amitriptyline has been researched along with Colitis, Mucous in 30 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomised, double-blind, placebo-controlled trial (Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment [ATLANTIS]) was conducted at 55 general practices in England." | 9.69 | Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial. ( Alderson, SL; Bianco, G; Bishop, FL; Chaddock, M; Cook, H; Cooper, D; Everitt, HA; Farrin, AJ; Fernandez, C; Ford, AC; Foy, R; Guthrie, EA; Hartley, S; Herbert, A; Howdon, D; Muir, DP; Nath, T; Newman, S; Ow, PL; Ridd, MJ; Smith, T; Taylor, CA; Teasdale, EJ; Thornton, R; Wright-Hughes, A, 2023) |
| "Amitriptyline improves symptoms in functional abdominal pain disorders (FAPD) in adults with variable results in pediatric studies." | 9.51 | Efficacy of amitriptyline in pediatric functional abdominal pain disorders: A randomized placebo-controlled trial. ( Poddar, U; Seetharaman, J; Sen Sarma, M; Srivastava, A; Yachha, SK, 2022) |
| "In this open study, amitriptyline appears to decrease stress-induced electrical hypersensitivity; this effect is independent of autonomic tone." | 9.14 | Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome. ( Emmanuel, AV; Kamm, MA; Murray, CD; Pitcher, MC; Roy, AJ; Thoua, NM; Winchester, WJ, 2009) |
| "To compare the effects of low-dose amitriptyline in the treatment of diarrhoea-predominant irritable bowel syndrome in a double-blind randomized-controlled trial." | 9.13 | Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome. ( Ghaffari, N; Kazzazi, AS; Malekzadeh, R; Merat, S; Momtahen, S; Olfati, G; Vahedi, H, 2008) |
| "To determine the efficacy of amitriptyline (AMI) in treating irritable bowel syndrome (IBS) in adolescents." | 9.13 | Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. ( Ament, ME; Bahar, RJ; Collins, BS; Steinmetz, B, 2008) |
| "We aimed to evaluate the efficacy of amitriptyline as a therapeutic option for irritable bowel syndrome (IBS) through a meta-analysis of randomized controlled trials." | 8.89 | A meta-analysis of the therapeutic effects of amitriptyline for treating irritable bowel syndrome. ( Chao, GQ; Zhang, S, 2013) |
| "Low-dose amitriptyline (AMT) is an effective treatment for diarrhea-dominant irritable bowel syndrome (IBS-D)." | 8.02 | Role of serum amitriptyline concentration and CYP2C19 polymorphism in predicting the response to low-dose amitriptyline in irritable bowel syndrome. ( Deng, Q; Dou, GY; Huang, YX; Jia, L; Liu, Y; Ni, XJ; Shang, DW; Wen, YG; Yang, M; Zhao, HB; Zhou, WC, 2021) |
| "Amitriptyline (AMT) is commonly used in the management of children with irritable bowel syndrome." | 7.78 | Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain. ( Hussain, SZ; Jackson, R; Patra, KP; Sankararaman, S, 2012) |
| "Amitriptyline was associated with reduced pain related cerebral activations in the perigenual ACC and the left posterior parietal cortex, but only during stress." | 6.71 | Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. ( Gautam, S; Kessler, R; Mertz, H; Morgan, V; Pickens, D, 2005) |
| "This randomised, double-blind, placebo-controlled trial (Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment [ATLANTIS]) was conducted at 55 general practices in England." | 5.69 | Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial. ( Alderson, SL; Bianco, G; Bishop, FL; Chaddock, M; Cook, H; Cooper, D; Everitt, HA; Farrin, AJ; Fernandez, C; Ford, AC; Foy, R; Guthrie, EA; Hartley, S; Herbert, A; Howdon, D; Muir, DP; Nath, T; Newman, S; Ow, PL; Ridd, MJ; Smith, T; Taylor, CA; Teasdale, EJ; Thornton, R; Wright-Hughes, A, 2023) |
| "Amitriptyline improves symptoms in functional abdominal pain disorders (FAPD) in adults with variable results in pediatric studies." | 5.51 | Efficacy of amitriptyline in pediatric functional abdominal pain disorders: A randomized placebo-controlled trial. ( Poddar, U; Seetharaman, J; Sen Sarma, M; Srivastava, A; Yachha, SK, 2022) |
| "80 children with functional abdominal pain participated in a study of the efficacy of amitriptyline." | 5.20 | Abdominal pain endpoints currently recommended by the FDA and EMA for adult patients with irritable bowel syndrome may not be reliable in children. ( Lavigne, JV; Saps, M, 2015) |
| "In this open study, amitriptyline appears to decrease stress-induced electrical hypersensitivity; this effect is independent of autonomic tone." | 5.14 | Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome. ( Emmanuel, AV; Kamm, MA; Murray, CD; Pitcher, MC; Roy, AJ; Thoua, NM; Winchester, WJ, 2009) |
| "In this multicenter placebo-controlled trial, children with irritable bowel syndrome, functional abdominal pain, or functional dyspepsia were randomized to 4 weeks of placebo or amitriptyline (10 mg/d, weight <35 kg; 20 mg/d, weight >35 kg)." | 5.14 | Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. ( Cocjin, J; Di Lorenzo, C; Hyman, P; Miranda, A; Nurko, S; Saps, M; Youssef, N, 2009) |
| "To compare the effects of low-dose amitriptyline in the treatment of diarrhoea-predominant irritable bowel syndrome in a double-blind randomized-controlled trial." | 5.13 | Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome. ( Ghaffari, N; Kazzazi, AS; Malekzadeh, R; Merat, S; Momtahen, S; Olfati, G; Vahedi, H, 2008) |
| "To determine the efficacy of amitriptyline (AMI) in treating irritable bowel syndrome (IBS) in adolescents." | 5.13 | Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. ( Ament, ME; Bahar, RJ; Collins, BS; Steinmetz, B, 2008) |
| "We aimed to evaluate the efficacy of amitriptyline as a therapeutic option for irritable bowel syndrome (IBS) through a meta-analysis of randomized controlled trials." | 4.89 | A meta-analysis of the therapeutic effects of amitriptyline for treating irritable bowel syndrome. ( Chao, GQ; Zhang, S, 2013) |
| "Low-dose amitriptyline (AMT) is an effective treatment for diarrhea-dominant irritable bowel syndrome (IBS-D)." | 4.02 | Role of serum amitriptyline concentration and CYP2C19 polymorphism in predicting the response to low-dose amitriptyline in irritable bowel syndrome. ( Deng, Q; Dou, GY; Huang, YX; Jia, L; Liu, Y; Ni, XJ; Shang, DW; Wen, YG; Yang, M; Zhao, HB; Zhou, WC, 2021) |
| "Amitriptyline (AMT) is commonly used in the management of children with irritable bowel syndrome." | 3.78 | Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain. ( Hussain, SZ; Jackson, R; Patra, KP; Sankararaman, S, 2012) |
| "Irritable bowel syndrome is a multisymptom construct, with abdominal pain (AP) acting as the driving symptom of patient-reported severity." | 2.79 | Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: are we ready for change? ( Di Lorenzo, C; Hyman, P; Miranda, A; Mohammad, S; Nurko, S; Saps, M; Youssef, NN, 2014) |
| "Amitriptyline was associated with reduced pain related cerebral activations in the perigenual ACC and the left posterior parietal cortex, but only during stress." | 2.71 | Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. ( Gautam, S; Kessler, R; Mertz, H; Morgan, V; Pickens, D, 2005) |
| "Abdominal pain-related functional gastrointestinal disorders (FGIDs) are among the most common medical problems in paediatric medicine." | 2.47 | Antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders in children and adolescents. ( Chapman, A; Gartlehner, G; Kaminski, A; Kamper, A; Thaler, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seetharaman, J | 1 |
| Poddar, U | 1 |
| Yachha, SK | 1 |
| Srivastava, A | 1 |
| Sen Sarma, M | 1 |
| Alderson, SL | 2 |
| Wright-Hughes, A | 2 |
| Ford, AC | 2 |
| Farrin, A | 1 |
| Hartley, S | 2 |
| Fernandez, C | 2 |
| Taylor, C | 1 |
| Ow, PL | 2 |
| Teasdale, E | 1 |
| Howdon, D | 2 |
| Guthrie, E | 1 |
| Foy, R | 2 |
| Ridd, MJ | 2 |
| Bishop, FL | 2 |
| Muir, D | 1 |
| Chaddock, M | 2 |
| Herbert, A | 2 |
| Cooper, D | 2 |
| Gibbins, R | 1 |
| Newman, S | 2 |
| Cook, H | 2 |
| Longo, R | 1 |
| Everitt, H | 1 |
| de Wit, N | 1 |
| Keszthelyi, D | 1 |
| Bianco, G | 1 |
| Guthrie, EA | 1 |
| Muir, DP | 1 |
| Nath, T | 1 |
| Smith, T | 1 |
| Taylor, CA | 1 |
| Teasdale, EJ | 1 |
| Thornton, R | 1 |
| Farrin, AJ | 1 |
| Everitt, HA | 1 |
| de Bruijn, CMA | 1 |
| Rexwinkel, R | 1 |
| Gordon, M | 1 |
| Benninga, M | 1 |
| Tabbers, MM | 1 |
| Zhou, WC | 1 |
| Jia, L | 1 |
| Deng, Q | 1 |
| Wen, YG | 1 |
| Shang, DW | 1 |
| Ni, XJ | 1 |
| Huang, YX | 1 |
| Liu, Y | 1 |
| Zhao, HB | 1 |
| Yang, M | 1 |
| Dou, GY | 1 |
| Cooper, TE | 1 |
| Heathcote, LC | 1 |
| Clinch, J | 1 |
| Gold, JI | 1 |
| Howard, R | 1 |
| Lord, SM | 1 |
| Schechter, N | 1 |
| Wood, C | 1 |
| Wiffen, PJ | 1 |
| Howell, CA | 1 |
| Mikhalovsky, SV | 1 |
| Markaryan, EN | 1 |
| Khovanov, AV | 1 |
| Chao, GQ | 1 |
| Zhang, S | 1 |
| Mohammad, S | 1 |
| Di Lorenzo, C | 2 |
| Youssef, NN | 1 |
| Miranda, A | 2 |
| Nurko, S | 2 |
| Hyman, P | 2 |
| Saps, M | 3 |
| Ding, Z | 1 |
| Xu, X | 1 |
| Ke, M | 1 |
| Lavigne, JV | 1 |
| Pilcher, H | 1 |
| Lundberg, GD | 1 |
| Lakhan, SE | 1 |
| Kapoor, S | 1 |
| van Leeuwen, Y | 1 |
| Rafiee, M | 1 |
| Thoua, NM | 1 |
| Murray, CD | 1 |
| Winchester, WJ | 1 |
| Roy, AJ | 1 |
| Pitcher, MC | 1 |
| Kamm, MA | 1 |
| Emmanuel, AV | 1 |
| Chassany, O | 1 |
| Duracinsky, M | 1 |
| Leeds, JS | 1 |
| Leeds, CM | 1 |
| Sanders, DS | 1 |
| Youssef, N | 1 |
| Cocjin, J | 1 |
| Benninga, MA | 1 |
| Mayer, EA | 1 |
| Kaminski, A | 1 |
| Kamper, A | 1 |
| Thaler, K | 1 |
| Chapman, A | 1 |
| Gartlehner, G | 1 |
| Teitelbaum, JE | 1 |
| Arora, R | 1 |
| Daling, AH | 1 |
| Holtman, GA | 1 |
| Laseur, MM | 1 |
| Weinans, MA | 1 |
| Lisman-van Leeuwen, Y | 1 |
| Patra, KP | 1 |
| Sankararaman, S | 1 |
| Jackson, R | 1 |
| Hussain, SZ | 1 |
| Sohn, W | 1 |
| Lee, OY | 1 |
| Kwon, JG | 1 |
| Park, KS | 1 |
| Lim, YJ | 1 |
| Kim, TH | 1 |
| Jung, SW | 1 |
| Kim, JI | 1 |
| Morgan, V | 1 |
| Pickens, D | 1 |
| Gautam, S | 1 |
| Kessler, R | 1 |
| Mertz, H | 1 |
| Vahedi, H | 1 |
| Merat, S | 1 |
| Momtahen, S | 1 |
| Kazzazi, AS | 1 |
| Ghaffari, N | 1 |
| Olfati, G | 1 |
| Malekzadeh, R | 1 |
| Bahar, RJ | 1 |
| Collins, BS | 1 |
| Steinmetz, B | 1 |
| Ament, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain[NCT01269671] | Phase 1 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI has left institution) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for amitriptyline and Colitis, Mucous
| Article | Year |
|---|---|
Antidepressants for functional abdominal pain disorders in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive | 2021 |
Antidepressants for chronic non-cancer pain in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Child; Chronic | 2017 |
A meta-analysis of the therapeutic effects of amitriptyline for treating irritable bowel syndrome.
Topics: Amitriptyline; Humans; Irritable Bowel Syndrome; Randomized Controlled Trials as Topic | 2013 |
Antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Gastrointestinal | 2011 |
11 trials available for amitriptyline and Colitis, Mucous
| Article | Year |
|---|---|
Efficacy of amitriptyline in pediatric functional abdominal pain disorders: A randomized placebo-controlled trial.
Topics: Abdominal Pain; Adult; Aged, 80 and over; Amitriptyline; Child; Double-Blind Method; Humans; Irritab | 2022 |
Amitriptyline at low-dose and titrated for irritable bowel syndrome as second-line treatment (The ATLANTIS trial): protocol for a randomised double-blind placebo-controlled trial in primary care.
Topics: Adult; Amitriptyline; Double-Blind Method; Humans; Irritable Bowel Syndrome; Multicenter Studies as | 2022 |
Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial.
Topics: Amitriptyline; Double-Blind Method; England; Female; Humans; Irritable Bowel Syndrome; Male; Middle | 2023 |
Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: are we ready for change?
Topics: Abdominal Pain; Activities of Daily Living; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Chi | 2014 |
Abdominal pain endpoints currently recommended by the FDA and EMA for adult patients with irritable bowel syndrome may not be reliable in children.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Child; Double-Blind Method; Fem | 2015 |
Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Female; Humans; Hypersensitivity; Irritable Bowel Sy | 2009 |
Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders.
Topics: Abdominal Pain; Activities of Daily Living; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anx | 2009 |
Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Diarrhea; Female; Humans; Irritable Bo | 2012 |
Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Brain; Brain Mappi | 2005 |
Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Diarrhea; Double-Blind Method; Fem | 2008 |
Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Double-Blind Method; Fe | 2008 |
15 other studies available for amitriptyline and Colitis, Mucous
| Article | Year |
|---|---|
Low-dose amitriptyline in irritable bowel syndrome: ready for primary care?
Topics: Amitriptyline; Analgesics, Non-Narcotic; Diarrhea; Humans; Irritable Bowel Syndrome; Primary Health | 2023 |
Role of serum amitriptyline concentration and CYP2C19 polymorphism in predicting the response to low-dose amitriptyline in irritable bowel syndrome.
Topics: Amitriptyline; Antidepressive Agents; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Fe | 2021 |
Investigation of the adsorption capacity of the enterosorbent Enterosgel for a range of bacterial toxins, bile acids and pharmaceutical drugs.
Topics: Adsorption; Amitriptyline; Bacterial Toxins; Bile Acids and Salts; Cetirizine; Charcoal; Diarrhea; E | 2019 |
[Current status and recommendations for pediatric clinical trials in functional gastrointestinal disorders].
Topics: Amitriptyline; Child; Constipation; Dyspepsia; Gastrointestinal Agents; Gastrointestinal Diseases; H | 2014 |
Q&A: Peter Whorwell.
Topics: Amitriptyline; Diet; Fecal Microbiota Transplantation; Humans; Hypnosis; Irritable Bowel Syndrome; U | 2016 |
Evidence that amitriptyline may be effective in treating diarrhea-predominant irritable bowel syndrome.
Topics: Amitriptyline; Diarrhea; Evidence-Based Medicine; Humans; Irritable Bowel Syndrome; Randomized Contr | 2008 |
A reader responds to "Evidence that amitriptyline may be effective in treating diarrhea-predominant irritable bowel syndrome".
Topics: Amitriptyline; Controlled Clinical Trials as Topic; Diarrhea; Humans; Irritable Bowel Syndrome; Suic | 2008 |
Psychological associations of irritable bowel syndrome besides panic disorder: an often overlooked reality.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cognitive Behavioral Therapy; Drug Therapy, Combina | 2009 |
Amitriptyline for the treatment of irritable bowel syndrome.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Humans; Irritable Bowel Syndrome; Quality of Li | 2008 |
Is amitriptyline really effective in diarrhoea-predominant irritable bowel syndrome?
Topics: Amitriptyline; Analgesics, Non-Narcotic; Diarrhea; Humans; Irritable Bowel Syndrome | 2008 |
Irritable bowel syndrome. Don't forget amitriptyline.
Topics: Amitriptyline; Gastrointestinal Agents; Humans; Irritable Bowel Syndrome | 2009 |
The power of placebo in pediatric functional gastrointestinal disease.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Child; Dyspepsia; Gastrointesti | 2009 |
Long-term efficacy of low-dose tricyclic antidepressants for children with functional gastrointestinal disorders.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool | 2011 |
Observational research: the pitfall of drawing firm conclusions about efficacy.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Female; Humans; Imipramine; Irritable Bowel Syndrom | 2011 |
Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Arrhythmias, Cardiac; Child; Dr | 2012 |