans;	1973
[Treatment of hallucinatory disorders in schizophrenia with atropine comas]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:8 Topics: Amitriptyline; Atropine; Chlorpromazine; Coma; Drug Therapy, Combination; Epinephrine; Hallucination	1973
Effects of poisoning on serum enzyme activities, coagulation, and fibrinolysis. British medical journal, 1971, Aug-07, Volume: 3, Issue:5770 Topics: Adult; Aged; Alanine Transaminase; Amitriptyline; Aspartate Aminotransferases; Blood Coagulation; Bl	1971
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol. British journal of pharmacology, 1968, Volume: 34, Issue:2 Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine	1968