amitriptyline has been researched along with Colonic Diseases, Functional in 11 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Colonic Diseases, Functional: Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline was found to be significantly more effective than placebo in producing global improvement, increasing feelings of well-being, reducing abdominal pain and increasing satisfaction with bowel movements." | 2.69 | Symptom relief with amitriptyline in the irritable bowel syndrome. ( John, J; Kurian, G; Rajagopalan, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nigam, P | 1 |
| Kapoor, KK | 1 |
| Rastog, CK | 1 |
| Kumar, A | 1 |
| Gupta, AK | 1 |
| Rajagopalan, M | 1 |
| Kurian, G | 1 |
| John, J | 1 |
| Abe, M | 1 |
| Saito, K | 1 |
| Hyams, JS | 1 |
| Hyman, PE | 1 |
| Poitras, P | 1 |
| Riberdy Poitras, M | 1 |
| Plourde, V | 1 |
| Boivin, M | 1 |
| Verrier, P | 1 |
| Honzák, R | 1 |
| Skála, I | 1 |
| Pirk, F | 1 |
| Castiglione, F | 1 |
| Daniele, B | 1 |
| Mazzacca, G | 1 |
| Korkina, MV | 1 |
| Marilov, VV | 1 |
| Zizka, V | 1 |
| Trykarová, J | 1 |
| Kozická, O | 1 |
| Madzarovová-Nohejlová, J | 1 |
| Thompson, WG | 1 |
| Hislop, IG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Liquid Gastric Emptying and Plasma Ghrelin in Children With Functional Dyspepsia[NCT01591174] | 30 participants (Actual) | Observational | 2012-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amitriptyline and Colonic Diseases, Functional
| Article | Year |
|---|---|
Recurrent abdominal pain and the biopsychosocial model of medical practice.
Topics: Abdominal Pain; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Chronic Di | 1998 |
Therapeutic strategy for the irritable bowel syndrome.
Topics: Amitriptyline; Cholestyramine Resin; Colonic Diseases, Functional; Dietary Fiber; Food Hypersensitiv | 1991 |
1 trial available for amitriptyline and Colonic Diseases, Functional
| Article | Year |
|---|---|
Symptom relief with amitriptyline in the irritable bowel syndrome.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Colonic Diseases, Functional; Drug Administr | 1998 |
8 other studies available for amitriptyline and Colonic Diseases, Functional
| Article | Year |
|---|---|
Different therapeutic regimens in irritable bowel syndrome.
Topics: Adolescent; Adult; Amitriptyline; Butylscopolammonium Bromide; Chlordiazepoxide; Colonic Diseases, F | 1984 |
Reduction of wrap restraint stress-induced defecation by MKC-242, a novel benzodioxan derivative, via 5-HT1A-receptor agonist action in rats.
Topics: Amitriptyline; Animals; Colonic Diseases, Functional; Defecation; Dioxanes; Dioxoles; Male; Rats; Ra | 1998 |
Evolution of visceral sensitivity in patients with irritable bowel syndrome.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Catheterization; Colonic Diseases, Functional; | 2002 |
[Therapeutic use of amitriptyline in irritable colon (author's transl)].
Topics: Adult; Aged; Amitriptyline; Colonic Diseases, Functional; Female; Humans; Male; Middle Aged | 1978 |
[Psychosomatic disorders of the colon].
Topics: Adolescent; Adult; Amitriptyline; Colonic Diseases, Functional; Combined Modality Therapy; Female; H | 1989 |
[Comparison of the therapeutic effect of tranquilizers and amitriptyline in irritable colon].
Topics: Adolescent; Adult; Amitriptyline; Anti-Anxiety Agents; Clorazepate Dipotassium; Colonic Diseases, Fu | 1985 |
A strategy for management of the irritable bowel.
Topics: Amitriptyline; Cholestyramine Resin; Colonic Diseases, Functional; Diazepam; Dietary Fiber; Follow-U | 1986 |
Psychological significance of the irritable colon syndrome.
Topics: Abdomen; Adolescent; Adult; Affective Symptoms; Age Factors; Aged; Amitriptyline; Child; Colonic Dis | 1971 |