amitriptyline has been researched along with Central Nervous System Diseases in 7 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a case of tricyclic antidepressant poisoning where significant clinical toxicity (QRS prolongation, metabolic acidosis) was observed for up to 4 days following ingestion of a modified-release preparation of amitriptyline." | 7.73 | Prolonged clinical effects in modified-release amitriptyline poisoning. ( Dargan, P; Greene, S; Jones, A; O'Connor, N; Wyncoll, D, 2006) |
| "We describe a case of tricyclic antidepressant poisoning where significant clinical toxicity (QRS prolongation, metabolic acidosis) was observed for up to 4 days following ingestion of a modified-release preparation of amitriptyline." | 3.73 | Prolonged clinical effects in modified-release amitriptyline poisoning. ( Dargan, P; Greene, S; Jones, A; O'Connor, N; Wyncoll, D, 2006) |
| "Acute anticholinergic delirium has been reported to occur following ingestion of antidepressants, neuroleptics and antiparkinsonian drugs in toxic and therapeutic doses." | 1.27 | Chronic central anticholinergic toxicity in manic depressive illness mimicking dementia. ( Banno, V; Jones, BD; Moreau, A, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Connor, N | 1 |
| Greene, S | 1 |
| Dargan, P | 1 |
| Wyncoll, D | 1 |
| Jones, A | 1 |
| Small, JG | 1 |
| Small, IF | 1 |
| Rollin, P | 1 |
| Antaki, AJ | 1 |
| O'Brien, JP | 1 |
| Moreau, A | 1 |
| Jones, BD | 1 |
| Banno, V | 1 |
| Boleloucky-Bolen, P | 1 |
| Hofmann, G | 1 |
| Allert, ML | 1 |
1 review available for amitriptyline and Central Nervous System Diseases
| Article | Year |
|---|---|
[Poisoning due to tricyclic antidepressants in children and adolescents].
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Cardiovascular Diseases; Central Nervou | 1979 |
6 other studies available for amitriptyline and Central Nervous System Diseases
| Article | Year |
|---|---|
Prolonged clinical effects in modified-release amitriptyline poisoning.
Topics: Acidosis; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Central Nerv | 2006 |
EEG spikes in non-epileptic psychiatric patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antisocial Personality Disorder; Barbiturates; Brain; Brain | 1967 |
A study of low-dose amitriptyline overdoses.
Topics: Adolescent; Adult; Amitriptyline; Central Nervous System Diseases; Female; Humans; Male; Middle Aged | 1977 |
Chronic central anticholinergic toxicity in manic depressive illness mimicking dementia.
Topics: Aged; Amitriptyline; Benztropine; Bipolar Disorder; Central Nervous System Diseases; Dementia; Diagn | 1986 |
[Delirious syndrome in connection with treatment and overdosis (SMV) amitriptyline].
Topics: Adult; Age Factors; Aged; Alcoholism; Amitriptyline; Central Nervous System Diseases; Delirium; Fema | 1968 |
[nil nocere; side-effects, complications and dangers of psychopharmaceutical drug therapy].
Topics: Amitriptyline; Antidepressive Agents; Butyrophenones; Central Nervous System Diseases; Imipramine; M | 1965 |