amitriptyline has been researched along with Clinically Isolated CNS Demyelinating Syndrome in 4 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cuprizone animal model, also known as the toxic demyelination model, is a well-reproducible model of demyelination- and remyelination in mice, and has been useful in studying important aspect of human demyelinating diseases, including multiple sclerosis." | 3.85 | Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination. ( Anne Becker, K; Chami, M; Fassbender, K; Gulbins, E; Halmer, R; Meier, C; Schnoeder, L; Walter, S, 2017) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chami, M | 1 |
| Halmer, R | 1 |
| Schnoeder, L | 1 |
| Anne Becker, K | 1 |
| Meier, C | 1 |
| Fassbender, K | 1 |
| Gulbins, E | 1 |
| Walter, S | 1 |
| Collet, C | 1 |
| Haen, P | 1 |
| Laversanne, S | 1 |
| Brignol, L | 1 |
| Thiéry, G | 1 |
| Khan, N | 1 |
| Woodruff, TM | 1 |
| Smith, MT | 1 |
| Peruga, I | 1 |
| Hartwig, S | 1 |
| Thöne, J | 1 |
| Hovemann, B | 1 |
| Gold, R | 1 |
| Juckel, G | 1 |
| Linker, RA | 1 |
4 other studies available for amitriptyline and Clinically Isolated CNS Demyelinating Syndrome
| Article | Year |
|---|---|
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Topics: Amitriptyline; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Axons; Cell Count; Cuprizo | 2017 |
Trigeminal neuralgia: a new therapy?
Topics: Adipose Tissue; Amitriptyline; Cosmetic Techniques; Demyelinating Diseases; Face; Female; Humans; Li | 2013 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Inflammation modulates anxiety in an animal model of multiple sclerosis.
Topics: Acoustic Stimulation; Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic | 2011 |