amitriptyline has been researched along with Colonic Inertia in 17 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Colonic Inertia: Symptom characterized by the passage of stool once a week or less.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an attempt to create an animal model of constipation in monkeys, amitriptyline was administered to cynomolgus monkeys at doses of 10-160 mg/kg body weight via a nasogastric tube." | 7.70 | Amitriptyline-induced constipation in cynomolgus monkeys is beneficial for the evaluation of laxative efficacy. ( Kishimoto, S; Kohri, H; Koshitani, O; Tsusumi, K, 2000) |
| "In an attempt to create an animal model of constipation in monkeys, amitriptyline was administered to cynomolgus monkeys at doses of 10-160 mg/kg body weight via a nasogastric tube." | 3.70 | Amitriptyline-induced constipation in cynomolgus monkeys is beneficial for the evaluation of laxative efficacy. ( Kishimoto, S; Kohri, H; Koshitani, O; Tsusumi, K, 2000) |
| "Somatic side effects of antidepressant medications and of depression and anxiety were quantified in depressed patients before and after 4 weeks of treatment with amitriptyline (N = 11), or desipramine (N = 12)." | 3.66 | Somatic symptoms in depression and antidepressants. ( Claghorn, JL; Mathew, RJ; Reck, JJ; Thapar, R; Weinman, ML, 1983) |
| "A total of 73 patients with migraine headache with or without aura are included in this single-center, double-blind, randomized, and controlled trial." | 2.73 | A double-blind randomized controlled trial of topiramate and amitriptyline either alone or in combination for the prevention of migraine. ( Aydinli, I; Keskinbora, K, 2008) |
| "Amitriptyline was dosed as follows: 8 mg/day for 6 days, 8 mg twice a day for 6 days, 20 mg/day for 6 days, and 20 mg twice a day for 45 days." | 2.70 | Amitriptyline versus amitriptyline combined with fluoxetine in the preventative treatment of transformed migraine: a double-blind study. ( Alves, LA; Barbosa, JS; Krymchantowski, AV; Silva, MT, 2002) |
| "Amitriptyline was associated with more autonomic and circulatory side effects, while epigastric complaints occurred more often with sertraline." | 2.69 | Double-blind, multicenter comparative study of sertraline and amitriptyline in hospitalized patients with major depression. ( Arató, M; Bauer, H; Gallinat, J; Hegerl, U; Janka, Z; Möller, HJ; Pflug, B, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, Z | 1 |
| Xu, X | 1 |
| Ke, M | 1 |
| Keskinbora, K | 1 |
| Aydinli, I | 1 |
| Krymchantowski, AV | 1 |
| Silva, MT | 1 |
| Barbosa, JS | 1 |
| Alves, LA | 1 |
| MILNER, G | 2 |
| BUCKLER, EG | 1 |
| Mathew, RJ | 1 |
| Weinman, ML | 1 |
| Thapar, R | 1 |
| Reck, JJ | 1 |
| Claghorn, JL | 1 |
| James, B | 1 |
| Bremner, JD | 1 |
| Bocchetta, A | 1 |
| Bernardi, F | 1 |
| Burrai, C | 1 |
| Pedditzi, M | 1 |
| Del Zompo, M | 1 |
| Möller, HJ | 1 |
| Gallinat, J | 1 |
| Hegerl, U | 1 |
| Arató, M | 1 |
| Janka, Z | 1 |
| Pflug, B | 1 |
| Bauer, H | 1 |
| Leroi, AM | 1 |
| Lalaude, O | 1 |
| Antonietti, M | 1 |
| Touchais, JY | 1 |
| Ducrotte, P | 1 |
| Menard, JF | 1 |
| Denis, P | 1 |
| Tsusumi, K | 1 |
| Kishimoto, S | 1 |
| Koshitani, O | 1 |
| Kohri, H | 1 |
| Bente, D | 1 |
| Feder, J | 1 |
| Helmchen, H | 1 |
| Hippius, H | 1 |
| Rosenberg, L | 1 |
| Myers, ED | 1 |
| Calvert, EJ | 1 |
| Hislop, IG | 1 |
| Ekdawi, MY | 1 |
1 review available for amitriptyline and Colonic Inertia
| Article | Year |
|---|---|
Gastro-intestinal side effects and psychotropic drugs.
Topics: Amitriptyline; Animals; Chlorpromazine; Constipation; Digestive System; Drug Synergism; Ethanol; Gas | 1969 |
7 trials available for amitriptyline and Colonic Inertia
| Article | Year |
|---|---|
A double-blind randomized controlled trial of topiramate and amitriptyline either alone or in combination for the prevention of migraine.
Topics: Adult; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Constipation; Disorders of | 2008 |
Amitriptyline versus amitriptyline combined with fluoxetine in the preventative treatment of transformed migraine: a double-blind study.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Constipation; Double-Blind Method; Drug Therapy, | 2002 |
A double-blind comparative clinical study of amoxapine and amitriptyline in depressed, hospitalised patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Amoxapine; Body Weight; Cardiovascular Diseases; Clinical Tr | 1982 |
A double-blind comparison of Org 3770, amitriptyline, and placebo in major depression.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Constipation; Depressive Disorder; Double-Blind Met | 1995 |
A double-blind study of L-sulpiride versus amitriptyline in lithium-maintained bipolar depressives.
Topics: Ambulatory Care; Amitriptyline; Bipolar Disorder; Constipation; Double-Blind Method; Drug Administra | 1993 |
Double-blind, multicenter comparative study of sertraline and amitriptyline in hospitalized patients with major depression.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amitriptyline; Antidepressive Agents; Constipation; Depre | 1998 |
[Double blind test of three antidepressants. 3. Methodical problems].
Topics: Affective Symptoms; Amitriptyline; Antidepressive Agents; Clinical Trials as Topic; Constipation; De | 1974 |
9 other studies available for amitriptyline and Colonic Inertia
| Article | Year |
|---|---|
[Current status and recommendations for pediatric clinical trials in functional gastrointestinal disorders].
Topics: Amitriptyline; Child; Constipation; Dyspepsia; Gastrointestinal Agents; Gastrointestinal Diseases; H | 2014 |
ADYNAMIC ILEUS AND AMITRIPTYLINE: THREE CASE REPORTS.
Topics: Aged; Amitriptyline; Constipation; Geriatrics; Humans; Intestinal Obstruction; Intestinal Pseudo-Obs | 1964 |
Somatic symptoms in depression and antidepressants.
Topics: Adult; Amitriptyline; Anxiety; Autonomic Nervous System Diseases; Constipation; Depressive Disorder; | 1983 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Anxiety Disorders; Cathartics; Cholinergic Antagonists; | 2000 |
Amitriptyline-induced constipation in cynomolgus monkeys is beneficial for the evaluation of laxative efficacy.
Topics: Amitriptyline; Animals; Anthraquinones; Bisacodyl; Cathartics; Constipation; Disease Models, Animal; | 2000 |
The effect of forewarning on the occurrence of side-effects and discontinuance of medication in patients on amitriptyline.
Topics: Amitriptyline; Constipation; Humans; Sleep; Suggestion; Sweating; Vertigo; Vision Disorders | 1973 |
Psychological significance of the irritable colon syndrome.
Topics: Abdomen; Adolescent; Adult; Affective Symptoms; Age Factors; Aged; Amitriptyline; Child; Colonic Dis | 1971 |
Dibenzepin and amitriptyline in the treatment of depression.
Topics: Adult; Amitriptyline; Anorexia Nervosa; Constipation; Depression; Dibenzazepines; Fatigue; Humans; P | 1971 |