amitriptyline has been researched along with Cognition Disorders in 18 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There were 1948 treatment histories for modafinil and 1394 treatment reports for amitriptyline reported across five PatientsLikeMe communities (multiple sclerosis, Parkinson's disease, mood conditions, fibromyalgia/chronic fatigue syndrome, and amyotrophic lateral sclerosis)." | 3.77 | Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe. ( Frost, J; Heywood, J; Okun, S; Vaughan, T; Wicks, P, 2011) |
| "Amitriptyline treatment also caused a significant potentiation of non-toxic Aβ monomer with a concomitant decrease in cytotoxic dimer Aβ load, compared to vehicle-treated 3×TgAD controls." | 1.37 | Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. ( Becker, KG; Caroll, J; Chadwick, W; Lehrmann, E; Martin, B; Maudsley, S; Mitchell, N; Park, SS; Wang, L; Wood, WH; Zhang, Y; Zhou, Y, 2011) |
| "However, whether neuropathic pain can induce cognition dysfunction remains uncertain." | 1.36 | Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory. ( Hu, Y; Li, W; Wang, Y; Yang, J, 2010) |
| " There is also a fairly broad consensus that gabapentin is safe and well tolerated, but the side-effect profile of gabapentin has not been adequately assessed in pain populations." | 1.33 | Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy. ( Bourin, C; Chen, P; Hogan, JB; Leet, JE; Lindner, MD; Machet, F; McElroy, JF; Stock, DA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borras, L | 1 |
| Constant, E | 1 |
| De Timary, P | 1 |
| Huguelet, P | 1 |
| Khazaal, Y | 1 |
| Hu, Y | 2 |
| Yang, J | 1 |
| Wang, Y | 1 |
| Li, W | 1 |
| Frost, J | 1 |
| Okun, S | 1 |
| Vaughan, T | 1 |
| Heywood, J | 1 |
| Wicks, P | 1 |
| Chadwick, W | 1 |
| Mitchell, N | 1 |
| Caroll, J | 1 |
| Zhou, Y | 1 |
| Park, SS | 1 |
| Wang, L | 1 |
| Becker, KG | 1 |
| Zhang, Y | 1 |
| Lehrmann, E | 1 |
| Wood, WH | 1 |
| Martin, B | 1 |
| Maudsley, S | 1 |
| Lindner, MD | 1 |
| Bourin, C | 1 |
| Chen, P | 1 |
| McElroy, JF | 1 |
| Leet, JE | 1 |
| Hogan, JB | 1 |
| Stock, DA | 1 |
| Machet, F | 1 |
| Rosenberg, C | 1 |
| Lauritzen, L | 1 |
| Brix, J | 1 |
| Jørgensen, JB | 1 |
| Kofod, P | 1 |
| Bayer, LB | 1 |
| Folstein, S | 1 |
| Folstein, M | 1 |
| Porter, D | 1 |
| Thompson, PJ | 1 |
| Trimble, MR | 1 |
| Busch, KT | 1 |
| Schulz, H | 1 |
| Kugaya, A | 1 |
| Akechi, T | 1 |
| Nakano, T | 1 |
| Okamura, H | 1 |
| Shima, Y | 1 |
| Uchitomi, Y | 1 |
| Gabriel, E | 1 |
| Küfferle, B | 1 |
| Lenz, G | 1 |
| Schuster, P | 1 |
| Szlabowicz, JW | 1 |
| Stewart, JT | 1 |
| Franzén, G | 1 |
| Thomasová, E | 1 |
| Mlcáková, K | 1 |
| Kümpel, Q | 1 |
| Luzecky, MH | 1 |
| Burman, KD | 1 |
| Schultz, ER | 1 |
| Davies, RK | 1 |
| Tucker, GJ | 1 |
| Harrow, M | 1 |
| Detre, TP | 1 |
1 review available for amitriptyline and Cognition Disorders
| Article | Year |
|---|---|
[Long-term psychiatric consequences of carbon monoxide poisoning: a case report and literature review].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Carbon Monoxide Poisoning; Child, Pres | 2009 |
1 trial available for amitriptyline and Cognition Disorders
| Article | Year |
|---|---|
Citalopram versus amitriptyline in elderly depressed patients with or without mild cognitive dysfunction: a danish multicentre trial in general practice.
Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Age | 2007 |
16 other studies available for amitriptyline and Cognition Disorders
| Article | Year |
|---|---|
Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain-Der | 2010 |
Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe.
Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Benzhydryl Compounds; Cognition Disorders; Community N | 2011 |
Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity.
Topics: Alzheimer Disease; Amitriptyline; Amyloid beta-Peptides; Animals; Antidepressive Agents, Tricyclic; | 2011 |
Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy.
Topics: Amines; Amitriptyline; Animals; Cognition Disorders; Cyclohexanecarboxylic Acids; Diabetes Mellitus, | 2006 |
Diagnosis and treatment of Huntington's disease.
Topics: Affective Symptoms; Amitriptyline; Chlorpromazine; Cognition Disorders; Counseling; Deglutition Diso | 1981 |
Drug induced confusional state.
Topics: Aged; Amitriptyline; Aspirin; Cognition Disorders; Confusion; Drug Interactions; Female; Humans; Sub | 1982 |
Non-MAOI antidepressant drugs and cognitive functions: a review.
Topics: Amitriptyline; Antidepressive Agents; Cognition; Cognition Disorders; Depressive Disorder; Dose-Resp | 1982 |
[The acute psychiatric emergency].
Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D | 1981 |
Successful antidepressant treatment for five terminally ill cancer patients with major depression, suicidal ideation and a desire for death.
Topics: Affect; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Attitude to Death; Clomipramine; Cogn | 1999 |
[Individual conditions of pharmacogenic confusion conditions. Comparison of amitriptyline and clozapine].
Topics: Adult; Amitriptyline; Austria; Clozapine; Cognition Disorders; Confusion; Delusions; Dibenzazepines; | 1976 |
Inappropriate antidiuretic hormone secretion.
Topics: Aged; Amitriptyline; Cognition Disorders; Depression; Female; Humans; Hyponatremia; Syndrome; Vasopr | 1975 |
Amitriptyline treatment of agitation associated with anoxic encephalopathy.
Topics: Adult; Aggression; Amitriptyline; Cognition Disorders; Confusion; Humans; Hypoxia, Brain; Male; Myoc | 1990 |
Serum cortisol in chronic schizophrenia. A study of the adrenocortical response to intravenously administered insulin and ACTH.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Age Factors; Aged; Amitriptyline; Blood Glucose; Chlorp | 1971 |
Confusional states in elderly mental patients treated with antidepressants.
Topics: Aged; Amitriptyline; Cognition Disorders; Confusion; Depression; Drug Therapy, Combination; Female; | 1974 |
The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline administration.
Topics: Amitriptyline; Cognition Disorders; Fatigue; Female; Humans; Hyponatremia; Middle Aged; Osmolar Conc | 1974 |
Confusional episodes and antidepressant medication.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Child; Cognition Disorde | 1971 |