amitriptyline has been researched along with Cholestasis in 6 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a patient in whom amitriptyline administration for 5 wk was followed by prolonged cholestasis." | 7.67 | Amitriptyline-induced prolonged cholestasis. ( Amouyal, G; Benhamou, JP; Danne, O; Degott, C; Feldmann, G; Larrey, D; Machayekhi, JP; Pessayre, D, 1988) |
| "Eosinophilia and jaundice occured in a depressed patient treated with amitriptyline, an association which is previously unreported." | 7.66 | Jaundice and eosinophilia associated with amitriptyline. ( Anderson, BN; Henrikson, IR, 1978) |
| "We report the case of a patient in whom amitriptyline administration for 5 wk was followed by prolonged cholestasis." | 3.67 | Amitriptyline-induced prolonged cholestasis. ( Amouyal, G; Benhamou, JP; Danne, O; Degott, C; Feldmann, G; Larrey, D; Machayekhi, JP; Pessayre, D, 1988) |
| "Eosinophilia and jaundice occured in a depressed patient treated with amitriptyline, an association which is previously unreported." | 3.66 | Jaundice and eosinophilia associated with amitriptyline. ( Anderson, BN; Henrikson, IR, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Biagi, RW | 1 |
| Bapat, BN | 1 |
| Anderson, BN | 1 |
| Henrikson, IR | 1 |
| Larrey, D | 1 |
| Amouyal, G | 1 |
| Pessayre, D | 1 |
| Degott, C | 1 |
| Danne, O | 1 |
| Machayekhi, JP | 1 |
| Feldmann, G | 1 |
| Benhamou, JP | 1 |
| Clarke, AE | 2 |
| Maritz, VM | 2 |
| Denborough, MA | 2 |
| Lajeunesse, BS | 1 |
6 other studies available for amitriptyline and Cholestasis
| Article | Year |
|---|---|
Intrahepatic obstructive jaundice from amitriptyline.
Topics: Amitriptyline; Chemical and Drug Induced Liver Injury; Cholestasis; Depression; Female; Humans | 1967 |
Jaundice and eosinophilia associated with amitriptyline.
Topics: Amitriptyline; Cholestasis; Depression; Eosinophilia; Female; Humans; Jaundice; Middle Aged | 1978 |
Amitriptyline-induced prolonged cholestasis.
Topics: Adult; Amitriptyline; Biopsy; Cholestasis; Depression; Humans; Liver; Male; Time Factors | 1988 |
Phenothiazines and jaundice.
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Bile; Centrifugation, Density Gradient; | 1972 |
[True and false adverse effects of thymoanaleptic medications].
Topics: Amitriptyline; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressio | 1968 |
Interaction of tricyclic drugs and human bile.
Topics: Amitriptyline; Bile Acids and Salts; Chemical Precipitation; Chlorpromazine; Cholestasis; Drug Inter | 1972 |