amitriptyline has been researched along with Chronic Insomnia in 32 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0 mg before bedtime) to amitriptyline (10-20 mg before bedtime) in patients with FM with chronic insomnia." | 9.14 | The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. ( Fitzcharles, MA; Joseph, L; Shir, Y; Ware, MA, 2010) |
| "The aim of this pilot study was to evaluate the effectiveness of cognitive-behavioral therapy (CBT) and use of amitriptyline, a tricyclic antidepressant, in patients with chronic temporomandibular disorders (TMD)." | 7.77 | Effectiveness of cognitive-behavioral therapy and amitriptyline in patients with chronic temporomandibular disorders: a pilot study. ( Calderon, Pdos S; Camargo, AP; Conti, PC; Oliveira, LC; Ramos Netto, Tde C; Tabaquim, Mde L, 2011) |
| "Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique." | 7.65 | Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977) |
| "Cognitive behavioral therapy for insomnia (CBT-I) is first choice treatment and effective for people with insomnia and comorbid long-term medical conditions." | 7.01 | TIMELAPSE study-efficacy of low-dose amitriptyline versus cognitive behavioral therapy for chronic insomnia in patients with medical comorbidity: study protocol of a randomized controlled multicenter non-inferiority trial. ( Boss, HM; Braamse, AMJ; Knoop, H; Pot, I; Rauwerda, NL; Rikkert, ME; Timmerhuis, TPJ; van Straten, A; Zondervan, A, 2021) |
| "0 mg before bedtime) to amitriptyline (10-20 mg before bedtime) in patients with FM with chronic insomnia." | 5.14 | The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. ( Fitzcharles, MA; Joseph, L; Shir, Y; Ware, MA, 2010) |
| "The aim of this pilot study was to evaluate the effectiveness of cognitive-behavioral therapy (CBT) and use of amitriptyline, a tricyclic antidepressant, in patients with chronic temporomandibular disorders (TMD)." | 3.77 | Effectiveness of cognitive-behavioral therapy and amitriptyline in patients with chronic temporomandibular disorders: a pilot study. ( Calderon, Pdos S; Camargo, AP; Conti, PC; Oliveira, LC; Ramos Netto, Tde C; Tabaquim, Mde L, 2011) |
| "Cerebrospinal fluid 5-hydroxyindoleacetic acid levels were determined in 31 women with unipolar involutional depression using the probenecid technique." | 3.65 | Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women. ( Banki, CM, 1977) |
| "Adults (18-85 years) with insomnia disorder (Diagnostic and Statistical Manual of Mental Disorders-5) who ask their general practitioner (GP) for sleep medication when non-pharmacological treatment is deemed not effective, are eligible." | 3.01 | Effectiveness of low-dose amitriptyline and mirtazapine for insomnia disorder: study protocol of a randomised, double-blind, placebo-controlled trial in general practice (the DREAMING study). ( Bakker, MH; Hugtenburg, JG; Slottje, P; van der Horst, HE; van Straten, A, 2021) |
| "Cognitive behavioral therapy for insomnia (CBT-I) is first choice treatment and effective for people with insomnia and comorbid long-term medical conditions." | 3.01 | TIMELAPSE study-efficacy of low-dose amitriptyline versus cognitive behavioral therapy for chronic insomnia in patients with medical comorbidity: study protocol of a randomized controlled multicenter non-inferiority trial. ( Boss, HM; Braamse, AMJ; Knoop, H; Pot, I; Rauwerda, NL; Rikkert, ME; Timmerhuis, TPJ; van Straten, A; Zondervan, A, 2021) |
| "Benzodiazepine use in the treatment of insomnia may cause benzodiazepine dependence, especially in opiate users." | 2.69 | Amitriptyline vs. lorazepam in the treatment of opiate-withdrawal insomnia: a randomized double-blind study. ( Jarusuraisin, N; Srisurapanont, M, 1998) |
| "Sixty depressed outpatients were allocated to treatment with either amitriptyline (75-225 mg/day) or flupenthixol (1-5-4-5 mg/day) in flexible dosage for six weeks under double-blind procedures." | 2.64 | A controlled comparison of flupenthixol and amitriptyline in depressed outpatients. ( Hughes, WC; Lader, MH; Young, JP, 1976) |
| "Within the conditions of the double-blind trial, it appears that long-acting amitriptyline (Diffucaps), given at the dosage of 25 mg at the evening meal, is more active and better tolerated than a dosage of 40 mg of ordinary amitriptyline at bedtime in depressive sleep disorders." | 2.64 | [Double-blind comparison between amitriptyline Diffucaps and ordinary amitriptyline in sleep disorders of depressive origin]. ( Brasseur, R, 1975) |
| "Such approach to treatment of insomnia in depressed patients protects them against dependence on hypnotic drugs." | 2.47 | [The effects of antidepressants on sleep in depressed patients with particular reference to trazodone in comparison to agomelatine, amitriptyline, doxepin, mianserine and mirtazapine]. ( Wichniak, A; Wierzbicka, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (65.63) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 4 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bakker, MH | 2 |
| Hugtenburg, JG | 2 |
| van Straten, A | 2 |
| van der Horst, HE | 2 |
| Slottje, P | 2 |
| Rauwerda, NL | 1 |
| Knoop, H | 1 |
| Pot, I | 1 |
| Rikkert, ME | 1 |
| Zondervan, A | 1 |
| Timmerhuis, TPJ | 1 |
| Braamse, AMJ | 1 |
| Boss, HM | 1 |
| Smits, MG | 1 |
| Everitt, H | 1 |
| McDermott, L | 1 |
| Leydon, G | 1 |
| Yules, H | 1 |
| Baldwin, D | 1 |
| Little, P | 1 |
| Ware, MA | 1 |
| Fitzcharles, MA | 1 |
| Joseph, L | 1 |
| Shir, Y | 1 |
| Wichniak, A | 1 |
| Wierzbicka, A | 1 |
| Calderon, Pdos S | 1 |
| Tabaquim, Mde L | 1 |
| Oliveira, LC | 1 |
| Camargo, AP | 1 |
| Ramos Netto, Tde C | 1 |
| Conti, PC | 1 |
| Clark, MS | 1 |
| Smith, PO | 1 |
| Jamieson, B | 1 |
| Rosenlicht, NZ | 1 |
| Riley-Lazo, KP | 1 |
| Rose, D | 1 |
| Duron, B | 1 |
| Montgomery, SA | 1 |
| Srisurapanont, M | 1 |
| Jarusuraisin, N | 1 |
| Elwan, O | 1 |
| Taher, Y | 1 |
| Allam, M | 1 |
| Hassan, MA | 1 |
| Young, JP | 1 |
| Hughes, WC | 1 |
| Lader, MH | 1 |
| Brasseur, R | 1 |
| Banki, CM | 1 |
| Díaz Solano, C | 1 |
| Aurón Zaltzman, D | 1 |
| Lee, HK | 1 |
| Scharf, MB | 1 |
| Hirschowitz, J | 1 |
| Zemlan, FP | 1 |
| Lichstein, M | 1 |
| Woods, M | 1 |
| Sandyk, R | 1 |
| Consroe, PF | 1 |
| Iacono, RP | 1 |
| Zung, WW | 1 |
| Kupfer, DJ | 1 |
| Foster, FG | 1 |
| White, RB | 1 |
| Gathman, LT | 1 |
| Bente, D | 1 |
| Feder, J | 1 |
| Belmchen, H | 1 |
| Hippius, H | 1 |
| Rosenberg, L | 1 |
| Barton, JL | 1 |
| Snaith, RP | 1 |
| Gannon, P | 1 |
| Itil, T | 1 |
| Keskiner, A | 1 |
| Hsu, B | 1 |
| Kerr, MM | 1 |
| McKnight, E | 1 |
| Bodger, JN | 1 |
| Ekdawi, MY | 1 |
2 reviews available for amitriptyline and Chronic Insomnia
| Article | Year |
|---|---|
[The effects of antidepressants on sleep in depressed patients with particular reference to trazodone in comparison to agomelatine, amitriptyline, doxepin, mianserine and mirtazapine].
Topics: Amitriptyline; Antidepressive Agents; Depression; Doxepin; Humans; Mianserin; Mirtazapine; Sleep; Sl | 2011 |
The pharmacology of disordered sleep: a laboratory approach.
Topics: Amitriptyline; Anxiety; Arousal; Barbiturates; Brain; Cerebral Cortex; Depression; Desipramine; Huma | 1970 |
14 trials available for amitriptyline and Chronic Insomnia
| Article | Year |
|---|---|
Effectiveness of low-dose amitriptyline and mirtazapine for insomnia disorder: study protocol of a randomised, double-blind, placebo-controlled trial in general practice (the DREAMING study).
Topics: Adult; Amitriptyline; Antidepressive Agents; Double-Blind Method; General Practice; Humans; Mirtazap | 2021 |
TIMELAPSE study-efficacy of low-dose amitriptyline versus cognitive behavioral therapy for chronic insomnia in patients with medical comorbidity: study protocol of a randomized controlled multicenter non-inferiority trial.
Topics: Adult; Amitriptyline; Cognitive Behavioral Therapy; Comorbidity; Humans; Multicenter Studies as Topi | 2021 |
The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial.
Topics: Adult; Aged; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Cross-Over Studies; Double-B | 2010 |
Zimelidine: a second generation antidepressant. A report from the general practitioner research group.
Topics: Adolescent; Adult; Aged; Amitriptyline; Brompheniramine; Clinical Trials as Topic; Depressive Disord | 1982 |
Amitriptyline vs. lorazepam in the treatment of opiate-withdrawal insomnia: a randomized double-blind study.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Double-Blind Method; Fe | 1998 |
A comparative study of antidepressants in the treatment of depressive states.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Dibenzazepines; Dibenzocycloheptenes; | 1976 |
A controlled comparison of flupenthixol and amitriptyline in depressed outpatients.
Topics: Adult; Aged; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Female; Flupenthixol; Hum | 1976 |
[Double-blind comparison between amitriptyline Diffucaps and ordinary amitriptyline in sleep disorders of depressive origin].
Topics: Amitriptyline; Asthenia; Clinical Trials as Topic; Delayed-Action Preparations; Depression; Female; | 1975 |
Comparative effects of limbitrol and amitriptyline on sleep efficiency and architecture.
Topics: Adult; Amitriptyline; Anxiety Disorders; Chlordiazepoxide; Clinical Trials as Topic; Depressive Diso | 1986 |
[Double-blind study on 3 antidepressive agents. 2. Clinical comparison of noxiptiline, nor-noxiptiline, and amitryptiline using the AMP system].
Topics: Adjustment Disorders; Adolescent; Adult; Affective Symptoms; Aged; Amitriptyline; Analysis of Varian | 1973 |
A clinical assessment of a sustained release preparation of amitriptyline.
Topics: Administration, Oral; Adult; Amitriptyline; Delayed-Action Preparations; Depression; Fatigue; Hospit | 1972 |
Clinical and quantitative electroencephalographical effects of MK 940.
Topics: Adjustment Disorders; Adult; Amitriptyline; Anorexia Nervosa; Attention; Clinical Trials as Topic; C | 1970 |
Amitriptyline in emotional states at the menopause.
Topics: Adult; Affective Symptoms; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Estrogens; | 1970 |
A comparative clinical trial of amitriptyline-perphenazine and chlordiazepoxide in anxious university students.
Topics: Adult; Amitriptyline; Anxiety; Chlordiazepoxide; Clinical Trials as Topic; Female; Humans; Male; Per | 1971 |
16 other studies available for amitriptyline and Chronic Insomnia
| Article | Year |
|---|---|
Off-label low dose amitriptyline for insomnia disorder: Patient-reported outcomes.
Topics: Amitriptyline; Cross-Sectional Studies; Fatigue; Humans; Off-Label Use; Patient Reported Outcome Mea | 2023 |
In brief: Off-label amitriptyline for insomnia.
Topics: Amitriptyline; Antidepressive Agents; Humans; Off-Label Use; Sleep Initiation and Maintenance Disord | 2023 |
GPs' management strategies for patients with insomnia: a survey and qualitative interview study.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety; Attitude of Health Personnel; Benzodiazepi | 2014 |
Effectiveness of cognitive-behavioral therapy and amitriptyline in patients with chronic temporomandibular disorders: a pilot study.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Pain; Cognitive Behavior | 2011 |
FPIN's clinical inquiries: Antidepressants for the treatment of insomnia in patients with depression.
Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Dose-Response Re | 2011 |
Interactions of cyclobenzaprine and tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Mal | 2005 |
[Effect of various anxiolytics on sleep, apropos of the polygraph study of a case of insomnia].
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Female; Humans; Lie Detection; Methotrimeprazine; Pregnan | 1981 |
Anxiety as part of depression.
Topics: Amitriptyline; Anxiety Disorders; Depressive Disorder; Humans; Serotonin; Sleep Initiation and Maint | 1983 |
Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women.
Topics: Adult; Amitriptyline; Anxiety; Depression; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pr | 1977 |
[Amitriptyline in the treatment of anxiety and insomnia anal as a tranquilizer].
Topics: Adolescent; Adult; Amitriptyline; Anxiety Disorders; Drug Evaluation; Female; Humans; Male; Middle A | 1976 |
[Amitriptyline hydrochloride in the treatment of anxiety and insomnia and as a tranquilizer].
Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety Disorders; Drug Evaluation; Female; Humans; Male; Mi | 1976 |
Dystonic reactions to amitriptyline and doxepin.
Topics: Adult; Amitriptyline; Basal Ganglia Diseases; Depressive Disorder; Doxepin; Dystonia; Female; Humans | 1988 |
L-tryptophan in drug-induced movement disorders with insomnia.
Topics: Aged; Amitriptyline; Dyskinesia, Drug-Induced; Female; Humans; Perphenazine; Sleep Initiation and Ma | 1986 |
Sleep and activity in a psychotic depression.
Topics: Amitriptyline; Bipolar Disorder; Electroencephalography; Female; Humans; Middle Aged; Remission, Spo | 1973 |
The syndrome of ordinary grief.
Topics: Adjustment Disorders; Adolescent; Adult; Amitriptyline; Child; Crying; Death; Feeding and Eating Dis | 1973 |
Dibenzepin and amitriptyline in the treatment of depression.
Topics: Adult; Amitriptyline; Anorexia Nervosa; Constipation; Depression; Dibenzazepines; Fatigue; Humans; P | 1971 |