amitriptyline and Chronic Illness studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Research Excerpts

Excerpt	Relevance	Reference
"Efficacy of antidepressants fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache has been studied."	9.13	[Fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache]. ( Amelin, AV; Skoromets, AA; Tarasova, SV, 2008)
"The acute and subchronic effects of low doses nocturnally administered amitriptyline were compared to placebo in a double-blind crossover randomized study on driving ability and driving-related skills involving seven chronic neuropathic pain patients."	9.12	Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Verster, JC; Volkerts, ER, 2006)
"The objective of this prospective, randomized, controlled study (N = 28) was to evaluate the effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy."	9.12	Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. ( Brickman, TM; Haben, M; Jeyakumar, A, 2006)
"The aim of this study was to compare the efficacy and side effects of gabapentin, amitriptyline, and their combination in women with chronic pelvic pain."	9.11	Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. ( Ellend, A; Frickey, N; Gleiss, A; Kozek-Langenecker, SA; Kress, HG; Sator-Katzenschlager, SM; Scharbert, G, 2005)
"The tricyclic antidepressant amitriptyline is the only documented and most widely used prophylactic drug for chronic tension-type headache (CTTH)."	9.11	Analgesic effect of amitriptyline in chronic tension-type headache is not directly related to serotonin reuptake inhibition. ( Ashina, S; Bendtsen, L; Jensen, R, 2004)
"We found no evidence that chronic tension-type headaches that failed to respond to tricyclic antidepressant therapy with amitriptyline improved when subsequently treated with paroxetine."	9.10	Treating chronic tension-type headache not responding to amitriptyline hydrochloride with paroxetine hydrochloride: a pilot evaluation. ( Cordingley, GE; Holroyd, KA; Labus, JS; O'Donnell, FJ, 2003)
"Headache frequency decreased by 45% in the amitriptyline group and by 28% in the trihexyphenidyl group."	9.09	Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. ( Albucher, JF; Brefel-Courbon, C; Descombes, S; Montastruc, JL; Rascol, O; Senard, JM; Thalamas, C, 2001)
"Although the tricyclic antidepressant amitriptyline is extensively used in the prophylactic treatment of chronic tension-type headache, only few studies have investigated the efficacy of this treatment and the results are contradictory."	9.08	A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. ( Bendtsen, L; Jensen, R; Olesen, J, 1996)
"In a double-blind, placebo-controlled trial, the effect of 75 mg of a slow-release formulation of amitriptyline on the clinical severity of chronic tension-type headache and on headache-associated neurophysiological parameters (EMG activity, exteroceptive suppression of temporal muscle activity, contingent negative variation (CNV) and experimental pain sensitivity) was investigated."	9.07	Chronic tension-type headache: amitriptyline reduces clinical headache-duration and experimental pain sensitivity but does not alter pericranial muscle activity readings. ( Göbel, H; Hamouz, V; Hansen, C; Heininger, K; Heuss, D; Hirsch, S; Lindner, V; Soyka, D, 1994)
"The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks."	9.06	Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986)
"Sixty-two patients with fibromyalgia were randomly assigned to receive 25 mg of amitriptyline at night, 500 mg of naproxen twice daily, both amitriptyline and naproxen, or placebo in a 6-week, double-blind trial."	9.06	A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. ( Dinerman, H; Felson, DT; Goldenberg, DL, 1986)
"The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain."	9.06	The analgesic effect of amitriptyline on chronic facial pain. ( Dionne, RA; Dubner, R; Schmidt, E; Sharav, Y; Singer, E, 1987)
"The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain."	7.73	Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005)
"The tricyclic antidepressant, amitriptyline, is an effective drug for the treatment of chronic tension-type headache and for other chronic pain syndromes, but it is also effective in the prophylaxis of an episodic type of headache such as migraine."	7.70	Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications. ( Barbanti, P; Catarci, T; Cerbo, R; Fabbrini, G; Pascali, MP, 1998)
"Amitriptyline proved to be an efficient alternative treatment for chronic pain in TMD patients."	6.71	Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders. ( Ambrosano, GM; de Andrade, ED; de Barbosa, JR; Nogueira, MT; Rizzatti-Barbosa, CM, 2003)
"Depression was assessed by the Beck Depression Inventory (BDI) short form."	6.69	Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. ( Curtis, D; Levine, J; McCall, WD; Plesh, O, 2000)
"Ritanserin was highly effective in reducing Pain Total Index and analgesic consumption in chronic headache, and its activity was similar to that observed during amitriptyline treatment."	6.67	A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline. ( Blandini, F; Cerutti, G; Facchinetti, F; Granella, F; Manzoni, GC; Nappi, G; Ruiz, L; Sandrini, G, 1990)
" In the context of chronic pain, the analgesic effect of amitriptyline was shown to have a dose-response unrelated to mood elevation, but there was a dose-response for the incidence of adverse effects."	6.67	Dose-response for analgesic effect of amitriptyline in chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1993)
"Amitriptyline is a tricyclic antidepressant, considered the treatment of choice for different types of chronic pain, including chronic myofascial pain."	6.44	Use of amitriptyline for the treatment of chronic tension-type headache. Review of the literature. ( Gay Escoda, C; Torrente Castells, E; Vázquez Delgado, E, 2008)
" Low starting doses and careful dosage titration may help to minimise these effects."	6.39	Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996)
"Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment."	5.51	[Treatment of complex regional pain syndrome with amitriptyline]. ( Komoly, S, 2019)
" Participants were randomly assigned to cognitive-behavioral therapy plus amitriptyline (CBT+A, N=64) or headache education plus amitriptyline (HE+A, N=71)."	5.24	Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial. ( Allen, JR; Hershey, AD; Hommel, K; Kabbouche, MA; Kacperski, J; Kashikar-Zuck, S; Kroner, JW; Kroon Van Diest, AM; LeCates, S; O'Brien, HL; Peugh, J; Powers, SW; Ramsey, RR; Slater, S, 2017)
"Among young persons with chronic migraine, the use of CBT plus amitriptyline resulted in greater reductions in days with headache and migraine-related disability compared with use of headache education plus amitriptyline."	5.17	Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. ( Allen, JR; Hershey, AD; Kabbouche, MA; Kashikar-Zuck, SM; LeCates, SL; O'Brien, HL; Powers, SW; Rausch, JR; Shenk, CE; Slater, SK; Zafar, M, 2013)
"Efficacy of antidepressants fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache has been studied."	5.13	[Fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache]. ( Amelin, AV; Skoromets, AA; Tarasova, SV, 2008)
"The objective of this prospective, randomized, controlled study (N = 28) was to evaluate the effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy."	5.12	Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. ( Brickman, TM; Haben, M; Jeyakumar, A, 2006)
"The acute and subchronic effects of low doses nocturnally administered amitriptyline were compared to placebo in a double-blind crossover randomized study on driving ability and driving-related skills involving seven chronic neuropathic pain patients."	5.12	Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Verster, JC; Volkerts, ER, 2006)
"The aim of this study was to compare the efficacy and side effects of gabapentin, amitriptyline, and their combination in women with chronic pelvic pain."	5.11	Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. ( Ellend, A; Frickey, N; Gleiss, A; Kozek-Langenecker, SA; Kress, HG; Sator-Katzenschlager, SM; Scharbert, G, 2005)
"The tricyclic antidepressant amitriptyline is the only documented and most widely used prophylactic drug for chronic tension-type headache (CTTH)."	5.11	Analgesic effect of amitriptyline in chronic tension-type headache is not directly related to serotonin reuptake inhibition. ( Ashina, S; Bendtsen, L; Jensen, R, 2004)
"We found no evidence that chronic tension-type headaches that failed to respond to tricyclic antidepressant therapy with amitriptyline improved when subsequently treated with paroxetine."	5.10	Treating chronic tension-type headache not responding to amitriptyline hydrochloride with paroxetine hydrochloride: a pilot evaluation. ( Cordingley, GE; Holroyd, KA; Labus, JS; O'Donnell, FJ, 2003)
"Headache frequency decreased by 45% in the amitriptyline group and by 28% in the trihexyphenidyl group."	5.09	Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. ( Albucher, JF; Brefel-Courbon, C; Descombes, S; Montastruc, JL; Rascol, O; Senard, JM; Thalamas, C, 2001)
"Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproex sodium, amitriptyline, amitriptyline plus phenelzine, or methadone."	5.09	Management of chronic daily headache utilizing a uniform treatment pathway. ( Rothrock, JF, 1999)
"In a randomized, double-blind, parallel study, fluoxetine and amitriptyline were compared with placebo in the treatment of chronic rheumatic pain."	5.08	An evaluation of antidepressants in rheumatic pain conditions. ( Naidu, MU; Prasad, VB; Rani, PU; Rao, TR; Shobha, JC, 1996)
"Although the tricyclic antidepressant amitriptyline is extensively used in the prophylactic treatment of chronic tension-type headache, only few studies have investigated the efficacy of this treatment and the results are contradictory."	5.08	A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. ( Bendtsen, L; Jensen, R; Olesen, J, 1996)
"Amitriptyline is the medication of first choice in the treatment of chronic tension-type headache."	5.07	Efficacy and tolerability of amitriptylinoxide in the treatment of chronic tension-type headache: a multi-centre controlled study. ( Diener, HC; Fischer, W; Haase, W; Isler, H; Meyer, C; Pfaffenrath, V; Scholz, E; Taneri, Z; Wessely, P; Zaiser-Kaschel, H, 1994)
"In a double-blind, placebo-controlled trial, the effect of 75 mg of a slow-release formulation of amitriptyline on the clinical severity of chronic tension-type headache and on headache-associated neurophysiological parameters (EMG activity, exteroceptive suppression of temporal muscle activity, contingent negative variation (CNV) and experimental pain sensitivity) was investigated."	5.07	Chronic tension-type headache: amitriptyline reduces clinical headache-duration and experimental pain sensitivity but does not alter pericranial muscle activity readings. ( Göbel, H; Hamouz, V; Hansen, C; Heininger, K; Heuss, D; Hirsch, S; Lindner, V; Soyka, D, 1994)
"The efficacy of amitriptyline was evaluated in 28 patients with chronic oral-facial pain."	5.06	The analgesic effect of amitriptyline on chronic facial pain. ( Dionne, RA; Dubner, R; Schmidt, E; Sharav, Y; Singer, E, 1987)
"The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks."	5.06	Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986)
"Sixty-two patients with fibromyalgia were randomly assigned to receive 25 mg of amitriptyline at night, 500 mg of naproxen twice daily, both amitriptyline and naproxen, or placebo in a 6-week, double-blind trial."	5.06	A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. ( Dinerman, H; Felson, DT; Goldenberg, DL, 1986)
"Benefit from neuromodulator treatment with amitriptyline, gabapentin, pregabalin, and baclofen in chronic, idiopathic cough patients was demonstrated."	4.89	Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review. ( Cohen, SM; Misono, S, 2013)
"The purpose of this review is to present relatively detailed information on the characteristics of tricyclic antidepressants, mainly amitriptyline hydrochloride and doxepin hydrochloride, for use as an integral part of the safe and effective management of fibromyalgia and, to a lesser extent, other chronic pain syndromes."	4.79	A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. ( Godfrey, RG, 1996)
"Recent data has signaled that in addition to its therapeutic indications as antidepressant and analgesic, amitriptyline (AM) exerts anti-inflammatory effects in humans and experimental animal models of acute inflammation."	4.02	Amitriptyline Downregulates Chronic Inflammatory Response to Biomaterial in Mice. ( Andrade, SP; Campos, PP; Capettini, LSA; Lazari, MGT; Machado, CT; Orellano, LAA; Scheuermann, K; Viana, CTR, 2021)
"Objective To evaluate the short- and long-term effects of tricyclic antidepressants (TCAs) and gabapentin in the treatment of unexplained chronic cough (UCC)."	3.88	Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough. ( Adessa, M; Benninger, MS; Bowen, AJ; Bryson, PC; Contrera, K; Kaltenbach, J; Milstein, CF; Nowacki, AS; Taliercio, R; Trask, D, 2018)
" The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition."	3.74	Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. ( Jerome, L, 2007)
"To describe our experience with chronic sensory neuropathic cough and its response to amitriptyline in a first group of patients."	3.73	Sensory neuropathic cough: a common and treatable cause of chronic cough. ( Bastian, RW; Delsupehe, KG; Vaidya, AM, 2006)
"Participants in a clinical trial of amitriptyline for pain (n = 84 with spinal cord injury [SCI], n = 38 with amputation) provided responses to the study measures via telephone interview."	3.73	Reliability and validity of a self-report FIM (FIM-SR) in persons with amputation or spinal cord injury and chronic pain. ( Cardenas, DD; Ehde, D; Hanley, M; Jensen, MP; Masedo, AI, 2005)
"The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain."	3.73	Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005)
"The tricyclic antidepressant, amitriptyline, is an effective drug for the treatment of chronic tension-type headache and for other chronic pain syndromes, but it is also effective in the prophylaxis of an episodic type of headache such as migraine."	3.70	Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications. ( Barbanti, P; Catarci, T; Cerbo, R; Fabbrini, G; Pascali, MP, 1998)
" We demonstrate this patient-focused method using published data from 23 N-of-1 trial results comparing amitriptyline and placebo for the treatment of fibromyalgia."	3.69	Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. ( D'Agostino, RB; Lau, J; McIntosh, MW; Schmid, CH; Selker, HP; Zucker, DR, 1997)
"Amitriptyline was the most useful drug in that it provided pain relief in musculoskeletal, vascular, and some neuropathic pain conditions."	3.69	Diagnosis and treatment of persistent pain after trauma to the head and neck. ( Benoliel, R; Eliav, E; Elishoov, H; Sharav, Y, 1994)
"Concentrations of amitriptyline (AT), nortriptyline (NT) and E-10-hydroxynortriptyline (E-10-OH-NT) were measured in 18 women with bulimia receiving 100 mg AT/day for at least 6 wk."	3.67	Therapeutic drug monitoring of amitriptyline: impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women. ( de Wolff, FA; Edelbroek, PM; Knoppert-van der Klein, EA; van Putten, PM; Zitman, FG, 1987)
"Youth with chronic migraine who received CBT+A improved faster than those in the control group."	2.84	Trajectory of Improvement in Children and Adolescents With Chronic Migraine: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial. ( Allen, JR; Hershey, AD; Kabbouche, MA; Kashikar-Zuck, SM; Kroner, JW; Kroon Van Diest, AM; LeCates, SL; O'Brien, HL; Peugh, J; Powers, SW; Shenk, CE; Slater, SK; Zafar, M, 2017)
"Chronic migraine sufferers were randomized into two groups and treated with 25 or 50mg/day of amitriptyline or 250U of botulinum toxin type A."	2.75	Botulinum toxin type A versus amitriptyline for the treatment of chronic daily migraine. ( Cardeal, M; Magalhães, E; Melo, A; Menezes, C, 2010)
"Taking into account that migraine is associated with major depression, in the present research the effect of the antidepressant amitriptyline was also evaluated."	2.73	Emotional memory and migraine: effects of amitriptyline and sex related difference. ( Arnone, B; Cifariello, A; Gasbarri, A; Marini, C; Pompili, A; Tavares, MC; Tomaz, C, 2008)
"Forty-five inpatients with a chronic Major Depressive Disorder were randomized to 5 weeks of either Interpersonal Psychotherapy (IPT) modified for an inpatient setting (15 individual and 8 group sessions) plus pharmacotherapy or to medication plus Clinical Management (CM)."	2.73	Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients. ( Berger, M; Dykierek, P; Härter, M; Kech, S; Schneider, D; Schramm, E; van Calker, D; Zobel, I, 2008)
"Amitriptyline proved to be an efficient alternative treatment for chronic pain in TMD patients."	2.71	Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders. ( Ambrosano, GM; de Andrade, ED; de Barbosa, JR; Nogueira, MT; Rizzatti-Barbosa, CM, 2003)
"Depression was assessed by the Beck Depression Inventory (BDI) short form."	2.69	Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. ( Curtis, D; Levine, J; McCall, WD; Plesh, O, 2000)
" In the context of chronic pain, the analgesic effect of amitriptyline was shown to have a dose-response unrelated to mood elevation, but there was a dose-response for the incidence of adverse effects."	2.67	Dose-response for analgesic effect of amitriptyline in chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1993)
"Ritanserin was highly effective in reducing Pain Total Index and analgesic consumption in chronic headache, and its activity was similar to that observed during amitriptyline treatment."	2.67	A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline. ( Blandini, F; Cerutti, G; Facchinetti, F; Granella, F; Manzoni, GC; Nappi, G; Ruiz, L; Sandrini, G, 1990)
" Following a 4 week placebo period, high dosage tranquilizers were given for 16 weeks and amitriptyline was added for the following 16 weeks."	2.64	Tranquilizers or anti-depressants for chronic schizophrenics: a long term study. ( Clums, JM; Grey, WH; Teja, JS; Warren, C, 1975)
"We define chronic migraine as that clinical situation in which migraine attacks appear 15 or more days per month."	2.48	[Chronic migraine: treatment]. ( Pascual, J, 2012)
"Amitriptyline is a tricyclic antidepressant, considered the treatment of choice for different types of chronic pain, including chronic myofascial pain."	2.44	Use of amitriptyline for the treatment of chronic tension-type headache. Review of the literature. ( Gay Escoda, C; Torrente Castells, E; Vázquez Delgado, E, 2008)
"The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder."	2.44	[The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 2: Treatment]. ( Binder, I; Rossbach, G; van Ophoven, A, 2008)
"Interstitial cystitis/painful bladder syndrome is a chronic disease characterized by pain, frequency, urgency, and nocturia and diagnosed primarily in women."	2.44	Interstitial cystitis/painful bladder syndrome. ( Warren, JW, 2007)
"Pain is associated with myriad medical conditions and affects millions of Americans."	2.41	Pharmacologic management of chronic pain. ( Argoff, CE, 2002)
"Chronic daily headache is a heterogeneous group of daily or near-daily headaches that afflicts close to 5% of the general population and accounts for close to 35% to 40% of patients at headache centers."	2.41	Cognitive-behavioral issues in the treatment and management of chronic daily headache. ( Lipchik, GL; Nash, JM, 2002)
" Low starting doses and careful dosage titration may help to minimise these effects."	2.39	Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996)
"Neurogenic pain is defined as pain due to dysfunction of the peripheral or central nervous system, in the absence of nociceptor (nerve terminal) stimulation by trauma or disease."	2.38	Neurogenic pain syndromes and their management. ( Bowsher, D, 1991)
"Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment."	1.51	[Treatment of complex regional pain syndrome with amitriptyline]. ( Komoly, S, 2019)
"Treatment with ketamine, minocycline and amitriptyline were able to exert antidepressant effects in the forced swimming test."	1.48	Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events. ( Abelaira, HM; de Moura, AB; de Souza, TG; Fileti, ME; Garbossa, L; Goldim, MP; Maciel, AL; Mathias, K; Matos, D; Petronilho, F; Quevedo, J; Réus, GZ; Rosa, T; Strassi, AP; Tuon, T, 2018)
" Chronic administration of amitriptyline reversed the despaired behavior induced by exposure to UCMS paradigm and, fully recovered pNF-H labeling to control values."	1.46	Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression. ( Galeotti, N; Ghelardini, C; Sanna, MD, 2017)
"L-acetylcarnitine treatment enhanced mGlu2/3 receptor protein levels in the dorsal region of the spinal cord."	1.46	Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. ( Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C, 2017)
"In the chronic nausea group, 62% had migraines, and 71% (vs 22%) had familial migraines (P < ."	1.40	Chronic idiopathic nausea of childhood. ( Chelimsky, G; Kovacic, K; Li, BU; Miranda, A; Simpson, P; Williams, S, 2014)
"In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures."	1.37	Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011)
"Management of patients affected by chronic daily headache (CDH) with medication overuse constitutes one of the most important unresolved problems."	1.36	The efficacy of withdrawal therapy in subjects with chronic daily headache and medication overuse following prophylaxis with topiramate and amitriptyline. ( Tanganelli, P; Valguarnera, F, 2010)
"Unexplained cough is a diagnosis of exclusion that should not be made until a thorough validated diagnostic evaluation is performed, specific and appropriate validated treatments have been tried and failed, and uncommon causes have been ruled out."	1.36	Unexplained cough in the adult. ( Irwin, RS, 2010)
"In the present study we have investigated the effects of a chronic administration of olanzapine (Ola) on visual and spatial memory in normal and anhedonic rats."	1.34	Modification of spatial recognition memory and object discrimination after chronic administration of haloperidol, amitriptyline, sodium valproate or olanzapine in normal and anhedonic rats. ( Canonico, PL; Colella, L; Dellarole, A; Ghi, P; Orsetti, M, 2007)
"The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)."	1.33	Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006)
"Abdominal migraine has to be taken in to account when diagnosing chronic abdominal pain in children."	1.33	[Abdominal migraine as a cause of chronic recurrent abdominal pain in a 9-years-old girl--case report]. ( Karczewska, K; Kasner, J; Kwiecień, J; Piasecki, L, 2005)
"Six children with cerebral palsy are presented who developed neuropathic pain following multilevel orthopedic surgery."	1.33	Neuropathic pain following multilevel surgery in children with cerebral palsy: a case series and review. ( Lauder, GR; White, MC, 2005)
"Gabapentin has been shown to be useful in treatment of different conditions which may be caused by increased neuronal excitability."	1.32	Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin. ( Haller, H; Leblhuber, F; Schmidhammer, R; Trenkler, J, 2003)
" The present study is a retrospective analysis of the effect of drug withdrawal therapy in patients with CDH and frequent long-term use of headache symptomatic medication."	1.31	Withdrawal therapy improves chronic daily headache associated with long-term misuse of headache medication: a retrospective study. ( Dahlöf, C; Linde, M; Linton-Dahlöf, P, 2000)
"Gabapentin has been shown to reduce pain associated with diabetic neuropathia and postherpetic neuralgia."	1.31	[Gabapentin in the treatment of chronic intractable pain]. ( Gustorff, B; Kress, HG; Nahlik, G; Spacek, A, 2002)
"Chronic tension headache sufferers received structured massage therapy treatment directed toward neck and shoulder muscles."	1.31	Massage therapy and frequency of chronic tension headaches. ( Chandler, C; Moraska, A; Quinn, C, 2002)
"Fibromyalgia is rarely included in the differential diagnosis of dyspnea, and timely diagnosis and treatment may be delayed."	1.30	Dyspnea resulting from fibromyalgia. ( Albert, RK; Kreck, T; Weiss, DJ, 1998)
"The response to prophylactic anti-migraine medication (propranolol or amitriptyline used alone or in combination) was gratifying, with 21 of 30 adequately treated patients (70%) reporting dramatic reduction in the frequency and severity of their headaches."	1.28	Post-traumatic migraine: chronic migraine precipitated by minor head or neck trauma. ( Goldberg, J; Stern, BJ; Weiss, HD, 1991)
" N of 1 RCTs can also generate initial estimates of the proportion of patients who respond to a new agent and for determining sample size, inclusion criteria, and dosage regimen(s) for subsequent parallel group trials."	1.28	N of 1 randomized trials for investigating new drugs. ( Adachi, JD; Guyatt, GH; Heyting, A; Jaeschke, R; Keller, J; Roberts, RS, 1990)
" Proper dosage is determined by the patient's age and metabolic capabilities, and patient education increases compliance."	1.28	Chronic depression. Issues in long-term management. ( Bacani-Oropilla, T; Lippmann, SB, 1989)
" Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication."	1.27	Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. ( Callies, AL; Popkin, MK, 1987)
"Chronic mood disorders were also assessed using RDC criteria."	1.26	Chronic mood disorders in depressed outpatient--diagnosis and response to pharmacotherapy. ( Prusoff, BA; Rounsaville, BJ; Sholomskas, D, 1980)
" Unit dose packaging is used because the oral solid dosage forms (including placebos) are made to look alike."	1.25	Drug use and distribution in a pain rehabilitation center. ( Beckner, TF; Idsvoog, P, 1975)

Research

Studies (160)

Authors

Clinical Trials (14)

Trial Overview

Trial Outcomes

7-Point Guy/Farrar Patient Global Impression of Change (PGIC)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (30.63)	18.7374
1990's	32 (20.00)	18.2507
2000's	44 (27.50)	29.6817
2010's	33 (20.63)	24.3611
2020's	2 (1.25)	2.80

Authors	Studies
Guilleminault, L	1
Demoulin-Alexikova, S	1
de Gabory, L	1
Bruley des Varannes, S	1
Brouquières, D	1
Balaguer, M	1
Chapron, A	1
Grassin Delyle, S	1
Poussel, M	1
Guibert, N	1
Reychler, G	1
Trzepizur, W	1
Woisard, V	1
Crestani, S	1
Komoly, S	1
Scheuermann, K	1
Orellano, LAA	1
Viana, CTR	1
Machado, CT	1
Lazari, MGT	1
Capettini, LSA	1
Andrade, SP	1
Campos, PP	1
Lee, HG	1
Grossman, SK	1
Valdes-Rodriguez, R	1
Berenato, F	1
Korbutov, J	1
Chan, YH	1
Lavery, MJ	1
Yosipovitch, G	1
Notartomaso, S	1
Mascio, G	1
Bernabucci, M	1
Zappulla, C	1
Scarselli, P	1
Cannella, M	1
Imbriglio, T	1
Gradini, R	1
Battaglia, G	1
Bruno, V	1
Nicoletti, F	1
Maciel, AL	1
Abelaira, HM	1
de Moura, AB	1
de Souza, TG	1
Rosa, T	1
Matos, D	1
Tuon, T	1
Garbossa, L	1
Strassi, AP	1
Fileti, ME	1
Goldim, MP	1
Mathias, K	1
Petronilho, F	1
Quevedo, J	1
Réus, GZ	1
Bowen, AJ	1
Nowacki, AS	1
Contrera, K	1
Trask, D	1
Kaltenbach, J	1
Milstein, CF	1
Adessa, M	1
Benninger, MS	1
Taliercio, R	1
Bryson, PC	1
Stein, DJ	1
Noordzij, JP	1
Poterucha, TJ	1
Murphy, SL	1
Sandroni, P	1
Rho, RH	1
Warndahl, RA	1
Weiss, WT	1
Davis, MD	1
Powers, SW	3
Kashikar-Zuck, SM	2
Allen, JR	3
LeCates, SL	2
Slater, SK	2
Zafar, M	2
Kabbouche, MA	3
O'Brien, HL	3
Shenk, CE	2
Rausch, JR	1
Hershey, AD	3
Kovacic, K	1
Miranda, A	1
Chelimsky, G	1
Williams, S	1
Simpson, P	1
Li, BU	1
Kalita, J	1
Kohat, AK	1
Misra, UK	1
Bhoi, SK	1
Santiago, MD	1
Carvalho, Dde S	1
Gabbai, AA	1
Pinto, MM	1
Moutran, AR	1
Villa, TR	1
Arco, L	1
Kudryashov, NV	1
Kalinina, TS	1
Voronina, TA	1
Dogishi, K	1
Kodera, M	1
Oyama, S	1
Shirakawa, H	1
Nakagawa, T	1
Kaneko, S	1
Robertson, KL	1
Marshman, LA	1
Sanna, MD	1
Ghelardini, C	1
Galeotti, N	1
Giliberto, JP	1
Cohen, SM	2
Misono, S	2
Kroner, JW	2
Peugh, J	2
Kroon Van Diest, AM	2
Ramsey, RR	1
Kashikar-Zuck, S	1
Slater, S	1
Hommel, K	1
LeCates, S	1
Kacperski, J	1
Tarasova, SV	1
Amelin, AV	1
Skoromets, AA	1
Binder, I	1
Rossbach, G	1
van Ophoven, A	1
Torrente Castells, E	1
Vázquez Delgado, E	1
Gay Escoda, C	1
Ziegler, D	1
Greene, SM	1
Simpson, CB	1
Irwin, RS	1
Goldman, RH	1
Stason, WB	1
Park, SK	1
Kim, R	1
Mudgal, S	1
Davis, RB	1
Kaptchuk, TJ	1
Magalhães, E	1
Menezes, C	1
Cardeal, M	1
Melo, A	1
Valguarnera, F	1
Tanganelli, P	1
Zucker, DR	2
Ruthazer, R	1
Schmid, CH	2
Taylor, J	1
Goodkin, HP	1
Maigne, JY	1
Pigeau, I	1
Aguer, N	1
Doursounian, L	1
Chatellier, G	1
Gunduz, O	1
Oltulu, C	1
Guven, R	1
Buldum, D	1
Ulugol, A	1
Keller, K	1
Beule, J	1
Dippold, W	1
Straube, A	1
Gaul, C	1
Pascual, J	1
Wielage, R	1
Bansal, M	1
Wilson, K	1
Klein, R	1
Happich, M	1
Liu, X	1
Emery, CJ	1
Laude, E	1
Herget, J	1
Gill, G	1
Cope, G	1
Barer, GR	1
Goadsby, P	1
Argoff, CE	1
Quinn, C	1
Chandler, C	1
Moraska, A	1
Lipchik, GL	2
Nash, JM	1
Gilden, DH	1
Cohrs, RJ	1
Hayward, AR	1
Wellish, M	1
Mahalingam, R	1
Rizzatti-Barbosa, CM	1
Nogueira, MT	1
de Andrade, ED	1
Ambrosano, GM	1
de Barbosa, JR	1
Haller, H	1
Leblhuber, F	1
Trenkler, J	1
Schmidhammer, R	1
GUILLAMONALCANTARA, A	1
Holroyd, KA	2
Labus, JS	1
O'Donnell, FJ	2
Cordingley, GE	2
Ashina, S	1
Bendtsen, L	2
Jensen, R	2
Bomholt, SF	1
Mikkelsen, JD	1
Blackburn-Munro, G	1
Masedo, AI	1
Hanley, M	1
Jensen, MP	1
Ehde, D	1
Cardenas, DD	2
Lauder, GR	1
White, MC	1
Meyer, MA	1
Kwiecień, J	1
Piasecki, L	1
Kasner, J	1
Karczewska, K	1
Veldhuijzen, DS	1
van Wijck, AJ	1
Verster, JC	1
Kenemans, JL	1
Kalkman, CJ	1
Olivier, B	1
Volkerts, ER	1
Sator-Katzenschlager, SM	1
Scharbert, G	1
Kress, HG	2
Frickey, N	1
Ellend, A	1
Gleiss, A	1
Kozek-Langenecker, SA	1
Bettucci, D	1
Testa, L	1
Calzoni, S	1
Mantegazza, P	1
Viana, M	1
Monaco, F	1
Son, BC	1
Lee, SW	1
Choi, ES	1
Sung, JH	1
Hong, JT	1
Orsetti, M	1
Colella, L	1
Dellarole, A	1
Canonico, PL	1
Ghi, P	2
Bastian, RW	1
Vaidya, AM	1
Delsupehe, KG	1
Jeyakumar, A	1
Brickman, TM	1
Haben, M	1
Hibi, S	1
Yamaguchi, Y	1
Teramoto, S	1
Yamamoto, H	1
Eto, M	1
Akishita, M	1
Ouchi, Y	1
Silver, N	1
Warren, JW	1
van Doorn, PA	1
Jerome, L	1
Gourley, SL	1
Wu, FJ	1
Kiraly, DD	1
Ploski, JE	1
Kedves, AT	1
Duman, RS	1
Taylor, JR	1
Schramm, E	1
Schneider, D	1
Zobel, I	1
van Calker, D	1
Dykierek, P	1
Kech, S	1
Härter, M	1
Berger, M	1
Gasbarri, A	1
Arnone, B	1
Pompili, A	1
Cifariello, A	1
Marini, C	1
Tavares, MC	1
Tomaz, C	1
Benbouzid, M	1
Choucair-Jaafar, N	1
Yalcin, I	1
Waltisperger, E	1
Muller, A	1
Freund-Mercier, MJ	1
Barrot, M	1
Blaine, JD	1
Prien, RF	1
Levine, J	2
Rounsaville, BJ	2
Sholomskas, D	1
Prusoff, BA	3
Morse, RH	1
Portenoy, RK	1
Rapscak, S	1
Kanner, R	1
Pilowsky, I	1
Hallett, EC	1
Bassett, DL	1
Thomas, PG	1
Penhall, RK	1
Harkness, L	2
Giller, EL	1
Bialos, D	2
Waldo, MC	1
Stein, MK	1
Rickels, K	1
Weise, CC	1
Van Sweden, B	1
Dumon-Radermecker, M	1
Padian, N	1
Ferretti, C	1
Blengio, M	1
Gamalero, SR	1
Berlanga, C	1
Ortega-Soto, HA	1
Göbel, H	1
Hamouz, V	1
Hansen, C	1
Heininger, K	1
Hirsch, S	1
Lindner, V	1
Heuss, D	1
Soyka, D	1
Benoliel, R	1
Eliav, E	1
Elishoov, H	1
Sharav, Y	2
Strouse, WS	1
Pfaffenrath, V	1
Diener, HC	1
Isler, H	1
Meyer, C	1
Scholz, E	1
Taneri, Z	1
Wessely, P	1
Zaiser-Kaschel, H	1
Haase, W	1
Fischer, W	2
McQuay, HJ	1
Carroll, D	1
Glynn, CJ	1
Godfrey, RG	1
Rani, PU	1
Naidu, MU	1
Prasad, VB	1
Rao, TR	1
Shobha, JC	1
Bryson, HM	1
Wilde, MI	1
Olesen, J	1
Hobson, WH	1
Shiraki, R	1
Steiner, D	1
Van Horn, M	1
Mynors-Wallis, L	1
Gath, D	1
McIntosh, MW	1
D'Agostino, RB	1
Selker, HP	1
Lau, J	1
Brenne, E	1
van der Hagen, K	1
Maehlum, E	1
Husebø, S	1
Weiss, DJ	1
Kreck, T	1
Albert, RK	1
Pertes, RA	1
Bailey, DR	1
Milone, AS	1
Cerbo, R	1
Barbanti, P	1
Fabbrini, G	1
Pascali, MP	1
Catarci, T	1
Jevoux, Cda C	1
Moreira Filho, PF	1
de Souza, JA	1
Hyams, JS	1
Hyman, PE	1
Zed, PJ	1
Loewen, PS	1
Robinson, G	1
Scott, MA	1
Letrent, KJ	1
Hager, KL	1
Burch, JL	1
Kiefer, G	1
Feuerstein, TJ	1
Borgaonkar, MR	1
Lumb, B	1
Plesh, O	1
Curtis, D	1
McCall, WD	1
Bauherz, G	1
Linton-Dahlöf, P	1
Linde, M	1
Dahlöf, C	1
Descombes, S	1
Brefel-Courbon, C	1
Thalamas, C	1
Albucher, JF	1
Rascol, O	1
Montastruc, JL	1
Senard, JM	1
Rothrock, JF	1
Lofland, JH	1
Szarlej, D	1
Buttaro, T	1
Shermock, S	1
Jalali, S	1
Stensland, M	1
Carlson, BW	1
Gustorff, B	1
Nahlik, G	1
Spacek, A	1
Warms, CA	1
Turner, JA	1
Marshall, H	1
Brooke, MM	1
Loeser, JD	1
Teja, JS	1
Grey, WH	1
Clums, JM	1
Warren, C	1
Garelis, E	1
Gillin, JC	1
Wyatt, RJ	1
Neff, N	1
Montgomery, BJ	1
Williams, DH	1
Weissman, MM	1
Astrachan, BM	1
Duthie, AM	1
Beckner, TF	1
Idsvoog, P	1
Fong, GR	1
Zitman, FG	3
Linssen, AC	2
Edelbroek, PM	3
Van Kempen, GM	1
Gonzales, GR	1
Hampf, G	1
Kuoppasalmi, K	1
Henriksson, M	1
Achté, K	1
Weiss, HD	1
Stern, BJ	1
Goldberg, J	1
Bowsher, D	1
Nappi, G	1
Sandrini, G	1
Granella, F	1
Ruiz, L	1
Cerutti, G	1
Facchinetti, F	1
Blandini, F	1
Manzoni, GC	1
Egbunike, IG	1
Chaffee, BJ	1
Guyatt, GH	1
Heyting, A	1
Jaeschke, R	1
Keller, J	1
Adachi, JD	1
Roberts, RS	1
Bacani-Oropilla, T	1
Lippmann, SB	1
Jay, GW	1
Brunson, J	1
Branson, SJ	1
Tuchman, AJ	1
Daras, M	1
Ventafridda, V	1
Bonezzi, C	1
Caraceni, A	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Drug and Non-Drug Treatment of Pediatric Chronic Headache[NCT00389038]	Phase 3	132 participants (Anticipated)	Interventional	2006-10-31	Active, not recruiting
Impact of Physical Activity for Chronic Pelvic Pain[NCT02867774]		22 participants (Actual)	Interventional	2016-08-31	Completed
Efficacy of Physiotherapy Intervention Among University Students With Migraine Symptoms[NCT05741775]	Early Phase 1	87 participants (Anticipated)	Interventional	2022-09-18	Recruiting
Single Case Experimental Design (SCED) Comparing an Off-the-shelf Carbon Ankle Foot Orthosis (SPRYSTEP) Versus an off-the Shelf Standard Plastic Ankle Foot Orthosis in the Treatment of Walking Functional Impairment[NCT05131399]		20 participants (Anticipated)	Interventional	2022-02-28	Recruiting
Randomised Control Trial of the Clinical and Cost Effectiveness of a Specialist Expert Mood Disorder Team for Refractory Unipolar Depressive Disorder[NCT01047124]		219 participants (Anticipated)	Interventional	2009-09-30	Recruiting
Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662]	Phase 4	50 participants (Anticipated)	Interventional	2015-02-28	Recruiting
Internet-Enhanced Management of Fibromyalgia[NCT00423631]		118 participants (Actual)	Interventional	2006-09-30	Completed
Combining N-of-1 Trials to Assess Fibromyalgia Therapies[NCT00000428]	Phase 4	58 participants (Actual)	Interventional	2000-09-30	Completed
EN20-01: A 24 Week Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Moderate to Severe Knee Osteoarthritis Pain.[NCT05025787]	Phase 2	77 participants (Anticipated)	Interventional	2021-10-25	Recruiting
Evaluation of Liquid Gastric Emptying and Plasma Ghrelin in Children With Functional Dyspepsia[NCT01591174]		30 participants (Actual)	Observational	2012-05-31	Completed
Effects of Myofascial Trigger Points Therapy in Migraine.[NCT05646160]		100 participants (Anticipated)	Interventional	2018-01-15	Recruiting
Management of Chronic Pain in Rehabilitation Project I - Management of Chronic Pain in Persons With Spinal Cord Injury[NCT00006428]	Phase 4	100 participants	Interventional	1996-08-31	Completed
Subcutaneous Injection of Botulinum Toxin A for At--Level Back Pain in Patients With Spinal Cord Injury[NCT02736890]	Phase 2	8 participants (Actual)	Interventional	2016-03-31	Terminated (stopped due to funding not available to continue)
Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313]		152 participants (Actual)	Interventional	2015-03-31	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Mean change from baseline. Participants are asked Taking into account your pain level and how it affects your life, are you feeling better, the same or worse than when you started treatment? and then to quantify the magnitude of the change. with the 7-Point guy Farrar which measures the global treatment effect from with scale from 0 to 6, higher score indicates worse outcomes." (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

International Basic Pain Dataset - Pain Affecting Day-to-day Activities

Intervention	score on a scale (Mean)
	2 week post injection	4 week post injection	8 week post injection	12 week post injection	crossover 2 week follow up	crossover 4 week follow up	crossover 8 week follow up	crossover 12 week follow up
Botulinum Toxin A Then Placebo	2.2	2.4	2	2	0	0	0	0
Placebo Then Botulinum Toxin A	0.3	0.3	0	0	5	5	3	1

The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting day-to-day activities subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

International Basic Pain Dataset - Pain Affecting Mood

Intervention	units on a scale (Mean)
	Baseline	2 week post injection	4 week post injection	8 week post injection	12 week post injection	crossover 2 week follow up	crossover 4 week follow up	crossover 8 week follow up	crossover 12 week follow up
Botulinum Toxin A Then Placebo	4.2	5.4	5	5	4.8	7	6.7	7	6.7
Placebo Then Botulinum Toxin A	5.3	2.7	2.7	2.7	2.7	2	3	4	5

The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting mood subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

International Basic Pain Dataset - Pain Affecting Sleep

Intervention	units on a scale (Mean)
	Baseline	2 week post injection	4 week post injection	8 week post injection	12 week post injection	crossover 2 week follow up	crossover 4 week follow up	crossover 8 week follow up	crossover 12 week follow up
Botulinum Toxin A Then Placebo	5.6	6.6	5.8	5.2	5.6	7	7	7.3	6.7
Placebo Then Botulinum Toxin A	5.7	2.7	2.7	4.3	5.7	2	3	4	7

The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting sleep subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

Numeric Pain Rating Scale (NPRS)

Intervention	units on a scale (Mean)
	Baseline	2 week post injection	4 week post injection	8 week post injection	12 week post injection	crossover 2 week follow up	crossover 4 week follow up	crossover 8 week follow up	crossover 12 week follow up
Botulinum Toxin A Then Placebo	5.8	4.6	5	6	6.2	8	8	8	7.3
Placebo Then Botulinum Toxin A	6.7	4.7	3.3	6	6.7	1	3	4	5

Participant rated pain intensity from 0-10, with higher score indicating more pain (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

Patient-generated Index (PGI)

Intervention	score on a scale (Mean)
	baseline	2 week post injection	4 week post injection	8 week post injection	12 week post injection	crossover 2 week follow up	crossover 4 week follow up	crossover 8 week follow up	crossover 12 week follow up
Botulinum Toxin A Then Placebo	7.6	6.4	5.6	5.6	5.6	8	8	6.7	8
Placebo Then Botulinum Toxin A	8	8	8	8	8	5	5	6	7

PGI measures activity affected by pain. Full score is 0 to 10000, with higher score indicating better function (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

Intervention	score on a scale (Mean)
	Baseline	2 week post injection	4 week post injection	8 week post injection	12 week post injection	crossover 2 week follow up	crossover 4 week follow up	crossover 8 week follow up	crossover 12 week follow up
Botulinum Toxin A Then Placebo	4250	5240	5219	3725	4330	3333.3	3333.3	3333.3	3333.3
Placebo Then Botulinum Toxin A	1500	1550	1825	2800	1800	3500	3750	3000	1500

Article	Year
Are neuromodulating medications effective for the treatment of chronic neurogenic cough? The Laryngoscope, 2017, Volume: 127, Issue:5 Topics: Amines; Amitriptyline; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob	2017
[The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 2: Treatment]. Aktuelle Urologie, 2008, Volume: 39, Issue:4 Topics: Administration, Intravesical; Administration, Oral; Amitriptyline; Arginine; Botulinum Toxins, Type	2008
Use of amitriptyline for the treatment of chronic tension-type headache. Review of the literature. Medicina oral, patologia oral y cirugia bucal, 2008, Sep-01, Volume: 13, Issue:9 Topics: Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Humans; Tension-Type Headache	2008
Painful diabetic neuropathy: advantage of novel drugs over old drugs? Diabetes care, 2009, Volume: 32 Suppl 2 Topics: Amitriptyline; Analgesics; Antioxidants; Antipruritics; Capsaicin; Chronic Disease; Diabetic Neuropa	2009
Evidence for sensory neuropathy and pharmacologic management. Otolaryngologic clinics of North America, 2010, Volume: 43, Issue:1 Topics: Adrenergic Uptake Inhibitors; Amines; Amitriptyline; Anticonvulsants; Chronic Disease; Cough; Cycloh	2010
Dizziness and vertigo in the adolescent. Otolaryngologic clinics of North America, 2011, Volume: 44, Issue:2 Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Dizziness; Female; Headache; H	2011
[Chronic migraine: treatment]. Revista de neurologia, 2012, Apr-10, Volume: 54 Suppl 2 Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antihypertensiv	2012
Cost-effectiveness of duloxetine in chronic low back pain: a Quebec societal perspective. Spine, 2013, May-15, Volume: 38, Issue:11 Topics: Age Factors; Aged; Amitriptyline; Analgesics; Cardiovascular Diseases; Celecoxib; Chronic Disease; C	2013
Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013, Volume: 148, Issue:3 Topics: Amines; Amitriptyline; Baclofen; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin; ga	2013
Chronic tension-type headache. Clinical evidence, 2002, Issue:7 Topics: Amitriptyline; Chronic Disease; Humans; Randomized Controlled Trials as Topic; Tension-Type Headache	2002
Pharmacologic management of chronic pain. The Journal of the American Osteopathic Association, 2002, Volume: 102, Issue:9 Suppl 3 Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N	2002
Cognitive-behavioral issues in the treatment and management of chronic daily headache. Current pain and headache reports, 2002, Volume: 6, Issue:6 Topics: Amitriptyline; Analgesics, Non-Narcotic; Biofeedback, Psychology; Chronic Disease; Cognitive Behavio	2002
Headache (chronic tension-type). American family physician, 2007, Jul-01, Volume: 76, Issue:1 Topics: Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents; Biofeedback, Psychology; Chronic Dis	2007
Interstitial cystitis/painful bladder syndrome. Urologic nursing, 2007, Volume: 27, Issue:3 Topics: Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; C	2007
[Guideline on polyneuropathy]. Nederlands tijdschrift voor geneeskunde, 2007, Jul-14, Volume: 151, Issue:28 Topics: Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Chronic Disease; Diabetes Complications; Ele	2007
The role of antidepressants in the treatment of affective disorders. American journal of psychotherapy, 1983, Volume: 37, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Chronic Disease; Clinical Trials as Topic; C	1983
A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. Archives of internal medicine, 1996, May-27, Volume: 156, Issue:10 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Doxepin; Fibromyalgia; Humans; Lif	1996
Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. Drugs & aging, 1996, Volume: 8, Issue:6 Topics: Aged; Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Chronic Di	1996
Recurrent abdominal pain and the biopsychosocial model of medical practice. The Journal of pediatrics, 1998, Volume: 133, Issue:4 Topics: Abdominal Pain; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Chronic Di	1998
Medication-induced headache: overview and systematic review of therapeutic approaches. The Annals of pharmacotherapy, 1999, Volume: 33, Issue:1 Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents; Chronic Disease; Ergolines; Headache; Humans; M	1999
[Chronic headaches]. Revue medicale de Bruxelles, 2000, Volume: 21, Issue:4 Topics: Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Craniocerebral Trauma;	2000
Neurogenic pain syndromes and their management. British medical bulletin, 1991, Volume: 47, Issue:3 Topics: Amitriptyline; Chronic Disease; Humans; Nervous System Diseases; Pain; Pain Management; Syndrome	1991
Antidepressants in the management of chronic pain syndromes. Pharmacotherapy, 1990, Volume: 10, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Arthritis; Back Pain; Chronic Disease; Diabetic Neuropathies;	1990
Social implications of recent advances in psychopharmacology. British medical bulletin, 1970, Volume: 26, Issue:3 Topics: Affective Symptoms; Amitriptyline; Chronic Disease; Depression; Electroconvulsive Therapy; Hospitali	1970

Article	Year
Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. JAMA, 2013, Dec-25, Volume: 310, Issue:24 Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Chronic Disease; Cognitive Behav	2013
An open labeled randomized controlled trial of pregabalin versus amitriptyline in chronic low backache. Journal of the neurological sciences, 2014, Jul-15, Volume: 342, Issue:1-2 Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Disability Evalua	2014
Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study. Arquivos de neuro-psiquiatria, 2014, Volume: 72, Issue:11 Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Combined Modality Thera	2014
Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study. Arquivos de neuro-psiquiatria, 2014, Volume: 72, Issue:11 Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Combined Modality Thera	2014
Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study. Arquivos de neuro-psiquiatria, 2014, Volume: 72, Issue:11 Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Combined Modality Thera	2014
Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study. Arquivos de neuro-psiquiatria, 2014, Volume: 72, Issue:11 Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Combined Modality Thera	2014
Gabapentin Superadded to a Pre-Existent Regime Containing Amytriptyline for Chronic Sciatica. Pain medicine (Malden, Mass.), 2016, Volume: 17, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Chronic Disease; Cohort Studies;	2016
Trajectory of Improvement in Children and Adolescents With Chronic Migraine: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial. The journal of pain, 2017, Volume: 18, Issue:6 Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Child; Chronic Disease; Cognitive Behavioral Th	2017
Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial. The Clinical journal of pain, 2017, Volume: 33, Issue:10 Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Child; Chronic Disease; Cognitive Behavioral Th	2017
[Fluvoxamine, amitriptyline and transcranial electrostimulation of the brain in the treatment of chronic daily headache]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2008, Volume: 108, Issue:6 Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Chronic Disease; Electric Stimulation Therapy; F	2008
Low-dose amitriptyline for treatment of persistent arm pain due to repetitive use. Pain, 2010, Volume: 149, Issue:1 Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Arm; Arthralgia; Chronic Disease; Cumulative Trauma	2010
Botulinum toxin type A versus amitriptyline for the treatment of chronic daily migraine. Clinical neurology and neurosurgery, 2010, Volume: 112, Issue:6 Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Botulinum Toxins, Type A; Chroni	2010
Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders. Cranio : the journal of craniomandibular practice, 2003, Volume: 21, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Double-Blind Method; Facial Pain;	2003
Treating chronic tension-type headache not responding to amitriptyline hydrochloride with paroxetine hydrochloride: a pilot evaluation. Headache, 2003, Volume: 43, Issue:9 Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Double-Blind Me	2003
Analgesic effect of amitriptyline in chronic tension-type headache is not directly related to serotonin reuptake inhibition. Pain, 2004, Volume: 108, Issue:1-2 Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Blood Platelets; Chronic Disease; Citalo	2004
Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients. Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:6 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Attention; Automobile Driving; Chronic Disea	2006
Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. Wiener klinische Wochenschrift, 2005, Volume: 117, Issue:21-22 Topics: Adult; Amines; Amitriptyline; Austria; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Combinatio	2005
Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life. The journal of headache and pain, 2006, Volume: 7, Issue:1 Topics: Adult; Amitriptyline; Analgesics; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Hea	2006
Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. The Laryngoscope, 2006, Volume: 116, Issue:12 Topics: Amitriptyline; Antitussive Agents; Chronic Disease; Codeine; Cough; Drug Combinations; Expectorants;	2006
Efficacy of Interpersonal Psychotherapy plus pharmacotherapy in chronically depressed inpatients. Journal of affective disorders, 2008, Volume: 109, Issue:1-2 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Chronic Disease; Combined Modality Th	2008
Emotional memory and migraine: effects of amitriptyline and sex related difference. Behavioural brain research, 2008, May-16, Volume: 189, Issue:1 Topics: Adult; Affect; Amitriptyline; Analysis of Variance; Antidepressive Agents, Tricyclic; Arousal; Chron	2008
The role of antidepressants in the treatment of affective disorders. American journal of psychotherapy, 1983, Volume: 37, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Chronic Disease; Clinical Trials as Topic; C	1983
A controlled study of amitriptyline in the treatment of chronic pain. Pain, 1982, Volume: 14, Issue:2 Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Pain	1982
Maintenance therapy with amitriptyline: a controlled trial. The American journal of psychiatry, 1980, Volume: 137, Issue:3 Topics: Adult; Amitriptyline; Chronic Disease; Clinical Trials as Topic; Depression; Double-Blind Method; Dr	1980
Chronic tension-type headache: amitriptyline reduces clinical headache-duration and experimental pain sensitivity but does not alter pericranial muscle activity readings. Pain, 1994, Volume: 59, Issue:2 Topics: Adult; Amitriptyline; Chronic Disease; Contingent Negative Variation; Double-Blind Method; Electroen	1994
Efficacy and tolerability of amitriptylinoxide in the treatment of chronic tension-type headache: a multi-centre controlled study. Cephalalgia : an international journal of headache, 1994, Volume: 14, Issue:2 Topics: Adolescent; Adult; Aged; Amitriptyline; Chronic Disease; Depression; Dose-Response Relationship, Dru	1994
Dose-response for analgesic effect of amitriptyline in chronic pain. Anaesthesia, 1993, Volume: 48, Issue:4 Topics: Adult; Aged; Amitriptyline; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; Double-Bl	1993
An evaluation of antidepressants in rheumatic pain conditions. Anesthesia and analgesia, 1996, Volume: 83, Issue:2 Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents, Second-Generation; Antidepressive Agents, T	1996
A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. Journal of neurology, neurosurgery, and psychiatry, 1996, Volume: 61, Issue:3 Topics: Adolescent; Adult; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Citalo	1996
Spinal manipulation vs. amitriptyline for the treatment of chronic tension headache: a randomized clinical trial. Journal of manipulative and physiological therapeutics, 1996, Volume: 19, Issue:4 Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Chronic Disease; Humans; Manipulation, Orthopedic; Pain	1996
Predictors of treatment outcome for major depression in primary care. Psychological medicine, 1997, Volume: 27, Issue:3 Topics: Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents, Tricyclic; Chronic Disease; Cogni	1997
[Treatment chronic pain with amitriptyline. A double-blind dosage study with determination of serum levels]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1997, Oct-10, Volume: 117, Issue:24 Topics: Adult; Aged; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Double-Bl	1997
Amitriptyline treatment of chronic pain in patients with temporomandibular disorders. Journal of oral rehabilitation, 2000, Volume: 27, Issue:10 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depression; Facial Pain; Fe	2000
Amitriptyline treatment in chronic drug-induced headache: a double-blind comparative pilot study. Headache, 2001, Volume: 41, Issue:2 Topics: Adult; Aged; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Chronic Disease; Double-Blind Meth	2001
Management of chronic daily headache utilizing a uniform treatment pathway. Headache, 1999, Volume: 39, Issue:9 Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Dru	1999
Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination: a randomized controlled trial. JAMA, 2001, May-02, Volume: 285, Issue:17 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Behavior Therapy; Chronic Disease; Cognitive	2001
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial. Pain, 2002, Volume: 96, Issue:3 Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged;	2002
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial. Pain, 2002, Volume: 96, Issue:3 Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged;	2002
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial. Pain, 2002, Volume: 96, Issue:3 Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged;	2002
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial. Pain, 2002, Volume: 96, Issue:3 Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged;	2002
Tranquilizers or anti-depressants for chronic schizophrenics: a long term study. The Australian and New Zealand journal of psychiatry, 1975, Volume: 9, Issue:4 Topics: Adult; Amitriptyline; Antipsychotic Agents; Chronic Disease; Clinical Trials as Topic; Drug Therapy,	1975
Psychotropic agents finding analgesic use. JAMA, 1978, Sep-15, Volume: 240, Issue:12 Topics: Amitriptyline; Analgesics; Chronic Disease; Clinical Trials as Topic; Drug Synergism; Fluphenazine;	1978
Treatment of secondary depression in schizophrenia. A double-blind, placebo-controlled trial of amitriptyline added to perphenazine. Archives of general psychiatry, 1979, Volume: 36, Issue:5 Topics: Adolescent; Adult; Aged; Ambulatory Care; Amitriptyline; Blood Pressure; Body Weight; Chronic Diseas	1979
Clinical effectiveness of antidepressants and antipsychotics in chronic benign pain. Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chronic Disease; Double-Blind Method; Hu	1992
A new 5-HT2 antagonist (ritanserin) in the treatment of chronic headache with depression. A double-blind study vs amitriptyline. Headache, 1990, Volume: 30, Issue:7 Topics: Adult; Amitriptyline; Chronic Disease; Depression; Double-Blind Method; Female; Headache; Humans; Ma	1990
Antidepressants for cancer pain and other painful syndromes with deafferentation component: comparison of amitriptyline and trazodone. Italian journal of neurological sciences, 1987, Volume: 8, Issue:6 Topics: Adult; Aged; Amitriptyline; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans;	1987
The analgesic effect of amitriptyline on chronic facial pain. Pain, 1987, Volume: 31, Issue:2 Topics: Adult; Amitriptyline; Analysis of Variance; Chronic Disease; Depression; Dose-Response Relationship,	1987
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:2 Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic;	1986
A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. Arthritis and rheumatism, 1986, Volume: 29, Issue:11 Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Fibromyalgia; Humans;	1986
A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men. The Journal of clinical psychiatry, 1985, Volume: 46, Issue:1 Topics: Adult; Ambulatory Care; Amitriptyline; Chronic Disease; Clinical Trials as Topic; Depressive Disorde	1985
Long-term amitriptyline in chronic depression. The Hillside journal of clinical psychiatry, 1985, Volume: 7, Issue:1 Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method;	1985
Cyclobenzaprine in the treatment of chronic tension headache. The Medical journal of Australia, 1972, Dec-16, Volume: 2, Issue:25 Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Dibenz	1972
The monoamine oxidase inhibitor, phenelzine, in the treatment of depressive -anxiety states. A controlled clinical trial. Archives of general psychiatry, 1973, Volume: 29, Issue:3 Topics: Adult; Amitriptyline; Anxiety; Chlordiazepoxide; Chronic Disease; Clinical Trials as Topic; Depressi	1973
Therapy possibilities for therapy-resistant depressions. Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1974, Volume: 7, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Depression; Desipra	1974
A double-blind trial of amitriptyline/perphenazine, perphenazine and placebo in chronic withdrawn inert schizophrenics. The British journal of psychiatry : the journal of mental science, 1967, Volume: 113, Issue:505 Topics: Adult; Affect; Amitriptyline; Analysis of Variance; Body Weight; Chronic Disease; Clinical Trials as	1967
[Doxepin, a new antidepressant: comparison of effects with amitriptyline]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:10 Topics: Acute Disease; Adjustment Disorders; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Amitri	1969
Evaluation of an amitriptyline-perphenazine combination in chronic schizophrenia. The American journal of psychiatry, 1970, Volume: 127, Issue:6 Topics: Adult; Aged; Amitriptyline; Chronic Disease; Clinical Trials as Topic; Female; Humans; Middle Aged;	1970
Doxepin as adjuvant medication in the treatment of chronic schizophrenic patients: a comparative study. Current therapeutic research, clinical and experimental, 1971, Volume: 13, Issue:1 Topics: Adult; Amitriptyline; Chlordiazepoxide; Chronic Disease; Clinical Trials as Topic; Dibenzoxepins; Fe	1971
Role of antidepressants and neuroleptics in the treatment of depression. Archives of general psychiatry, 1972, Volume: 27, Issue:3 Topics: Adult; Amitriptyline; Chronic Disease; Depression; Female; Humans; Imipramine; Male; Middle Aged; Pi	1972

Article	Year
[Guidelines for the management of chronic cough in adults]. Revue des maladies respiratoires, 2023, Volume: 40, Issue:5 Topics: Adult; Amitriptyline; Chronic Disease; Cough; Gabapentin; Humans; Quality of Life	2023
[Treatment of complex regional pain syndrome with amitriptyline]. Ideggyogyaszati szemle, 2019, Jul-30, Volume: 72, Issue:7-8 Topics: Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Chronic Disease; Complex	2019
Amitriptyline Downregulates Chronic Inflammatory Response to Biomaterial in Mice. Inflammation, 2021, Volume: 44, Issue:2 Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Biocompatible Materials; Biomarkers; Blotting, Wes	2021
Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability. Journal of the American Academy of Dermatology, 2017, Volume: 76, Issue:4 Topics: Aged; Amines; Amitriptyline; Analgesics; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Therapy,	2017
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. Molecular pain, 2017, Volume: 13 Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigen	2017
Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events. Brain research bulletin, 2018, Volume: 137 Topics: Amitriptyline; Animals; Antidepressive Agents; Antioxidants; Brain; Chronic Disease; Depressive Diso	2018
Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2018, Volume: 159, Issue:3 Topics: Adult; Aged; Amitriptyline; Chronic Disease; Cohort Studies; Cough; Dose-Response Relationship, Drug	2018
Amitriptyline for symptomatic treatment of idiopathic chronic laryngeal irritability. The Annals of otology, rhinology, and laryngology, 2013, Volume: 122, Issue:1 Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Ethnicity; Female; Follow-Up	2013
Topical amitriptyline combined with topical ketamine for the management of recalcitrant localized pruritus: a retrospective pilot study. Journal of the American Academy of Dermatology, 2013, Volume: 69, Issue:2 Topics: Administration, Topical; Adult; Aged; Amitriptyline; Chronic Disease; Female; Follow-Up Studies; Hum	2013
Chronic idiopathic nausea of childhood. The Journal of pediatrics, 2014, Volume: 164, Issue:5 Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety; Child; Chronic	2014
A case study in treating chronic comorbid obsessive-compulsive disorder and depression with behavioral activation and pharmacotherapy. Psychotherapy (Chicago, Ill.), 2015, Volume: 52, Issue:2 Topics: Amitriptyline; Antidepressive Agents; Behavior Therapy; Chronic Disease; Clomipramine; Depressive Di	2015
[Unpredictable chronic mild stress effects on antidepressants activities in forced swim test]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2015, Volume: 101, Issue:2 Topics: Adaptation, Psychological; Amitriptyline; Animals; Antidepressive Agents; Chronic Disease; Drug Admi	2015
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide. Journal of pharmacological sciences, 2015, Volume: 129, Issue:4 Topics: Administration, Intravesical; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals;	2015
Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression. Brain research bulletin, 2017, Volume: 128 Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; CA3 Region, Hippocampal; Ch	2017
Unexplained cough in the adult. Otolaryngologic clinics of North America, 2010, Volume: 43, Issue:1 Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Analgesics, Opioid; Angiotensin-Converting Enzym	2010
The efficacy of withdrawal therapy in subjects with chronic daily headache and medication overuse following prophylaxis with topiramate and amitriptyline. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2010, Volume: 31 Suppl 1 Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Fr	2010
Individual (N-of-1) trials can be combined to give population comparative treatment effect estimates: methodologic considerations. Journal of clinical epidemiology, 2010, Volume: 63, Issue:12 Topics: Amitriptyline; Antidepressive Agents; Bayes Theorem; Chronic Disease; Clinical Trials as Topic; Drug	2010
Chronic coccydynia in adolescents. A series of 53 patients. European journal of physical and rehabilitation medicine, 2011, Volume: 47, Issue:2 Topics: Adolescent; Adult; Age Factors; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, N	2011
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2011, Volume: 32, Issue:6 Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexane	2011
[Stereotypical episodes of vomiting for 11 years in a 33-year-old patient]. Der Internist, 2012, Volume: 53, Issue:3 Topics: Adult; Amitriptyline; Antiemetics; Chronic Disease; Humans; Male; Treatment Outcome; Vomiting	2012
[Chronic migraine: not well known but not rare!]. MMW Fortschritte der Medizin, 2011, Mar-24, Volume: 153, Issue:12 Topics: Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Chronic Disease; Femal	2011
Adverse pulmonary vascular effects of high dose tricyclic antidepressants: acute and chronic animal studies. The European respiratory journal, 2002, Volume: 20, Issue:2 Topics: Acute Disease; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cats; Chronic Disease; Dise	2002
Massage therapy and frequency of chronic tension headaches. American journal of public health, 2002, Volume: 92, Issue:10 Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Humans; Incidence; Massage; Pain Measureme	2002
Chronic varicella-zoster virus ganglionitis--a possible cause of postherpetic neuralgia. Journal of neurovirology, 2003, Volume: 9, Issue:3 Topics: 2-Aminopurine; Acyclovir; Amitriptyline; Analgesics, Non-Narcotic; Antibodies, Viral; Antiviral Agen	2003
Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:9 Topics: Acetates; Amines; Amitriptyline; Analgesics; Arm; Carbamazepine; Central Cord Syndrome; Cervical Ver	2003
[TREATMENT OF MENTAL DISORDERS IN DECOMPENSATED COR PULMONALE WITH AMITRIPTYLINE]. Revista espanola de cardiologia, 1964, Volume: 17 Topics: Amitriptyline; Chronic Disease; Drug Therapy; Humans; Hypertension, Pulmonary; Mental Disorders; Pul	1964
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology, 2005, Volume: 48, Issue:2 Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra	2005
Reliability and validity of a self-report FIM (FIM-SR) in persons with amputation or spinal cord injury and chronic pain. American journal of physical medicine & rehabilitation, 2005, Volume: 84, Issue:3 Topics: Adult; Amitriptyline; Amputation, Surgical; Analgesics, Non-Narcotic; Chronic Disease; Disability Ev	2005
Neuropathic pain following multilevel surgery in children with cerebral palsy: a case series and review. Paediatric anaesthesia, 2005, Volume: 15, Issue:5 Topics: Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Cerebral Palsy; Chi	2005
Persistent low back pain. The New England journal of medicine, 2005, Sep-01, Volume: 353, Issue:9 Topics: Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Humans; Low Back Pain; Muscle Relaxants, C	2005
[Abdominal migraine as a cause of chronic recurrent abdominal pain in a 9-years-old girl--case report]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2005, Volume: 19, Issue:110 Topics: Abdominal Pain; Amitriptyline; Analgesics, Non-Narcotic; Child; Chronic Disease; Diagnosis, Differen	2005
Motor cortex stimulation for central pain following a traumatic brain injury. Pain, 2006, Volume: 123, Issue:1-2 Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju	2006
Modification of spatial recognition memory and object discrimination after chronic administration of haloperidol, amitriptyline, sodium valproate or olanzapine in normal and anhedonic rats. The international journal of neuropsychopharmacology, 2007, Volume: 10, Issue:3 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antimanic Agents; Antipsychotic Agents; Be	2007
Sensory neuropathic cough: a common and treatable cause of chronic cough. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2006, Volume: 135, Issue:1 Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amitriptyline; Bronchial Provocation Tests; Bronchoscopy;	2006
[Reproducible efficacy of tricyclic antidepressant on chronic pain in an elderly patient with osteoporosis]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2007, Volume: 44, Issue:2 Topics: Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Back P	2007
Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. Pain research & management, 2007,Autumn, Volume: 12, Issue:3 Topics: Amitriptyline; Analgesics; Anti-Ulcer Agents; Anticoagulants; Antidepressive Agents; Anxiety; Cardio	2007
Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression. Biological psychiatry, 2008, Feb-15, Volume: 63, Issue:4 Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Chronic Disease;	2008
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice. European journal of pain (London, England), 2008, Volume: 12, Issue:8 Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di	2008
Chronic mood disorders in depressed outpatient--diagnosis and response to pharmacotherapy. Journal of affective disorders, 1980, Volume: 2, Issue:2 Topics: Adolescent; Adult; Affective Symptoms; Amitriptyline; Chronic Disease; Cyclothymic Disorder; Depress	1980
Chronic pain and the risks of psychotropics. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1984, Volume: 136, Issue:5 Topics: Amitriptyline; Chronic Disease; Female; Fluphenazine; Heart Failure; Humans; Meperidine; Middle Aged	1984
Tricyclic antidepressants in chronic pain. Pain, 1984, Volume: 18, Issue:2 Topics: Adult; Aged; Amitriptyline; Chronic Disease; Female; Humans; Male; Middle Aged; Pain; Pilot Projects	1984
Chronic depression: response to amitriptyline after discontinuation. Biological psychiatry, 1982, Volume: 17, Issue:8 Topics: Amitriptyline; Chronic Disease; Depressive Disorder; Double-Blind Method; Female; Humans; Long-Term	1982
The EEG in chronic psychotropic drug intoxications. Clinical EEG (electroencephalography), 1982, Volume: 13, Issue:4 Topics: Adult; Aged; Amitriptyline; Chlorpromazine; Chlorprothixene; Chronic Disease; Drug Therapy, Combinat	1982
The course of nonbipolar, primary major depression. A prospective 16-month study of ambulatory patients. The Journal of nervous and mental disease, 1980, Volume: 168, Issue:7 Topics: Adolescent; Adult; Aged; Amitriptyline; Chronic Disease; Depression; Female; Humans; Male; Middle Ag	1980
Biochemical and behaviour changes induced by acute stress in a chronic variate stress model of depression: the effect of amitriptyline. European journal of pharmacology, 1995, Jun-23, Volume: 280, Issue:1 Topics: Amitriptyline; Animals; Behavior, Animal; Chronic Disease; Depression; Disease Models, Animal; Male;	1995
A 3-year follow-up of a group of treatment-resistant depressed patients with a MAOI/tricyclic combination. Journal of affective disorders, 1995, Jun-08, Volume: 34, Issue:3 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depressiv	1995
Diagnosis and treatment of persistent pain after trauma to the head and neck. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1994, Volume: 52, Issue:11 Topics: Adult; Amitriptyline; Carbamazepine; Chronic Disease; Craniocerebral Trauma; Facial Pain; Female; He	1994
Pain medication. The Journal of family practice, 1994, Volume: 39, Issue:1 Topics: Amitriptyline; Chronic Disease; Humans; Pain	1994
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of clinical epidemiology, 1997, Volume: 50, Issue:4 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bayes Theorem; Chronic Disease; Cross-Over Studies;	1997
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of clinical epidemiology, 1997, Volume: 50, Issue:4 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bayes Theorem; Chronic Disease; Cross-Over Studies;	1997
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of clinical epidemiology, 1997, Volume: 50, Issue:4 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bayes Theorem; Chronic Disease; Cross-Over Studies;	1997
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. Journal of clinical epidemiology, 1997, Volume: 50, Issue:4 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bayes Theorem; Chronic Disease; Cross-Over Studies;	1997
Dyspnea resulting from fibromyalgia. Chest, 1998, Volume: 113, Issue:1 Topics: Adrenergic Uptake Inhibitors; Aged; Amitriptyline; Bronchoscopy; Chest Pain; Chronic Disease; Dyspne	1998
Atypical odontalgia--a nondental toothache. Journal of the New Jersey Dental Association, 1995,Winter, Volume: 66, Issue:1 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Autonomic Nerve Block; Chronic Disease; Diag	1995
Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications. Headache, 1998, Volume: 38, Issue:6 Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics; Chronic Disease; Humans; Recurrence; Tensio	1998
[Primary chronic daily headache: a report on 52 cases]. Arquivos de neuro-psiquiatria, 1998, Volume: 56, Issue:1 Topics: Adolescent; Adult; Aged; Amitriptyline; Chronic Disease; Drug Administration Schedule; Female; Follo	1998
Use of transdermal amitriptyline gel in a patient with chronic pain and depression. Pharmacotherapy, 1999, Volume: 19, Issue:2 Topics: Administration, Cutaneous; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease;	1999
Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen. Arzneimittel-Forschung, 1999, Volume: 49, Issue:10 Topics: Acetylcholine; Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic A	1999
Acute on chronic intestinal pseudoobstruction responds to neostigmine. Digestive diseases and sciences, 2000, Volume: 45, Issue:8 Topics: Acute Disease; Adult; Amitriptyline; Cholinergic Antagonists; Cholinesterase Inhibitors; Chronic Dis	2000
Withdrawal therapy improves chronic daily headache associated with long-term misuse of headache medication: a retrospective study. Cephalalgia : an international journal of headache, 2000, Volume: 20, Issue:7 Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Drug-Related Side	2000
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond. The Clinical journal of pain, 2001, Volume: 17, Issue:1 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Drug Therapy, Combination;	2001
[Gabapentin in the treatment of chronic intractable pain]. Schmerz (Berlin, Germany), 2002, Volume: 16, Issue:1 Topics: Acetates; Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non	2002
Elevated blood serotonin concentrations in unmediated chronic schizophrenic patients: a preliminary study. The American journal of psychiatry, 1975, Volume: 132, Issue:2 Topics: Adolescent; Adult; Amitriptyline; Antipsychotic Agents; Benztropine; Blood Cell Count; Blood Platele	1975
The use of phenothiazines and tricyclic antidepressants in the treatment of intractable pain. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Feb-19, Volume: 51, Issue:8 Topics: Adult; Aged; Amitriptyline; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle	1977
Drug use and distribution in a pain rehabilitation center. American journal of hospital pharmacy, 1975, Volume: 32, Issue:3 Topics: Adult; Amitriptyline; Barbiturates; Chronic Disease; Diet; Female; Formularies, Hospital as Topic; H	1975
Letter: Drug use in a pain rehabilitation center. American journal of hospital pharmacy, 1975, Volume: 32, Issue:11 Topics: Amitriptyline; Chronic Disease; Drug Combinations; Humans; Methadone; Pain; Phenytoin; Snake Venoms	1975
Postherpes simplex type 1 neuralgia simulating postherpetic neuralgia. Journal of pain and symptom management, 1992, Volume: 7, Issue:5 Topics: Amitriptyline; Chronic Disease; Diagnosis, Differential; Female; Herpes Simplex; Herpes Zoster; Huma	1992
Chronic facial pain together with severe depression is responsive to electroconvulsive therapy. A case report. Acta odontologica Scandinavica, 1992, Volume: 50, Issue:3 Topics: Amitriptyline; Chronic Disease; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Facial P	1992
Post-traumatic migraine: chronic migraine precipitated by minor head or neck trauma. Headache, 1991, Volume: 31, Issue:7 Topics: Adolescent; Adult; Amitriptyline; Chronic Disease; Craniocerebral Trauma; Female; Humans; Male; Midd	1991
N of 1 randomized trials for investigating new drugs. Controlled clinical trials, 1990, Volume: 11, Issue:2 Topics: Amitriptyline; Chronic Disease; Drug Administration Schedule; Drug Evaluation; Drugs, Investigationa	1990
Chronic depression. Issues in long-term management. Postgraduate medicine, 1989, Feb-01, Volume: 85, Issue:2 Topics: Aged; Amitriptyline; Chronic Disease; Depressive Disorder; Humans; Long-Term Care; Male; Quality of	1989
The effectiveness of physical therapy in the treatment of chronic daily headaches. Headache, 1989, Volume: 29, Issue:3 Topics: Adult; Aged; Amitriptyline; Biofeedback, Psychology; Chronic Disease; Combined Modality Therapy; Ele	1989
Muscle contraction headache: dexamethasone suppression test and response to amitriptyline. European neurology, 1989, Volume: 29, Issue:5 Topics: Adult; Aged; Amitriptyline; Chronic Disease; Dexamethasone; Female; Headache; Humans; Hydrocortisone	1989
Selected tricyclic antidepressants in the management of chronic benign pain. Southern medical journal, 1988, Volume: 81, Issue:5 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Doxepin; Huma	1988
Therapeutic drug monitoring of amitriptyline: impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women. Clinica chimica acta; international journal of clinical chemistry, 1987, Jun-15, Volume: 165, Issue:2-3 Topics: Adolescent; Adult; Aging; Amitriptyline; Bulimia; Chronic Disease; Contraceptives, Oral, Hormonal; D	1987
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. Archives of general psychiatry, 1987, Volume: 44, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Di	1987
Tolerance to therapeutic effects of antidepressants. The American journal of psychiatry, 1985, Volume: 142, Issue:4 Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Disorder; Desipramine	1985
Serum cortisol in chronic schizophrenia. Changes in the response to intravenously administered insulin and ACTH on withdrawal of drugs. Acta psychiatrica Scandinavica, 1971, Volume: 47, Issue:2 Topics: Adrenocorticotropic Hormone; Aged; Amitriptyline; Blood Glucose; Chronic Disease; Female; Haloperido	1971
Serum cortisol in chronic schizophrenia. A study of the adrenocortical response to intravenously administered insulin and ACTH. Acta psychiatrica Scandinavica, 1971, Volume: 47, Issue:1 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Age Factors; Aged; Amitriptyline; Blood Glucose; Chlorp	1971
[The possibilities and limitations of psychotropic drug therapy for patients with glaucoma]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:9 Topics: Aged; Alcoholism; Amitriptyline; Antidepressive Agents; Bipolar Disorder; Chronic Disease; Dementia;	1974
Letter: Painful shoulder syndrome. Canadian Medical Association journal, 1974, Oct-19, Volume: 111, Issue:8 Topics: Amitriptyline; Bursitis; Chronic Disease; Depression; Humans; Lithium; Pain; Shoulder; Tendinopathy	1974
[Some characteristics of the peripheral microcirculation and capillary permeability in schizophrenia]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:3 Topics: Adult; Amitriptyline; Capillary Permeability; Chronic Disease; Drug Therapy, Combination; Female; Hu	1974
Drug treatment of chronic intractable pain in patients referred to a psychiatry clinic. Journal of the Indian Medical Association, 1971, Jun-01, Volume: 56, Issue:11 Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Chlordiazepoxide; Chronic Disease; Depression; Fema	1971
Serum cortisol in chronic schizophrenia. Changes in the diurnal rhythm and psychiatric mental status on withdrawal of drugs. Psychiatria clinica, 1971, Volume: 4, Issue:4 Topics: Aged; Amitriptyline; Chronic Disease; Circadian Rhythm; Cognition; Female; Haloperidol; Humans; Hydr	1971
[Saroten retard and its therapeutic possibilities in chronic schizophrenic psychoses. Results of clinical-experimental tests]. Der Nervenarzt, 1971, Volume: 42, Issue:12 Topics: Adult; Amitriptyline; Body Weight; Cardiovascular Diseases; Chronic Disease; Delayed-Action Preparat	1971
Disproportionately severe breathlessness in chronic bronchitis. The Quarterly journal of medicine, 1969, Volume: 38, Issue:151 Topics: Adult; Aged; Amitriptyline; Anxiety Disorders; Bronchitis; Chronic Disease; Depression; Female; Huma	1969
Some reflections on the etiologic role of depression in head pain. Headache, 1968, Volume: 8, Issue:1 Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Depression; Facial Neuralgia; Headache; Human	1968

amitriptyline and Chronic Illness